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Combination intraoral radiation mouthguard-positioning stent
Zain Uddin Ahmed, Joseph D Randazzo, Joseph M Huryn, Evan B RosenJournal of Cancer Research and Therapeutics 2022 18(4):1162-1164 The sequelae of head-and-neck radiation may include hyposalivation, dysgeusia, trismus, mucositis, and osteoradionecrosis. A mouthguard used during radiation therapy can mitigate the effects of backscatter radiation from dental restorations. In addition, an intraoral positioning stent can assist in repositioning oral structures, such as the tongue, away from the field of radiation during treatment, thereby limiting dose delivery. The purpose of this article is to provide a technique to fabricat...
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Zain Uddin Ahmed Joseph D Randazzo Joseph M Huryn Evan B Rosen Source Type: research

Validation of a simple technique for accurate treatment delivery for bilateral breast irradiation using the electronic portal imaging device
Conclusion: The study has validated a simple EPID-based technique for routine use in the field matching for radiotherapy of bilateral breast cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Debojoyti Dhar Suman Mallik Jyotirup Goswami Source Type: research

Inter-fractional entrance dose monitoring as quality assurance using Gafchromic EBT3 film
Conclusions: The methodology described in this study, based on Gafchromic EBT3 film, can be utilized for inter-fractional entrance dose monitoring as quality assurance during RT. Clinical application of this method to patients can verify the accuracy of beam delivery in the treatment room. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Sun Young Moon Yunhui Jo Jaehyeon Seo Dongho Shin Myonggeun Yoon Source Type: research

Calcitriol potentially alters HeLa cell viability via inhibition of autophagy
Conclusion: We suggest that Calcitriol may shut down mitochondrial homeostasis in HeLa cells by inducing the PI3K-AKT-mTOR pathway and inhibiting autophagy, which leads to cell death. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Iwan Setiawan Ronny Lesmana Hanna Goenawan Dodi Suardi Vesara Ardhe Gatera Rizky Abdulah Raden Tina Dewi Judistiani Unang Supratman Budi Setiabudiawan Source Type: research

Extranodal natural-killer/T-cell lymphoma, nasal type: An immunomorphological study from a regional cancer institute in India
Conclusion: ENKTL is an aggressive NHL and should be differentiated from other T- and B-cell lymphomas as the prognosis and therapy differ. Nasal biopsies showing predominant necrosis and atypical lymphoid cells with angiocentricity must raise the suspicion of ENKTL and should be confirmed by immunomorphological and molecular studies. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Mohit Agrawal G Champaka Usha Amirtham Linu Abraham Jacob CS Premalata Source Type: research

Immunohistochemical subtyping of diffuse large B-cell lymphoma into germinal center B-cell and activated B-cell subtype, along with correlation of the subtypes with extranodal involvement, serum lactate dehydrogenase, and positron emission tomography scan-based response assessment to chemotherapy
Conclusions: The mean baseline level of LDH is significantly higher in ABC subtype. The proportion of cases with extranodal involvement was comparatively higher in ABC and shows poor response to chemotherapy as compared to GCB. Baseline LDH level was found to be important prognostic marker in the DLBCL. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Aarti Tyagi Andleeb Abrari Anuj Khurana Shantanu Tyagi Source Type: research

Effect of TENS and stabilization exercises on pelvic pain in pelvic cancer survivors following multimodal treatment: A clinical trial
Conclusion: The trial suggests that a combination of pelvic stabilization exercises and conventional TENS may be used as a strategic tool to reduce pain and improve PFM strength after multimodal treatments in pelvic cancer survivors in the clinical setup of an Indian Scenario. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Oshin Diana Mathias Renu B Pattanshetty Source Type: research

Cancer resilience in parents of children with cancer; the role of general health and self-efficacy on resiliency
Conclusion: Cancer resilience in families of children with cancer is significantly associated with higher social support, more self-efficacy, and better general health. Interventional programs aimed at increasing family resilience and reducing stress by increasing the social support and self-efficacy in patients' families are helpful and necessary. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Narges Mohammadsalehi Azadeh Asgarian Marzieh Ghasemi Abolfazl Mohammadbeigi Source Type: research

The relationship between adjuvant chemotherapy and thiol-disulfide compounds
In this study, we aimed to evaluate the possible changes of thiol/disulfide levels with the recurrent CT cycles and type of cancer. Materials and Methods: The 40 healthy individuals and 40 patients who had been newly diagnosed with early-stage breast, ovary and endometrium cancer receiving adjuvant CT. Blood samples were taken from all patients three times as basal and after the first and second CT sessions. Results: We compared preadjuvant treatment levels of thiol and disulfide parameters in the patients group with the control group. The median of native thiol and total thiol was found to be higher in the control group...
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: P & #305;nar Akyol Didem & #350;ener Dede Burak Bilgin Arife Ula & #351; Mehmet Ali Nahit & #350;endur Muhammed B & #252;lent Ak & #305;nc & #305; Salih Ba & #351;er Cihan Erol Mutlu H & #305;zal B & #252;lent Yal & #231; & #305;n Source Type: research

A mathematical model to predict the different isodose volumes using TRAK value in HDR intracavitary brachytherapy for revised Manchester and ICRU-89 based Point A plans using computer tomography images
Conclusions: The developed formula calculated isodose volumes within the accuracy of ± 3% in ICBT plans. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Ankur Mourya Sunil Choudhary Neeraj Sharma Uday Pratap Shahi Gaganpreet Singh Satyajit Pradhan Lalit Mohan Aggarwal Source Type: research

Development of in-house heterogeneous thorax phantom and evaluation of pretreatment patient-specific transit dosimetry for intensity-modulated radiotherapy and volumetric modulated arc therapy plans
Conclusions: In-house developed HTP is a cost-effective phantom which resembles with that of the human thorax in terms of its radiological properties. Moreover, it can be a better QA medium for pretreatment plan verification of the actual patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Priyusha Bagdare Source Type: research

Hepatosplenic T-cell lymphoma diagnosed using flow cytometry. A single-center study of 12 cases from North India
Conclusion: The incidence of leukocytosis and a blastoid morphology is quite frequent in HSTCL. Hence, a differential diagnosis of HSTCL should always be considered in young patients presenting with splenomegaly and exhibiting atypical lymphoid/blastoid cells in the PB or a marrow. An FCI can readily diagnose and differentiate them from an acute lymphoblastic leukemia/lymphoma. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Khaliqur Rahman Tanvi Gupta Ruchi Gupta Lakshita Singh Dinesh Chandra Manoj Kumar Sarkar Manish Kumar Singh Sanjeev Kumar Soniya Nityanand Source Type: research

Use of methylene blue dye for sentinel lymph node mapping in early-stage gynecological cancers & #8211; An option for low resource settings
Conclusions: Methylene blue is an efficient, feasible, and safe dye for SLN mapping in early-stage gynecological cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Nisha Singh Shuchi Agrawal Source Type: research

Clinical impact of extended field radiation therapy in Stage III carcinoma cervix versus conventional field techniques: A comparative study
Conclusion: Majority of patients achieved CR with minimal acute and late toxicities with similar results in both arms. No patient had pelvic or para-aortic metastasis until recent follow-up. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Prateek Daga HS Kumar Neeti Sharma Shankar Lal Jakhar Kamlesh Kumar Harsh Saroj Dhaka Source Type: research

Expression of epithelial & #8211;mesenchymal transition biomarkers: Discoidin domain receptor 2, Snail-1, and Ovol-2 as predictors of clinical outcome in patients with epithelial ovarian carcinoma
Conclusion: DDR-2 and Snail-1 are markers of poor prognosis in EOC while Ovol-2 is a marker of good prognosis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Ola A Harb Mariem A Elfeky Wafaa El-Beshbishi Ahmed A Obaya Wael M Abdallah Amr Ibrahim Amr A Awd Ahmed Embaby Source Type: research