COVID-19 in Iran: A model for Crisis Management and Current Experience
In February 2020, the first sample test was confirmed as positive for corona virus in Masih Daneshvari Hospital that is the reference center in Iran for all pulmonary and respiratory diseases. The decisions made in a hospital or organization to manage a crisis is very vital. Success in managing any crisis requires a scientific and scholarly attitude. This paper was distilled from experiences gained in Masih Daneshvari Hospital in Tehran, capital of Iran, in March 2020 at the stubborn time of coping and managing corona virus crisis. This endeavor was an action research. This Action research involves five stages: statement o...
Source: Iranian Journal of Pharmaceutical Research - May 29, 2020 Category: Drugs & Pharmacology Source Type: research

The effect of Allograft Transplantation of Sertoli Cell on Expression of NF- кB, Bax Proteins, ...
In this study, a remarkable decrease in neurological deficits, infection, blood-brain barrier permeability, and brain edema was observed in the cell transplant recipient group in comparison with the ischemia group. Probably, a reduction in inflammation (NF-кB factor) an d apoptosis (Bax) following injection of Sertoli cells result in amelioration of ischemic damages induced by MCAO surgery. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - May 27, 2020 Category: Drugs & Pharmacology Source Type: research

Chemical Composition and Biological Activities of Endophytic Fungus Talaromyces Wortmannii ...
In the present study, nine compounds (1-9) were isolated from Talaromyces wortmannii LGT-4 (anendophytic fungus from Tripterygium wilfordi) which was cultured in CYM Medium. Their structures were determined as 4-hydroxyphthalide (1), Fumitremorgin C (2), Ergosterol (3), 3-(2-hydroxypropyl)-8-hydroxy-3,4- dihydroisocoumarin (4), Cis-cyclo(L-Ala-L-Pro) (5), 6-Amino-3-(4-hydroxybenzyl)- 1,4-diazonane-2,5-dione (6), Aspergillumarin B (7), Deacetylisowortmin B (8), and Entonaemin A (9) based on NMR spectral data, as well as comparing with previous literature data. This is the first report of the isolation of compounds 1-2 and 4...
Source: Iranian Journal of Pharmaceutical Research - May 24, 2020 Category: Drugs & Pharmacology Source Type: research

Nano-micelle Curcumin; A Hazardous and/or Boosting Agent? Relation with Oocyte In-vitro ...
The present study was done to uncover the possible beneficial and/or detrimental effect(s) of nano-micelle curcumin (NMC) on oocyte in-vitro maturation and pre-implantation embryo development. Forty-eight mature female Wistar rats were assigned to control, 7.5, 15, and 30 mg/kg-1 NMC-receiving (orally, for 48 days) groups. To assess the cumulus-oocyte complexes (COCs), the ovaries were stimulated by administrating (i.p.) a 25 IU of the pregnant mare's serum gonadotropin (PMSG) hormone. Following 48-h, 15 IU of hCG was injected (i.p.), and the COCs were taken after 16-18-h. To analyze the pre-implantation embryo development...
Source: Iranian Journal of Pharmaceutical Research - May 4, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of Anti-oxidant and Anti-biofilm Activities of Biogenic Surfactants Derived from ...
Biosurfactants, the microbial originated surface active agents, can modify the physicochemical properties of surfaces and reduce the bacterial adhesion via changing bacterial adhesion interactions on surfaces.  They were also able to block oxidative chain reactions and might show antioxidant properties. The goal of this study was to evaluate the antioxidant and antibiofilm activities of biosurfactants which were derived from two autochthonous biosurfactant-producing strains, Bacillus amyloliquefaciens NS6 (surfactin), andPseudomonas aeruginosaMN1 (rhamnolipids). Their antioxidant activities were determined by ferric r...
Source: Iranian Journal of Pharmaceutical Research - April 25, 2020 Category: Drugs & Pharmacology Source Type: research

Lomustine Loaded Superparamagnetic Iron Oxide Nanoparticles Conjugated with Folic Acid for ...
This study aimed to improve delivery of lomustine as a chemotherapeutic agent and to increase its uptake by U87-MG cancer cells via synthesizes LN-FA-PG-SPIONs (lomustine loaded polyglycerol coated superparamagnetic iron oxide nanoparticles conjugated with folic acid). Nanoparticles were synthesized by thermal decomposition method and characterized using TEM (transmission microscope), FTIR (Fourier transform infrared spectroscopy), and VSM (vibrating sample magnetometer). Lomustine release from nanoparticles was determined by dialysis-bag diffusion technique. Nanoparticles cytotoxicity was evaluated by MTT assay. Mean size...
Source: Iranian Journal of Pharmaceutical Research - April 25, 2020 Category: Drugs & Pharmacology Source Type: research

Propranolol Hydrochloride Buccoadhesive Tablet: Development and In-vitro Evaluation
Conclusion: Although the efficiency and mucosal irritation of propranolol HCl buccoadhesive tablets should be monitored under the in vivo conditions, However, based on the results, it seems that such tablets can be considered as an alternative route to bypass the first pass metabolism of propranolol HCl. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - April 23, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of Blood and Liver Cytotoxicity and Apoptosis-necrosis Induced by Nanochelating ...
This study aimed to evaluate the in-vitro and in-vivo biological activities of newly synthesized nanochelating based silver nanoparticles (AgNPs) in mouse model. Nanochelating technology was used to design and synthesize the AgNPs. The animals studies were including the lethal dose (LD50) determination by the intraperitoneal administration in mice, and determination of liver enzymes levels and hematological parameters. Flow cytometry analysis was used to quantitatively determine apoptosis and necrotic cells in-vitro. The NPs A and NPs B have LD50 = 250 mg/kg and LD50 = 350 mg/kg, respectively and classified as non-toxic. I...
Source: Iranian Journal of Pharmaceutical Research - April 14, 2020 Category: Drugs & Pharmacology Source Type: research

Calixarbutin: A novel calixarene-based potential water-soluble anti-tyrosinase agent with high ...
Since melanocytes are the origin of melanoma and some skin disorders such as melasma, they are important cells from the perspective of medicinal chemistry. Therefore, a medication that can simultaneously overcome these diseases will be a successful potential therapeutic agent. Arbutin with phenolic structure is a powerful natural anti-tyrosinase agent. Hence, the phenolic structure of this drug, prompted us to design its novel calix[4]arene-based cluster. Therefore, the present study reports the synthesis and in vitro bio-activities of cyclic tetramer of arbutin in comparison to its simple drug unit as the reference medica...
Source: Iranian Journal of Pharmaceutical Research - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Atorvastatin sensitizes breast and lung cancer cells to ionizing radiation
Tumour cells may be resistance to radiotherapy that results in unsuccessful cancer treatment in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) on breast cancer (MDA-MB-231) and non-small lung cancer (A-549) cells following exposure to ionizing radiation (IR). These cells were treated with ATV and exposed to X-ray at dose 4 Gy. The radiosensitizing effects of ATV were evaluated by flow cytometry and anti-proliferation assays. The production of reactive oxygen species (ROS) was determined in irradiated and treated cells with ATV. The findings of this study showed that ATV increas...
Source: Iranian Journal of Pharmaceutical Research - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Green synthesis and characterization of bismuth oxide nanoparticle using mentha pulegium extract
The objectives of this study were the green synthesis of bismuth oxide nanoparticles using aqueous extract with a good potential for UV blocking and antibacterial activity. Based on the obtained results, Bi2O3 NPs can have a good candidate for different applications. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

A Fourteen-day Experience with Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory ...
COVID-19 is currently causing concern in the medical community as the virus is spreading around the world. It has a heavy global burden, particularly in low-income countries. The clinical spectrum of COVID-19 pneumonia ranges from mild to critically ill cases and Acute Respiratory Distress Syndrome. An expert panel was held and an internal protocol was developed to manage the COVID-19 induced ARDS according to WHO recommendations and NIH guidelines. Different therapeutic regimens were employed on this protocol based on the ARDS severity and the patients’ special characteristics. The mortality rate, the rate of surviv...
Source: Iranian Journal of Pharmaceutical Research - March 25, 2020 Category: Drugs & Pharmacology Source Type: research

Thalidomide against Coronavirus Disease 2019 (COVID-19): A Medicine with a Thousand Faces
(Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - March 18, 2020 Category: Drugs & Pharmacology Source Type: research

Calixarbutin: A novel calixarene-based potential water-soluble anti-tyrosinase agent with high ...
Since melanocytes are the origin of melanoma and some skin disorders such as melasma, they are important cells from the perspective of medicinal chemistry. Therefore, a medication that can simultaneously overcome these diseases will be a successful potential therapeutic agent. Arbutin with phenolic structure is a powerful natural anti-tyrosinase agent. Hence, the phenolic structure of this drug, prompted us to design its novel calix[4]arene-based cluster. Therefore, the present study reports the synthesis and in vitro bio-activities of cyclic tetramer of arbutin in comparison to its simple drug unit as the reference medica...
Source: Iranian Journal of Pharmaceutical Research - March 18, 2020 Category: Drugs & Pharmacology Source Type: research

LED photo-polymerization, a novel strategy for triggered release liposomes
LED light is used for many medical and cosmetic applications such as phototherapy and skin rejuvenation. Such physical methods can be combined with drug therapy, such as LED-responsive drug delivery system, the subject of present investigation. To perform this investigation, a nanoliposome composed of DPPC, DSPE-PEG2000 and DC8,9PC, was prepared as LED-sensitive systems. Calcein was loaded in the liposomes as a fluorescent probe for drug release studies. Different LED wavelengths (blue, green and red) were used for triggering release of calcein from nanoliposome. Indoor daylight, darkness and sunlight were applied as contr...
Source: Iranian Journal of Pharmaceutical Research - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

STAT3-mediated apoptotic-enhancing function of sclareol against breast cancer cells and cell ...
Sclareol is an organic compound with potential anti-tumor effects against various cancer types. However, its precise molecular mechanism in suppression of tumor growth has not been fully elucidated. In the present study the anti-proliferative and apoptosis-inducing effects of sclareol with cyclophosphamide was investigated in breast cancer cells and the involvement of JAK/STAT pathway was evaluated. For this purpose, MCF-7 breast cancer cells were cultured and treated with various concentrations of sclareol to determine its IC50. Cell viability was measured by MTT assay and apoptosis was assessed by fluocytometric analysis...
Source: Iranian Journal of Pharmaceutical Research - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

Docking, Synthesis and Evaluation of the Antifungal Activity of Pyrimido[4,5-b]Quinolins
Conclusion:5-(3,4-dihydroxyphenyl)-8,8-dimethyl-2-(methylthio)-5,8,9,10 tetrahydropyrimido[4,5-b]quinoline-4,6(3H,7H)-dione (D13) exhibited inhibitory and fungicidal activities against the tested yeasts. The specific binding mode or the binding orientation of more efficient compounds to CYP51 active site, have been also performed by molecular modeling investigations and showed that there is a good correlation with biological test. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - March 16, 2020 Category: Drugs & Pharmacology Source Type: research

Preparation, optimization and characterization of chitosan-coated for solubility enhancement of ...
In this study effective parameters to preparation of nanoliposomes coated by chitosan (CCLs) were screened optimized by experimental design. Particle size, polydispersity index and surface potential of optimized CCLs have 155.8±3.5 nm, 0.229±0.022 and 25.2±3.5 mV, respectively. FMD was loaded in optimized CCLs 98.94±0.7%. Size of CCLs have verified by atomic force electron microscope. CCLs loaded by FMD were dried and in vitro study was performed to test release of FMD from powder. Results showed that solubility and dissolution of FMD increased by loading in CCLs in comparison to crystalline FMD...
Source: Iranian Journal of Pharmaceutical Research - March 15, 2020 Category: Drugs & Pharmacology Source Type: research

Antidiabetic Properties of Hydroalcoholic Leaf and Stem Extract of Levisticum officinale: An ...
This study evaluated this and the other antidiabetic aspects of the stem and leaf hydroalcoholic extract of it (LOE). Regarding to oral glucose tolerance test results, LOE (500 mg/kg) administration 30 min before glucose loading significantly decreased the blood glucose level (13%) at 90 min in male rats. Additionally LOE treatment (500 mg/kg, orally, once a day) for 14 days significantly reduced the serum glucose level (24.97%) and markedly improved the lipid profile and the insulin, creatinine, alanine aminotransferase and aspartate aminotransferase serum levels in diabetic rats. Moreover, LOE effectively amended the imp...
Source: Iranian Journal of Pharmaceutical Research - March 15, 2020 Category: Drugs & Pharmacology Source Type: research

Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation
Tumour cells may be resistance to radiotherapy that results in unsuccessful cancer treatment in patients. The aim of this study was to evaluate the sensitizing effect of atorvastatin (ATV) on breast cancer (MDA-MB-231) and non-small lung cancer (A-549) cells following exposure to ionizing radiation (IR). These cells were treated with ATV and exposed to X-ray at dose 4 Gy. The radiosensitizing effects of ATV were evaluated by flow cytometry and anti-proliferation assays. The production of reactive oxygen species (ROS) was determined in irradiated and treated cells with ATV. The findings of this study showed that ATV in...
Source: Iranian Journal of Pharmaceutical Research - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Improvement of Ocular Efficacy of Levofloxacin by Bioadhesive Chitosan Coated PLGA ...
Conjunctivitis is considered as a common infection of ocular surfaces. Eye drop is most commonly used for treatment of conjunctivitis, but has some drawback like 95% drug eliminated after administration. Administration of levofloxacin to the anterior site in form of chitosan coated poly (lactic-co-glycolic acid) nanoparticles (LFV-CS-PLGA-NPs) expected to overcome these problem and increasing corneal contact time and permeability for effective treatment of bacterial conjunctivitis. TheNanoparticles were developed by single emulsion solvent evaporation technique and optimized for different variables (chitosan, poly (lactide...
Source: Iranian Journal of Pharmaceutical Research - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

3-Hydroxypyrimidine-2,4-dione derivatives as HIV Reverse Transcriptase-Associated RNase H ...
AIDS, as a lethal disease, is caused by infection with the HIV virus that affects millions of people. Three essential enzymes should be encoded for replication of HIV virus: protease, integrase and reverse transcriptase (RT). RT has two different activities including DNA polymerase and ribonuclease H (RNase H). However, all of the marketed RT inhibitors target only the DNA polymerase activity. Therefore, ribonuclease H activity may serve as a new target for drug discovery. In the present study, a series of 3-Hydroxypyrimidine-2,4-dione derivatives as potent RT-associated RNase H inhibitors were applied to QSAR analysis. Tw...
Source: Iranian Journal of Pharmaceutical Research - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Erythromycin releasing PVA/sucrose and PVA/honey hydrogels as wound dressings with ...
This study indicates that these hybrid hydrogels are capable of being used as functional wound dressings aiming to control the rate of antibiotic delivery to the wound site and prevent the wounds from infection. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Noncompetitive inhibition of bovine liver catalase by lawsone: Kinetics, binding mechanism and ...
In this study, the structural and functional effects of LAW on bovine liver catalase (BLC), has been studied utilizing ultraviolet-visible (UV-vis) absorption, fluorescence and ATR-FTIR spectroscopic techniques, and molecular docking approach. In vitro kinetic study showed that by adding gradual concentrations of LAW, catalase activity was significantly decreased through noncompetitive inhibition mechanism. UV–vis and ATR-FTIR spectroscopic results illustrated that additional concentration of LAW lead to significant change in secondary structure of the enzyme. The fluorescence spectroscopic results at different tempe...
Source: Iranian Journal of Pharmaceutical Research - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Antioxidant activity and hemocompatibility study of quercetin loaded plga nanoparticles
In this study, in which conducted to improve these properties of the quercetin, quercetin-encapsulated PLGA nanoparticles were prepared, characterized and evaluated for antioxidant and hemolytic activity. Nanoparticles were produced by single emulsion solvent evaporation method. Four different process parameters initial QU amount, PVA concentration, PVA volume, and initial PLGA amount, were investigated to obtain the nanoparticles which have minimum particle size and maximum entrapment efficiency. Synthesized nanoparticles were evaluated for particle size, entrapment efficiency, and reaction yield. Additionally, antioxidan...
Source: Iranian Journal of Pharmaceutical Research - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

Early Graft Function in Deceased Donor Renal Recipients: Role of N-Acetylcysteine
Reduced graft function (RGF) in donor renal transplant recipients is caused by oxidative damage due to extensive ischemia-reperfusion (I/R) injury during transplantation. Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker to detect tubular injury early after renal transplantation. N-acetylcysteine (NAC) is a potent antioxidant that can reduce I/R injury by improving oxidative damage. The aim of the present study is to assess the efficacy of NAC in improving graft function and reducing renal tubular injury in deceased donor renal transplant recipients. A double-blind, randomized clinical trial was co...
Source: Iranian Journal of Pharmaceutical Research - March 14, 2020 Category: Drugs & Pharmacology Source Type: research

CB2 Agonist (AM1241) Improving Effect on Ovalbumin-Induced Asthma in Rats
Asthma is a disease characterized by spontaneous contraction of the airways in response to a wide variety of endogenous and exogenous stimuli. Many asthma models are used to mimic the human asthma model in the literature. In order to better understand the role of the cannabinoid (CB) 2 receptor in the ovalbumin (OVA)-induced asthma model, a combination of both selective CB2 agonist (AM1241) and antagonist (AM630) was used to improve inflammatory hypersensitivity and edema in rats. In the present study, it was found that OVA decreased body weight (p
Source: Iranian Journal of Pharmaceutical Research - March 13, 2020 Category: Drugs & Pharmacology Source Type: research

Logic of Selecting Suitable Dissolution Parameters in New Drug Formulations Based on A BCS Approach
Since the biopharmaceutical quality of generic drug formulations depends on the quality of the reference products and also information about the in-vitro release performance of drugs under different conditions is scarce in the literature, a dissolution study of four reference tablets was performed. Each drug was representative of one Class of the Biopharmaceutical Classification System. The in-vitro release performance of propranolol-HCl, carbamazepine, ranitidine-HCl, and metronidazole was evaluated using a USP basket and paddle apparatus at different agitation rates (50, 75, and 100 rpm) with two doses of each drug. In a...
Source: Iranian Journal of Pharmaceutical Research - March 7, 2020 Category: Drugs & Pharmacology Source Type: research

A Preliminary Study of NER and MMR Pathways Involved in Chemotherapy Response in Bladder ...
This study was conducted to provide basic data for selecting and designing a gene profile for further cohort and RCT studies in the future to improve response to treatment in bladder cancer. The expression levels of ERCC1, MLH1, MSH2, and CTR1 mRNA were determined in the tumor tissue using real-time q-PCR. Progression-free survival (PFS) was analyzed in term of the level of genes expression. The results revealed that the level of ERCC1 mRNA expression was higher in the recurrence (R) group compared to the no recurrence (NR) group. Moreover, the PFS time was increased in the patients with an ERCC1 expression level of below ...
Source: Iranian Journal of Pharmaceutical Research - February 29, 2020 Category: Drugs & Pharmacology Source Type: research

The Potential Effect of Intravenous Calcitriol on the Ischemia-Reperfusion Injury and ...
This study aimed to investigate the efficacy of calcitriol on Ischemia-reperfusion Injury (IRI) and inflammatory biomarkers in patients with non-ST-segment elevation acute coronary syndromes (NSTEACS) undergoing elective Percutaneous Coronary Intervention (PCI). Methods: A total of 72 patients with NSTEACS were randomly divided into two groups: (1) the calcitriol-treated group, treated with three mcg intravenous calcitriol administered before PCI (n = 36), and (2) the control-treated group (n = 36). The serum high-sensitivity C-reactive protein (hs-CRP), high-sensitivity interleukin-6 (hs-IL-6), creatinine kinase (CK)-MB a...
Source: Iranian Journal of Pharmaceutical Research - February 28, 2020 Category: Drugs & Pharmacology Source Type: research

An Overview on Probiotics as an Alternative Strategy for Prevention and Treatment of Human Diseases
Conclusion: according to the current available data on probiotics and related health-promoting benefits, it seems that, consumption of probiotics can lead to the prevention and reduction the risk of cancer, diabetes, and multiple sclerosis. Although for the better and more decisive conclusion, there is a need to larger sample size clinical studies with more focus on the safety of these biological agents and their possible beneficial effects on different population. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - February 28, 2020 Category: Drugs & Pharmacology Source Type: research

Osmolyte-Induced Folding and Stability of Proteins: Concepts and Characterization
It is well-known that the typical protein’s three-dimensional structure is relatively unstable in harsh conditions. A practical approach to maintain the folded state and thus improve the stability and activity of proteins in unusual circumstances is to directly apply stabilizing substances such as osmolytes to the protein-containing solutions. Osmolytes as natural occurring organic molecules typically called“compatible” solutes, based on the concept that they do not perturb cellular components. However, urea and guanidine hydrochloride (GuHCl) as denaturing osmolytes destabilize many macromolecular struct...
Source: Iranian Journal of Pharmaceutical Research - February 28, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmaceutical Advances and Proteomics Researches
Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the cell activities and physiological processes. Proteomics shows the observed protein changes to the causal effects and generate a complete three-dimensional map of the cell indicating their exact location. Proteomics is used in differ...
Source: Iranian Journal of Pharmaceutical Research - February 28, 2020 Category: Drugs & Pharmacology Source Type: research

Therapeutic metallic ions in bone tissue engineering: A systematic review of the literature
An important field of bone tissue engineering (BTE) concerns the design and fabrication of smart scaffolds capable of inducing cellular interactions and differentiation of osteo-progenitor cells. One of these additives that has gained growing attention is metallic ions as therapeutic agents (MITAs). The specific biological advantage that these ions bring to scaffolds as well as other potential mechanical, and antimicrobial enhancements may vary depending on the ion entity, fabrication method, and biomaterials used. Therefore, this article provides an overview on current status of in-vivo application of MITAs in BTE and the...
Source: Iranian Journal of Pharmaceutical Research - February 22, 2020 Category: Drugs & Pharmacology Source Type: research

The Photothermal Effect of Targeted Methotrexate-Functionalized Multi-Walled Carbon Nanotubes ...
Conclusions: The release profile of MTX in MWCNT-MTX-PEI-FA showed that the presence of PEI acts as a barrier against release and reduces the MTX release rate. In the absence of a laser, MWCNT-MTX-PEI-FA exhibits the highest degree of cytotoxicity. In the presence of a laser, the cytotoxicity of MWCNT-MTX and MWCNT-MTX-PEI-FA has no significant difference. Targeting studies have shown that MWCNT-MTX-PEI-FA can be absorbed by cancer cells exclusively. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - February 18, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of Bedtime Melatonin Administration in Patients With Type 2 Diabetes: A Triple-Blind, ...
Melatonin is widely available as over the counter product. Despite promising effects of melatonin supplementation on glycemic control, there is a significant heterogeneity between studies. The current study aimed at determining the effect of melatonin on fasting blood glucose (FBG), insulin resistance/sensitivity indices, glycosylated hemoglobin A1c (HbA1c), and high sensitivity C-reactive protein (hs-CRP) among type 2 diabetes mellitus (T2D) population during 8 weeks in a randomized, triple-blind, placebo-controlled trial. Thirty four subjects with the mean age± standard deviation of 57.74± 8.57 years and 36...
Source: Iranian Journal of Pharmaceutical Research - February 18, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of anticonvulsant effect of aqueous and methanolic extracts of seven Inula species
In Iranian traditional medicine, plants belonging to Inula genus have been used for the treatment of seizure. We decided to investigate the anticonvulsant activity of seven species from this genus to find an effective remedy for seizure with less adverse effects compared to available medicines. Aqueous and methanolic extracts of Inula britannica, Inula helenium, Inula viscidula, Inula oculus-christi, Inula aucheriana, Inula thapsoides and Inula salicina were prepared and their antiepileptic activity was investigated by maximal electroshock and pentylentetrazole tests. Diazepam was used as positive control in both tests. Tw...
Source: Iranian Journal of Pharmaceutical Research - February 17, 2020 Category: Drugs & Pharmacology Source Type: research

Comparison of Intravenous Ampicillin –sulbactam Plus Nebulized Colistin with Intravenous ...
The purpose of this study was evaluating the efficacy and safety of intravenous (IV) ampicillin–sulbactam plus nebulized colistin in the treatment of Ventilator-Associated Pneumonia (VAP) caused by MDR Acinetobacter (MDRA)in ICU patients as an alternative to IV plus nebulized colistin. In this single-blinded RCT, one group received IV colistin and another group IV ampicillin–sulbactam (16 and 12 patients from total 28 patients, respectively) for 14 days or since clinical response. Both groups received nebulized colistin by mesh nebulizer. There were no statistically significant differences between the 2 groups ...
Source: Iranian Journal of Pharmaceutical Research - February 16, 2020 Category: Drugs & Pharmacology Source Type: research

The attenuating effect of curcumin on morphine dependence in rats: the involvement of spinal ...
Conclusion: In conclusion, the results of this study demonstrated that curcumin exerts a remarkable reducing effect on morphine dependence in rats. The findings showed that the therapeutic effect of curcumin on morphine dependence is mediated through the suppression of activated microglial cells and reduction of inflammatory cytokines levels in the spinal cord. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - February 16, 2020 Category: Drugs & Pharmacology Source Type: research

Validation of an UHPLC-MS/MS method for simultaneous analysis of 11 mycotoxins in wheat flour ...
This study focuses on optimization and validation of an Ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous analysis of 11mycotoxins: Aflatoxin B1, T-2 Toxin, Ochratoxin A, Deoxynivalenol and Zearalenone in wheat matrix. Sample extraction and cleanup procedure is based on a single extraction step using acetonitrile/water/acetic acid mixture (79.5/20/0.5 v/v/v) and rapid clean-up of samples were performed with the Myco6in1+ Immunoaffinity column. Electrospray ionization at positive mode was operated to the simultaneously analysis of selected mycotoxins in a single run t...
Source: Iranian Journal of Pharmaceutical Research - February 11, 2020 Category: Drugs & Pharmacology Source Type: research

The effect of Glycyrrhiza glabra L. on Primary Dysmenorrhea compared with Ibuprofen: A ...
This study was designed to evaluate the effect of the G. glabra on primary dysmenorrhea. Sixty patients with moderate and severe dysmenorrhea were randomly divided into two groups; one group received 400 mg Ibuprofen tablets every 8 hours and placebo syrup and the other received 5 cc of G. glabra syrup two times a day and placebo tablets. The patients took the drugs from the first day of menstruation to fifth for two consequent cycles. The primary pain intensity and its changes evaluated in each group and compared between two groups. Results: The reduction of pain intensity was 5.85 (±3.11) in the G. glabra group co...
Source: Iranian Journal of Pharmaceutical Research - February 11, 2020 Category: Drugs & Pharmacology Source Type: research

Raise up of Scopolamine In Hairy Roots Via Agrobacterium rhizogenes ATC15834 as Compared With ...
Atropa komarovii generates tropane alkaloids and three other compounds such as hyoscyamine. Racemate atropine and scopolamine (hyoscine) are the main alkaloids that have anticholinergic, antispasmodic and sedative agents. A proficient convention has been reported for the formation of transgenic Atropa komarovii by the use of Agrobacterium rhizogenes. Root culture by utilizing leaves explants that were contaminated by Agrobacterium rhizogenes ATCC 15834, a strain with the paired vector. The hairy roots after contamination for three weeks shaped specifically from the cut edges of leaves. The PCR intensification demonstrated ...
Source: Iranian Journal of Pharmaceutical Research - February 9, 2020 Category: Drugs & Pharmacology Source Type: research

NF- κB-dependent Mechanism of Action of c-Myc Inhibitor 10058-F4: Highlighting a Promising ...
In conclusion, the results of the present study shed light on the favorable anti-leukemic effect of 10058-F4, especially in combination with PI3K inhibitors in acute promyelocytic leukemia; however, further investigations should be accomplished to determine the efficacy of the inhibitor, either as a single agent or in a combined-modal strategy, in leukemia treatment. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - February 8, 2020 Category: Drugs & Pharmacology Source Type: research

Noscapine Modulates Neuronal Response to Oxygen-glucose Deprivation/Reperfusion Injury Via ...
 In the present study, we investigated the effects of noscapine (0.5-2µM), an alkaloid from the opium poppy(Papaver somniferum), on primary murine cortical neurons exposed to 60 min oxygen–glucose deprivation (OGD) in the presence of 5µM BD-1047, a selective sigma-1 receptor antagonist. The experiments were performed on cortical neurons after 11–16 days of culture. To initiate oxygen–glucose deprivation, the culture medium was transferred to glucose-free DMEM, and placed in a humidified incubation chamber containing a mixture of 95% N2 and 5% CO2 at 37 °C for 60 min. In...
Source: Iranian Journal of Pharmaceutical Research - February 8, 2020 Category: Drugs & Pharmacology Source Type: research

In-vitro Study of Hottentotta Schach Crude Venom Anticancer Effects on MCF-7 and Vero Cell Lines
In this study, antitumor effects of Hottentotta schach crude venom on MCF-7 (breast cancer cell line) as test group and Vero (African green monkey kidney normal cell line) as control group were analyzed. Cell toxicity was analyzed using MTT and neutral red (NR) uptake assays and apoptosis induction was analyzed using comet assay and caspase-3 activity. Oxidative stress following Hottentotta schach crude venom treatment was analyzed using nitrite oxide (NO) determination assay, reduced glutathione (GSH) and catalase enzyme activity assays. Results showed that crude venom (25-200μg/mL) induced apoptosis and inhibited the ...
Source: Iranian Journal of Pharmaceutical Research - February 8, 2020 Category: Drugs & Pharmacology Source Type: research

Novel Bi-heterocycles as Potent Inhibitors of Urease and Less Cytotoxic Agents: ...
  The synthesis of a novel series of bi-heterocyclic propanamides, 7a-l, was accomplished by S-substitution of 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-thiol (3). The synthesis was initiated from ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (1) which was converted to corresponding hydrazide, 2, by hydrazine hydrate in methanol. The refluxing of hydrazide, 2, with carbon disulfide in basic medium, resulted in 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-thiol (3). A series of electrophiles, 6a-l, was synthesized by stirring un/substituted anilines (4a-l) with 3-bromopropanoyl chloride (5) in a basi...
Source: Iranian Journal of Pharmaceutical Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Erythromycin releasing PVA/sucrose and PVA/honey hydrogels as wound dressings with ...
This study indicates that these hybrid hydrogels are capable of being used as functional wound dressings aiming to control the rate of antibiotic delivery to the wound site and prevent the wounds from infection. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Isolation, purification and antioxidant activity of the polysaccharides from Chinese truffle ...
The content of polysaccharides in Tuber sinense was investigated by isolation and purification, followed with the further antioxidant studies in total reducing capacity and radical scavenging activities. The crude extract of polysaccharides was purified by dialysis, column chromatography and High Performance Liquid Chromatography. The main components of monosaccharide(s) and molecular structure of single polysaccharide were studied by using methylation, GC-MS, and NMR analysis. One new water-soluble non-starch polysaccharide (PTS-A with the yield of 0.41%) from T. sinense was purified and identified on structural character...
Source: Iranian Journal of Pharmaceutical Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Antioxidant Activity and Hemocompatibility Study of Quercetin Loaded Plga Nanoparticles
In this study, in which conducted to improve these properties of the quercetin, quercetin-encapsulated PLGA nanoparticles were prepared, characterized and evaluated for antioxidant and hemolytic activity. Nanoparticles were produced by single emulsion solvent evaporation method. Four different process parameters initial QU amount, PVA concentration, PVA volume, and initial PLGA amount, were investigated to obtain the nanoparticles which have minimum particle size and maximum entrapment efficiency. Synthesized nanoparticles were evaluated for particle size, entrapment efficiency, and reaction yield. Additionally, antioxidan...
Source: Iranian Journal of Pharmaceutical Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Development of a sensitive and rapid method for determination of acrylamide in bread by ...
A new sample preparation procedure and a liquid chromatography–tandem mass spectrometry (LC–MS/MS) method were developed for the quantitative analysis of acrylamide in bread. The method is based on sample extraction in methanol, purification with Carrez solutions and clean up with Primary Secondary Amine (PSA).The developed method offers an efficient, inexpensive, easy sample preparation and very sensitive procedure for determination of acrylamide in bread. The use of spiked calibration curves for constructing the calibration curve substantially reduced adverse matrix-related effects. Recoveries were between 96...
Source: Iranian Journal of Pharmaceutical Research - January 31, 2020 Category: Drugs & Pharmacology Source Type: research