Two subsequent metachronous diseases: Granuloma annulare and colon adenocarcinoma
Hatice Ataş, Fatma Aksoy Khurami, Müzeyyen Gönül, Murat AlperJournal of Cancer Research and Therapeutics 2018 14(12):1247-1248 (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Hatice Ata & #351; Fatma Aksoy Khurami M & #252;zeyyen G & #246;n & #252;l Murat Alper Source Type: research

Severe hypercalcemia: A rare and unusual presentation of acute lymphoblastic leukemia
Swaminathan Dhivyasree, Jeevarathnam Dhivyalakshmi, Shuba Sankaranarayanan, Julius Xavier ScottJournal of Cancer Research and Therapeutics 2018 14(12):1244-1246 Hypercalcemia is a rare and unusual complication of childhood malignancies. Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and lytic bone lesions is very rare in children. Here, we report a case of a 4-year-old girl with ALL who presented with severe hypercalcemia and radiological evidence of osteolytic lesions. Malignancies are the most common parathyroid hormone-independent cause of hypercalcemia. Severe hypercalcemia is a life-threatening emer...
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Swaminathan Dhivyasree Jeevarathnam Dhivyalakshmi Shuba Sankaranarayanan Julius Xavier Scott Source Type: research

Paratesticular rhabdomyosarcoma mimicking complicated epididymal cyst
We report a 16-year-old boy with a paratesticular RMS mimicking epididymal cyst. To our knowledge, this is the first case reported in the literature presenting as an epididymal cyst. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Mete Kilciler Mustafa Kadihasanoglu Ozcan Atahan Source Type: research

Ultrasonographic diagnosis of benign masseter muscle hypertrophy: A case report
This article reports two cases of bilateral masseter hypertrophy having characteristic diagnostic features, along with specialized imaging modalities and review of literature. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Vihag Vinod Naphade Sameer G Kedia Pallavi Patil Siddhant Khare Source Type: research

Treatment strategy for huge hepatocellular carcinoma with intrahepatic metastasis and macrovascular invasion: a case report and literature review
Chuanchao He, Zhenyu Zhou, Zhiyu Xiao, Jie WangJournal of Cancer Research and Therapeutics 2018 14(12):1233-1236 Macrovascular invasion, such as tumor thrombus in the major portal vein (mPVTT) or major hepatic vein (mHVTT), is regarded as indicative of an advanced stage of hepatocellular carcinoma (HCC). To date, no effective treatment has been established for this kind of HCC. We herein present a case of huge HCC with intrahepatic metastasis, mPVTT, and mHVTT. The patient was successfully treated with surgical resection-based multidisciplinary treatment. The clinical presentation, treatment strategy, and outcome of this ...
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Chuanchao He Zhenyu Zhou Zhiyu Xiao Jie Wang Source Type: research

Gastric metastasis of recurrent hepatocellular carcinoma: A case report and literature review
Long Peng, Kehan Yu, Yong Li, Weidong XiaoJournal of Cancer Research and Therapeutics 2018 14(12):1230-1232 Hepatocellular carcinoma (HCC) with gastric metastasis is seldom reported. It is extremely easy to misdiagnose for primary gastric cancer with liver metastasis, especially gastric hepatoid adenocarcinoma. Here, we report a case of recurrent HCC with gastric metastasis in a 22-year-old man. He had a history of left side hepatic tumor local resection due to ruptured HCC 10 years ago. Computed tomography revealed tumors in the right liver and stomach. Endoscopy identified a massive protrusion-like malignant stromal tum...
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Long Peng Kehan Yu Yong Li Weidong Xiao Source Type: research

Fatal interstitial lung disease associated with AZD9291
Sheng-ming Deng, Jian-an Huang, Yan-bin ChenJournal of Cancer Research and Therapeutics 2018 14(12):1227-1229 AZD9291 is one of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) for non-small cell lung cancer (NSCLC). Interstitial lung disease (ILD) induced by AZD9291 is very seldom. We provide a case of NSCLC treated with AZD9291 who developed ILD and died in order to improve the knowledge on AZD9291. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Sheng-ming Deng Jian-an Huang Yan-bin Chen Source Type: research

Symptomatic treatment of brain metastases in renal cell carcinoma with sorafenib
Dongyan Hu, Yu Hu, Jisheng Li, Xiuwen WangJournal of Cancer Research and Therapeutics 2018 14(12):1223-1226 Brain metastasis is synchronous to the diagnosis of renal cell carcinoma (RCC). The prognosis of brain metastasis in RCC with the current treatment options is dismissal. Therefore, we present a case of an elderly female patient with RCC showing a partial response of brain metastasis after 18 months of 600 mg once daily sorafenib treatment who underwent right-sided nephrectomy. Further, withdrawal of sorafenib resulted in psychiatric changes along with increased metastasis lesions, which were recovered upon resuming ...
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Dongyan Hu Yu Hu Jisheng Li Xiuwen Wang Source Type: research

Multiple intercostal neurilemmomas in a Chinese woman
Wen-Kui Sun, Wen Yang, Chen-Hui Ma, Xin-Wu Xiao, Yi Shi, Yong SongJournal of Cancer Research and Therapeutics 2018 14(12):1220-1222 Neurilemmomas are rare tumors of neural crest cell origin that occur most commonly in the head and neck region. Intercostal neurilemmomas are extremely rare and are mostly seen as solitary tumors in the posterior mediastinum. Only one case report of multiple intercostal neurilemmomas has been documented previously. In this article, we report a case of multiple intercostal neurilemmomas in a 54-year-old woman who had initially presented with progressive dull left chest pain over a 1-year perio...
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Wen-Kui Sun Wen Yang Chen-Hui Ma Xin-Wu Xiao Yi Shi Yong Song Source Type: research

Malignant solitary fibrous tumor of the kidney with liver metastasis: A case report and literature review
We report a case of SFT with liver metastasis in an adult female and discuss the pathological features as it appears in our case. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Ning Zhang Dongxiao Zhou Kai Chen Hongyan Zhang Bingcang Huang Source Type: research

Cutaneous metastasis in prostate cancer: Two cases with similar clinical findings
Ayşe Kavak, Murat Yılmaz, Haydar Kamil Çam, Volkan Tuğcu, Hülya Albayrak, Damlanur Sakız, Ümran YıldırımJournal of Cancer Research and Therapeutics 2018 14(12):1213-1216 Cutaneous metastasis of prostate cancer is rare. Lesions in this type of skin metastasis are usually seen as suprapubic nodules. Here, we presented two cases with skin metastases of prostate cancer characterized by grouped cutaneous and subcutaneous nodules. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Ay & #351;e Kavak Murat Y & #305;lmaz Haydar Kamil & #199;am Volkan Tu & #287;cu H & #252;lya Albayrak Damlanur Sak & #305;z & #220;mran Y & #305;ld & #305;r & #305;m Source Type: research

Uterine tumors resembling ovarian sex-cord tumor: A case report and literature review
This article is to summarize clinical and pathological features, diagnosis and differential diagnosis, treatment, and prognosis of UTROSCT. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Li-li Fan Yang Shen Kenneth Chanda Mu-Lan Ren Source Type: research

The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma
Conclusions: This study suggests that TTF-1 is not a favorable prognostic factor in lung adenocarcinoma patients. The prognostic role of CK7 and relationship between TFF-1 expression in lung adenocarcinoma and predictive role of TTF-1 expression for the selection of first-line treatment in Stage IV lung adenocarcinoma should be validated in prospective and randomized studies. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Esin Oktay Utku Oflazoglu Yelda Varol Ozgur Tanriverdi Necla Mermur Hayri Ustun Arda Lutfiye Demir Ozge Keskin Tural Ahmadli Isil Somali Ilhan Oztop Nezih Meydan Source Type: research

Combinatorial effect of curcumin and tumor necrosis factor- & #945;-related apoptosis-inducing ligand (TRAIL) in induction of apoptosis via inhibition of nuclear factor kappa activity and enhancement of caspase-3 activity in chronic myeloid cells: An In-vitro study
Conclusion: Our results conclude that curcumin and TRAIL effectively induce the apoptosis through the inhibition of NFkB activity and by enhancing the caspase-3 activity. Thus, curcumin may prove as a potent inhibitor of NFkB by representing its role in cancer pathogenesis, especially in chronic myeloid leukemia cells. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Bushra Iqbal Archna Ghildiyal Shraddha Singh Sahabjada Siddiqui Pratibha Kumari M Arshad AA Mahdi Source Type: research

Expression of programmed death ligand-1 and programmed death 1 in hepatocellular carcinoma and its clinical significance
Conclusion: PD-L1 and PD-1 are overexpressed in HCC tissues. PD-L1 expression plays a critical role in the pathogenesis of human HCC, suggesting that it might be used as a new biomarker to predict the disease progression and prognosis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: J Long Tao Qu XF Pan X Tang HH Wan P Qiu Yan-Hua Xu Source Type: research

Influence of pharmorubicin on the left ventricular ejection fraction of patients with breast cancer: A mechanism study
Conclusions: Pharmorubicin treatment decreased EF and FS of patients with breast cancer through increasing oxygen free radical level in hemocytes. Adjunctive therapy of NAC could be a potential treatment to ameliorated side effect pharmorubicin treatment. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Hu Liu Ming-rui Xie Hui Gao Jian Li Source Type: research

Association of X-ray cross-complementing group 3 Thr241Met gene polymorphism with osteosarcoma risk and its development and prognosis
Conclusion: XRCC3 Thr241Met gene polymorphism was associated with osteosarcoma risk, but XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Yanwei Wang Guanliang Wang Zhiyong Dong Source Type: research

Meta-analysis on the association between xeroderma pigmentosum Group A A23G polymorphism and esophageal cancer in a Chinese population
Conclusions: This meta-analysis suggested that XPA A23G gene polymorphism may be one low-penetrant risk factor for esophageal cancer in Chinese individuals. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Jiang-Lan Xu Jing Bai Jian-Feng Jiao Li Ding Li Lei Xiao-Ping Bai Yu-Feng Cheng Source Type: research

Laminin is over expressed in breast cancer and facilitate cancer cell metastasis
Conclusion: This results revealed laminin is involved in breast cancer invasion and metastasis, and we can use this to determine whether the integrity of a basement membrane for differential diagnosis of benign and malignant breast tumors. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Xia Qiu Haosheng Tan Deyuan Fu Yuxiang Zhu Jiaxin Zhang Source Type: research

Concurrent computed tomography-guided radioactive iodine-125 seeds percutaneous interstitial implantation and chemotherapy for treatment of cervical lymph node metastases
Conclusion: Concurrent CT-guided 125I seeds implantation and chemotherapy is superior to routine chemotherapy in efficacy, safety, and pain relief in patients with cervical lymph nodes metastasis. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Zhaodong Li Xiangguo Wang Kexia Fang Jian Shi Xiangjie Qi Runming Sun Source Type: research

Percutaneous transhepatic cholangial drainage combined with percutaneous endoscopic jejunostomy for maintaining nutrition state in patients with advanced ampullary neoplasms
Conclusion: PTCD combined with PEJ is a safe and effective method for maintaining nutrition state in patients with advanced ampullary neoplasms. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Yanbo Sun Weiming Li Dali Sun Shumin Li Qingwen Xu Yijun Li Yueying Lin Yuxing Qi Ting Yang Kun Su Yunyun Cen Xiongzhi Chen Pengyuan Xu Source Type: research

Detection of urinary trace elements and pattern recognition analysis in patients with renal cell carcinoma by inductively coupled plasma mass spectrometry
Conclusions: Patients with RCC exhibit differences in such urinary trace elements as Mg, V, Mo, Sn, and Cd with healthy populations, and the discriminant accuracy is high. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Jiaxin Zheng Bin Chen Rongfu Liu Huiqiang Wang Jinchun Xing Wei Hang Source Type: research

Endostar continuous intravenous infusion combined with S-1 and oxaliplatin chemotherapy could be effective in treating liver metastasis from gastric cancer
Conclusion: Continuous infusion of Endostar combined with SOX chemotherapy could be recommended for the treatment of liver metastasis from gastric cancer due to its high effective rate, and Endostar did not increase the incidence of adverse reactions. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Honglan Yang Yanmin Sui Xingjun Guo Xiaojing Tan Yan Li Minglin Wang Source Type: research

Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells
Conclusion: Our study provides both of pharmacological and genetic evidence to support that autophagy facilitates anticancer effect of the chemotherapeutic agent. The associated application of autophagy inducer with 5-FU would be beneficial for the chemotherapy in HCT-116 cancer cells. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Jing-wen Yang Qing-huai Zhang Tong Liu Source Type: research

Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules
Conclusions: In this study, we successfully identified 4 DMs, three significant pathways, and a key gene MPO in ESCC, which might play key roles during the occurrence and development of ESCC and could be chosen as good indicators and therapeutic schedule for ESCC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Meng-Li Zheng Nai-Kang Zhou Cheng-Hua Luo Source Type: research

Survival and the prognosticators of peritoneal cytology-positive pancreatic cancer patients undergoing curative resection followed by adjuvant chemotherapy
Conclusions: The number of metastatic lymph nodes is the most important prognostic factor for OS and RFS in peritoneal CY-positive pancreatic cancer patients who underwent curative resection followed by adjuvant chemotherapy. To improve the survival of these patients, it is necessary to establish optimal treatments. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Toru Aoyama Yosuke Atsumi Keisuke Kazama Masaaki Murakawa Manabu Shiozawa Satoshi Kobayashi Makoto Ueno Manabu Morimoto Norio Yukawa Takashi Oshima Takaki Yoshikawa Yasushi Rino Munetaka Masuda Soichiro Morinaga Source Type: research

Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway
Conclusion: PI3K inhibitor decreased the levels of phosphorylated FOXO3a and increased the levels of nuclear FOXO3a. It also inhibited cell proliferation of liver cancer cells partly by PI3K/Akt/FOXO3a signaling pathways. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Yibin Hou Ge Sun Xu Jiang Zhongsheng Zhu Jijin Yang Source Type: research

Overexpression of forkhead box M1 is associated poor survival in patients with nonsmall cell lung cancer
Conclusions: This meta-analysis showed that overexpression of FOXM1 might be associated with shorter OS of NSCLC patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Bo Liu Fang Su Ronghua Lin Haifeng Teng Yuanrong Ju Source Type: research

Association of cytotoxic T-lymphocyte antigen-4 & #43; 49A/G gene polymorphism with hepatocellular carcinoma risk in Chinese
Conclusion: CTLA4 A/G gene polymorphism was associated with HCC risk and CTLA4 G allele/GG genotype is associated with CHB patients developing into HCC in Chinese. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Cunchuan Wang Weimin Liu Lei Zhao Zhiyong Dong Source Type: research

Evaluation of electron dose calculations accuracy of a treatment planning system in radiotherapy of breast cancer with photon-electron technique
Conclusions: It is concluded that the accuracy of electron dose calculations of Prowess Panther TPS is not adequate for internal mammary field treatment. Therefore, it is recommended that for fields with electron beams Prowess Panther TPS calculations should not be entirely relied upon. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Mohammad Taghi Bahreyni Toossi Shokouhozaman Soleymanifard Bagher Farhood Ashraf Farkhari Courtney Knaup Source Type: research

Association of hypoxia-inducible factor-1 alpha gene polymorphism with renal cell carcinoma susceptibility
Conclusion: HIF-1α C1772T TT genotype and HIF-1α G1790A AA genotype were associated with RCC susceptibility. However, more investigations are required to further clarify the association. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Lei Huang Mei-qin Li Chao Ou Wen-cheng Huang Jin-feng Liu Hao Huang Source Type: research

Evaluation of the effect of hesperidin on vascular endothelial growth factor gene expression in rat skin animal models following cobalt-60 gamma irradiation
Conclusions: We can conclude that hesperidin is a potent angiogenic factor. Hesperidin as a radioprotector can initiate angiogenesis by VEGF gene induction. It may stimulate epithelialization, collagen deposition, and enhanced cellular proliferation. These changes can together accelerate wound healing, in particular, radiation-induced skin damage. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Gholamhassan Haddadi Akbar Abbaszadeh Mohammad Amin Mosleh-Shirazi Mohammad Ali Okhovat Ashkan Salajeghe Zhila Ghorbani Source Type: research

Impact of season of diagnosis on mortality among breast cancer survivors
Conclusions: The diagnosis in summer and autumn was associated with a better overall prognosis. The effect of season of diagnosis on survival rate was most pronounced in the young age patients receiving chemotherapy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Irena Kuzmickiene Vydmantas Atkocius Eduardas Aleknavicius Valerijus Ostapenko Source Type: research

An updated meta-analysis for association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer
Conclusion: GSTP1 G allele/GG genotype is associated with the lung cancer susceptibility. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Wen-Zhou Liu Yu Sun Xu Feng Xiao-Han Bi Tao Liu Hua-Fu Zhou Source Type: research

Irinotecan plus cisplatin compared with etoposide plus cisplatin in patients with previously untreated extensive-stage small cell lung cancer: A meta-analysis
Conclusion: IP regimen significantly improves the 1- and 2-year survival rates, but not significantly improves the ORR and DCR, compared with EP regimen in patients with previously untreated E-SCLC. IP regimen has less Grade 3 or 4 hematological adverse events. IP regimen is an alternative of EP regimen in patients with previously untreated E-SCLC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Zi-Li Liu Bin Wang Ji-Zhu Liu Wei-Wei Liu Source Type: research

Radioprotective effect of melatonin on expression of Cdkn1a and Rad50 genes in rat peripheral blood
Conclusions: Based on our results, pretreatment with melatonin (100 mg/kg) may ameliorates injurious effects of 2 and 8 Gy ionization radiation by increasing the expression level of Cdkn1a and Rad50 in rat peripheral blood and assist in DNA double-strand breaks repair, especially during the early postradiation. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Hamed Rezaeejam Alireza Shirazi Pantea Izadi Javad Tavakkoly Bazzaz Mahmoud Ghazi-Khansari Majid Valizadeh Ghasem Azizi Tabesh Source Type: research

Expression of programmed death-ligand 1 and hypoxia-inducible factor-1 & #945; proteins in endometrial carcinoma
Conclusions: PD-L1 and HIF-1α proteins are promising potential prognostic biomarkers in endometrial carcinomas since their overexpression is associated with clinicopathologic variables of advanced disease. A potential role of HIF-1α in upregulation of PD-L1 expression is suggested based on the finding of positive correlation between PD-L1 and HIF-1α expression in endometrial carcinoma. These findings point to a potential role of biomarkers inhibitors in controlling endometrial cancer progression. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Ashraf Ishak Fawzy Tawadros Mohamed Mohamed Mohamed Khalafalla Source Type: research

Network strategy to investigate differential pathways in sporadic amyotrophic lateral sclerosis
Conclusion: We have investigated 217 differential pathways and 21 significant differential pathways between SALS and normal controls based on network strategy. The findings might provide potential biomarkers for detection and therapy of SALS clinically and give great insights to reveal molecular mechanism underlying this disease. However, how these pathways cooperated with each other is still not clear, and future study should focus on this aspect. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Li-Hong Han Xiao-Yan Fan Hong Guo Wei Wei Mao-Meng Chen Shu-Fang Yan Source Type: research

Glutathione S-transferase mu-1, glutathione S-transferase theta-1 null genotypes, and oral cancer risk: A meta-analysis in the Chinese population
Conclusion: Our meta-analysis suggested that GSTM1 null genotype might be associated with an increased risk of developing oral cancer in individuals from Mainland China. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Jie-Yi Li Li-Na Huang Hong-Lei Xue Qing-Qing Zhu Cong-Hua Li Source Type: research

A prospective longitudinal evaluation of cognition and depression in postoperative patients with high-grade glioma following radiotherapy and chemotherapy
Conclusion: This prospective study showed that although cognition was not significantly affected, the treatment caused depression, particularly at the 3rd month. These data implicated that interventions should be designed to deal with depression in the 3rd month. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Qiang Wang Fei Qi Xiaopeng Song Jie Di Licheng Zhang Yuan Zhou Xin Lu Jin Chang Yonghua Yu Source Type: research

Meta-analysis of the relationship between excision repair cross-complementing Group 5 rs17655 gene polymorphism and head and neck cancer susceptibility
Conclusions: Our investigations demonstrate that genotypes for the ERCC5 rs17655 polymorphism may be not associated with overall cancer risk. In a subgroup meta-analysis, the results suggest that the ERCC5 rs17655 polymorphism is probably associated with HNC risk in European, but the results should be interpreted with caution for the low number of studies. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Tao Li Huahuang Ling Yaoyong Lu Xiangcheng Wu Maode Cai Binguang Su Ying Zou Source Type: research

Norcantharidin combined with diamminedichloroplatinum inhibits tumor growth and cancerometastasis of hepatic carcinoma in murine
Conclusion: Based on the findings, we concluded that NCTD plus diamminedichloroplatinum may have an additive anticancer efficacy because the two drugs work in different ways, and thus, their combination had inhibited cancer cell proliferations and tumor angiogenesis more effectively than either of the compounds alone. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Xiao-Ping Zhang Lu-Lu Luo Yong-Qi Liu Xue-Song Liu Fang-Yu An Shao-Bo Sun Xiao-Rong Xie Guang-Qin Geng Xue-Juan Chen Zhen-Dong Li Source Type: research

Determination of core pathways for oral squamous cell carcinoma via the method of attract
Conclusions: We predict that pathways such as ECM-receptor interaction, neuroactive ligand-receptor interaction, and CAMs may play significant roles in OSCC and targeting these pathways may provide an effective avenue to combat the complicated illness. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Guoying Zhang Mingxing Bi Shaolai Li Qingchen Wang Dong Teng Source Type: research

Identification of significant ego networks and pathways in rheumatoid arthritis
Conclusion: Ego networks and pathways identified in this work might be potential therapeutic markers for RA treatment and give a hand for further studies of this disease. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Wen-Zheng Zhou Liao-Gang Miao Hong Yuan Source Type: research

Appleby operation for carcinoma of the body and tail of the pancreas
Conclusions: Appleby operation is both safe and effective with regard to pain relief and improvement of overall quality of life. Appleby operation can also achieve a high survival rate and a long overall survival time. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Quan Shen Qing-Feng Jiang Yu-Wei Tian Miao Yu Jiang-Kun Jia Huan-Zhou Xue Source Type: research

Xi huang pills enhance the tumor treatment efficacy when combined with chemotherapy: A meta-analysis and systematic review
Conclusion: Xi huang pill combined with chemotherapy can enhance the short-term efficacy and overall survival, alleviate treatment-induced side effects, and serve as a suitable regimen for the treatment of patients with tumors. However, the findings of the current study require validation in further high-quality trials. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Qiujun Guo Xinyao Xu Shulin He Yuan Yuan Shuntai Chen Baojin Hua Source Type: research

miR-27a is highly expressed in H1650 cancer stem cells and regulates proliferation, migration, and invasion
Conclusions: CD133+ CD34− is a CSC marker in H1650. miR-27a is highly expressed in H1650 CSCs and regulates cancer development in H1650. miR-27a may be a potential target for NSCLC therapy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Wenwen Luo Deyi Zhang Shumin Ma Chenyao Wang Qian Zhang Huafei Wang Kunyan He Zhixue Liu Source Type: research

Identification of disrupted pathways associated with colon cancer based on combining protein & #8211;protein interactions and pathway data
Conclusions: We successfully identified several biologically disrupted pathways, and these pathways might be potential biomarkers in detection and treatment for colon cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Jiqun He Weidong Liu Source Type: research

Glutathione S-transferase M1 and T1 null genotypes and bladder cancer risk: A meta-analysis in a single ethnic group
Conclusion: Our meta-analysis suggested that GSTM1-null genotype is associated with an increased bladder cancer risk in the Chinese individuals. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Da-Ke Chen Wei-Wen Huang Lin-Jin Li Qiang-Wei Pan Wen-Shuo Bao Source Type: research

Role of dalteparin sodium on the growth of cancer cells and tumor-associated angiogenesis in A549 human lung cancer cell line and grafted mouse model
Conclusion: Dalteparin sodium had the inhibitory effects on the growth of human LC A549 cells in vitro and A549 LC xenograft model, which could be enhanced when administrated together with DDP. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - December 11, 2018 Category: Cancer & Oncology Authors: Yan Rui Dongsheng Wang Danfeng Hu Linian Huang Source Type: research