Iranian Journal of Pharmaceutical Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

New cytotoxic premyrsinane type diterpenes from Euphorbia aleppica against breast cancer cells
Introduction: Euphorbia aleppica from the Euphorbiaceae family was collected from Kuhdasht, Lorestan, Iran. Euphorbia has been used in traditional medicine to remove warts, possibly due to its cytotoxic or antiviral effects. Therefore, this study investigates its phytochemistry and isolates its bioactive compounds.Method: Plant material was dried and ground. Extraction was performed by maceration using dichloromethane: acetone solvent. After defating, fractionation was done by open column chromatography. Based on the initial H-NMR spectra, fractions containing diterpenoid compounds were identified. Isolation was performed ...
Source: Iranian Journal of Pharmaceutical Research - April 12, 2022 Category: Drugs & Pharmacology Source Type: research

Influenza vaccine and COVID-19 pandemic:Could this vaccine help limiting the potential adverse consequences from SARS-CoV-2?
COVID-19 pandemic has prompted Scientists to find treatment and vaccine responses to control SARS-CoV-2. There are some hypotheses for benefit of respiratory virus vaccines (like MMR) on COVID-19 pneumonia severity and its morbidity and mortality.Influenza is one of the frequently used respiratory virus vaccines which was covered by one of the Iranian insurance institutes. We have a symmetrical group of participants that have received this vaccine and could be compared with each other. We have compared 3379 persons aged 20-75 years for the effect of influenza vaccine on COVID-19 mortality, ultimately have found that it doe...
Source: Iranian Journal of Pharmaceutical Research - April 12, 2022 Category: Drugs & Pharmacology Source Type: research

Complementary medicines and dietary Supplement in eradication of Helicobacter pylori; A comprehensive review
Helicobacter pylori (H. pylori) is one of the most common causes of gastrointestinal disorders in humans, and approximately about 50% of the world's population are infected with this bacterium. Recently, the standard triple or quadruple therapies have become the most effective protocol for the eradication of H. pylori infections. However, the emergence of antibiotic-resistant H. pylori isolates has become a global problem. There are evidence regarding the impact of different complementary or dietary supplements on H. pylori eradication. This review article intended to search electronic bibliographic databases for ...
Source: Iranian Journal of Pharmaceutical Research - April 11, 2022 Category: Drugs & Pharmacology Source Type: research

Investigation of Enzyme Inhibitory, Antioxidant Activities and Chemical Properties of Pistacia vera Leaves by Using LC-QTOF-MS and RP-HPLC
Since the leaves of some Pistacia species are used in traditional folk medicine for diabetes, the in vitro antidiabetic effect (α-glucosidase andα-amylase) of Pistacia vera leaves, as well as the antihypercholesterolemic (cholesterol esterase), antiobesity (pancreatic lipase) and antioxidant activities (total antioxidant capacity, DPPH radical scavenging activity, metal chelating activity and ferric reducing antioxidant power) of P. vera leaves, were investigated. Aqueous alcoholic leaf extract inhibitedα-amylase,α-glucosidase, and pancreatic lipase with 7.74± 0.72, 11.08&...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Indomethacin sustained-release anti-adhesion membrane composed of a phospholipid and polycaprolactone blend
Conclusion: This investigation suggests that indomethacin-eluting PCL-PC membrane acting through the combination of physical barrier, anti-inflammatory agents, and controlled drug delivery warrant a significant approach for intra-abdominal adhesion prevention. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

A single-centered Cohort Study on Favipiravir safety and efficacy in pediatric patients with COVID-19
Conclusion: The administration of favipiravir in pediatrics is associated with higher ADR occurrence in pediatric patients. Also, no positive effect in regard to the need for invasive mechanical ventilation, hospital stay, and the mortality rate was observed. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Enzyme and thermo dual-stimuli responsive DOX carrier based on PNIPAM conjugated mesoporous silica
In this study, a temperature and redox dual stimuli-responsive system using mesoporous silica nanoparticles (MSNs) for targeted delivery of doxorubicin (DOX) was developed. MSNs were capped with poly(N-isopropylacrylamide) (PNIPAM), a thermo-sensitive polymer, with ATRP method, via disulfide bonds (DOX-MSN-S-S-PNIPAM) to attain a controlled system that releases DOX under glutathione-rich (GSH-rich) environments and temperatures above PNIPAM’s LCST. Morphological and physicochemical properties of the nanoparticles were indicated using transmission electron microscopy (TEM), dynamic light scattering (DLS), energy-d...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastro-Retentive Drug Delivery System
The main purpose of the present study was to fabricate the mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. In these bio-nanocomposite hydrogels, chitosan (CH) was used as the bioadhesive matrix, montmorillonite (MMT) was applied to modulate the release rate, and tripolyphosphate (TPP) was the crosslinking agent. The test samples analyzed via different methods such as XRD, FT-IR, TGA, and SEM. Drug incorporation efficacy and mucoadhesive strength of these nanocomposite hydrogel beads were studied. Swelling and in vitro drug release behaviors of these bio-nanocomposite hydrogels we...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

A neglected challenge in analysis of active pharmaceutical substances with aldehyde functional group in aqueous matrices
Aldehydes are compounds that are widely used and popular in organic synthesis due to their high reactivity. However, due to the ability of aldehydes to participate in nucleophilic addition reactions, especially in biological aqueous media, drugs with aldehydic functional groups should be always used with caution and carefully quantified in biological fluids.Our experience in working on biologically active aldehydes indicates the transformation of these group of compounds in aqueous or alcoholic solution and thus the failure of analytical methods for their accurate monitoring in such media specially when mass spectrometry i...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Selective and Simple Determination of Isoquinoline Alkaloids in Papaver Species by Ion Mobility Spectrometry
A fast and precise method to determine the content of three opium alkaloids (morphine, codeine and thebaine) in different parts of some Papaver species was developed and validated down to a low detection limits (LOD) of 0.05-0.20µg L-1. The method was based on three extraction steps by basic aqueous solution/chloroform/acidic aqueous solution and analysis by ion mobility spectrometry (IMS) and high performance liquid chromatography (HPLC). After optimization of IMS parameters based on experimental design, the method was applied for the analysis of seeds, steams, leaves and capsules of seven Papaver species collec...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Assessment of Ascorbic Acid Niosomes as a Potential Detoxifier in Oxidative Stress-induced HEK-293 Cells by Arsenic trioxide
Background and objectives: Arsenic (As) as an environmental contaminant has many risks to human health. Vitamin C (Vit C), as a powerful antioxidant and water-soluble vitamin, protects cells and tissues against oxidation and has a wide range of healing properties. In this regard, the current study aimed to formulate a suitable niosome of ascorbic acid (Vit C) and compare it with vitamin C in preventing As-induced toxicity in HEK-293 cells.Methods: Various formulas of the niosomes of Vit C were prepared by C-SPAN mixed with cholesterol. The physicochemical characteristics of niosomal formulations, including load size, zeta-...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Identifying factors affecting the product life cycle of generic medicines
This study investigated a generic antibiotic PLCs and the factors affecting them in the competitive pharmaceutical market of Iran to improve PLC management of such drugs. To study the antibiotic’s PLC, we used data from 2002-2017, then analyzed the PLC curves and the factors affecting them in two sections: all PLC curves and the PLC curves with one sales peak. Using a generalized linear model combined with a machine learning approach, we identified the sales patterns and the impact of the product-related and the competition-related factors on the PLC curves, peak height, and the time to reach peak sales. The resu...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Simultaneous Determination of Multi-Component Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-phenobarbital combination Tablet
The use of nuclear magnetic resonance (NMR) spectroscopy, as a tool for the determination of pharmaceutical molecules in bulk drugs and their dosage forms is growing. New advancements of benchtop NMR spectrometers with cryogen-free magnets have made this technique more appealing and accessible. Herein, we developed a method using benchtop NMR spectrometer for the quantification of phenytoin (PhT) and phenobarbital (PhB) in bulk and combination dosage form and the results were compared to those obtained by HPLC, as a well-characterized procedure.Three signals atδ 0.79, 7.30, and 8.57 ppm were used for the quantifi...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Synthesis, structural characterization, and cytotoxic activity of new Benzo[d]imidazo[2,1-b]thiazole derivatives against MCF-7 breast cancer cells
This study is aimed to synthesize a new series of diaryl benzo[d]imidazo[2,1-b]thiazole compounds containing aminoethoxy side chain and in vitro investigation of their cytotoxicity on a human breast cancer cell line (MCF-7). Twelve derivates (6a-6l) were synthesized from this scaffold, which the structures were spectroscopically confirmed. Their cytotoxic effects on the MCF-7 cell line were also assessed using an MTT assay. All these compounds showed a good inhibitory effect on the MCF-7 cell line compared to that of tamoxifen. Among them, compounds (6i) and (6j) showed higher cytotoxicity with relevant inhibitory effects ...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

A review on virus-like particle-based SARS-CoV-2 vaccines that are in clinical trial phases
Coronavirus disease 2019 (COVID-19) pandemic has affected more than 269 million people worldwide, with more than 5 million deaths as early December 2021. The main concerns in this pandemic include the asymptomatic nature of COVID-19 disease leading to infection of many healthy people, and the infectious nature of the pathogen and its high spreading rate. The disease features have highlighted the importance of the control of this pandemic via vaccines. There has been a worldwide race to produce better, more protective, and efficacious vaccines and simultaneously different new variants of the virus are emerging. Therefore, t...
Source: Iranian Journal of Pharmaceutical Research - April 5, 2022 Category: Drugs & Pharmacology Source Type: research