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The Renin –Angiotensin System, Not the Kinin–Kallikrein System, Affects Post-Exercise Proteinuria
Conclusion: The results indicated Ang II up-regulation, not bradykinin elevation, plays a role in post-exercise proteinuria.Nephron (Source: Nephron)
Source: Nephron - May 18, 2018 Category: Urology & Nephrology Source Type: research

Safety of Iohexol Administration to Measure Glomerular Filtration Rate in Different Patient Populations: A 25-Year Experience
Conclusion: Iohexol administration for GFR measurement is a safe procedure, even in repeated investigations in the same subject, that should be adopted in clinical research and, when needed, also in clinical practice.Nephron (Source: Nephron)
Source: Nephron - May 17, 2018 Category: Urology & Nephrology Source Type: research

Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine
Conclusions: VA-AKI can manifest with a precipitous rise in sCr shortly after a high cumulative dose of vancomycin. True toxic tubular injury overrepresented by the sCr rise is postulated.Nephron 2018;139:1 –12 (Source: Nephron)
Source: Nephron - April 27, 2018 Category: Urology & Nephrology Source Type: research

Erratum
Nephron 2018;139:112 (Source: Nephron)
Source: Nephron - April 26, 2018 Category: Urology & Nephrology Source Type: research

MicroRNA-10b Promotes Apoptosis via JNK Pathway in Clear Cell Renal Cell Carcinoma
Conclusion: We suggested a tumour suppressor function of miR-10b in tumourigenesis of ccRCC via proliferation suppression and apoptosis induction, and the latter was mediated by the JNK pathway activation.Nephron (Source: Nephron)
Source: Nephron - April 19, 2018 Category: Urology & Nephrology Source Type: research

Office Visit: Kidney Transplantation of a Dreamer
This editorial describes a patient who was cared for by the author. The patient developed end-stage kidney disease in the United States at the age of 17 but was denied kidney transplantation due to lack of insurance because of her immigration status. With the enactment of the Deferred Action for Childhood Arrivals (DACA) program, the patient was able to obtain a job and health insurance. The patient then received a kidney transplant when she was 27 years, after undergoing peritoneal dialysis for 10 years. The editorial describes how the DACA program improves the care of undocumented immigrants to the United States who are ...
Source: Nephron - April 19, 2018 Category: Urology & Nephrology Source Type: research

The Use of Low-Calcium Hemodialysis in the Treatment of Hypercalcemic Crisis
Conclusion: Hypercalcemic crisis is a life-threatening condition and should be managed immediately.Nephron (Source: Nephron)
Source: Nephron - April 19, 2018 Category: Urology & Nephrology Source Type: research

Accuracy of Acid-Base Diagnoses Using the Central Venous Blood Gas in the Medical Intensive Care Unit
Conclusions: In critically ill adult patients, central VBG may be used to detect and diagnose acid-base disturbances with reasonable diagnostic accuracy, even in shock states, compared to the ABG. This study supports the use of central VBG for diagnosis of acid-base disturbances in critically ill patients.Nephron (Source: Nephron)
Source: Nephron - April 12, 2018 Category: Urology & Nephrology Source Type: research

The Impact of Preexisting Chronic Kidney Disease on the Severity and Recovery of Acute Kidney Injury
Conclusion: Taken together, reduced nephron mass have a negative effect on the repair process that is partially mediated by the disruption of the cell cycle regulation.Nephron (Source: Nephron)
Source: Nephron - April 12, 2018 Category: Urology & Nephrology Source Type: research

Abstracts of the 30th Meeting of the European Renal Cell Study Group (ERCSG)
Nephron 2018;139:83 –111 (Source: Nephron)
Source: Nephron - April 12, 2018 Category: Urology & Nephrology Source Type: research

The Burden of Untreated Hepatitis C Virus Infection in Renal Patients in the United Kingdom
Nephron (Source: Nephron)
Source: Nephron - April 5, 2018 Category: Urology & Nephrology Source Type: research

Modest Impact of Serial Measurements of Acute Kidney Injury Biomarkers in an Adult Intensive Care Unit
Conclusion: Serial measurement of AKI biomarkers used in clinical models could contribute to the prediction of AKI outcomes in a heterogeneous cohort of adult mixed ICU patients, although its reliability seemed to be modest.Nephron (Source: Nephron)
Source: Nephron - April 3, 2018 Category: Urology & Nephrology Source Type: research

Renoprotective Postoperative Monitoring: What Is the Best Method for Computing Renal Perfusion Pressure? An Observational, Prospective, Multicentre Study
Conclusion: We found that the best parameter predicting AKI is the MAP-2 × IAP-CVP-Pmean. Further investigation is needed to analyze the role of CVP and Pmean, and to characterize renal venous congestion and tubular pressure more in detail.Nephron (Source: Nephron)
Source: Nephron - April 3, 2018 Category: Urology & Nephrology Source Type: research

Dialysis Modality towards Kidney Transplant Outcomes
Nephron (Source: Nephron)
Source: Nephron - April 3, 2018 Category: Urology & Nephrology Source Type: research

The Spectrum of Glomerulopathies in Kashmir: A Tertiary Care Experience
Conclusion: MCD and MGN were the most common primary glomerular diseases observed in our centre.Nephron (Source: Nephron)
Source: Nephron - March 29, 2018 Category: Urology & Nephrology Source Type: research

Effect of Sodium Thiosulfate on Arterial Stiffness in End-Stage Renal Disease Patients Undergoing Chronic Hemodialysis (Sodium Thiosulfate-Hemodialysis Study): A Randomized Controlled Trial
Conclusion: The intradialytic STS treatment significantly reduced the AS, as measured by the CAVI, and stabilized the vascular calcification in the HD patients. STS may be a novel therapeutic strategy for delaying and treating the structural and functional vascular wall abnormalities in HD patients.Nephron (Source: Nephron)
Source: Nephron - March 23, 2018 Category: Urology & Nephrology Source Type: research

Reclassification of Chronic Kidney Disease Stage, Eligibility for Cystatin-C and Its Associated Costs in a UK Primary Care Cohort
Conclusions: The mean eGFR was lower with the CKD-EPI formula and individuals were more likely to be reclassified to more advanced CKD. This may be related to the higher mean age of this unselected population compared to previous studies. Refinements of eGFR formulae, CKD definitions and cystatin-C eligibility in unselected populations are required.Nephron 2018;139:39 –46 (Source: Nephron)
Source: Nephron - March 22, 2018 Category: Urology & Nephrology Source Type: research

Contents Vol. 138, 2018
Nephron 2018;138:I –VI (Source: Nephron)
Source: Nephron - March 19, 2018 Category: Urology & Nephrology Source Type: research

Non-Proximal Renal Tubule-Derived Urinary Exosomal miR-200b as a Biomarker of Renal Fibrosis
Conclusions: Non-proximal renal tubule-derived urinary exosomal miR-200b is a biomarker of renal fibrosis. Exosomes can be used as a liquid biopsy and may replace the traditional invasive renal biopsy in the diagnosis of renal fibrosis.Nephron (Source: Nephron)
Source: Nephron - March 14, 2018 Category: Urology & Nephrology Source Type: research

Atypical Hemolytic Uremic Syndrome in Children Aged < 2 Years
Conclusion: One-third of the aHUS patients had disease onset during infancy. The prognosis of this life-threatening disease seems to get better with improved treatment modalities.Nephron (Source: Nephron)
Source: Nephron - March 13, 2018 Category: Urology & Nephrology Source Type: research

Cinacalcet for Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: A Meta-Analysis of Randomized Controlled Trials
Conclusions: Use of cinacalcet in dialysis patients improves several CKD-MBD-related surrogate markers. However, the benefit on all-cause mortalities was not demonstrated.Nephron (Source: Nephron)
Source: Nephron - March 7, 2018 Category: Urology & Nephrology Source Type: research

The Relationship between Carotid and Femoral Artery Intima-Media Thickness and Histopathologic Grade of Atherosclerosis in Patients with Chronic Kidney Disease
Conclusion: Higher values of cIMT and fIMT in CKD patients are associated with higher rates and degrees of histopathological atherosclerosis. Additionally, when compared to fIMT, cIMT has a higher sensitivity for detecting atherosclerosis in CKD patients.Nephron (Source: Nephron)
Source: Nephron - March 7, 2018 Category: Urology & Nephrology Source Type: research

Ten-Year Survival of End-Stage Renal Disease Patients Treated with High-Efficiency Online Hemodiafiltration: A Cohort Study of a Center in South East Asia
Conclusions: High-efficiency OL-HDF could provide an excellent long-term survival nearly comparable to the KT sub-group.Nephron (Source: Nephron)
Source: Nephron - March 7, 2018 Category: Urology & Nephrology Source Type: research

Does Endothelin-1 Raise or Lower Blood Pressure in Humans?
Conclusion: Alternatively, hypertension could be attributed to renal actions of ET-1. Either of these pathophysiological actions may explain a hypertensive role of ET-1 despite a lower risk of hypertension associated with the G allele at rs9349379, the common SNP in thePHACTR1 gene that is a distal regulator ofEDN1 and leads to an increased expression of ET-1.Nephron (Source: Nephron)
Source: Nephron - March 5, 2018 Category: Urology & Nephrology Source Type: research

A Genetic Variant Associated with the Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression
Gupta et al. [Cell 2017; 170: 522 –533] have shown that a genetic variant associated with the 5 vascular diseases is a distal regulator of endothelin (ET)-1 gene (EDN1) expression. A common single nucleotide polymorphism (SNP) in the third intron of thePHACTR1 gene, rs9349379, is the potential variant responsible for increased risk of coronary artery disease, and lower risk of migraine, carotid dissection, fibromuscular dysplasia, and hypertension. Since ET-1 acts through ET type B receptors (ETBR) on endothelial cells to stimulate the production of nitric oxide and prostacyclin and induce vasodilation, this may cont...
Source: Nephron - February 15, 2018 Category: Urology & Nephrology Source Type: research

Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients
Conclusion: Decreased brain oxygenation is associated with weaker cognitive performance in patients undergoing chronic HD. Further understanding the causes of cerebral ischemia in HD patients could lead to the prevention of cognitive decline in this population.Nephron (Source: Nephron)
Source: Nephron - February 13, 2018 Category: Urology & Nephrology Source Type: research

< b > < i > Mannose-Binding Lectin2 < /i > < /b > Gene Polymorphism and IgG4 in Membranous Nephropathy
Conclusions: Our data suggests thatMBL2 polymorphisms may be associated with the activation of the lectin pathway by IgG4 subclass antibodies in MN.Nephron (Source: Nephron)
Source: Nephron - February 13, 2018 Category: Urology & Nephrology Source Type: research

Nephrocalcinosis in Amelogenesis Imperfecta Caused by the < b > < i > FAM20A < /i > < /b > Mutation
Conclusion: AI patients with similar clinical phenotypes andFAM20A mutations should be examined for nephropathy even if they lack pertinent symptoms. Nephrology referral is warranted for patients who have clinical phenotypes related to AI-gingival fibromatosis even if they are not symptomatic.Nephron (Source: Nephron)
Source: Nephron - February 13, 2018 Category: Urology & Nephrology Source Type: research

What We Do and Do Not Know about Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Women ’s Day
Chronic kidney disease affects approximately 10% of the world ’s adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women’s Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women’s health and specificall y their kidney health, on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50%...
Source: Nephron - February 13, 2018 Category: Urology & Nephrology Source Type: research

Assessing Extracellular Volume in Hemodialysis Patients Using Intradialytic Blood Pressure Slopes
Conclusions: In hypertensive hemodialysis patients, measurements of ECV excess are more strongly associated with IBPSs than with pre-dialysis, post-dialysis, or change in systolic BP. Among varying volume metrics, post-dialysis ECW/weight has the strongest association with these slopes. Determining IBPS is a novel method to optimize clinical assessment of ECV in hemodialysis patients.Nephron (Source: Nephron)
Source: Nephron - February 13, 2018 Category: Urology & Nephrology Source Type: research

< b > < i > Campylobacter rectus < /i > < /b > in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients
Conclusion: Our results suggest that harbouringC. rectus in the oral cavity could be associated with proteinuria in IgAN patients.Nephron (Source: Nephron)
Source: Nephron - February 9, 2018 Category: Urology & Nephrology Source Type: research

Serum Soluble Interleukin 2 Receptor Level as a Marker of Acute Rejection in Pediatric Kidney Transplant Recipients
Conclusion: Serum sIL2R level may serve as a noninvasive diagnostic indicator in pediatric kidney transplant recipients experiencing AR.Nephron (Source: Nephron)
Source: Nephron - February 8, 2018 Category: Urology & Nephrology Source Type: research

Restless Legs Syndrome: An  Unresolved Uremic Disorder after Renal Transplantation
Conclusion: The prevalence of RLS after transplantation remains high (14.8%). This condition is twice more prevalent for females. Contribution of RAAS, graft function and phosphate overload requires further investigation.Nephron (Source: Nephron)
Source: Nephron - February 1, 2018 Category: Urology & Nephrology Source Type: research

Vascular Endothelial Growth Factor-A < sub > 165 < /sub > b Restores Normal Glomerular Water Permeability in a Diphtheria-Toxin Mouse Model of Glomerular Injury
Conclusion: Although only a mild model of podocyte injury, over-expression of the anti-permeability VEGF-A165b isoform in the podocytes of Pod-DTR mice had a protective effect. Therefore, this study further highlights the therapeutic potential of VEGF-A165b in glomerular disease.Nephron (Source: Nephron)
Source: Nephron - January 26, 2018 Category: Urology & Nephrology Source Type: research

Ultra-Low Contrast Volume for Patients with Advanced Chronic Kidney Disease Undergoing Coronary Procedures
Conclusions: In patients with advanced chronic kidney disease, the ultra-low contrast technique is feasible and effective and can be used safely without a significant deterioration in renal function. This technique may increase the utilization of PCI in high-risk coronary patients with chronic kidney disease.Nephron (Source: Nephron)
Source: Nephron - January 24, 2018 Category: Urology & Nephrology Source Type: research

Clinical Heterogeneity in Familial IgA Nephropathy
Conclusion: These data suggests familial aggregation of IgA nephropathy, confirm the clinical and histopathological heterogeneity and raise the possibility of monogenic inheritance.Nephron (Source: Nephron)
Source: Nephron - January 19, 2018 Category: Urology & Nephrology Source Type: research

Association of Ultrafiltration Rate with Mortality in Incident Hemodialysis Patients
Conclusions: Higher UFR is independently associated with higher all-cause and CV mortality in incident HD patients. Clinical trials are warranted to examine the effects of lowering UFR on outcomes.Nephron (Source: Nephron)
Source: Nephron - January 18, 2018 Category: Urology & Nephrology Source Type: research

The < b > < i > von Hippel-Lindau < /i > < /b > Gene Is Required to Maintain Renal Proximal Tubule and Glomerulus Integrity in Zebrafish Larvae
Conclusions: Our data indicates thatvhl is required to maintain pronephric tubule and glomerulus integrity during zebrafish development, and suggests a role for VHL in endocytic vesicle trafficking.Nephron (Source: Nephron)
Source: Nephron - January 17, 2018 Category: Urology & Nephrology Source Type: research

Unravelling Pathophysiology of Crystalline Nephropathy in Ceftriaxone-Associated Acute Kidney Injury: A Cellular Proteomic Approach
Conclusions: This study, for the first time, used the in vitro model of crystalline nephropathy to investigate the underlying pathophysiology of ceftriaxone-associated AKI, which should be investigated in vivo for potential clinical benefits in the future.Nephron (Source: Nephron)
Source: Nephron - January 16, 2018 Category: Urology & Nephrology Source Type: research

Erratum
Nephron 2018;138:88 (Source: Nephron)
Source: Nephron - January 11, 2018 Category: Urology & Nephrology Source Type: research

Hospital Readmission among New Dialysis Patients Associated with Young Age and Poor Functional Status
Conclusions: Overall, 30-day readmissions are common within the first year of dialysis start. The first 10-day period after discharge, young patients, and those with poor functional status represent key areas for targeted interventions to reduce readmissions.Nephron (Source: Nephron)
Source: Nephron - January 9, 2018 Category: Urology & Nephrology Source Type: research

Safety of Outpatient Kidney Biopsies
Conclusion: We found that kidney biopsy performed in an outpatient setting in select patients is only rarely associated with adverse events and is a safe procedure.Nephron (Source: Nephron)
Source: Nephron - January 4, 2018 Category: Urology & Nephrology Source Type: research

Associations of Fibroblast Growth Factor 23 with Markers of Inflammation and Leukocyte Transmigration in Chronic Kidney Disease
Conclusion: FGF23 levels are associated with various inflammatory markers such as pro-inflammatory cytokines and adhesion molecules on innate immune cells. However, further studies are warranted to define the direct role of FGF23 in modulation of the innate immune system in CKD.Nephron (Source: Nephron)
Source: Nephron - January 4, 2018 Category: Urology & Nephrology Source Type: research

Vanishing Immunoglobulins: The Formation of Pauci-Immune Lesions in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Nephron (Source: Nephron)
Source: Nephron - December 21, 2017 Category: Urology & Nephrology Source Type: research

Renal PGC1 α May Be Associated with Recovery after Delayed Graft Function
Conclusions: These data suggest that higher PGC1 α expression is associated with faster and more complete recovery from DGF. Mitochondrial biogenesis may be a therapeutic target for DGF. Larger studies are needed to validate these findings.Nephron (Source: Nephron)
Source: Nephron - December 21, 2017 Category: Urology & Nephrology Source Type: research

Factors Associated with Chronic Kidney Disease and Their Clinical Utility in Primary Care Clinics in a Multi-Ethnic Southeast Asian Population
Conclusions: CKD prevalence in our Southeast Asian population is high and under-documented even in high-risk patients. Our findings highlight factors associated with CKD, and the predictive value of hypertension, diabetes, and advancing age as EHR-based screening targets for CKD. Our results also suggest that complementary educational efforts will be needed to increase physician detection and optimize the management of CKD, especially in high risk and marginalized groups across all clinics in Singapore, and possibly in the region.Nephron (Source: Nephron)
Source: Nephron - December 15, 2017 Category: Urology & Nephrology Source Type: research

Erratum
Nephron (Source: Nephron)
Source: Nephron - December 14, 2017 Category: Urology & Nephrology Source Type: research

Atypical Hemolytic Uremic Syndrome Associated with Complement Factor H Mutation and IgA Nephropathy: A Case Report Successfully Treated with Eculizumab
We present a rare case of IgA nephropathy in a patient who developed atypical hemolytic uremic syndrome (aHUS) associated with a complement factor H (CFH) gene mutation, and who was successfully treated with eculizmab. A 76-year-old man was admitted as the patients had thrombotic microangiopathies findings. The patient was treated with plasma exchange, hemodialysis and methylprednisolone. A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 level was not decreased. Light microscopy findings were consistent with hemolytic uremic syndrome and immunofluorescence analysis revealed IgA and C3 were d...
Source: Nephron - December 14, 2017 Category: Urology & Nephrology Source Type: research

Peritoneal Dialysis Catheter Revision and Replacement by Nephrologist for Peritoneal Dialysis Catheter Malfunction
Conclusion: PD catheter revision and replacement by nephrologist has an acceptable catheter survival and a reasonable complication rate. Given that prompt intervention is an important consideration, catheter revision and replacement by nephrologist is a suitable method for the management of catheter malfunction.Nephron (Source: Nephron)
Source: Nephron - December 14, 2017 Category: Urology & Nephrology Source Type: research

Impact of Kidney Transplantation on Reproductive Hormone Levels in Males: A Longitudinal Study
Conclusion: Sertoli cell function, based on AMH and inhibin B levels, does not improve to the same extent or as fast as Leydig cell function after kidney transplantation, as determined by testosterone and LH levels.Nephron (Source: Nephron)
Source: Nephron - December 14, 2017 Category: Urology & Nephrology Source Type: research