Effectiveness and cost-effectiveness of trastuzumab emtansine in women with HER2-positive locally advanced or metastatic breast cancer: A systematic review and meta-analysis
Conclusions: T-DM1 is effective for the treatment of patients with HER2-positive metastatic breast cancer, and it demonstrates a tolerable safety profile compared with other active controls. Little evidence was available regarding the cost-effectiveness of T-DM1 so no conclusions can be drawn. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Yingchih Yeh Chiehfeng Chen Yu Ko Source Type: research

Induction of apoptosis and suppression of Ras gene expression in MCF human breast cancer cells
This study aimed at evaluating the anti-apoptotic activity of p-Coumaric acid (PCA) on MCF-7 breast cancer cell line. Experiments were conducted in which the MCF-7 cell line was treated with PCA. which showed decreased cell viability, increased lactate dehydrogenase activity, and caspase-3 activation. The results were evaluated with real-time polymerase chain reaction which revealed that PCA reduced the amount of H-Ras and K-Ras transcript in MCF-7 breast cancer cells. In the presence of PCA there was a significant increase in the levels of mRNA gene Bax and late apoptotic cells which was dose dependent. It also retarded t...
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Sadegh Saremi Maryam Kolahi Mohammad Reza Tabandeh Mahmoud Hashemitabar Source Type: research

The role of metabolic tumor parameters predicting cervical lymph node metastasis in patients with head and neck squamous cell carcinoma
Conclusion: MTV of the primary tumor can predict regional LNM and guide the selection of the treatment modalities and clinical decisions in patients with HNSCC at initial staging. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Sibel Goksel Ozlem C Erdivanli Ogun Bulbul Engin Dursun Source Type: research

Assessment of preoperative thyroglobulin levels in papillary thyroid cancer
Conclusion: Patients with a preoperative Tg values above 102 ng/mL may more likely to have PTC. It is thought that Tg levels may be accepted as a criterion for distinguish malignant/benign situations that should be supported with new studies. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Mehmet Ali Melik Ilyas Baskonus Latif Yilmaz Source Type: research

Significance of platelet parameters in squamous cell carcinoma of oral cavity & #8211; A case-control study
Conclusions: Platelet count, morphology, and functions are altered in oral SCC. Platelet activation plays an important role in oral cancer. PCT and PMR can be used to predict the progress of oral SCC as a cost-effective inflammatory marker. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Ankit Anand Kalyani Raju SM Azeem Mohiyuddin Source Type: research

Micronucleus assay in the exfoliated cells of buccal mucosa of gasoline station workers in Tehran
Conclusion: The results indicated that exposure to gasoline could increase the frequency of micronucleus. It was also revealed that cigarette and hookah smoking and alcohol consumption, together with working in gasoline stations, increase micronucleus abundance, implying the cumulative carcinogenic effect of these factors. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Fatemeh Shahsavari Sina Mikaeli Maedeh Ghorbanpour Source Type: research

Characterization of genetic polymorphisms in oral cancer-related genes pertaining to oxidative stress, carcinogen detoxifying, and DNA repair: A case & #8211;control study
Conclusion: The polymorphisms of XRCC1, XRCC3, XPD, and hOGG1 genes were associated with a higher susceptibility to oral cancer as compared to controls. This information may be a useful novel marker in oral oncology for primary prevention and intervention. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Neville Hoshedar Tata Ashok Kshirsagar Nitin Nangare Source Type: research

Osteoradionecrosis of the jaws: A retrospective cohort study
Conclusion: ORN is mainly a chronic long standing pathology which is difficult to treat completely. Stabilization of symptoms and preventing further spread of the necrotic lesion should be the ultimate aim of the treatment to improve the quality of life of the patients. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Kanchan P Dholam Madhura R Sharma Sandeep V Gurav Gurkaran Preet Singh Karthik M Sadashiva Sarbani Ghosh Laskar Source Type: research

Evaluating the relationship between dosimetric parameters and esophagitis in patients who experienced radiotherapy in the cervicothoracic region
Conclusions: Based on the correlation analysis of the current study, concurrent chemoradiotherapy, DMean, D50, D80, and V40 are known as reliable predictive dosimetric parameters of acute esophagitis incidence in patients who experienced radiotherapy in the cervicothoracic region. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Zahra Siavashpour Nazanin Rabiee Mohsen Bakhshandeh Amir Anvari Farid Zayeri Source Type: research

Can dual staining with p16 and Ki67 be biomarkers of epithelial dysplasia in oral lesions ?
Conclusion: P16INK4/Ki67 assessment by dual staining is a promising biomarker for identifying dysplasia in cases with diagnostic dilemmas. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Anju Bharti Sumaira Qayoom Riddhi Jaiswal Preeti Agarwal RK Singh SP Agarwal Shalini Bhalla Annu Makker Madhu Mati Goel Source Type: research

Comparative evaluation of immunohistochemical expression of MCM2 and Ki67 in oral epithelial dysplasia and oral squamous cell carcinoma
Conclusion: MCM2, as a proliferation marker, is superior to Ki67 as it indicates the capacity of proliferation and the ability of DNA replication of a cell. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Sushmita Swain Roquaiya Nishat Sujatha Ramachandran Malvika Raghuvanshi Shyam Sundar Behura Harish Kumar Source Type: research

Exploring quality of life among head-and-neck cancer patients in Western India using European organization for research and treatment of cancer questionnaires
Conclusion: Both questionnaires were comprehensive and well accepted by the patients. These questionnaires provided the information-related disease-specific QoL data, which otherwise is often missed. Health-care providers should not only focus on the clinical effects of treatment but also on QoL issues because it will improve overall patient care and survival. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Sujal Parkar Abhishek Sharma Mihir Shah Source Type: research

Correlation of the activities of antioxidant enzymes superoxide dismutase and glutathione reductase with micronuclei counts among areca nut chewers of Manipuri population using exfoliative cytology: A preliminary study
Conclusions: Detection of MN in AN chewers with or without tobacco can be a useful biomarker for clinical screening procedures that may be used as a risk marker for oral cancer. It is important to increase the awareness programs to educate the public about the deleterious effects of AN chewing, emphasize on early intervention of AN chewing habit and thus prevent the development of oral cancer. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Ngairangbam Sanjeeta Sumita Banerjee Saikat Mukherjee T Premlata Devi DB Nandini P Aparnadevi Source Type: research

The predictive value of depth of invasion and tumor size on risk of neck node metastasis in squamous cell carcinoma of the oral cavity: A prospective study
Conclusions: DOI is a significant predictor of cervical nodal metastasis and tumor depth 5 mm can be considered as a cutoff value in staging and management of early oral squamous cell carcinoma. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Naresh Kumar Jangir Akash Singh Preeti Jain Shruti Khemka Source Type: research

Necrosis onstaging 18F FDG PET/CT is associated with worse progression-free survival in patients with stage IIIB non-small cell lung cancer
Conclusion: PETNECROSİS is helpful to distinguish the patients who would suffer worse survival in stage IIIB NSCLC. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - September 22, 2022 Category: Cancer & Oncology Authors: Gulnihan Eren Osman Kupik Source Type: research