The minocycline ameliorated the synaptic plasticity impairment in vascular dementia
Chronic cerebral hypoperfusion (CCH) leads to vascular dementia with progressive hippocampal damage and cognitive impairments. In the present study, we compared early and late treatment of Minocycline (MINO) on cognitive function, long and short-term synaptic-plasticity following CCH. We used bilateral common carotid arteries occlusion model (2VO) for induction of hypoperfusion. Male Sprague-Dawley rats were divided into 5 following groups (each having 2 subgroups): 2VO + V (vehicle), 2VO+MINO-E (early treatment of MINO on days 0 to 3 after 2VO), 2VO+MINO-L (late-treatment on days 21 to 32 after 2VO), control, and sham. Pa...
Source: Iranian Journal of Pharmaceutical Research - February 16, 2021 Category: Drugs & Pharmacology Source Type: research

Leishmanicidal, Trypanocidal andAntioxidant Activity of Amyrin-Rich Extracts from Eugenia ...
Conclusions: This is the first study demonstrating the activity of an amyrin rich extract against the parasites of Chagas disease and leishmaniasis, as well as its antioxidant capacity, justifying further studies for future in vivo tests. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 31, 2021 Category: Drugs & Pharmacology Source Type: research

Preventive and Tumor-Suppressive Effects of Lactobacillus Paracasei X12 in Rat Model of ...
In conclusion, this study provides insights into the therapeutic potential of L. paracasei X12 with emphasis on the issue that modulation of apoptosis pathway could leave beneficial effects in the prevention and suppression of colorectal cancer (CRC). However, further studies are in support to clarify the mechanisms involved in the tumor-suppressive effect of probiotics. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 29, 2021 Category: Drugs & Pharmacology Source Type: research

Healing Influence o f Melilotus Officinalis Herbal Extract on Experimental Autoimmune ...
The present study was designed to primarily examine the therapeutic potential of the herbal extract of Melilotus Officinalis for the treatment of multiple sclerosis in the experimental autoimmune encephalomyelitis (EAE) model of the disease. The animal model was induced in C57BL/6 female mice, and then the herbal extract was intraperitoneally administered for a total of 21 days after the first day of post-immunization. The phenotypic signs, a gene expression profile of inflammatory cytokines, antioxidant state, and pathological hallmarks of the disease in the corpus callosum were evaluated. The prophylactic administration ...
Source: Iranian Journal of Pharmaceutical Research - January 25, 2021 Category: Drugs & Pharmacology Source Type: research

Green Synthesized Silver Nanoparticles Using Feijoa Sellowiana Leaf Extract, Evaluation of ...
In this study, Feijoa sellowiana leaf extract was used for synthesizing SNPs which reduces silver nitrate into silver zero-valent. SNPs were characterized by UV, FTIR, XRD, SEM-EDS and TEM analysis. They were also examined for their biological activities. The presence of biosynthesized SNPs was characterized by UV–visible spectroscopy and also crystal nature of SNPs identified with XRD analysis. FT-IR spectrum was used to confirm the presence of different functional groups in the biomolecules which act as a capping agent for the nanoparticles. The morphology of SNPs was explored using SEM and the presence of silver w...
Source: Iranian Journal of Pharmaceutical Research - January 25, 2021 Category: Drugs & Pharmacology Source Type: research

The Expression Efficiency of Recombinant Human Clotting Factor IX Analogs, Rationally Designed ...
Glyco-engineering has attracted lots of interests in studies dealing with pharmacokinetics of therapeutic proteins. Based on our previous in silico studies, two sites were selected in the N-terminal gamma-carboxy glutamic acid-rich (Gla) domain of the human clotting factor IX (hFIX), to add new N-glycosylation sites. Site-directed mutagenesis was employed to conduct K22N and R37N substitutions and introduce new N-glycosylation sites in the mature hFIX. The expression efficiencies of the mutants, in parallel with the wild type hFIX (hFIXwt), were assessed in suspension adapted Chinese hamster ovary (CHO-s) cells, at transcr...
Source: Iranian Journal of Pharmaceutical Research - January 19, 2021 Category: Drugs & Pharmacology Source Type: research

Chitosan/PVA/Doxycycline film and nanofiber accelerate diabetic wound healing in a Rat model
In this study, we evaluated the effects of nanofiber and film polymers with doxycycline for treating a wound in a diabetic rat model. 108 male rats were divided into six groups, the control group, the diabetic control, and the groups were diabetic rats receiving different wound dressing. At the 3rd, 7th, and 14th days, macroscopic/histologic imaging and tissue sampling were performed. Tissues were analyzed for IL-1β, TNF-α, IL-10, TIMP-1, and MMP-2 by using ELISA. Dressings of chitosan, polyvinyl alcohol and doxycycline increased the rate of wound closure, the volume of collagen, dermal, and epidermis; in additi...
Source: Iranian Journal of Pharmaceutical Research - January 13, 2021 Category: Drugs & Pharmacology Source Type: research

Microindoline 581, an indole derivative from Microbacterium sp. ...
Screening of bioactive compounds with potential binding affinity to DNA as one of the target molecules in fighting against cancer cells has gained the attention of many scientists. Finding such compounds in the cellular content of microorganisms, especially marine bacteria as valuable and rich natural resources, is of great importance. Microbacterium sp. RP581, as a member of Actinobacteria phylum, was isolated from the Persian Gulf coastal area and the production of the target compound was optimized using statistical methods in cheap culture ingredients. The purification of the target compound was performed by flash chrom...
Source: Iranian Journal of Pharmaceutical Research - January 12, 2021 Category: Drugs & Pharmacology Source Type: research

Identification of candidate biomarkers for Idiopathic Thrombocytopenic Purpura by ...
This study was intended to identify critical genes associated with chronic ITP. The gene expression profile GSE46922 was downloaded from the Gene Expression Omnibus database to recognize Differentially Expressed Genes (DEGs) by R software. Gene ontology and pathway analyses were performed by DAVID. The biological network was constructed by Cytoscape. Molecular Complex Detection (MCODE) was applied for detecting module analysis. Transcription factors were identified by the PANTHER classification system database and the gene regulatory network was constructed by Cytoscape. 132 DEGs were screened from comparison newly diagnos...
Source: Iranian Journal of Pharmaceutical Research - January 10, 2021 Category: Drugs & Pharmacology Source Type: research

Fibroblast growth factor 1 gene-transfected adipose-derived mesenchymal stem cells modulate ...
Conclusion: These data suggest that the administration of AD-MSCs FGF1 through modulating apoptosis and neuroinflammation could be considered as a promising medicine for the treatment of neuropathic pain. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 9, 2021 Category: Drugs & Pharmacology Source Type: research

Are molecularly imprinted polymers (MIPs) beneficial in detection and determination of ...
The process of matrix clean-up and extraction of analytes has a significant influence on the detection and determination of the analyte, especially in trace amounts. Molecularly imprinted polymers (MIPs) are solid particles that can absorb specific molecules regarding the template molecule used in the synthesis process of each type of MIP. As a result, they can be used in more effective and more specific solid-phase extraction processes. On the others hand, mycotoxins are second metabolites of molds and fungus which are potentially cytotoxic and/or genotoxic even in trace amounts, and due to extensive consumption of cereal...
Source: Iranian Journal of Pharmaceutical Research - January 8, 2021 Category: Drugs & Pharmacology Source Type: research

Centrality analysis of protein-protein interaction networks and molecular docking prioritize ...
This study presented promising results for the prioritization of potential drug-targets which might facilitate T1D targeted therapy and its drug discovery process more effectively. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - January 2, 2021 Category: Drugs & Pharmacology Source Type: research

Quantification of 4-methylimidazol in plasma and cerebrospinal fluid (CSF) of mice using liquid ...
This study was the first report for determination of 4-MI in plasma and CSF samples in mice. Our results suggest that LC-MS/MS-based on ion-pair extraction is a robust method with high detection ability for measurement of 4-MI in plasma and CSF samples. Therefore the developed method can be useful for evaluation and monitoring of imidazole derivatives in biological samples. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - December 27, 2020 Category: Drugs & Pharmacology Source Type: research

Satureja khuzestanica mediated synthesis of silver nanoparticles and its evaluation of ...
In conclusion, the formulation of Ag -S. khuzistanica has the apoptotic properties on the colorectal cancer cell line. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - December 27, 2020 Category: Drugs & Pharmacology Source Type: research

Microencapsulation of Omeprazole by Lactobacillus acidophilus ATCC 4356 surface layer protein ...
The present study introduces a novel method for encapsulation of the acid-labile drugcalled Omeprazole using Lactobacillus acidophilus ATCC 4356 S-layer protein. Before preparing the Omeprazole suspension, a series of preliminary studies were performed on the Omeprazole powder. For this purpose, some parameters such asmelting point, IR spectrum, UV spectrum and the particle size of Omeprazole powder were investigated. The size reduction process was donein order to achieve an ideal formulation. Ultimately, the resulting powder had an average particle size of 35.516μm and it was almost uniform. After calculating the amoun...
Source: Iranian Journal of Pharmaceutical Research - December 25, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of morphine on serum reproductive hormone levels and the expression of genes involved ...
The effects of morphine on serum reproductive hormone levels and on markers of the involved in fertility-related pathways were evaluated. A total of 30 male Wistar rats were divided into three groups (n = 10) and intraperitoneally administered the following substances for 20 days: two single daily doses of morphine (10 mg/kg; morphine group), saline (healthy saline), intact group. After confirming the morphine dependence of the experimental groups, all the animals were sacrificed and their total testis tissue was extracted and stored at−80°C until use. Male reproductive parameters (blood serum of testosterone, lu...
Source: Iranian Journal of Pharmaceutical Research - December 25, 2020 Category: Drugs & Pharmacology Source Type: research

Buccal buspirone as add – on therapy to omeprazole versus omeprazole in treatment of ...
Proton pump inhibitors (PPIs) are recommended as first line treatments for gastroesophageal reflux disease (GERD). Failure to PPIs has been mentioned as a problem in pharmacotherapy of GERD. The present study compared the symptom relief, quality of life (QoL) and adverse drug reactions (ADRs) of omeprazole plus buccal buspirone with that of omeprazole alone.This was a prospective, randomized trial between buccal buspirone (10 mg/d) plus omeprazole (20 mg/d) and omeprazole (20 mg/d) plus placebo administered for 4 weeks to patients with GERD symptoms. Patients who had GERD symptoms enrolled in this study.67 patients were ra...
Source: Iranian Journal of Pharmaceutical Research - December 20, 2020 Category: Drugs & Pharmacology Source Type: research

Isolation of two isochlorogenic acid isomers from phenolic rich fraction of Artemisia turanica ...
Total phenolic content (TPC) and antioxidant capacity of five different extracts (petroleum ether (40-60), dichloromethane, ethyl acetate, ethanol and ethanol-water (1:1 v/v)) of Artemisia turanica (A. turanica) aerial parts were determined and phytochemical study on the most promising extract was carried out. Folin–Ciocalteu method, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test,β-carotene bleaching (BCB) method and ferrous ion chelating (FIC) assay were performed. Vacuum liquid chromatography (VLC) and semi-preparative HPLC were used for bioassay-guided phytochemical isolation. Structures of iso...
Source: Iranian Journal of Pharmaceutical Research - December 14, 2020 Category: Drugs & Pharmacology Source Type: research

Para-Aminobenzohydrazide Derivatives as Fatty Acid Amide Hydrolase Inhibitors: Design, ...
In this study, we designed, synthesized, and evaluated novel fatty acid amide hydrolase (FAAH) inhibitors based on 4-aminobenzohydrazide derivatives. Most of the synthesized compounds exhibited a proper affinity for the catalytic triad of FAAH in docking studies and had a considerable in-vitro FAAH inhibitory activity in comparison with JZL-195, a potent inhibitor of FAAH. Compound 2-(2-(4-(2-carboxybenzamido)benzoyl)hydrazine-1-carbonyl)benzoic acid, 12, was found to be the most potent inhibitor with IC50 value of 1.62 nM targeting FAAH enzyme. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - December 11, 2020 Category: Drugs & Pharmacology Source Type: research

Involvement of Nnos, and Α1, Α2, Β1, and Β2 Subunits of Soluble Guanylyl Cyclase Genes ...
In conclusion, the anticonvulsant activity of sumatriptan at least, in part, is mediated through inhibiting NO-cGMP pathway. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - December 11, 2020 Category: Drugs & Pharmacology Source Type: research

Histone Deacetylase Inhibitory and Cytotoxic Activities of the Constituents from the Roots of ...
Four prenylated flavonoids including isosophoranone, sophoraflavanone G, alopecurone J, alopecurone P and a resveratrol derivative HPD (2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b] furan-3,4,6-triol), were isolated from the roots of Sophora pachycarpa. The cytotoxic activity of obtained compounds was evaluated against A2780, A549, HeLa, and HCT116 human cancer cell lines. We also evaluated their histone deacetylase (HDAC) inhibitory activities. Of all compounds tested, alopecurone J was the most active with IC50 values in the range of 9.97−30.91μM against four cancer cell lines with potent pan-HDAC inhibitory activity ...
Source: Iranian Journal of Pharmaceutical Research - December 11, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluating the Effect of Dexmedetomidine on Hemodynamic Status of Patients with Septic Shock ...
Septic shock, known as the most severe complication of sepsis, is a serious medical condition that can lead to death. Clinical symptoms of sepsis include changes in body temperature in the form of hypothermia or hyperthermia, tachypnea or hyperventilation, tachycardia, leukocytosis or leukopenia, and variations in blood pressure, as well as altered state of consciousness. One of the main problems in septic shock is poor response along with reduced vascular reactivity to vasopressors used to increase blood pressure. In addition to being the state-of-the-art treatment including volume load and vasopressor, use of alpha-2 ago...
Source: Iranian Journal of Pharmaceutical Research - December 11, 2020 Category: Drugs & Pharmacology Source Type: research

Association between Serum Vitamin D Concentration Status and Matrix Metalloproteinase-9 in ...
Cardiovascular diseases (CVD) have become increasingly life-threatening during recent decades. Several studies have shown that matrix metalloproteinase-9 (MMP-9) plays an important role in the process of atherosclerosis and heart remodeling. On the other hand, Vitamin D deficiency has been recognized as a risk factor for CVD. According to the prevalence of vitamin D deficiency in our country, Iran, we aimed to evaluate the relationship between vitamin D status and the level of MMP-9 in patients undergoing percutaneous coronary intervention (PCI). In this prospective cross-sectional study, patients who were candidates for e...
Source: Iranian Journal of Pharmaceutical Research - December 11, 2020 Category: Drugs & Pharmacology Source Type: research

Assessment of Antibiotic Dispensing Practice in Community Pharmacies of Tehran, for 2 Common ...
Resistance to antibiotics is a worldwide concern and community pharmacies can play a strategic role in controlling this issue through rationalizing antibiotic consumption. Considering that dispensing any type of antibiotics without a prescription is prohibited in according to Iran’s regulations, this study was conducted to quantify the rate of antibiotic dispensing without a prescription by pharmacists in Tehran, Iran. A descriptive cross-sectional study was conducted from September 2016 through May 2017. Two scenarios of common infectious symptoms including sore throat and dysuria were simulated by pharmacy student ...
Source: Iranian Journal of Pharmaceutical Research - December 11, 2020 Category: Drugs & Pharmacology Source Type: research

Imaging of Clot by 99mTc-HMPAO Labeled Platelet in Animal Model Induced Thrombosis
99mTc-HMPAO labeled platelet (LP) imaging may integrate thrombosis imaging into routine clinical procedures. In the current study, we assessed the feasibility of the use of 99mTc-HMPAO LP for imaging of small clots in an animal model. Thrombosis was induced by application of FeCl3 solution in the distal part of the inferior vena cava (IVC) of a 6100 g anesthetized rabbit and in a male Wistar rat weighing 420 g. Twenty minutes later, 178 MBq 99mTc-HMPAO LP was injected. 99mTc-HMPAO LP preparation was done as defined and standardized in a previous report. Whole body and SPECT imaging were done 60, 90, and 120 min after trace...
Source: Iranian Journal of Pharmaceutical Research - December 7, 2020 Category: Drugs & Pharmacology Source Type: research

Preparation and characterization magnetic polypyrrole composite microspheres decorated with ...
With a facile solvothermal technique, Ssynthesis and application of Fe3O4@PPy–CuIIcomposite microspheres in the carbon ionic liquid matrix have been reported as highly sensitive sensors for voltammetric determination of Carbamazepine (CBZ). The morphology, crystal phase and structure of synthesized The nanocomposite structure was confirmed by routine methods such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Fourier translation infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), and inductively coupled pla...
Source: Iranian Journal of Pharmaceutical Research - December 6, 2020 Category: Drugs & Pharmacology Source Type: research

In Vitro Studies on Selected Jordanian Plants as Dipeptidyl Peptidase-IV Inhibitors for ...
In this study, in vitro biological evaluation of the isolated compounds calotoxin, calotropin, pectolinarigenin, apigenin7-O-(3 " ,6 " -di-O-E-p-coumaroyl)-β-glycoside and extracts of Calotropis procera, Ephedra foeminea, Artemisia herba-alba, Hylocereus undatus and Marrubium vulgare showed potential inhibitory activity, where the butanol extract of Calotropis procera was found to have 85.3% inhibition of dipeptidyl peptidase-IV at 0.2 mg/100µL concentration. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - December 6, 2020 Category: Drugs & Pharmacology Source Type: research

Neuroprotective and Anti-inflammatory Role of Atorvastatin and Its Interaction with Nitric ...
In this study, we assessed the effect of atorvastatin through NO mechanism, on inflammation, thermal hyperalgesia, thermal allodynia, and mechanical allodynia as well as sciatic nerve histological score in rat with chronic constriction injury (CCI) model. Finally, we specified the role of cytokines such as TNF-α and IL-6 in the spinal cord. Treatment with atorvastatin and L-NAME (NO inhibitor) attenuated the thermal hyperalgesia, thermal allodynia and mechanical allodynia induced by CCI. The antinociceptive consequence was better elevated with a combination of atorvastatin and L-NAME in comparison with the other grou...
Source: Iranian Journal of Pharmaceutical Research - December 5, 2020 Category: Drugs & Pharmacology Source Type: research

Diterpenoids from Roots of Salvia lachnocalyx; In-silico and In-vitro Toxicity against Human ...
Further investigations on phytochemical constituents of dichloromethaneextract from roots of Salvia lachnocalyx (S. lachnocalyx) led to the isolation and identification of eight known diterpenoids from this plant for the first time. The chemical structures of the purified compounds were elucidated using spectroscopic analyses including EI-MS, 1H and 13C NMR and by comparison of the resulting spectra with those reported in the literature. Then, the cytotoxic activity of identified compounds was examined against two human cancer cell linesMCF-7 (human breast adenocarcinoma) and K562 (human chronic myelogenous leukemia). Mole...
Source: Iranian Journal of Pharmaceutical Research - December 5, 2020 Category: Drugs & Pharmacology Source Type: research

Nut Consumption and Lung Cancer Risk: Is Linoleic Acid the Secret Weapon?
(Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - November 11, 2020 Category: Drugs & Pharmacology Source Type: research

Synthesis of Novel Peptides Using Unusual Amino Acids
Small peptides are valuable peptides due to their extended biological activities. Their activities could be categorized according to their low antigenicity, osmotic pressure, and also because of their astonishing bioactivities. For example, the aggression of Phe-Phe fibers via self-assembly and intermolecular hydrogen bonding is the main reason for the formation of Alzheimer’sβ-amyloid fibrils. Hydrogen bonding is the main intramolecular interaction in peptides, while the presence of aromatic ring leads to theπ-π stacking and affects the self-assembly and aggression. Thus, insertion of an unusual amino aci...
Source: Iranian Journal of Pharmaceutical Research - November 6, 2020 Category: Drugs & Pharmacology Source Type: research

Dextran-based Nanomicelle System with Directly Ester-bound Gadolinium Chelates as a Magnetic ...
There is a strong need to develop MRI contrast agents (CAs) with lower in vivo retention, stronger signal enhancement, and more specific imaging. Here, we report a novel dextran (DEX)-based nanomicelle system as an MRI CA with superior tumor imaging and relatively short intravascular persistence. Gadolinium (Gd)-chelate (DTPA-Gd) was conjugated directly to DEX hydroxyl via a degradable ester bond. DEX-DTPA-Gd was then modified with dodecylsuccinic anhydride to obtain the amphiphilic derivative, 2-dodecylsuccinic acid (DSA)-grafted DEX-DTPA-Gd. Nanomicelles were prepared by dissolving DSA-DEX-DTPA-Gd in water using ultrason...
Source: Iranian Journal of Pharmaceutical Research - November 6, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacological evidence for curcumin neuroprotective effects against lead-stimulated ...
One of the main herbal compounds with neuroprotective effects is curcumin. Lead poisoning cause neurodegeneration effect, however, its mechanism is unclear. The present study assesses the role of Akt/GSK3 signaling pathway in mediating the neuroprotective actions of curcumin against lead-stimulated neurodegeneration. Sixty, adult male, rats were divided in to: Group 1 and 2 received normal saline and drinking water containing 0.075% of lead acetate. Groups 3, 4, 5 and 6 were treated simultaneously with lead acetate (0.075% in drinking water) and I.P. injection of curcumin (10, 20, 40 and 60 mg/kg).Morris water maze (MWM) w...
Source: Iranian Journal of Pharmaceutical Research - November 6, 2020 Category: Drugs & Pharmacology Source Type: research

Glutamate Signaling Pathway in Absence Epilepsy: Possible Role of Ionotropic AMPA Glutamate ...
In this study, the role of the GluR1 subunit in the development, as well as features of absence seizures were assessed. Both Wistar and WAG/Rij (a genetic animal model of absence epilepsy) rats with 2 and 6-month ages were included in the study. The expression of GluR1 was measured in the somatosensory cortex. Moreover, the effects of pharmacological activation and inhibition of AMPA receptors on the characteristic of absence epileptic activities were evaluated by microinjection of agonist or antagonist of AMPA receptors on the somatosensory cortex in the epileptic WAG/Rij rats. Distribution of the GluR1 subunit of AMPA re...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Coenzyme Q0 immobilized on Magnetic Nanoparticle: Synthesis and Antitumoral Effect on Saos, ...
In this study a novel derivatives of Coenzyme Q as an anticancer agent have been introduced. The prepared magnetic nanoparticle, containing CoQ0 were prepared using common chemical methods and also characterized by means of nuclear magnetic resona nce (NMR), fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA), and differential scanning calorimetric (DSC). To evaluate the antiproliferative effects of the nanoparticle, the prepared compound was treated with cell lines such as Hela, MCF-7 and Saos. Moreover, the outcomes were compared with normal fibroblast cell line. These assessments were performed by mea...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of Methylene Tetrahydro Folate Reductase Gene Polymorphisms on Methotrexate Toxicity in ...
This study was designed to evaluate the effect of Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms on MTX toxicity in pediatric Egyptian ALL patients. Ninety-Four of Pediatric ALL patients aged 3–13 years (7.6± 3.6) on oral maintenance dose of 50 mg/m2 weekly of MTX. MTHFR c.677C>T (rs1801133) and c.1298A>C (rs1801131) genotyping were performed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The allele frequencies of c.677C>T were 42.6%, 46.8%, and 10.6% for CC, CT, and TT respectively, while c.1298A>C alleles frequencies were62.7%, 24.5%, and 12.8...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, ...
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a ubiquitous multifunctional protein required in the DNA base excision repair pathway and a noteworthy reducing-oxidizing factor that regulates the activity of various transcription factors. Cyclin-dependent kinases (CDKs) assume a key role in directing the progression of the cell- cycle. The present study evaluated the synergistic efficacy of using licochalcone B (LCB) and fullerene C60 (FnC60) nanoparticles against diethylnitrosamine (DEN)-induced hepatocarcinoma in rats and relevant signaling pathways, with APE1/Ref-1 and CDK-4, as novel anti-cancer- ta...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy and Side Effects of Combined Capecitabine Plus Intensity Modulated Radiotherapy as an ...
This study aims to evaluate the clinical outcomes and the toxicities associated with intensity modulated radiotherapy (IMRT) administered in combination with capecitabine for gastric cancer. This study was conducted between July 2009 and October 2011, and included 31 patients (23 female and eight male patients; mean age: 57 years old) with pathologically confirmed gastric cancer (pathological staging T3 or T4 or positive lymph node). All patients underwent D2 surgery and adjuvant chemoradiotherapy, followed by combined treatment with IMRT and capecitabine. All patients received follow-up examinations every 3-6 months by ph...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Protective Effects of Cydonia oblonga Mill. ...
Quince (Cydonia oblonga Mill.) is one of the medicinal plant with a broad range of pharmacological activities such as hepatoprotective effect. The present study was conducted to evaluate the effect of aqueous extract of Cydonia oblonga Mill. fruit (ACOF) against carbon tetrachloride (CCl4)-induced liver damage in rats. Hepatotoxicity was induced by CCl4 and all tested group animals were treated with the plant extract at a dose of 75, 150, and 300 mg/kg orally for 5 days. Blood was collected for the assessment of serum marker enzymes (alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and ...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Leishmanicidal, Trypanocidal and Antioxidant Activity of Amyrin-Rich Extracts from Eugenia ...
Conclusions: This is the first study demonstrating the activity of an amyrin rich-extract against microorganisms that cause Chagas disease and leishmaniasis, as well as its antioxidant capacity, justifying further studies for future in-vivo tests. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Preventive and Tumor-Suppressive Effects of Lactobacillus Paracasei X12 in Rat Model of ...
In conclusion, this study provides insights into the therapeutic potential of L. paracasei X12 with emphasis on the issue that modulation of apoptosis pathway could leave benefcial effects in the prevention and suppression of colorectal cancer (CRC). However, further studies are in support to clarify the mechanisms involved in the tumor-suppressive effect of probiotics. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Healing In fluence of Melilotus Offcinalis Herbal Extract on Experimental Autoimmune ...
This study fnding disclosed the therapeutic effciency of this compound in MS treatment. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Green Synthesized Silver Nanoparticles Using Feijoa Sellowiana Leaf Extract, Evaluation of ...
In this study, Feijoa sellowiana leaf extract was used for synthesizing SNPs which reduces silver nitrate into silver zero-valent. SNPs were characterized by UV, FTIR, XRD, SEM-EDS and TEM analysis. They were also examined for their biological activities. The presence of biosynthesized SNPs was characterized by UV–visible spectroscopy and also crystal nature of SNPs identified with XRD analysis. FT-IR spectrum was used to confirm the presence of different functional groups in the biomolecules which act as a capping agent for the nanoparticles. The morphology of SNPs was explored using SEM and the presence of silver w...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Microindoline 581, an indole derivative from Microbacterium sp. ...
Screening of bioactive compounds with potential binding affinity to DNA as one of the target molecules in fighting against cancer cells has gained the attention of many scientists. Finding such compounds in the cellular content of microorganisms, especially marine bacteria as valuable and rich natural resources, is of great importance. Microbacterium sp. RP581, as a member of Actinobacteria phylum, was isolated from the Persian Gulf coastal area and the production of the target compound was optimized using statistical methods in cheap culture ingredients. The purification of the target compound was performed by flash chrom...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Identification of candidate biomarkers for Idiopathic Thrombocytopenic Purpura by ...
This study was intended to identify critical genes associated with chronic ITP. The gene expression profile GSE46922 was downloaded from the Gene Expression Omnibus database to recognize Differentially Expressed Genes (DEGs) by R software. Gene ontology and pathway analyses were performed by DAVID. The biological network was constructed by Cytoscape. Molecular Complex Detection (MCODE) was applied for detecting module analysis. Transcription factors were identified by the PANTHER classification system database and the gene regulatory network was constructed by Cytoscape. 132 DEGs were screened from comparison newly diagnos...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Phenolic, Antioxidant, Antimicrobial, and In-vivo Wound Healing Properties of Potentilla erecta ...
In this study, we aimed to investigate to time-course effects of the methanolic extract of Potentilla erecta (P. erecta) (MEPE) on diabetic wounds. The subject of the experiments was 36 Wistar rats, divided into three main groups: non-diabetic control (NDM), diabetic control (STZ-DM), and P. erecta-treated (MEPE). Diabetes was induced by streptozotocin (STZ). Full-thickness excisional skin wounds were opened in rats. The wounds were treated with P. erecta root extract in the MEPE groups. The wound area, wound contraction rate, collagen, thiobarbituric-acid reactive substances (TBARs), nitric oxide (NOx), and glutathione (G...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluating the Effect of Dexmedetomidine on Hemodynamic Status of Patients with Septic Shock ...
Septic shock, known as the most severe complication of sepsis, is a serious medical condition that can lead to death. Clinical symptoms of sepsis include changes in body temperature in the form of hypothermia or hyperthermia, tachypnea or hyperventilation, tachycardia, leukocytosis or leukopenia, and variations in blood pressure, as well as altered state of consciousness. One of the main problems in septic shock is poor response along with reduced vascular reactivity to vasopressors used to increase blood pressure. In addition to being the state-of-the-art treatment including volume load and vasopressor, use of alpha-2 ago...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Microencapsulation of Omeprazole by Lactobacillus acidophilus ATCC 4356 Surface Layer Protein ...
The present study introduces a novel method for encapsulation of the acid-labile drug calledOmeprazole using Lactobacillus acidophilus (L. acidophilus) ATCC 4356 S-layer protein. Beforepreparing the Omeprazole suspension, a series of preliminary studies were performed on theOmeprazole powder. For this purpose, some parameters such as melting point, IR spectrum,UV spectrum, and the particle size of Omeprazole powder were investigated. The size reductionprocess was done in order to achieve an ideal formulation. Ultimately, the resulting powder hadan average particle size of 35.516μm and it was almost uniform. After calcul...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Chitosan/PVA/Doxycycline Film and Nanofber Accelerate Diabetic Wound Healing in a Rat Model
In this study, we evaluated the effects of nanofiber and film polymers with doxycycline for treating a wound in a diabetic rat model. 108 male rats were divided into six groups, the control group, the diabetic control, and the groups were diabetic rats receiving different wound dressing. At the 3rd, 7th, and 14th days, macroscopic/histologic imaging and tissue sampling were performed. Tissues were analyzed for IL-1β, TNF-α, IL-10, TIMP-1, and MMP-2 by using ELISA. Dressings of chitosan, polyvinyl alcohol and doxycycline increased the rate of wound closure, the volume of collagen, dermal, and epidermis; in additi...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research

Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels ( Prunus ...
Apricot (Prunus armeniaca L.) is a fruit cultivated in various parts of the world. Both sweet and bitter kernels of apricot have been used for the treatment of different diseases such as loss of memory in Iranian traditional medicine (ITM). In the present study, the cholinesterase (ChE) both acetyl- and butyrylcholinesterase inhibitory activity of sweet and bitter extracts of apricot kernels was examined through Ellman's method. In addition, neuroprotectivity of all extracts was investigated against H2O2-induced cell death in PC12 neurons. Among them, the best acetylcholinesterase (AChE) inhibitory activity (IC50 = 134.93&...
Source: Iranian Journal of Pharmaceutical Research - October 31, 2020 Category: Drugs & Pharmacology Source Type: research