A Clinical Score to Predict Severe Acute Kidney Injury in Chinese Patients after Cardiac Surgery
Conclusion: We developed and validated a practical risk prediction model for SAKI after cardiac surgery based on routinely available perioperative clinical and laboratory data. The prediction model can be easily applied at the bedside and provides a simple and interpretable estimation of risk.Nephron (Source: Nephron)
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Predicting Risk of Recurrent Acute Kidney Injury: A Systematic Review
Background: Although the epidemiology of acute kidney injury (AKI) has been well described, less is known about recurrent AKI (r-AKI). We undertook a systematic review to identify incidence, risk factors, and outcomes of r-AKI.Methods: MEDLINE, EMBASE, CINAHL, Cochrane, Web of Science were searched, from inception to December 2017, for quantitative studies on adults with AKI, where follow-up included ­reporting of r-AKI. Two reviewers independently identified studies and assessed study quality.Summary: From 2,824 citations, 10 cohort studies met inclusion criteria (total patientsn = 538,667). There were 2 distinct set ...
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Hyperosmolality, High Blood Pressure, and Decreased Estimated Glomerular Filtration Rate in US Adolescents, National Health and Nutrition Examination Survey 1999 –2012
Conclusion: Among adolescents in a nationally representative survey, hypernatremia and hyperosmolality were associated with high SBP and decreased eGFR. These findings may support the hypothesis that an imbalance of salt and water contribute to hypertension and CKD.Nephron (Source: Nephron)
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Hemolytic Uremic Syndrome in an Infant with Primary Hyperoxaluria Type II: An Unreported Clinical Association
A 6-month-old boy presented with acute renal failure, thrombocytopenia, and severe non-immune hemolytic anemia. Infection by Shiga-like toxin-producingEscherichia coli and other causes of microangiopathic hemolysis were ruled out, leading to a diagnosis of atypical hemolytic uremic syndrome (aHUS). Neither pathogenic variants in HUS-associated genes nor anti-factor H antibodies were identified. Copy number variation analysis uncovered 4 copies of complement factor H related genes,CFHR1-CFHR4, conceivably leading to higher than normal levels of the corresponding proteins. However, this abnormality was also found in the heal...
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Mother and Child Reunion in “Hypertensive” End-Stage Renal Disease: Will They Complement Each Other?
We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation, indicating atypical hemolytic uremic syndrome (HUS). The pathogenic variant inCD46 was also found in the mother who donated the kidney, indicating that the TMA occurred on the background of atypical HUS instead of severe hypertension. The patient died from disseminated cancer originated in the mother ’s kidney. Knowledge of the genetic background would have prevent...
Source: Nephron - March 14, 2019 Category: Urology & Nephrology Source Type: research

Salidroside Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis by Inhibiting the Hypoxia-Inducible Factor-1 α Expression Through Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
Conclusions: In summary, SAL ameliorates FSGS mainly by inhibiting the expression of HIF-1 α through PI3K/Akt pathway, which might offer an array of hope for ameliorating FSGS.Nephron (Source: Nephron)
Source: Nephron - March 7, 2019 Category: Urology & Nephrology Source Type: research

Serum miR-192 Is Related to Tubulointerstitial Lesion and Short-Term Disease Progression in IgA Nephropathy
Conclusions: Lower serum miR-192 in IgA nephropathy patients indicates lower intrarenal miR-192 expression, more severe tubular atrophy, interstitial inflammation, and fibrotic tendency (with higher TGF- β and E-cadherin in renal miR-192). IgA nephropathy patients with higher serum miR-192 are less likely to have renal function decline over the course of 2 years.Nephron (Source: Nephron)
Source: Nephron - February 26, 2019 Category: Urology & Nephrology Source Type: research

Effect of Dapagliflozin Treatment on the Expression of Renal Sodium Transporters/Channels on High-Fat Diet Diabetic Mice
Conclusion: Our findings suggest that dapagliflozin treatment augments compensatory changes in the renal PT in diabetic mice.Nephron (Source: Nephron)
Source: Nephron - February 22, 2019 Category: Urology & Nephrology Source Type: research

Association of Thyrotropin Concentration with Chronic Kidney Disease in a Japanese General Population Cohort
Conclusions: Our data indicate that higher TSH concentrations are positively correlated with CKD prevalence and that  a high TSH concentration is a risk factor for CKD development.Nephron (Source: Nephron)
Source: Nephron - February 22, 2019 Category: Urology & Nephrology Source Type: research

Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction
Conclusion: Our data suggest that the activation of MR is involved in NLRP3/caspase-1 pathway-induced cell pyroptosis in the contralateral kidney of UUO model.Nephron (Source: Nephron)
Source: Nephron - February 21, 2019 Category: Urology & Nephrology Source Type: research

CD44-Positive Glomerular Parietal Epithelial Cells in a Mouse Model of Calcineurin Inhibitors-Induced Nephrotoxicity
Conclusion: CD44-positive (activated) PECs reflect extremely early podocyte injury in the progression of FSGS formation and may be a good marker for early detection of CNI-induced nephrotoxicity.Nephron (Source: Nephron)
Source: Nephron - February 20, 2019 Category: Urology & Nephrology Source Type: research

Burden, Access, and Disparities in Kidney Disease
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight the need for strengthening basic infrastructure for kidney care services for early detec...
Source: Nephron - February 18, 2019 Category: Urology & Nephrology Source Type: research

Amelioration of Uremic Toxin Indoxyl Sulfate-Induced Osteoblastic Calcification by SET Domain Containing Lysine Methyltransferase 7/9 Protein
Conclusions: Our data demonstrated that SET7/9 downregulation and autophagy activation may be the key mechanism of IS-induced VC in CKD.Nephron (Source: Nephron)
Source: Nephron - February 15, 2019 Category: Urology & Nephrology Source Type: research

Reversal Unilateral Ureteral Obstruction: A Mice Experimental Model
Conclusion: This R-UUO model is an easy, reproducible and reliable method to assess kidney recovery after obstructive uropathy. In this setting, the use of this model may help to a better understanding of the process of kidney repair.Nephron (Source: Nephron)
Source: Nephron - February 15, 2019 Category: Urology & Nephrology Source Type: research

Fabry Disease Prevalence in Renal Replacement Therapy in Turkey
Conclusions: There are important implications of the screening. First, detection of the undiagnosed patients leads to starting appropriate therapies for these patients. Second, the transmission of the disease to future generations may be prevented by prenatal screening after appropriate genetic counseling. In conclusion, we suggest screening of kidney Tx candidates for FD, regardless of etiologies of chronic kidney disease.Nephron (Source: Nephron)
Source: Nephron - February 8, 2019 Category: Urology & Nephrology Source Type: research

The Role of Extracellular Phosphate Levels on Kidney Disease Progression in a Podocyte Injury Mouse Model
Conclusions: Hyperphosphatemia caused by renal function decline was observed in a FSGS-induced NEP25 mouse model. Studies using this model showed that Pi regulation had a positive impact on kidney disease progression, and notably on tubular epithelial cell injury, which indicates the importance of Pi regulation in the treatment of kidney disease progression.Nephron (Source: Nephron)
Source: Nephron - February 7, 2019 Category: Urology & Nephrology Source Type: research

Clinical Characteristics and Outcomes of Kidney Transplantation under Urgency Priority Condition
Conclusion: Patients transplanted under UP status remained a longer time on dialysis off the WL, suggesting that long-term dialysis led to exhaustion of accesses. After transplantation, outcomes are inferior and UP status was a risk factor for graft loss. These results point to the need for local policies to encourage and monitor the early referral to KT.Nephron (Source: Nephron)
Source: Nephron - February 7, 2019 Category: Urology & Nephrology Source Type: research

Utility of Cardiac Biomarkers in the Setting of Kidney Disease
Cardiovascular disease is prevalent in patients with chronic kidney disease (CKD) and responsible for approximately half of all CKD-related deaths. Unfortunately, the presence of CKD can lead to a challenging interpretation of cardiac biomarkers essential in accurate diagnosis and prompt management of heart failure and acute coronary syndrome. There is growing interest in novel cardiac biomarkers that may improve diagnostic accuracy reflecting myocardial injury, inflammation, and remodeling. Interpretation of these biomarkers in CKD can be complicated, since elevated levels may not reflect myocardial injury or wall tension...
Source: Nephron - February 6, 2019 Category: Urology & Nephrology Source Type: research

Renal Consequences of Therapeutic Interventions in Premature Neonates
An infant is described as “preterm” if they are born before 37 weeks of gestation. As nephrogenesis does not complete until 36 weeks of gestation, premature infants are often born with underdeveloped kidneys. Current evidence strongly suggests that this leaves those born prematurely more susceptible to developing kidney -related conditions later in life. Although the incidence of premature birth steadily increases each year in the United Kingdom, reports of perinatal death following preterm labour are falling. This is mainly attributed to the development of antenatal drugs, such as tocolytics, corticostero...
Source: Nephron - February 6, 2019 Category: Urology & Nephrology Source Type: research

Dynamic Thiol/Disulphide Homeostasis in Children with Nephrotic Syndrome
Conclusions: The present findings show that DTDH shifted toward disulphide formation in the NS patients, even during remission. A clearer understanding of the mechanism of this disruption to homeostasis in NS patients might lead to the development of novel therapeutic strategies.Nephron (Source: Nephron)
Source: Nephron - February 6, 2019 Category: Urology & Nephrology Source Type: research

Low Sodium Diet Decreases Stone Formation in Genetic Hypercalciuric Stone-Forming Rats
Conclusion: Thus, a low Na diet reduced uCa and stone formation in GHS rats, even though SS with respect to CaP and CaOx was unchanged and effects on bone were modest. These data, if confirmed in humans, support dietary Na restriction to prevent recurrent Ca nephrolithiasis.Nephron (Source: Nephron)
Source: Nephron - February 6, 2019 Category: Urology & Nephrology Source Type: research

Endogenous Erythropoietin and Hepatic Dysfunction in Acute Kidney Injury Requiring Renal Replacement Therapy
Conclusion: Elevated EPO was not associated with anemia or RRT dependence. However, higher rates of mortality and hepatic dysfunction were observed in high EPO patients than in low EPO patients.Nephron (Source: Nephron)
Source: Nephron - February 1, 2019 Category: Urology & Nephrology Source Type: research

Effects of Long-Term Cinacalcet Administration on Parathyroid Gland in Hemodialysis Patients with Secondary Hyperparathyroidism
Conclusion: In the present patients, long-term treatment with cinacalcet progressively decreased the total volume of parathyroid glands, as well as levels of intact PTH and phosphate in serum in a time-dependent manner. On the contrary, cinacalcet administration did not cause secondary failure or over-suppress the transition of parathyroid gland activity to hypoparathyroid status. These results suggest that cinacalcet treatment may postpone the need for parathyroidectomy and/or reduce its use even after long-term administration for up to 8 years.Nephron (Source: Nephron)
Source: Nephron - February 1, 2019 Category: Urology & Nephrology Source Type: research

Longitudinal Experience with Remote Monitoring for Automated Peritoneal Dialysis Patients
Conclusion: These data confirm the long-term benefits of RM applied to APD. RM-APD is cost-effective; it allows early detection and resolution of problems, improved treatment compliance, reduction of patient ’s access to hospital center for technical and clinical complications with consequent savings, and improved patient’s quality of life.Nephron (Source: Nephron)
Source: Nephron - January 30, 2019 Category: Urology & Nephrology Source Type: research

Amelioration of Early Markers of Diabetic Nephropathy by Linagliptin in Fructose-Streptozotocin-Induced Type 2 Diabetic Rats
Conclusions: This study suggests that linagliptin exerts renoprotection against early features of DN in rats probably by inhibition of high glucose-induced renal tubular and glomerular injury thereby hampering KIM-1 and NGAL as well as vanin-1 associated with renal inflammation, fibrosis and oxidative stress.Nephron (Source: Nephron)
Source: Nephron - January 30, 2019 Category: Urology & Nephrology Source Type: research

Hyperbilirubinemia Induces Pro-Apoptotic Effects and Aggravates Renal Ischemia Reperfusion Injury
Conclusions: Our results reveal that the hyperbilirubinemia induces pro-apoptotic effects and aggravates RIRI.Nephron (Source: Nephron)
Source: Nephron - January 27, 2019 Category: Urology & Nephrology Source Type: research

The Prevalence and Clinical Features of Fabry Disease in Hemodialysis Patients: Russian Nationwide Fabry Dialysis Screening Program
Conclusions: Screening in at-risk patients remains the feasible approach to diagnose Fabry disease in patients with ESRD and their family members, given a low awareness of Fabry disease among the Russian nephrologists.Nephron (Source: Nephron)
Source: Nephron - January 27, 2019 Category: Urology & Nephrology Source Type: research

Roles of 12-Lipoxygenase and Its Interaction with Angiotensin II on p21 and p27 Expression in Diabetic Nephropathy
Conclusion: 12-LO is involved in diabetic renal hypertrophy via the induction of p21 and p27 protein expression and interacts with Ang II to induce p27 upregulation in diabetes. The current results suggest a potential amplifying loop in the pathogenesis of diabetic nephropathy.Nephron (Source: Nephron)
Source: Nephron - January 27, 2019 Category: Urology & Nephrology Source Type: research

A Comment on the Diagnosis and Definition of Acute Kidney Injury
This article critiques current, clinical approaches to determining AKI aetiology alongside future areas in which significant developments in patient phenotyping based on pathophysiological principles may occur. In the absence of current alternatives to serum creatinine, current AKI criteria (e.g., those from Kidney Disease Improving Global Outcomes) bring significant advantages in clinical and research environments, including facilitation of efforts to address current variations in the delivery of AKI care. However, their application needs to be accompanied by 2 aspects: an appreciation of the limitations of serum creatini...
Source: Nephron - January 18, 2019 Category: Urology & Nephrology Source Type: research

Possible Digenic Disease in a Caucasian Family with < b > < i > COL4A3 < /i > < /b > and < b > < i > COL4A5 < /i > < /b > Mutations
We describe a Caucasian family with concomitantCOL4A3 andCOL4A5 mutations, consisting of a novel c.4484A#x3e;GCOL4A3 (p.Gln1495Arg) mutation and a previously reported c.1871G#x3e;ACOL4A5 (p.Gly624Asp) mutation. Our segregation analysis raises the possibility that Alport syndrome resembles also digenic inheritance byCOL4A3/COL4A5.Nephron (Source: Nephron)
Source: Nephron - January 18, 2019 Category: Urology & Nephrology Source Type: research

Malnutrition Risk in Hemodialysis Patients in Israel: Results of the Status of Nutrition In Hemodialysis Patients Survey Study
Discussion: Elevated malnutrition risk is a frequent finding in HD patients treated in hospital settings in Israel. Dietary intake does not meet guidelines but does not differ across malnutrition risk categories. Nutrition supplements are underused in HD patients with high malnutrition risk. There is a need to expand the survey to community HD centers.Nephron (Source: Nephron)
Source: Nephron - January 18, 2019 Category: Urology & Nephrology Source Type: research

Beta Cell Functional Adaptation and Dysfunction in Insulin Resistance and the Role of Chronic Kidney Disease
Background: Beta cells are central in the pathophysiology of diabetes, since their functional adaptation maintains euglycemia in insulin-resistant individuals and beta cell dysfunction is required for the clinical picture of frank diabetes. The pathophysiological mechanisms driving compensation and decompensation are incompletely understood and little is known about the influence of chronic kidney disease (CKD) on beta cell function.Summary: In compensated insulin resistance, beta cells enhance their function at all stages in the stimulus-secretion coupling cascade, from the most proximal membrane depolarization to the int...
Source: Nephron - January 16, 2019 Category: Urology & Nephrology Source Type: research

Mean Corpuscular Volume and Mortality in Incident Hemodialysis Patients
Conclusions: Higher MCV was associated with higher all-cause, cardiovascular, and infectious mortality in HD patients. Further investigation is necessary to understand the underlying nature of the observed association.Nephron (Source: Nephron)
Source: Nephron - January 13, 2019 Category: Urology & Nephrology Source Type: research

Underlying Mechanisms of Renal Lipotoxicity in Obesity
The recent and ongoing worldwide increase in the prevalence of obesity parallels the increase in the incidence of chronic kidney disease (CKD). This association suggests an implication of lipotoxicity in the development of kidney diseases. The increased influx of lipids into the kidney can be explained in the context of the “Adipose Tissue Expandability Hypothesis”. This hypothesis states that the adipose tissue has a limited expansion capability, which is different for each individual, and once this limit is reached, the adipose tissue cannot store any more lipids and will thus release them into the bloodstrea...
Source: Nephron - January 13, 2019 Category: Urology & Nephrology Source Type: research

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease
Background: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives. This pathophysiological concept links tubulointerstitial oxidative stress, inflammation, hypoxia, and fibrosis with the progression of DKD. In this new angle for DKD, the prevailing molecular mechanisms on proximal tubular cells emerge as an innovative opportunity for prevention and management of DKD as well as to improve diabetic dysmetabolism.Summary: The mercapturate pathway (MAP) is a classical metabolic detoxification route for xenobiotics tha...
Source: Nephron - January 13, 2019 Category: Urology & Nephrology Source Type: research

The Role of Renal Interstitial Cells in Proximal Tubular Regeneration
The healthy kidney is considered to be a relatively stable organ with little baseline cell turnover. Nevertheless, cells are constantly replaced to conserve the structural and functional integrity of the organ. The mechanisms of the baseline regenerative processes may also be relevant in situations of insults to the kidney, when the need for cellular replacement considerable exceeds the baseline cell turnover. This review will focus on the mechanisms of the regeneration of the tubular system, in particular the proximal tubule. Specifically, we will cover new aspects of (i), the regenerative capacity of the proximal tubule ...
Source: Nephron - January 13, 2019 Category: Urology & Nephrology Source Type: research

Furosemide Stress Test as a Predicting Biomarker for Delayed Graft Function in Kidney Transplantation
Conclusions: The FST is a simple and accurate biomarker for predicting DGF in early post-KT period. Close monitoring and well prepared dialysis are suggested in patients with urine volume #x3c; 350 mL after 4 h of FST. The FST non-responsive patients could be the target for further DGF preventive intervention. ClinicalTrials.gov identifier: NCT03071536.Nephron (Source: Nephron)
Source: Nephron - January 13, 2019 Category: Urology & Nephrology Source Type: research

Do Endocannabinoids Regulate Glucose Reabsorption in the Kidney?
Diabetic nephropathy (DN), a distinct manifestation of diabetic kidney disease, affects approximately 30% of patients with diabetes. While most attention has been focused on glomerular changes related to DN, there is growing evidence that tubulopathy is a key feature in the pathogenesis of this disease. The renal proximal tubule cells (RPTCs) are particularly sensitive to the deleterious effect of chronic hyperglycemia. However, the cellular changes that control the dysfunction of the RPTCs are not fully understood. Controlling glucose reabsorption in the proximal tubules via inhibition of glucose transporters (GLUT) has e...
Source: Nephron - January 13, 2019 Category: Urology & Nephrology Source Type: research

Immune Checkpoint Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 is Upregulated and Independently Predicts Unfavorable Prognosis in Bladder Urothelial Carcinoma
Conclusions: HHLA2 can independently predict unfavorable prognosis in BUC.Nephron (Source: Nephron)
Source: Nephron - January 2, 2019 Category: Urology & Nephrology Source Type: research

Fanconi Syndrome in Alcoholic Patients: Old Concept, New Idea
Nephron (Source: Nephron)
Source: Nephron - January 2, 2019 Category: Urology & Nephrology Source Type: research

Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients
Conclusions: This study highlights that MMP-9 or CUBN-SNPs may exert effects on risk of susceptibility to DN or ESRD. We provide novel evidence on genetic susceptibility for macroangiopathy in patients with a missense variant of CUBN (Ile2984Val) in patients with T2D.Nephron (Source: Nephron)
Source: Nephron - December 17, 2018 Category: Urology & Nephrology Source Type: research

Better Being Single? Omics Improves Kidney Organoids
Context: Human kidney organoids are complex structures resembling nephron arrays, which can be derived in a variety of ways. Whether all of these differentiation protocols produce qualitatively similar organoid cell types is not yet clear.Subject of Review: A comparative analysis of 2 organoid differentiation protocols is recently reported inCell Stem Cell [Wu et al.: Cell Stem Cell 2018;pii:S1934-5909(18)30491-0], using single cell RNA sequencing (scRNA-seq) as an analytical tool. This demonstrates that the 2 protocols have much in common, and that neither produces kidney cells in a pure or comprehensive manner. Ureteric ...
Source: Nephron - December 14, 2018 Category: Urology & Nephrology Source Type: research

Molecular Basis of Cystinosis: Geographic Distribution, Functional Consequences of Mutations in the < b > < i > CTNS < /i > < /b > Gene, and Potential for Repair
Mutations in theCTNS gene encoding the lysosomal membrane cystine transporter cystinosin are the cause of cystinosis, an autosomal recessive lysosomal storage disease. More than 140CTNS mutations have been reported worldwide. Recent studies have discovered that cystinosin exerts other key cellular functions beyond cystine transport such as regulation of oxidative state, lysosomal dynamics and autophagy. Here, we review the different mutations described in theCTNS gene and the geographical distribution of incidence. In addition, the characteristics of the various mutations in relation to the functions of cystinosin needs to...
Source: Nephron - December 14, 2018 Category: Urology & Nephrology Source Type: research

A Family with Autosomal Dominant Distal Renal Tubular Acidosis Presents with Atypical Phenotype Caused by a Missence Mutation (R388C) of the Human Kidney Anion Exchanger
Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. A 30-year-old male patient has a history of paroxysmal paralysis for 7 years, presenting with mild hypokalemia, alkalization of urine, normal blood PH value and increased urinary calcium. Patient ’s father has similar presentations but never came to the hospital. We f...
Source: Nephron - December 14, 2018 Category: Urology & Nephrology Source Type: research

Diagnostic Accuracy of Frailty Screening Methods in Advanced Chronic Kidney Disease
Conclusions: Walking speed can be used to accurately screen for frailty in CKD populations. If it is not practical to perform a physical assessment to screen for frailty, the Clinical Frailty Scale is a useful alternative.Nephron (Source: Nephron)
Source: Nephron - December 14, 2018 Category: Urology & Nephrology Source Type: research

Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis
Conclusion: These data suggest that a portion of urinary FSP1 is secreted as EVs originating from podocytes, and that FSP1 levels reflect active and ongoing glomerular injury and disease activity, such as cellular crescent formation.Nephron (Source: Nephron)
Source: Nephron - December 13, 2018 Category: Urology & Nephrology Source Type: research

Factors Influencing Cyst Infection in Autosomal Dominant Polycystic Kidney Disease
Conclusions: Hepatomegaly was strongly associated with both death and longer hospital stay due to cyst infection.Nephron (Source: Nephron)
Source: Nephron - December 4, 2018 Category: Urology & Nephrology Source Type: research

Acknowledgement to the Reviewers
Nephron 2018;140:289 –291 (Source: Nephron)
Source: Nephron - November 30, 2018 Category: Urology & Nephrology Source Type: research

Contents Vol. 140, 2018
Nephron 2018;140:I –V (Source: Nephron)
Source: Nephron - November 30, 2018 Category: Urology & Nephrology Source Type: research

Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease
Conclusions: Our study showed a negative correlation between eGFR and age, and with proteinuria levels and the presence of cardiovascular and other manifestations of FD. These data favor the view that HF in Fabry patients could be related predominantly to a predisease state. Even in the absence of a “measured” GFR, HF should be regarded as an early marker of Fabry nephropathy, and its recognition and confirmation by true GFR seems a relevant feature to address the issue of the potential benefit of nephroprotective treatments at the early stage of Fabry nephropathy.Nephron (Source: Nephron)
Source: Nephron - November 22, 2018 Category: Urology & Nephrology Source Type: research