Editorial Board
Publication date: December 2019Source: Progress in Biophysics and Molecular Biology, Volume 149Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - December 7, 2019 Category: Molecular Biology Source Type: research

Supervised and unsupervised algorithms for bioinformatics and data science
Publication date: Available online 6 December 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ayesha Sohail, Fatima ArifAbstractBioinformatics refers to an ever evolving huge field of research based on millions of algorithms, designated to several data banks. Such algorithms are either supervised or unsupervised. In this article, a detailed overview of the supervised and unsupervised techniques is presented with the aid of examples. The aim of this article is to provide the readers with the basic understanding of the state of the art models, which are key ingredients of explainable machine learning in th...
Source: Progress in Biophysics and Molecular Biology - December 7, 2019 Category: Molecular Biology Source Type: research

Current density as routine parameter for description of ionic membrane current: is it always the best option?
Publication date: Available online 30 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Roman Kula, Markéta Bébarová, Peter Matejovič, Jiří Šimurda, Michal PásekAbstractThe current density (J) is a parameter routinely used to characterize individual ionic membrane currents. Its evaluation is based on the presumption that the magnitude of whole-cell ionic membrane current (I) is directly proportional to the cell membrane capacitance (C), i.e. I positively and strongly correlates with C and the regression line describing I–C relation intersects the y...
Source: Progress in Biophysics and Molecular Biology - December 1, 2019 Category: Molecular Biology Source Type: research

Possible traces of resonance signaling in the genome
Publication date: Available online 29 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ivan Savelyev, Max Myakishev-RempelAbstractAlthough theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various sizes are good candidates for serving as resonators. Moreover, it was suggested that for the two DNA sequences to resona...
Source: Progress in Biophysics and Molecular Biology - November 30, 2019 Category: Molecular Biology Source Type: research

Non-coding RNAs regulate autophagy process via influencing the expression of associated protein
Publication date: Available online 28 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Yunyi Zhao, Ze Wang, Wenhui Zhang, Linbo ZhangAbstractAutophagy is a tightly-regulated multi-step process involving the lysosomal degradation of proteins and cytoplasmic organelles. Central to this process is the formation of the autophagosome, a double membrane-bound vesicle, which is fuse with lysosomes or endosomes, and then deliver its cytoplasmic cargo to the lysosomes. Here, we summarize the recent process of autophagy, focusing on protein molecules, their complexes, and its essential roles of autophagy i...
Source: Progress in Biophysics and Molecular Biology - November 28, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: November 2019Source: Progress in Biophysics and Molecular Biology, Volume 148Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - November 28, 2019 Category: Molecular Biology Source Type: research

The ATPases of the mycobacterial type VII secretion system: structural and mechanistic insights into secretion
Publication date: Available online 22 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Thomas D. Crosskey, Katherine S.H. Beckham, Matthias WilmannsAbstractTuberculosis (TB) remains the foremost cause of death by infectious disease and is propagated by the pathogen Mycobacterium tuberculosis (Mtb). The virulence associated with Mtb is mediated by proteins secreted into host cells by the type VII secretion system (T7SS), making this system a candidate for future drug and vaccine development. However, while many of the components involved in the T7SS have been identified, the mechanism of transloca...
Source: Progress in Biophysics and Molecular Biology - November 24, 2019 Category: Molecular Biology Source Type: research

Recent treatment progress of triple negative breast cancer
Publication date: Available online 21 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Yang Chang-Qing, Liu Jie, Zhao Shi-Qi, Zhu Kun, Gong Zi-Qian, Xu Ran, Lu Hui-Meng, Zhou Ren-Bin, Zhao Gang, Yin Da-Chuan, Zhang Chen-YanAbstractBreast cancer (BC) is a serious worldwide disease that threatens women’s health. Particularly, the morbidity of triple-negative breast cancer (TNBC) is higher than that of other BC types due to its high molecular heterogeneity, metastatic potential and poor prognosis. TNBC lacks of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth facto...
Source: Progress in Biophysics and Molecular Biology - November 22, 2019 Category: Molecular Biology Source Type: research

Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials
Publication date: Available online 15 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ludovica Mascolo, Dirk BaldAbstractThe branched respiratory chain of Mycobacterium tuberculosis has attracted attention as a highly promising target for next-generation antibacterials. This system includes two terminal oxidases of which the exclusively bacterial cytochrome bd represents the less energy-efficient one. Albeit dispensable for growth under standard laboratory conditions, cytochrome bd is important during environmental stress. In this review, we discuss the role of cytochrome bd during infection of ...
Source: Progress in Biophysics and Molecular Biology - November 16, 2019 Category: Molecular Biology Source Type: research

Cardiac pacing using transmural multi-LED probes in channelrhodopsin-expressing mouse hearts
Publication date: Available online 16 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): C.M. Zgierski-Johnston, S. Ayub, M.C. Fernández, E.A. Rog-Zielinska, F. Barz, O. Paul, P. Kohl, P. RutherAbstractOptogenetics enables cell-type specific monitoring and actuation via light-activated proteins. In cardiac research, expressing light-activated depolarising ion channels in cardiomyocytes allows optical pacing and defibrillation. Previous studies largely relied on epicardial illumination. Light penetration through the myocardium is problematic when moving to larger animals and humans. To overco...
Source: Progress in Biophysics and Molecular Biology - November 16, 2019 Category: Molecular Biology Source Type: research

Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design
Publication date: Available online 16 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Neelagandan Kamariah, Priya Ragunathan, Joon Shin, Wuan-Geok Saw, Chui-Fann Wong, Thomas Dick, Gerhard GrüberAbstractThe causative agent of Tuberculosis (TB) Mycobacterium tuberculosis (Mtb) encounters unfavourable environmental conditions in the lungs, including nutrient limitation, low oxygen tensions and/or low/high pH values. These harsh conditions in the host triggers Mtb to enter a dormant state in which the pathogen does not replicate and uses host-derived fatty acids instead of carbohydrates as an ...
Source: Progress in Biophysics and Molecular Biology - November 16, 2019 Category: Molecular Biology Source Type: research

Targeted protein degradation in antibacterial drug discovery?
Publication date: Available online 16 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Pooja Gopal, Thomas DickAbstractDrug induced degradation of a target protein is a novel concept in drug discovery. Traditionally drugs modulate activity, as opposed to abundance, of their targets. Degradation inducing ligands act catalytically. Thus, one advantage of target degradation over the classical on-target mechanism is that lower drug concentration may be sufficient to cause the desired cellular effects. The first promoters of target degradation were discovered unintentionally: it turned out that some d...
Source: Progress in Biophysics and Molecular Biology - November 16, 2019 Category: Molecular Biology Source Type: research

Two for the price of one: attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents
Publication date: Available online 13 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Kiel Hards, Cara Adolph, Liam K. Harold, Matthew B. McNeil, Chen-Yi Cheung, Adrian Jinich, Kyu Y. Rhee, Gregory M. CookAbstractCellular bioenergetics is an area showing promise for the development of new antimicrobials, antimalarials and cancer therapy. Enzymes involved in central carbon metabolism and energy generation are essential mediators of bacterial physiology, persistence and pathogenicity, lending themselves natural interest for drug discovery. In particular, succinate and malate are two major focal po...
Source: Progress in Biophysics and Molecular Biology - November 13, 2019 Category: Molecular Biology Source Type: research

Implication of frequency-dependent protocols in antiarrhythmic and proarrhythmic drug testing
Publication date: Available online 11 November 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Péter P. Nánási, Zoltán Szabó, Kornél Kistamás, Balázs Horváth, László Virág, Norbert Jost, Tamás Bányász, János Almássy, András VarróAbstractIt has long been known that the electrophysiological effects of many cardioactive drugs strongly depend on the rate dependent frequency. This was recognized first for class I antiarrhythmic agents: their Vmax suppressive effect was attenuate...
Source: Progress in Biophysics and Molecular Biology - November 12, 2019 Category: Molecular Biology Source Type: research

The Nobel Prize for medicine and physiology, 2019
Publication date: Available online 31 October 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Denis Noble (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - November 10, 2019 Category: Molecular Biology Source Type: research

Intra- and intercellular transport of substances: models and mechanisms
Publication date: Available online 31 October 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Alexey V. Melkikh, Maria SutorminaAbstractNon-equilibrium-statistical models of intracellular transport are built. The most significant features of these models are microscopic reversibility and the explicit considerations of the driving forces of the process - the ATP-ADP chemical potential difference. In this paper, water transport using contractile vacuoles, the transport and assembly of microtubules and microfilaments, the protein distribution within a cell, the transport of neurotransmitters from the synapt...
Source: Progress in Biophysics and Molecular Biology - October 31, 2019 Category: Molecular Biology Source Type: research

Editorial for Progress in Biophysics
Publication date: Available online 31 October 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Denis Noble (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - October 31, 2019 Category: Molecular Biology Source Type: research

Editorial for Progress in Biophysics and Molecular Biology
Publication date: Available online 23 October 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - October 23, 2019 Category: Molecular Biology Source Type: research

Percolation clusters of organics in interstellar ice grains as the incubators of life
Publication date: Available online 21 October 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Saibal MitraAbstractBiomolecules can be synthesized in interstellar ice grains subject to UV radiation and cosmic rays. I show that on time scales of ≳106 years, these processes lead to the formation of large percolation clusters of organic molecules. Some of these clusters would have ended up on proto-planets where large, loosely bound aggregates of clusters (superclusters) would have formed. The interior regions of such superclusters provided for chemical micro-environments that are filtered versions of the ...
Source: Progress in Biophysics and Molecular Biology - October 22, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: October 2019Source: Progress in Biophysics and Molecular Biology, Volume 147Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - October 19, 2019 Category: Molecular Biology Source Type: research

Tuberculosis control in crisis-causes and solutions
Publication date: Available online 15 October 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Gilla KaplanAbstractTuberculosis incidence is projected to decline at too slow a rate to meet the targets set at the UN high level meeting on ending tuberculosis, convened in New York in 2018. To understand the causes of the slow progress in tuberculosis control, the Bill and Melinda Gates Foundation supported a patient-pathway analysis that identified significant gaps with patients being “lost” at all points along the care cascade. Although each country differed in the reasons for failure, some comm...
Source: Progress in Biophysics and Molecular Biology - October 16, 2019 Category: Molecular Biology Source Type: research

SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange
Publication date: Available online 27 September 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Daniel J. Saltzberg, Morgan Hepburn, Kala Bharath Pilla, David C. Schriemer, Susan P. Lees-Miller, Tom L. Blundell, Andrej SaliAbstractX-ray crystallography and electron microscopy maps resolved to 3–8 Å are generally sufficient for tracing the path of the polypeptide chain in space, while often insufficient for unambiguously registering the sequence on the path (i.e., threading). Frequently, however, additional information is available from other biophysical experiments, physical principles, sta...
Source: Progress in Biophysics and Molecular Biology - September 28, 2019 Category: Molecular Biology Source Type: research

Investigation of machine learning techniques on proteomics: A comprehensive survey
Publication date: Available online 27 September 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Pravinkumar M. Sonsare, C. GunavathiAbstractProteomics is the extensive investigation of proteins which has empowered the recognizable proof of consistently expanding quantities of protein. Proteins are necessary part of living life form, with numerous capacities. The proteome is the complete arrangement of proteins that are created or altered by a life form or framework of the organism. Proteome fluctuates with time and unambiguous prerequisites, or stresses, that a cell or organism experiences. Proteomics is...
Source: Progress in Biophysics and Molecular Biology - September 28, 2019 Category: Molecular Biology Source Type: research

Polygenic scores: Are they a public health hazard?
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Keith BaverstockAbstractI argue here that polygenic scores are a public health hazard because the underlying methodology, genome wide association, from which they are derived, incorrectly assumes that the information encoded in the genomic DNA sequence is causal in terms of the cellular phenotype. This is not so when the cell is viewed from the perspective of a) fundamental physics, b) the protein chemistry that characterises the cellular cytoplasm and c) the fundamental requirement for evolution to yield unlimite...
Source: Progress in Biophysics and Molecular Biology - September 18, 2019 Category: Molecular Biology Source Type: research

Non-Uniformity of Projection Distributions Attenuates Resolution in Cryo-EM
Publication date: Available online 13 September 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Philip R. Baldwin, Dmitry LyumkisAbstractVirtually all single-particle cryo-EM experiments currently suffer from specimen adherence to the air-water interface, leading to a non-uniform distribution in the set of projection views. Whereas it is well accepted that uniform projection distributions can lead to high-resolution reconstructions, non-uniform (anisotropic) distributions can negatively affect map quality, elongate structural features, and in some cases, prohibit interpretation altogether. Although some ...
Source: Progress in Biophysics and Molecular Biology - September 15, 2019 Category: Molecular Biology Source Type: research

Towards Dewetting Monoclonal Antibodies For Therapeutical Purposes
We describe a novel type of high-affinity monoclonal antibody, that: a) targets specific trans-membrane receptor structures of harmful or redundant cells; b) is equipped with lipophilic and/or hydrophobic fragments that prevent physiological water flow inside ion channels. Therefore, we achieve an artificial dewetting transition inside receptor cavities, that causes discontinuity within transmembrane ionic flows, channel blockage, and subsequent damage of morbid cells. As an example, we describe dewetting monoclonal antibodies that target the M2 channel of the Influenza A virus: they might prevent water from entering pores...
Source: Progress in Biophysics and Molecular Biology - September 15, 2019 Category: Molecular Biology Source Type: research

The N-space Episenome unifies cellular information space-time within cognition-based evolution
Publication date: Available online 12 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): William B. Miller, John S. Torday, František BaluškaAbstractSelf-referential cellular homeostasis is maintained by the measured assessment of both internal status and external conditions based within an integrated cellular information field. This cellular field attachment to biologic information space-time coordinates environmental inputs by connecting the cellular senome, as the sum of the sensory experiences of the cell, with its genome and epigenome. In multicellular organisms, individual cellula...
Source: Progress in Biophysics and Molecular Biology - September 13, 2019 Category: Molecular Biology Source Type: research

No light without the dark: Perspectives and hindrances for translation of cardiac optogenetics
Publication date: Available online 9 September 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Claudia Richter, Tobias BruegmannAbstractOver the last decade, optogenetic stimulation of the heart and its translational potential for rhythm control attracted more and more interest. Optogenetics allows to stimulate cardiomyocytes expressing the light-gated cation channel Channelrhodopsin 2 (ChR2) with light and thus high spatio-temporal precision. Therefore this new approach can overcome the technical limitations of electrical stimulation. In regard of translational approaches, the prospect of pain-free stim...
Source: Progress in Biophysics and Molecular Biology - September 10, 2019 Category: Molecular Biology Source Type: research

Two-photon excitation of FluoVolt allows improved interrogation of transmural electrophysiological function in the intact mouse heart
ConclusionOur results demonstrate several advantages of two-photon excitation of FluoVolt in functional studies in intact heart preparations, including reduced toxicity and improved fluorescent properties. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - September 4, 2019 Category: Molecular Biology Source Type: research

Recent progress in optical voltage-sensor technology and applications to cardiac research: from single cells to whole hearts
Publication date: Available online 29 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Corey D. Acker, Ping Yan, Leslie M. LoewAbstractThe first workshop on Novel Optics-based approaches for Cardiac Electrophysiology (NOtiCE) was held in Florence Italy in 2018. Here, we learned how optical approaches have shaped our basic understanding of cardiac electrophysiology and how new technologies and approaches are being developed and validated to advance the field. Several technologies are being developed that may one day allow for new clinical approaches for diagnosing cardiac disorders and possibly inte...
Source: Progress in Biophysics and Molecular Biology - August 31, 2019 Category: Molecular Biology Source Type: research

PBMB Commentary on Editorial by Keith Baverstock
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Denis Noble, Tom Blundell, Peter Kohl (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 29, 2019 Category: Molecular Biology Source Type: research

DNA damage response mechanisms and structures fundamental to cancer research progress
Publication date: Available online 27 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Albino Bacolla, John A. Tainer (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 29, 2019 Category: Molecular Biology Source Type: research

Stability of Multi-Subunit Proteins and Conformational Lock
Publication date: Available online 27 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): L. Alaei, Ali A. Moosavi-MovahediAbstractOne of the important physicochemical features of the proteins specifically multi-subunit types is their stability at high temperatures. The kinetics of the dissociation and denaturation of proteins possessing at least two subunits has certain challenges because the overall mechanism of dissociation can include hidden reversible and/or irreversible steps (conformational lock). There are numerous proteins related to diseases which are in equilibrium with oligomer forms. This...
Source: Progress in Biophysics and Molecular Biology - August 29, 2019 Category: Molecular Biology Source Type: research

Lamarck and Panspermia - On the Efficient Spread of Living Systems Throughout the Cosmos
Publication date: Available online 22 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Edward J. Steele, Reginald M. Gorczynski, Robyn A. Lindley, Yongsheng Liu, Robert Temple, Gensuke Tokoro, Dayal T. Wickramasinghe, N. Chandra WickramasingheAbstractWe review the main lines of evidence (molecular, cellular and whole organism) published since the 1970s demonstrating Lamarckian Inheritance in animals, plants and microorganisms viz. the transgenerational inheritance of environmentally-induced acquired characteristics. The studies in animals demonstrate the genetic permeability of the soma-germline We...
Source: Progress in Biophysics and Molecular Biology - August 23, 2019 Category: Molecular Biology Source Type: research

Conjugation of NMR and SAXS for Flexible and Multidomain Protein Structure Determination: From Sample Preparation to Model Refinement
Publication date: Available online 21 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): P. Rodríguez-ZamoraAbstractExperimental information from small angle X-ray scattering (SAXS) is conjugated with nuclear magnetic resonance (NMR) spectroscopy data for the improvement of protein structure determination, particularly for flexible, multidomain or intrinsically disordered proteins. Individually, each of these techniques presents capabilities and limitations: NMR excels in local information, providing atomic resolution, but is limited by protein size, whereas SAXS yields a global envelope of th...
Source: Progress in Biophysics and Molecular Biology - August 22, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: September 2019Source: Progress in Biophysics and Molecular Biology, Volume 146Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 19, 2019 Category: Molecular Biology Source Type: research

The N-Space Episenome Unifies Cellular Information Space-Time within Cognition-Based Evolution
Publication date: Available online 12 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): William B. Miller, John S. Torday, František BaluškaAbstractSelf-referential cellular homeostasis is maintained by the measured assessment of both internal status and external conditions based within an integrated cellular information field. This cellular field attachment to biologic information space-time coordinates environmental inputs by connecting the cellular senome, as the sum of the sensory experiences of the cell, with its genome and epigenome. In multicellular organisms, individual cellula...
Source: Progress in Biophysics and Molecular Biology - August 13, 2019 Category: Molecular Biology Source Type: research

PBMB Editorial
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Denis Noble, Tom Blundell, Peter Kohl (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 11, 2019 Category: Molecular Biology Source Type: research

Editorial
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Denis Noble, Tom Blundell, Peter Kohl (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 7, 2019 Category: Molecular Biology Source Type: research

Comment on “Polygenic Scores: a public health hazard?”
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Michael J. Joyner (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 7, 2019 Category: Molecular Biology Source Type: research

Polygenic Scores: a public health hazard?
Publication date: Available online 6 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Keith Baverstock (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - August 7, 2019 Category: Molecular Biology Source Type: research

From epithelial remodelling to carcinogenesis
Publication date: Available online 2 August 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Leszek Satora, Jennifer Mytych, Anna Bilska-Kos, Katarzyna KoziołAbstractThe novel cancer theory named ‘The tissue organization field theory’ (TOFT) suggests that carcinogenesis is a process analogous to embryonic development, whereby organs are formed through interactions among different cell types. The suggested ‘morphological remodelling’ of the epithelium under hypoxia in gut breathing fish (GBF) has many common features with carcinogenesis. It appears that research into the relationsh...
Source: Progress in Biophysics and Molecular Biology - August 3, 2019 Category: Molecular Biology Source Type: research

Towards a clearer view of sympathetic innervation of cardiac and skeletal muscles
Publication date: Available online 20 July 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Anna Di Bona, Veronica Vita, Irene Costantini, Tania ZagliaAbstractIt is well appreciated that autonomic neurons have a central role in the homeostatic regulation of organs and systems and participate to the pathogenesis of several disease conditions. As such, the function and signalling pathways activated by sympathetic neurons (SNs) in different cell types and organs have become a matter of intense investigation throughout the years of modern biomedical research. This review is focused on the methods used to addr...
Source: Progress in Biophysics and Molecular Biology - July 21, 2019 Category: Molecular Biology Source Type: research

AI- modelling of molecular identification and feminization of wolbachia infected Aedes aegypti
ConclusionsFrom our analysis, we have concluded that the genetic control strategy is a promising technique and the role of Wolbachia infected male mosquitos, in genetic control strategies, can be better interpreted in an inexpensive manner with the aid of a theoretical model. (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - July 12, 2019 Category: Molecular Biology Source Type: research

Modeling the action of environment on proton tunneling in the adenine–thymine base pair
Publication date: Available online 9 July 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Ashkan Shekaari, Mahmoud JafariAbstractEffect of environment coupling on the quantum-biological phenomenon of proton tunneling in the hydrogen bonds of the adenine–thymine base pair in DNA was modeled within the framework of quantum statistics and perturbation theory. A number of important thermodynamic indicators including partition function, free energy, and entropy were then calculated and examined. The proton was then assumed to be subject to an attraction represented by a double-well potential energy surf...
Source: Progress in Biophysics and Molecular Biology - July 10, 2019 Category: Molecular Biology Source Type: research

Systems plant physiology: An integrated view of plants life
Publication date: Available online 28 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Gustavo M. Souza, Tony Trewavas, Danilo de Menezes Daloso (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

Studying β1 and β2 adrenergic receptor signals in cardiac cells using FRET-based sensors
Publication date: Available online 29 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Francesca Grisan, Alex Burdyga, Liliana F. Iannucci, Nicoletta C. Surdo, Tullio Pozzan, Giulietta Di Benedetto, Konstantinos LefkimmiatisAbstractCyclic 3′-5′ adenosine monophosphate (cAMP) is a key modulator of cardiac function. Thanks to the sophisticated organization of its pathway in distinct functional units called microdomains, cAMP is involved in the regulation of both inotropy and chronotropy as well as transcription and cardiac death. While visualization of cAMP microdomains can be achieved than...
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

Editorial Board
Publication date: August 2019Source: Progress in Biophysics and Molecular Biology, Volume 145Author(s): (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

“Systems Plant Physiology: an integrated view of plants life”
Publication date: Available online 28 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Gustavo M. Souza, Tony Trewavas, Danilo de Menezes Daloso (Source: Progress in Biophysics and Molecular Biology)
Source: Progress in Biophysics and Molecular Biology - June 30, 2019 Category: Molecular Biology Source Type: research

Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR
Publication date: Available online 27 June 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Domagoj Baretic, Taiana Maia de Oliveira, Martina Niess, Paul Wan, Hannah Pollard, Christopher M. Johnson, Caroline Truman, Eileen McCall, David Fisher, Roger Williams, Christopher PhillipsAbstractATM, ATR and DNA-PKCs are key effectors of DNA Damage response and have been extensively linked to tumourigenesis and survival of cancer cells after radio/chemotherapy. Despite numerous efforts, the structures of these proteins remained elusive until very recently. The resolution revolution in Cryo-EM allowed for molecula...
Source: Progress in Biophysics and Molecular Biology - June 28, 2019 Category: Molecular Biology Source Type: research