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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

NRBP1 modulates uric acid transporter ABCG2 expression by activating the Wnt/ β-catenin pathway in HK-2 cells
CONCLUSION: Taken together, our study demonstrated that NRBP1 inhibition played an essential role in attenuating hyperuricemia and gout by upregulation of ABCG2 via Wnt/β-catenin signaling pathway in HK-2 cells.PMID:36437206 | DOI:10.1016/j.nefroe.2022.11.015
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - November 27, 2022 Category: Urology & Nephrology Authors: Qiankun Zhang Hang Fang Zaihua Zhu Source Type: research

Transient receptor potential canonical 6 knockdown ameliorated diabetic kidney disease by inhibiting nuclear factor of activated T cells 2 expression in glomerular mesangial cells
CONCLUSION: These results demonstrate that inhibition of TRPC6/NFAT2 signaling attenuates GMC dysfunction and the development of DKD and suggest that pharmacological targeting of TRPC6/NFAT2 in GMCs may provide beneficial effects for DKD.PMID:36285371 | DOI:10.1080/0886022X.2022.2134796
Source: Renal Failure - October 26, 2022 Category: Urology & Nephrology Authors: Jian Yu Chunchun Li Lisha Ma Bin Zhai Aiping Xu Decui Shao Source Type: research

Angiotensin II type 2 receptor prevents extracellular matrix accumulation in human peritoneal mesothelial cell by ameliorating lipid disorder via LOX-1 suppression
Ren Fail. 2022 Dec;44(1):1687-1697. doi: 10.1080/0886022X.2022.2133729.ABSTRACTEvidence suggests that intracellular angiotensin II type 1 receptor (AT1) contributes to peritoneal fibrosis (PF) under high glucose (HG)-based dialysates. It is generally believed that AT2 antagonisticly affects AT1 function. The aim of this study was to explore whether AT2 activation is beneficial for attenuating human peritoneal mesothelial cell (HPMC) injury due to HG. We treated a HPMC line with HG to induce extracellular matrix (ECM) formation. AT2 was increased and blocked using CGP42112A and AT2 siRNA. Lipid deposition was detected, sign...
Source: Renal Failure - October 13, 2022 Category: Urology & Nephrology Authors: Jing Liu Bo Jin Jian Lu Yuan Feng Nan Li Cheng Wan Qing-Yan Zhang Chun-Ming Jiang Source Type: research

Cyclophilin A/CD147 signaling induces the epithelial-to-mesenchymal transition and renal fibrosis in chronic allograft dysfunction by regulating p38 MAPK signaling
CONCLUSIONS: Our study reported the positive relationship of CyPA-CD147 signaling with renal allograft dysfunction. The in vitro study suggested that CyPA-CD147 signaling induce the development of the EMT process by p38 MAPK signaling, thus contributing to renal allograft fibrosis and CAD.PMID:36203223 | DOI:10.1080/0886022X.2022.2126788
Source: Renal Failure - October 6, 2022 Category: Urology & Nephrology Authors: Xuzhong Liu Zhiwang Tang Xi Jiang Tianwei Wang Lun Zhao Zongyuan Xu Kun Liu Source Type: research

TGF ‐β3 induces lactate production in Sertoli cell through inhibiting the Notch pathway
ConclusionTGF- β3 induces lactate production in SC through up-regulating Lgl2, which weakened the Notch signaling activity and intensified glycolysis in SCs. Thus, besides the known function of TGF-β3 as the BTB regulator, TGF-β3-Lgl2-Notch may be considered an important pathway controlling SC glycolysis and sp ermatogenesis.
Source: Andrology - September 13, 2022 Category: Urology & Nephrology Authors: Ying Xu, Shuyi Jiang, Ying Hu, Qiang Zhang, Wenhui Su Tags: ORIGINAL ARTICLE Source Type: research

The hypoxia-inducible factor- α prolyl hydroxylase inhibitor FG4592 ameliorates renal fibrosis by inducing the H3K9 demethylase JMJD1A
Am J Physiol Renal Physiol. 2022 Sep 8. doi: 10.1152/ajprenal.00083.2022. Online ahead of print.ABSTRACTHypoxia-inducible factors 1α and 2α (HIF-1α/2α) transcription factors are the major regulators of the cellular response to hypoxia and also play a key role in renal fibrosis associated with acute and chronic kidney disease. Jumonji domain-containing 1a (JMJD1A), a histone H3 lysine 9 (H3K9) demethylase, is reported to be an important target gene of HIF-α. However, whether JMJD1A and H3K9 methylation status play a role in renal fibrosis is unclear. Here, we investigated the involvement of HIF-α, JMJD1A, and monometh...
Source: Am J Physiol Renal P... - September 8, 2022 Category: Urology & Nephrology Authors: Takeshi Ike Shigehiro Doi Ayumu Nakashima Kensuke Sasaki Naoki Ishiuchi Tomoichiro Asano Takao Masaki Source Type: research

Loss of sphingosine kinase 2 protects against cisplatin induced-kidney injury
Am J Physiol Renal Physiol. 2022 Jul 14. doi: 10.1152/ajprenal.00229.2021. Online ahead of print.ABSTRACTCisplatin is an established chemotherapeutic drug for treatment of solid-organ cancers, and is the primary drug utilized in the treatment of head and neck cancer; however, cisplatin-induced nephrotoxicity largely limits its clinical use. Inhibition of sphingosine kinase 2 (SphK2) has been demonstrated to alleviate various kidney diseases. Therefore, we hypothesized that inhibition of SphK2 could also protect against cisplatin-induced nephrotoxicity. Results from the present study showed that the SphK2 inhibitor, ABC2946...
Source: Am J Physiol Renal P... - July 14, 2022 Category: Urology & Nephrology Authors: Dengpiao Xie Gaizun Hu Chaoling Chen Fereshteh Ahmadinejad Weili Wang Pin-Lan Li David A Gewirtz Ningjun Li Source Type: research