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Specialty: Urology & Nephrology
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Total 430 results found since Jan 2013.
Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress
Ren Fail. 2021 Dec;43(1):556-565. doi: 10.1080/0886022X.2021.1902821.ABSTRACTAldosterone exerts an enormous function on proximal tubular cells (PTC) senescence, which is a common pathomechanism contributing to renal dysfunction. Numerous studies have shown that oxidative stress is deeply involved in the pathophysiologic processes of chronic kidney diseases. The study aims to investigate whether autophagy could regulate the process of senescence through oxidative stress in PTC both in vivo and ex vivo. Our results suggested that aldosterone treatment increased the senescence and oxidative stress as evidenced by increased pe...
Source: Renal Failure - March 24, 2021 Category: Urology & Nephrology Authors: Jing-Yuan Cao Li-Lu Ling Wei-Jie Ni Hong-Lei Guo Min Yang Source Type: research
Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Exposed to Hypoxic Environment is Regulated by Caveolin-1-dependent AMPK Activity
CONCLUSIONS: We suggest a new finding for the first time that AMPK activation can regulate Hif-1α induction as well as Hif-1α-induced Cav-1 expression, and the inhibitory effect of anti-apoptotic pathway on the exposure of RT4 cells to hypoxic environment is due to Cav-1-dependent AMPK activity.PMID:33752282 | DOI:10.5213/inj.2040444.222
Source: International Neurourology Journal - March 23, 2021 Category: Urology & Nephrology Authors: Tae Jin Cho Da-Hyun Lee Bo-Hwa Choi Helen K Shinn Chang-Shin Park Source Type: research
Activation of RAS contributes to peritoneal fibrosis via dysregulation of low-density lipoprotein receptor.
In conclusion, increased intracellular RAS activity impaired lipid homeostasis and induced ECM accumulation in HPMCs by disrupting the LDLr pathway, which contributed to PF.
PMID: 33427062 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - January 11, 2021 Category: Urology & Nephrology Authors: Liu J, Feng Y, Li N, Shao QY, Zhang Q, Sun C, Xu P, Jiang CM Tags: Am J Physiol Renal Physiol Source Type: research
Effect of Forkhead Box O1 in Renal Tubular Epithelial Cells on Endotoxin-Induced Acute Kidney Injury.
In conclusion, downregulation of FOXO1 in RTECs mediated endotoxin-induced AKI and mitochondrial damage. Overexpression of FOXO1 could improve renal injury and mitochondrial dysfunction, and this effect occurred at least in part as a result of PGC1-α signaling. FOXO1 might be a potential target for the prevention and treatment of endotoxin-induced AKI.
PMID: 33356954 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - December 28, 2020 Category: Urology & Nephrology Authors: Zhang M, Dong W, Li Z, Xiao Z, Xie Z, Ye Z, Liu S, Li R, Chen Y, Zhang L, Wang M, Liang H, Baihetiyaer R, Apaer R, Dong Z, Liang X Tags: Am J Physiol Renal Physiol Source Type: research
AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.
In this study, we demonstrated that cisplatin activates AMPK (Thr172 phosphorylation) in cultured renal tubular epithelial cells in a time-dependent manner, which is associated with p53 phosphorylation. Compound C, a selective AMPK inhibitor, suppressed cisplatin-induced AMPK activation, p53 phosphorylation, Bax induction and caspase 3 activation. Furthermore, silencing AMPK expression by siRNA attenuated cisplatin-induced p53 phosphorylation, Bax induction, and caspase 3 activation. In a mouse model of cisplatin-induced kidney injury, compound C inhibited p53 phosphorylation, Bax expression, caspase 3 activation, and apop...
Source: Am J Physiol Renal P... - October 26, 2020 Category: Urology & Nephrology Authors: Jin X, An C, Jiao B, Safirstein RL, Wang Y Tags: Am J Physiol Renal Physiol Source Type: research
Elevated expression of HDAC6 in clinical peritoneal dialysis patients and its pathogenic role on peritoneal angiogenesis.
In this study, we analyzed the expression of HDAC6 in the peritoneum from patients with non-PD and PD-related peritonitis and dialysis effluent from stable PD patients. Our study revealed that HDAC6 expressed highly in the peritoneum with peritonitis and co-stained with α-smooth muscle actin (α-SMA), a biomarker of the myofibroblast. And the level of HDAC6 in the dialysate increased with time and positively correlated with transforming growth factor-β1 (TGF-β1), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF), and negatively with cancer antigen 125 (CA125). In vitro, blockading HDAC6 with a selective...
Source: Renal Failure - September 1, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research
AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3.
CONCLUSIONS: Our studies provide a novel pathway how AGEs contribute to podocyte injury and the formation of the so-called metabolic memory in DKD.
PMID: 32854097 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - August 26, 2020 Category: Urology & Nephrology Authors: Liebisch M, Wolf G Tags: Am J Nephrol Source Type: research
