Exposure to Aflatoxin M1 through milk consumption in Tehran population, Iran
Milk would be contaminated with Aflatoxin M1 (AFM1) if it was obtained from lactating animal which fed with feedstuffs containing Aflatoxin B1 (AFB1). AFM1 is classified as group 2B, possibly carcinogenic to humans and exposure to AFM1 through milk consumption is a public concern. The purpose of this study was to determine the AFM1 exposure through liquid milk consumption for adult consumers in Tehran. Forty-five samples including raw, pasteurized and UHT milk samples were collected from markets in different cities of Tehran province in January and February 2017. The AFM1 was determined by HPLC method after immunoaffinity ...
Source: Iranian Journal of Pharmaceutical Research - June 18, 2019 Category: Drugs & Pharmacology Source Type: research

Improving Activity of Lycium Barbarum. Polysaccharide on Experimental Models of Depression in ...
Depressive disorder will be the second highest disease burden worldwide, which will impair life quality, reduce productivity, and increase disability and mortality. LBP is the main active fraction purified from Lycium barbarum. The aim of this study was to evaluate the potential therapeutic effects of LBP on depressive mice induced by reserpine, as well as the relevant mechanisms. The antidepressant effect of LBP was investigated by open field test (OFT), forced swimming test (FST), tail suspension test (TST) and antagonism of reserpine hypothermia and ptosis in mice. In addition, we examined the oxidative status and antio...
Source: Iranian Journal of Pharmaceutical Research - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Genotyping of Pseudomonas aeruginosa strains as a multidrug resistant (MDR) bacterium and ...
Pseudomonas aeruginosa is an important multi-drug resistant (MDR) opportunistic bacterium. 102 strains of Pseudomonas aeruginosa equally isolated from human and cow milk were subjected to Multiplex-PCR for detection of ESBLs and exoenzymes of U, T, S, OprI, and OprL, Integrons class A encoding genes and genotyping by the ERIC-PCR and PFGE methods. The disc diffusion and E-test based on CLSI (Clinical and Laboratory Standards Institute) were performed to identify the antibiotics’ resistant strains. Exotoxin A encoding gene was detected in more than 90% of the studied strains, exoenzyme S prevalence in isolated samples...
Source: Iranian Journal of Pharmaceutical Research - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Cardioprotective effect of ethanolic leaf extract of Melissa officinalis L against regional ...
Abstract Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. Aim of the study: We investigated the role of M. officinalis extract (MOE) against ischemia-induced arrhythmias and heart injury after five days of reperfusion in an in-vivo rat model of regional heart ischemia. The leaf extract of M. officinalis was standardized through HPLC analysis. Adult male rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion. The rats were randomized to receive vehicle or M. officinalis as follows: group I s...
Source: Iranian Journal of Pharmaceutical Research - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Therapeutic effects of nano-HAp in a rat model of AlCl3 induced neurotoxicity
With the advance in nanomedicine, the present study was conducted to explore the possible therapeutic role of intravenous nano- hydroxyapatite (nano-HAp) into male rats after chronic exposure to aluminum chloride (AlCl3). This exposure interposed DNA fragmentation, apoptosis, alters oxidant/antioxidant status as well as change in content of neurotransmitters. The rats were injected with 100 mg/kg. body weight (b.w.) of AlCl3 intraperitoneally for 90 days, after then nano-HAp was injected intravenously (i.v.) three times per week at a dose level 100 mg/kg b.w.Based on the results obtained, it can be concluded that the treat...
Source: Iranian Journal of Pharmaceutical Research - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of Chamomile (Matricaria chamomilla L. ...
Efficacy and safety of Chamomile (Matricaria chamomilla L.) Syrup versus Cabergoline for reducing Prolactin in women with Idiopathic Hyperprolactinemia: A pilot randomized controlled trial Chamomile is a fascinating plant from the past to the present which has broad-spectrum pharmacological activity and medicinal uses. The aim of this study was to assess the efficacy and safety of chamomile syrup in reducing serum prolactin in women with idiopathic hyperprolactinemia. The study was a pilot randomized, controlled clinical trial that was conducted on 56 women with idiopathic hyperprolactinemia for a period of four weeks. Pat...
Source: Iranian Journal of Pharmaceutical Research - June 16, 2019 Category: Drugs & Pharmacology Source Type: research

Purification of Sesquiterpenes from Saussurea LappaRoots by High Speed Counter Current ...
Sesquiterpenes lactones including costunolide and dehydrocostus lactone, were isolated from Saussurea lappa roots, which had exhibited a wide range of biological activities such as anti-cancer, anti-inflammatory, antiulcer, and immunomodulatory activities. High-speed counter-current chromatography (HSCCC) was applied for the rapid preparative isolation of sesquiterpenes lactones from Saussurea lappa roots. A solvent optimization method for HSCCC was presented, i.e. the separation factors of compounds after the partition coefficient (K) of solvent system should be investigated. Using this method, 150 mg of costunolide, 140 ...
Source: Iranian Journal of Pharmaceutical Research - June 14, 2019 Category: Drugs & Pharmacology Source Type: research

Efficient synthesis of norbuprenorphines coupled with enkephalins and investigation of their ...
An efficient approach for the synthesis of norbuprenorphin derivatives through coupling of enkephalins and norbuprenorphine intermediate is described. Norbuprenorphine derivative was synthesized from thebaine and then, its reaction with succinic acid and phthalic acid was also studied. Meanwhile, the synthesis of enkephalins was done using solid phase peptide synthesis approach. Furthermore, after cleavage of the peptide from the surface of the resin, the coupling of enkephalins with norbuprenorphine derivative was done using TBTU as a coupling reagent then the derivatives were purified using preparative high-pressure liqu...
Source: Iranian Journal of Pharmaceutical Research - June 14, 2019 Category: Drugs & Pharmacology Source Type: research

Natural alpha-glucosidase inhibitors rapid fishing from Cyperus rotundus using immobilized ...
An efficient and rapid affinity-based screening method for directly fishing out natural alpha-glucosidase inhibitors from Cyperus. rotundus extract by using immobilized enzyme technology combined with UHPLC-QTOF MS analysis was established. As a results, without time-consuming and laborious isolation workload and false positive interference, five natural alpha-glucosidase inhibitors were successfully recognized and identified from only 400 uL of C. rotundus extracts within only a couple of hours, which suggested that the screening method was rapid, economical, sensitive and feasible. In addition, the captured compounds wer...
Source: Iranian Journal of Pharmaceutical Research - June 11, 2019 Category: Drugs & Pharmacology Source Type: research

Statistical Optimization of The Four Key Factors on β-Carotene Production by Dunaliella salina ...
During recent years, there was growing demand in using microalga valuable products such asβ-carotene in health care.β-Carotene has anti-cancer and anti-aging properties for human. In Dunaliella salina cells,β-carotene has a major protecting role for biomolecules, when the production of reactive oxygen species elevated. In the present study, we investigated the influence of the four most effective factors (light intensity, temperature, nitrate and salinity concentration) and their interactions on theβ-carotene production and the total chlorophyll/β-carotene ratio in low light adapted D. salina cells...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Protective effect of dizocilpine (MK-801) on TNBS-induced experimental colitis in mice
Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in vitro and in vivo. The aim of present study was to evaluate the role of dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfonic acid)-induced murine model of colitis. Dizocilpine (0.1, 1 and 5 mg/kg) was given to mice intraperitoneally from 24 hours before induction of colitis and daily thereafter for 4 days. Dexamethasone (1 mg/kg) was used as the referenc...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Synthesis of a peptide derivative of microcin J25 and evaluation of antibacterial and ...
Microcin J25 (MccJ25) is a small ribosomally synthesized antimicrobial peptide that is produced by Enterobacteriacea family especially E.coli. The present study focuses on preparation and evaluation of in vitro antimicrobial and biological properties of a new peptide derived from MccJ25. We prepared a MccJ25-derived peptide containing 14 amino acids and a single intra-molecular disulfide bond according to solid phase synthesis strategy. The purified peptide was characterized by Liquid chromatography-mass spectrometry (LC-MS) and Fourier Transform Infrared (FTIR) spectroscopy. 96-well microdilution plate assay was exerted f...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and anti-oxidative effects of Myrtenol in the rats with allergic asthma
Abstract Aims: To investigate the effect of Myrtenol, the active ingredient of Myrtle, on the oxidant and anti-oxidant indices and cytokines in the allergic asthma. Methods: Allergic asthma was induced by ovalbumin (OVA) sensitization and inhalation in four groups of rats; Control, Asthma, Asthma+Dexamethasone and Asthma+Myrtenol. Myrtenol (50mg/kg) or Dexamethasone (2.5mg/kg) was administered intraperitoneally for 7 consecutive days after OVA inhalation. At the end, histopathological parameters and interleukins (Interleukin-10 (IL10), Interferon gamma (IFN-γ) , interleukin-1β (IL-1β), Tumor Necrosis Factor...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Validation of an Analytical Method for Simultaneous Determination of 18 Persistent Organic ...
In this study two categories of persistent organic pollutants: Organochlorine pesticides (OCPs) including HCB, Dieldrin, Methoxychlor,α-,ϒ-Chlordane,α-,β-Endosulfan and o,p’-DDE, p,p’-DDE, o,p’-DDT, p,p’-DDT and the second group Polychlonitated biphenyls (PCBs) including seven PCB congeners which are called indicator PCBs (IUPAC nos.: 28,52,101,118,138,153 and 180) were determined in trout by GC-MS/MS in MRM monitoring mode and LLE extraction. The average recoveries of OCPs and PCBs at five concentration levels were in the range of 73-112%. The relative standard deviations of ...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

The protective effect of auraptene against oxidative stress and pentylenetetrazol-induced ...
It is believed that some pitfalls in the treatment of epilepsy including serious side effects of medications and drug resistance may be resolved by natural compounds. Auraptene is a natural coumarin that is found in many plants, particularly citrus peel. We hypothesized that auraptene might have anticonvulsant properties. Kindling was induced by repeated intraperitoneal (IP) injections of pentylenetetrazol (PTZ, 35 mg/kg) with two-day intervals for 24 days in male mice. Three groups received IP injections of auraptene (12.5, 25, and 50 mg/kg). Three control groups received vehicle, diazepam (3 mg/kg, IP), and vitamin E (15...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Molecular Docking and QSAR Study of 2-Benzoxazolinone, Quinazoline and Diazocoumarin ...
A series of 2-benzoxazolinone, diazocoumarin and quinazoline derivatives have been shown to inhibit HIV replication in cell culture. To understand the pharmacophore properties of selected molecules and design new anti-HIV agents, quantitative structure–activity relationship (QSAR) study was developed using a descriptor selection approach based on the stepwise method. Multiple linear regression method was applied to relate the anti-HIV activities of dataset molecules to the selected descriptors. Obtained QSAR model was statistically significant with correlation coefficient R2 of 0.84 and leave one out coefficient Q2 o...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

prelimbic of medial prefrontal cortex GABA modulation through testosterone on spatial learning ...
Prefrontal cortex (PFC) is involved in multiple functions including attentional , spatial orientation, short and long-term memory. Our previous study indicated that microinjection of testosterone in CA1 impaired spatial learning and memory. Some evidence suggests that impairment effect of testosterone is mediated by GABAergic system. In the present study, we investigated the interaction of testosterone (androgenic receptor agonist) and bicuculline (GABAA receptor antagonist) on spatial learning and memory in the prelimbic (PL) of rats. Cannulae were bilaterally implanted into the PL region of PFC and drugs were daily micro...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Synthesis and biological assessment of 2-hydroxyiminoethanones as anti-inflammatory and ...
In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors ofβ-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b showed moreβ-amyloid disaggregation ability than reference drugs rifampicin and donepezil and compound 2b was the best compound in this series and could reduce the extent of amyloid aggregation to 50.9%. Interestingly, compounds 1b and 3b showed significant anti-inflammatory activity in carrageenan-induced paw edema compared to control group and equivalen...
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Tenecteplase versus reteplase in acute myocardial infarction: A network meta-analysis of ...
Conclusions: Indirect comparison suggests similar efficacy and safety of tenecteplase and reteplase. Hence, the use of each one of the two medicines depends on price, facility, and accessibility of the medicine. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Methylene Tetrahydro Folate Reductase Gene Polymorphisms on Methotrexate Toxicity in ...
This study was designed to evaluate the effect of MTHFR gene polymorphisms on MTX toxicity in pediatric Egyptian ALL patients. Ninety-Four of Pediatric ALL patients aged 3–13 years (7.6± 3.6) on oral maintenance dose of 50 mg/m2 weekly of MTX. c.677 C>T (rs1801133) and c. 1298 A>C (rs1801131) genotyping were performed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). c677C>T CC, CT, and TT allele frequencies were 42.6%, 46.8%, and 10.6%, while c1298C> A AA, AC, and CC alleles frequencies were 62.7%, 24.5%, and 12.8%. None of the investigated polymorphism (C677T or...
Source: Iranian Journal of Pharmaceutical Research - June 6, 2019 Category: Drugs & Pharmacology Source Type: research

Application of Genetic Algorithms for Pixel Selection in MIA-QSAR Studies on Anti-HIV HEPT ...
Quantitative structure-activity relationship (QSAR) analysis has been carried out with a series of 107 anti-HIV HEPT compounds with antiviral activity, which was performed by chemometrics methods. Bi-dimensional images were used to calculate some pixels and multivariate image analysis was applied to QSAR modelling of the anti-HIV potential of HEPT analogues by means of multivariate calibration, such as principal component regression (PCR) and partial least squares (PLS). In this paper, we investigated the effect of pixel selection by application of genetic algorithms (GAs) for the PLS model. GAs is very useful in the varia...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

Thiazolidinedione Derivative Suppresses LPS-induced COX-2 Expression and NO Production in RAW ...
The present study was designed to investigate the inhibitory effect of 2,4 bis-[(4-ethoxyphenyl)azo] 5-(3-hydroxybenzylidene) thiazolidine-2,4-dione (TZD-OCH2CH3) on the cyclo-oxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. The effects of TZD-OCH2CH3 on COX-2 and iNOS mRNA expression in LPS-activated RAW 264.7 cells were detected by real time PCR. Also, to understand structure and substrate specificity, we have utilized molecular docking simulations (AutoDock Vina) and the active residues in the binding pocket were determined from COX-2 and iNOS. The treatment of RAW 264.7 cells with TZD-...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

A Comparison Study of Efficacy and Safety of a Biosimilar Form of Intramuscular ...
In conclusion the biosimilar interferon 1-a can be considered as an effective and safe alternative to the reference product due to lower cost and more availability. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

An In-Vivo Study on Anticonvulsant, Anxiolytic, and Sedative-Hypnotic Effects of the ...
Antidepressant-like activity of T. kotschyanus has been recently reported by scientists but insufficient attention has‎so far been devoted to T. kotschyanus, and there is a lack of information on the other neurobehavioral effects and‎side effects of this species. In the current study, the anticonvulsant, anxiolytic and sedative-hypnotic, effects of‎Thymus kotschyanus extract on male NMRI mice were evaluated using pentylenetetrazole, maximal electroshock,‎elevated plus maze, and pentobarbital-induced sleeping tests. Since phenolic compounds and flavonoids have main‎roles in pharmacological effects of mos...
Source: Iranian Journal of Pharmaceutical Research - May 21, 2019 Category: Drugs & Pharmacology Source Type: research

Donepezil and rivastigmine: pharmacokinetics profile and brain-targeting after intramuscular ...
Current palliative pharmacotherapy of Alzheimer’s disease based on the cholinergic hypothesis led to the development of four cholinesterase inhibitors. These compounds can bring prolongation of the symptom-free period in some patients. This is the first report directly comparing donepezil and rivastigmine plasma and brain levels in in vivo study. Donepezil and rivastigmine were applied i.m. to rats; the dose was calculated from clinical recommendations. The samples were analysed on an Agilent 1260 Series LC with UV/VIS detector. An analytical column (Waters Spherisorb S5 W (250 mm× 4.6 i.d.; 5μm particle siz...
Source: Iranian Journal of Pharmaceutical Research - May 20, 2019 Category: Drugs & Pharmacology Source Type: research

Anticancer Activity of Polyisoprenoids from Avicennia Alba Blume. in WiDr Cells
Colorectal cancer is the third most common cancer world wide and has been occurred more in developing regions. The use of conventional chemotherapy agents may lead to various adverse effects. Therefore, it is required to find the potential drug for anticancer from alternative source of natural product including mangrove plants. The present study was conducted to determine the anticancer activity of polyisoprenoids from Avicennia alba Blume. leaves (PAL) in WiDr cells. Cell cycle inhibition, apoptosis activity, and suppression of cyclooxygenase-2 (COX-2) were also evaluated. The anticancer activity of PAL was determined by ...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Antimicrobial Activities of Extracts and Isolated Coumarins from the Roots of Four Ferulago ...
Ferulago species have been utilized since ancient times as digestive, sedative, aphrodisiac, along with in salads or as a spice due to their special odors. The study reports isolation and characterization of bioactive compounds of Ferulago pachyloba (F. pachyloba), Ferulago trachycarpa (F. trachycarpa), Ferulago bracteata (F. bracteata), and Ferulago blancheana (F. blancheana) via bioassay guided fractionation and isolation process. The structures of compounds were elucidated by detailed spectroscopic analyses. They were also assessed for their activities at 1000-31.25µg/mL concentrations by microbroth-dilution metho...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of a Natural Eye Drop, Made of Plantago Ovata Mucilage on Improvement of Dry Eye ...
This study was designed to evaluate efficacy of a natural eye drop made of Plantago ovata mucilage versus placebo to improve dry eye symptoms. In a Randomized, double-masked, placebo-controlled clinical trial, sixty dry eye patients with ocular symptom and total OSDI score≥12 were randomly assigned to receive either a natural ophthalmic drop, made of Plantago ovata mucilage or placebo 4 times a day for 6 weeks. Patients were evaluated at first, weeks 4 and 6 of treatment. Evaluations of efficacy and safety were conducted based on Ocular Surface Disease Index questionnaire, Noninvasive tear film break-up time (NI-BUT) w...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

A New Model to Describe the Single-dose Pharmacokinetics of Bevacizumab and Predict Its ...
In conclusion, the new model reasonably explained the complex elimination of bevacizumab, and it might play a big role in the PK studies of bevacizumab and other mAbs. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Mathematical Modeling and Release Kinetics of Green Tea Polyphenols Released from Casein ...
Drug release kinetics plays an important role in determining the mechanism of drug release, which in turn helps in formulating controlled/sustained release formulations.In our study, different concentrations of green tea polyphenols (GTP) were encapsulated into casein nanoparticles which showed a maximum encapsulation efficiency (76.9%) at a GTP concentration of 5 mg/mL. The casein nanoparticles were characterized through particle size analysis, zeta potential, AFM, and HR SEM, followed by molecular docking studies, which confirmed the binding of GTP to casein nanoparticles. In-vitro release studies carried out at differen...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Novel Palladium Complex: Cytotoxicity against Cisplatin-resistant K562 Cells
Today, development of resistance to anticancer drugs (including cisplatin) is noticed as a major problem. Recently several studies demonstrated that palladium complexes showed remarkable cytotoxic effects against K562 cell line and could be used efficiently for treatment of many human cancers including leukemia. Hereof, K562 cells were made resistant to cisplatin using increasing concentration of cisplatin up to 4.5 , and then cytotoxic effect of synthesized palladium complex was evaluated on this sub-line using MTT assay. Annexin V/PI staining using flow cytometry and scanning electron microscopy (SEM) were performe...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

The Relaxant Effect of Crocin on Rat Tracheal Smooth Muscle and Its Possible Mechanisms
Crocin, a component of saffron, showed hypotensive which is perhaps due to vascular smooth muscle relaxant effect. The relaxant effects of saffron on tracheal smooth muscle also could be due to its constituent, crocin. In the present study, the relaxant effects of crocin and its possible mechanisms on rat tracheal smooth muscle were investigated. The relaxant effects of three cumulative concentrations of crocin (30, 60, and 120μM) or theophylline (0.2, 0.4, 0.6 mM) as positive control was examined on pre-contracted tracheal smooth muscle by methacholine or KCl in non-incubated or incubated conditions with different agen...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Semi-IPN Films and Electrospun Nanofibers Based On Chitosan/PVA as an Antibacterial Wound Dressing
The antimicrobial activity of a wound dressing is a key factor for preventing and treating wound infection. The current study evaluated the physiochemical properties and antimicrobial activities of semi-IPNs (interpenetrating polymer networks) based on chitosan/polyvinyl alcohol (PVA) films and nanofibers as candidates for wound dressings and investigated the effects of morphologies (nanofibrous mats and films), crosslinking conditions of chitosan chains (uncrosslinked and crosslinked with genipin), and the presence of antibacterial drug (doxycycline) on their physicochemical and antibacterial properties. The morphology, c...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Mitochondrial Complex I Is an Essential Player in LPS-Induced Preconditioning in Differentiated ...
Preconditioning (PC) as a protective strategy against noxious insults can decline cell death and apoptosis. It has been approved that mitochondria play a key role in PC mechanism. The critical role of complex I (CI) in oxidative phosphorylation machinery and intracellular ROS production, particularly in the brain, accentuates its possible role in PC-induced neuroprotection. Here, differentiated PC12 cells were preconditioned with ultra-low dose LPS (ULD, 3μg/mL) prior to exposure to high concentration of LPS (HD, 750μg/mL). Our results showed that HD LPS treatment reduces cell viability and CI activity, and intensifi...
Source: Iranian Journal of Pharmaceutical Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

The Scarce Drugs Allocation Indicators in Iran: A Fuzzy Delphi Method Based Consensus
Conclusion: To reach a higher e ffective and efficient process of resource allocation, the paper suggests the use of a population needs-based approach in Iran's pharmaceutical sector. The scarce drug allocation indicators extracted in this study can make a considerable contribution to preventing, controlling, and mitigating drug s hortages. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Despite Affordability, Low Utilization of Lipid Lowering Drugs in Iran: Trend Analysis and ...
Dyslipidemia is responsible for great mortality and morbidity each year. Little data are available on the availability and affordability of Dyslipidemia medications in low and middle incomes countries. In a retrospective time-series study, we examined the utilization pattern and affordability of lipid-lowering medications in Iran as a lower middle-income country. We initially calculated the defined daily dose for 1000 inhabitants (DID) in different years and compared the results with OECD member countries in the same year. We also used 90% Drug Utilization method to rank and compare lipid lowering drugs with the WHO Essent...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Supply Chain Challenges in Pharmaceutical Manufacturing Companies: Using Qualitative System ...
This study is based on the results of literature review, experts’ opinion acquisition, and qualitative system dynamics modeling. So, according to method, triangular researches have been considered. The purpose of this research is to explore pharmaceutical supply chain (PSC) challenges and the dynamics behavior of variables playing a special role in PSC. Also, it provides different policies to overcome the challenges. For the first step to reach this goal, several semi-structured interviews with expert supply chain managers are conducted to explore the main challenges. Inaccuracy in forecasting, long lead times, lack ...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Genetic Polymorphism of CYP2C19 in Pakistani Population
In conclusion, the high allele frequency of PM (CYP2C19*2 and *17) in Pakistani population led to the recommendation of a pre-treatment test to monitor drug response and dosage (personalized medicine) to avoid post-treatment adverse drug reactions. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of minocycline on neurological outcomes in patients with acute traumatic brain injury: ...
Traumatic brain injury (TBI) is a public health problem worldwide. Secondary damage of brain injury begins within a few minutes after the trauma and can last a long time. It can be reversible, unlike primary injury. Therefore, therapeutic intervention can be used. The aims of this study were to assess the effects of minocycline on neurological function and serum S100B protein and neuron-specific enolase (NSE) levels in patients with moderate to severe TBI. Patients with acute onset of TBI and surgical evacuation of hematoma were randomized to receive either minocycline 100 mg orally twice daily or placebo for 7 days. The p...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Teriparatide in the Treatment of Severe Postmenopausal Osteoporosis: A Cost-Utility Analysis in Iran
Conclusion: Compared to no treatment, Teriparatide was indicated to be more costly and associated with fewer fractures, more life-years, and more QALYs. The result showed that Teriparatide may be considered a cost-effective intervention when targeted to the appropriate patients. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of High-Dose Vitamin D on Duration of Mechanical Ventilation in ICU Patients
The relationship of vitamin D3 with the duration of mechanical ventilation and mortality is still unknown. Therefore, this study aimed to determine the effect of using high-dose vitamin D on the duration of mechanical ventilation among the patients admitted to the intensive care unit. The current double-blinded clinical trial was performed on 44 mechanically ventilated, adult patients. Using permuted block randomization, the patients were recruited in intervention and placebo arms. In the placebo group, four patients were excluded due to death before 72 h. The vitamin D level was measured in both groups on entrance and 7th...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of ATG7 and Light Chain 3 (LC3) Autophagy Genes Expression in Newly Diagnosed AML ...
This study was performed on 55 de novo AML patients against 17 healthy volunteers, acquired samples from bone marrow (BM) and peripheral blood (PB) sources in different ages and gender. The evaluation was executed by mRNA extraction, cDNA synthesis, real-time PCR and data was analyzed by SPSS. Results: Analyzed data indicate a significant decrease between expression of ATG7 and LC3 in AML patients against control (Pv
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

The relationship of serum vitamin D level with the outcome in surgical intensive care unit patients
The aim of this study was to assess the correlation of serum vitamin D with ICU length of stay, mortality rate, length of mechanical ventilation, and incidence of sepsis. We conducted a descriptive analytic study on 793 patients admitted to surgical ICU wards in northwest of Iran from March 2015 to March 2016. Patients were assessed during the ICU stay and the following data were collected: Glasgow Coma Score (GCS), APACHE II score, incidence of sepsis, duration of mechanical ventilation, LoS, mortality rate, and laboratory data (such as serum vitamin D, calcium, phosphorus, etc). The effect of vitamin D deficiency and the...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Rapid desensitization for hypersensitivity reactions to chemotherapeutic drugs; a case series
Usage of cancer chemotherapeutics drugs can be associated with adverse drug reactions. When IgE-mediated drug reactions are formed following administration of a chemotherapeutic drug that is a drug of choice, drug desensitization protocols can be helpful. Hypersensitivity reactions can be allergic or nonallergic, but the clinical manifestations are similar. Rapid drug desensitization (RDD) is effective when used appropriately, however it is often over utilized instead of performing a drug challenge. RDD is both an acceptable approach and a high-risk treatment modality in patients in whom the first line chemotherapy is the ...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

A Randomized Double Blind Placebo Controlled Trial Examining the Effects of Pentoxifylline on ...
Contrast-induced nephropathy (CIN) (known as contrast-induced acute kidney injury) occurs as a result of acute worsening of renal function following a procedure with administration of iodine contrasts agent and remains a substantial concern in clinical practices. The purpose of this study is to investigate the preventive effect of Pentoxifylline supplementation on reduction of CIN occurrence after percutaneous coronary intervention among patients who were high risk of CIN according to Mehran score.In randomized, double-blind clinical trial patients who undergo coronary angiography with Mehran Score≥ 11 consisted of our ...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of the incidence and severity of side effects profile of FOLFOX and DCF regimens in ...
Conclusion: It seems that the adverse drug reactions of FOLFOX regimen were more favorable than DCF regimen. The results of this study may help clinicians choosing a more favorable chemotherapy regimen especially in patients with a low performance status who have difficulties in tolerating a chemotherapy regimen with a more severe adverse effect profile. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of Purgative Manna on Neonatal Hyperbilirubinemia : A Systematic Review and Metaanalysis
The aim of this systematic review was to evaluate the effect of purgative manna on the unconjugated hyperbilirubinemia in neonates. Pubmed, Scopus, Chochrane library, Iranmedex and Google scholar were last searched in February 2017. Randomized controlled trials that evaluated the effect of purgative manna on the treatment of neonatal hyperbilirubinemia were included in the study. For meta-analysis, weighted mean difference (WMD) with 95% confidence interval (CI) was used. The outcomes of interests were serum bilirubin levels and length of hospital stay in neonates with jaundice. Seven randomized controlled trials with 812 ...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of two different techniques of warfarin dosing determination - A chemometrics study
In this study, we investigated 47 patients with effective long-term therapy by warfarin well-controlled by monitoring of International Normalised Ratio (INR). All patients were tested for gene polymorphisms VKORC1, CYP2C9*C2, and CYP2C9*C3, which were used for a dose calculation employing a program www.WarfarinDosing.org. The main goal was to investigate whether the warfarin doses determined by INR are in accordance with the doses calculated according to the pharmacogenetic algorithm. For this purpose, several chemometric tools, namely principal component analysis, cluster analysis, correlation analysis, correspondence ana...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

How much vancomycin dose is enough for the MRSA infection in pediatric patients with various ...
This study was aimed at evaluating the dosage regimens of vancomycin in pediatric patients based on pharmacokinetics/pharmacodynamics (PK/PD) and to optimize dosage individualization. Population pharmacokinetics analysis was performed on 155 Chinese children (aged 1 month to 16 years), which were divided into various renal function subpopulations. Monte Carlo simulation was carried to evaluate the efficacy and safety of vancomycin dosage regimens on each subpopulation. Compared with children with normal renal function as glomerular filtration rate (GFR)≥90 mL/min•1.73m2, the clearance of vancomycin decreased by 39....
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for ...
Our aim was to examine the effect and cost-effectiveness of isosorbide mononitrate (IMN) for outpatient (at home) cervical ripening in Iranian women with term pregnancy. Term pregnant women were randomly selected to receive either 15 mg vaginally administered IMN or placebo. Patients were advised to take the second dose at home 24 h later and return to the hospital for admission after the next 24 h if the onset of spontaneous contraction does not occur. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate and various side effects were examined. IMN induced a significant increase in cervical ...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research