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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney
ConclusionThese findings suggest that NaPi-IIc is important for the expression of NaPi-IIa (NaPi-4) protein in OK cells. Suppression of Npt2c may downregulate Npt2a function in HHRH patients.
Source: Clinical and Experimental Nephrology - October 13, 2018 Category: Urology & Nephrology Source Type: research

The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation.
CONCLUSION: The expression of MALAT1 is increased in renal ischemia-reperfusion injury. It is likely that MALAT1 inhibits the hypoxia-induced inflammatory response through the NF-κB pathway. PMID: 30277425 [PubMed - in process]
Source: Renal Failure - October 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal  fibrosis
The cannabinoid receptor type 2 (CB2) is a G protein-coupled seven transmembrane receptor that transmits endogenous cannabinoid signaling. The role of CB2 in the pathogenesis of kidney injury and fibrosis remains poorly understood. Here we demonstrate that CB2 was induced, predominantly in kidney tubular epithelium, in various models of kidney disease induced by unilateral ureteral obstruction, adriamycin or ischemia/reperfusion injury. In  vitro, forced expression of CB2 or treatment with a CB2 agonist was sufficient to trigger matrix gene expression, whereas knockdown of CB2 by siRNA abolished transforming growth factor...
Source: Kidney International - August 6, 2018 Category: Urology & Nephrology Authors: Lili Zhou, Shan Zhou, Peng Yang, Yuan Tian, Zhiwei Feng, Xiang-Qun Xie, Youhua Liu Tags: Basic Research Source Type: research

Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification
Conclusion: Silencing of SHMT1 promotes osteo-/chondrogenic signaling in VSMCs, at least in part, by inducing cellular oxidative stress. It thus aggravates phosphate-induced calcification of VSMCs. The present findings support a regulatory role of SHMT1 in vascular calcification during conditions of hyperphosphatemia such as chronic kidney disease.Kidney Blood Press Res 2018;43:1212 –1221
Source: Kidney and Blood Pressure Research - August 2, 2018 Category: Urology & Nephrology Source Type: research

RANK Deficiency Ameliorates Podocyte Injury by Suppressing Calcium/Calcineurin/ NFATc1 Signaling
Conclusion: Our findings demonstrated that RANK deficiency ameliorates podocyte injury by suppressing calcium/calcineurin/NFATc1 signaling, which may present a promising target for therapeutic intervention.Kidney Blood Press Res 2018;43:1149 –1159
Source: Kidney and Blood Pressure Research - July 23, 2018 Category: Urology & Nephrology Source Type: research

Intrarenal ghrelin receptor inhibition ameliorates angiotensin ii-dependent hypertension in rats.
INTRARENAL GHRELIN RECEPTOR INHIBITION AMELIORATES ANGIOTENSIN II-DEPENDENT HYPERTENSION IN RATS. Am J Physiol Renal Physiol. 2018 Jun 20;: Authors: Kemp BA, Howell NL, Padia SH Abstract The intrarenal ghrelin receptor (GR) is localized to collecting duct (CD) cells where it increases αENaC-dependent sodium reabsorption in rodents. We hypothesized that chronic GR inhibition with intrarenal GR siRNA lowers blood pressure (BP) in Angiotensin II-dependent hypertension via reductions in αENaC-dependent sodium reabsorption. Uninephrectomized Sprague-Dawley rats (N=121) received subcutaneous osmotic pumps...
Source: Am J Physiol Renal P... - June 20, 2018 Category: Urology & Nephrology Authors: Kemp BA, Howell NL, Padia SH Tags: Am J Physiol Renal Physiol Source Type: research

Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.
In conclusion, deletion of exon 9 from Cul3 generates a protein that is itself ubiquitin ligase-defective, but also capable of enhanced autophagocytic KLHL3 degradation, thereby exerting dominant-negative effects on the WT-allele. PMID: 29897280 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - June 13, 2018 Category: Urology & Nephrology Authors: Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH Tags: Am J Physiol Renal Physiol Source Type: research

The Role of Palladin in Podocytes
Conclusions Palladin has an important role in podocyte function in vitro and in vivo.
Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Artelt, N., Ludwig, T. A., Rogge, H., Kavvadas, P., Siegerist, F., Blumenthal, A., van den Brandt, J., Otey, C. A., Bang, M.-L., Amann, K., Chadjichristos, C. E., Chatziantoniou, C., Endlich, K., Endlich, N. Tags: Basic Research Source Type: research

G-protein Pathway Suppressor 2 (GPS2) enhanced the renal large conductance Ca2+ activated potassium channel expression via inhibiting ERK 1/2 signaling pathway.
In this study, we investigated the effects of GPS2 on BK channel activity and protein expression. In HEK BK stably-expressing cells transfected with either GPS2 or its pCMV vector control, a single cell recording showed that GPS2 significantly increased BK channel activity (NPo), increasing BK open probability (Po) and channel number (N) compared to the control. In Cos-7 cells and HEK293T cells, GPS2 overexpression significantly enhanced the total protein expression of BK in a dose-dependent manner. Knockdown of GPS2 expression significantly decreased BK protein expression while increasing ERK1/2 phosphorylation. Knockdown...
Source: Am J Physiol Renal P... - May 16, 2018 Category: Urology & Nephrology Authors: Zhuang Z, Xiao J, Chen X, Hu X, Li R, Chen S, Feng X, Shen S, Ma HP, Zhuang J, Cai H Tags: Am J Physiol Renal Physiol Source Type: research

Gpr97 Exacerbates AKI by Mediating Sema3A Signaling
Conclusions Gpr97 is an important mediator of AKI, and pharmacologic targeting of Gpr97-mediated Sema3A signaling at multiple levels may provide a novel approach for the treatment of AKI.
Source: Journal of the American Society of Nephrology : JASN - April 30, 2018 Category: Urology & Nephrology Authors: Fang, W., Wang, Z., Li, Q., Wang, X., Zhang, Y., Sun, Y., Tang, W., Ma, C., Sun, J., Li, N., Yi, F. Tags: Basic Research Source Type: research

Protective effect of Gelofusine against cRGD-siRNA-induced nephrotoxicity in mice.
Authors: Liao W, Qin Y, Liao L, Cen B, Wu Z, Wei Y, Wang Z, Li G, Ji A Abstract Based on successful targeting to the αvβ3 integrin of cyclic arginine-glycine-aspartic acid (cRGD), cRGD-conjugated small interfering RNA (siRNA) exhibits tumor targeting and has become a new treatment strategy for solid tumors. However, the nephrotoxicity caused by its renal retention limits its clinical application. Here, we evaluated the protective effect of Gelofusine against cRGD-conjugated siRNA-induced nephrotoxicity in mice. Male Kunming mice (six per group) were either co-injected with Gelofusine and cRGD-siRNA or injected wi...
Source: Renal Failure - April 7, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Pd03-07 rna interference of hepatic lactate dehydrogenase reduces urinary oxalate in a mouse model of primary hyperoxaluria type 1
Endogenous oxalate synthesis primarily occurs via lactate dehydrogenase (LDH) activity in the liver. Liver specific RNAi therapeutics are currently in clinical trials for a number of diseases. Previous work using RNAi against liver glycolate oxidase demonstrated reduction of urinary oxalate in the Agxt knock out mouse, a model for primary hyperoxaluria Type 1 (PH1). Our objective was to evaluate the effects of siRNA knock down of liver LDHA in wild type (Wt) and PH1 mouse model (Agxt knock out (KO)).
Source: The Journal of Urology - April 1, 2018 Category: Urology & Nephrology Authors: Kyle Wood, John Knight, Dean Assimos, Ross Holmes Tags: Stone Disease: Basic Research & Pathophysiology I Source Type: research

Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine (ADMA) & dimethylarginine dimethylaminohydrolase (DDAH) 1.
CONCLUSIONS: Fluid reabsorption in the proximal tubule is reduced by tubular ADMA or by blocking its metabolism by DDAH-1. L-257 is a novel regulator of proximal tubule fluid reabsorption. PMID: 29513072 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - March 7, 2018 Category: Urology & Nephrology Authors: Bell T, Araujo M, Luo Z, Tomlinson J, Leiper J, Welch WJ, Wilcox CS Tags: Am J Physiol Renal Physiol Source Type: research

Knocking down Cabin1 induces glomerular podocyte injury
ConclusionsKnocking down Cabin1 induces the disruption of cytoskeleton and mitochondrial dysfunction in podocyte. Cabin1 could be a crucial factor in podocyte damage.
Source: International Urology and Nephrology - January 24, 2018 Category: Urology & Nephrology Source Type: research

Zhang L, Zhang Q, Liu S, et  al. DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury. Kidney Int. 2017;92:140–153
The above-mentioned article, in Figure  5h, the same fluorescence images presented in the HG group were mistakenly present in the HG+Con –siRNA group. The corrected image is as follows:
Source: Kidney International - December 29, 2017 Category: Urology & Nephrology Tags: Corrigendum Source Type: research