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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Loss of sphingosine kinase 2 protects against cisplatin induced-kidney injury
Am J Physiol Renal Physiol. 2022 Jul 14. doi: 10.1152/ajprenal.00229.2021. Online ahead of print.ABSTRACTCisplatin is an established chemotherapeutic drug for treatment of solid-organ cancers, and is the primary drug utilized in the treatment of head and neck cancer; however, cisplatin-induced nephrotoxicity largely limits its clinical use. Inhibition of sphingosine kinase 2 (SphK2) has been demonstrated to alleviate various kidney diseases. Therefore, we hypothesized that inhibition of SphK2 could also protect against cisplatin-induced nephrotoxicity. Results from the present study showed that the SphK2 inhibitor, ABC2946...
Source: Am J Physiol Renal P... - July 14, 2022 Category: Urology & Nephrology Authors: Dengpiao Xie Gaizun Hu Chaoling Chen Fereshteh Ahmadinejad Weili Wang Pin-Lan Li David A Gewirtz Ningjun Li Source Type: research

Vitamin D Receptor/Vitamin D Response Element Directly Modulate < b > < i > Nestin < /i > < /b > Transcription to Ameliorate PAN-Induced Podocyte Morphological Changes
Conclusions: Paricalcitol directly regulates nestin transcription through the interaction of VDR/VDRE, thereby preventing morphological changes of podocytes in PAN nephropathy.Nephron
Source: Nephron - May 6, 2022 Category: Urology & Nephrology Source Type: research

The potential of RNA-based therapy for kidney diseases
Abstract   Inherited kidney diseases (IKDs) are a large group of disorders affecting different nephron segments, many of which progress towards kidney failure due to the absence of curative therapies. With the current advances in genetic testing, the understanding of the molecular basis and pathophysiology of these disorders is increasing and reveals new potential therapeutic targets. RNA has revolutionized the world of molecular therapy and RNA-based therapeutics have started to emerge in the kidney field. To apply these therapies for inherited kidney disorders, several aspects require attention. First, the mRNA must be...
Source: Pediatric Nephrology - May 4, 2022 Category: Urology & Nephrology Source Type: research

Low androgen status inhibits erectile function by upregulating the expression of proteins of mitochondria ‐associated membranes in rat corpus cavernosum
ConclusionLow androgen status upregulated the expressions of patients in MAMs (FACL-4, PACS-2, and IP3R1) in the corpus cavernosum  and inhibited the eNOS/NO/cGMP signaling pathway, resulting in impaired erectile function in rats. Erectile function may be improved by inhibiting the high expression of PACS-2 in the corpus cavernosum under low androgen state.
Source: Andrology - May 2, 2022 Category: Urology & Nephrology Authors: Hao ‐Zhou Yang, Wen‐ju Xiong, Xiong Li, Jun Jiang, Rui Jiang Tags: ORIGINAL ARTICLE Source Type: research

Vitamin D/vitamin D receptor/Atg16L1  axis maintains podocyte autophagy and survival in diabetic kidney disease
CONCLUSION: Autophagy protects podocytes from damage in DN and is modulated by VitD3/VDR signaling and downstream regulation of Atg16L1 expression.PMID:35469547 | DOI:10.1080/0886022X.2022.2063744
Source: Renal Failure - April 26, 2022 Category: Urology & Nephrology Authors: Lang Shi Chao Xiao Yafei Zhang Yao Xia Hongchu Zha Jiefu Zhu Zhixia Song Source Type: research

Low androgen status inhibits erectile function by up ‐regulating the expression of proteins of mitochondria‐associated membranes in rat corpus cavernosum
ConclusionLow androgen status up-regulated the expressions of patients in MAMs (FACL-4, PACS-2 and IP3R1) in the corpus cavernosum  and inhibited the eNOS/NO/cGMP signaling pathway, resulting in impaired erectile function in rats. Erectile function may be improved by inhibiting the high expression of PACS-2 in the corpus cavernosum under low androgen state.This article is protected by copyright. All rights reserved
Source: Andrology - April 25, 2022 Category: Urology & Nephrology Authors: Hao ‐Zhou Yang, Wen‐ju Xiong, Xiong Li, Jun Jiang, Rui Jiang Tags: ORIGINAL ARTICLE Source Type: research

Correlations between forkhead box D1 expression and clinicopathological characteristics of patients with bladder cancer and influence on biological behaviors of bladder cancer cells
CONCLUSIONS: FOXD1 is highly expressed in bladdercancer tissues and cells, being closely associatedwith the development and progression of bladder cancer.It facilitates the proliferation, migration and invasionof cells and carcinogenesis. FOXD1 may be a newtarget for bladder cancer therapy.PMID:35435161
Source: Archivos Espanoles de Urologia - April 18, 2022 Category: Urology & Nephrology Authors: Fuke Wang Junfeng Yang Source Type: research