Disclosure Statement Editorial Board
Nephron 2019;142:271 –274 (Source: Nephron)
Source: Nephron - July 5, 2019 Category: Urology & Nephrology Source Type: research

Acute Kidney Injury following Cardiac Surgery: A Clinical Model
Background: Scientists use preclinical models of acute kidney injury (AKI) to decipher mechanisms and develop therapy, but translation of therapies to patients remains poor. Models that better resemble patients, including those within clinical care, should be considered.Summary: Mice provide many advantages to the study of human disease including an ability to dictate precise experimental conditions. To best isolate and measure phenomena, scientists reduce experimental variability – identical animals, environmental conditions, experimental exposures, and outcome assessments. This technique reduces effect size variabi...
Source: Nephron - July 3, 2019 Category: Urology & Nephrology Source Type: research

Pannexins in Acute Kidney Injury
Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently effluxes ATP and plays a central role in the progression of inflammatory diseases. Animal models that target Panx1 through pharmacological inhibition or genetic deficiency have better outcomes in minimizing inflammation and associated pathology. Given the involvement of Panx1 at multiple steps of ­inflammatory pathology, Panx1 could be a potentia...
Source: Nephron - June 26, 2019 Category: Urology & Nephrology Source Type: research

Evaluation of Beta 2-Microglobulin, Cystatin C, and Lipocalin-2 as Renal Biomarkers for Patients with Fabry Disease
Conclusion: Considering serum creatinine as gold standard, all renal parameters evaluated, including receiver operating characteristic curve, indicated β2M as the best biomarker, followed by cystatin C, proteinuria and microalbuminuria, while the results for lipocalin-2 and UCreat do not indicate good predictors of renal impairment. It suggests that at least 2 altered biomarkers should be considered to characterize a renal alteration, thereby esta blishing a better therapeutic course for FD patients. If possible, along with serum creatinine, measurement of β2M or cystatin C for renal evaluation of Fabry’s p...
Source: Nephron - June 19, 2019 Category: Urology & Nephrology Source Type: research

Association between Sodium Intake and Urinary Fractional Albumin and Immunoglobulin G Excretion in Chronic Nondialytic Renal Disease: A Prospective Longitudinal Study
Conclusion: In CKD patients, changes in estimated sodium intake were associated with changes in the fractional albumin and IgG excretion regardless of confounding factors. Findings of this study support the idea that reducing salt intake, and consequently, albumin and IgG fractional excretions could help to slow CKD progression. This hypothesis must be tested in long-term interventional studies.Nephron (Source: Nephron)
Source: Nephron - June 19, 2019 Category: Urology & Nephrology Source Type: research

Mechanisms of Nephrogenesis Revealed by Zebrafish Chemical Screen: Prostaglandin Signaling Modulates Nephron Progenitor Fate
Nephron development involves the creation of discrete segment populations that are specialized to fulfill unique physiological roles. As such, renal function is reliant on the proper execution of segment patterning programs. Despite the central importance of nephron segmentation, the genetic mechanisms that regulate this process are far from understood, in large part due to the experimental complexities and cost of interrogating these events in the mammalian metanephros. For this reason, forward genetics utilizing phenotypic screening in the zebrafish pronephros provides an avenue to gain novel insights about the mechanism...
Source: Nephron - June 19, 2019 Category: Urology & Nephrology Source Type: research

Inhibition of miR-155 Ameliorates Acute Kidney Injury by Apoptosis Involving the Regulation on TCF4/Wnt/ β-Catenin Pathway
Conclusion: We demonstrated that miR-155 exacerbated AKI involving the targeting and regulation of TCF4/Wnt/ β-catenin signaling pathway, indicating a novel regulatory network and elucidating a potential target for IRI-induced AKI treatment.Nephron (Source: Nephron)
Source: Nephron - June 19, 2019 Category: Urology & Nephrology Source Type: research

Is Chronic Kidney Disease Progression Influenced by the Type of Renin-Angiotensin-System Blocker Used?
Conclusions: In patients with CKD, treatment with ACEI or ARB had a superior effect than no ACEI or ARB treatment on slowing kidney disease progression and on proteinuria reduction. Efficacy of ACEI and ARB was comparable.Nephron (Source: Nephron)
Source: Nephron - June 14, 2019 Category: Urology & Nephrology Source Type: research

Generalized and Prolonged Use of Gentamicin-Lock Therapy Reduces Hemodialysis Catheter-Related Infections Due to Gram Negatives
Conclusion: In the current study, gentamicin-lock therapy was associated with a significant reduction in CRBSI specially withP. aeruginosa and other Gram-negative bacteria. It proved to be safe and effective intervention when applied to the entire population of HD patients.Nephron (Source: Nephron)
Source: Nephron - June 14, 2019 Category: Urology & Nephrology Source Type: research

Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for Clinicians
Background: Differentiating etiologies of acute kidney injury (AKI) is critical in determining the course of care in clinical practice. For example, acute interstitial nephritis (AIN) requires withdrawal of the offending drug and immunosuppressive therapy, while acute tubular injury (ATI) does not have any disease-specific therapies. Failure to distinguish AIN from ATI in a timely manner can lead to kidney fibrosis and chronic kidney disease. In this review, we discuss current tests and novel biomarkers to distinguish ATI from AIN.Summary: In a prospective cohort study of 32 participants with AIN and 41 with ATI, clinical ...
Source: Nephron - June 14, 2019 Category: Urology & Nephrology Source Type: research

Relationship between History of Ischemic Stroke and All-Cause Mortality in Incident Dialysis Patients
Conclusion: The present study revealed that history of ischemic stroke before dialysis initiation was associated with all-cause, non-CV-related, and infection-related mortality and stroke event after dialysis initiation during maintenance dialysis.Nephron (Source: Nephron)
Source: Nephron - June 11, 2019 Category: Urology & Nephrology Source Type: research

Intraoperative Arterial Biopsy in Incident Hemodialysis Patients: Differences Observed
Conclusion: Half of incident hemodialysis CKD patients have developed AC mainly in tunica media. Discrepancy in serum P can have an impact on calcification intensity.Nephron (Source: Nephron)
Source: Nephron - June 6, 2019 Category: Urology & Nephrology Source Type: research

Do not Miss Rare and Treatable Cause of Early-Onset Hemolytic Uremic Syndrome: Cobalamin C Deficiency
The most common disorder of vitamin B12 metabolism is methylmalonic aciduria and homocystinuria type cobalamin C (cblC), which accounts for most of the cases is referred to as cblC deficiency. Cobalamin deficiency is one of the causes of early-onset hemolytic uremic syndrome (HUS). Here, we present the cases of 2 infants with cobalamin deficiency who presented with early-onset HUS. The first patient was a 5-month-old female who was admitted to the hospital with seizure, pallor, and yellow-colored diarrheal stools. Initial laboratory examination showed direct Coombs test-negative hemolytic anemia. Later, she developed acute...
Source: Nephron - May 28, 2019 Category: Urology & Nephrology Source Type: research

6th Update on Fabry Disease: Biomarkers, Progression and Treatment Opportunities
Nephron (Source: Nephron)
Source: Nephron - May 22, 2019 Category: Urology & Nephrology Source Type: research

Enarodustat, Conversion and Maintenance Therapy for Anemia in Hemodialysis Patients: A Randomized, Placebo-Controlled Phase 2b Trial Followed by Long-Term Trial
Conclusions: Enarodustat corrected and maintained Hb levels in anemic patients with hemodialysis-dependent CKD. Phase 3 studies of enarodustat are currently ongoing.Nephron (Source: Nephron)
Source: Nephron - May 22, 2019 Category: Urology & Nephrology Source Type: research

Podocyte Injury in Autosomal Dominant Polycystic Kidney Disease
Conclusion: Urine biomarkers of podocytes injury were significantly higher in ADPKD patients even in the early stage of the disease than in the control group. It should be clarified whether these biomarkers can provide new prognostic parameters for disease surveillance.Nephron (Source: Nephron)
Source: Nephron - May 22, 2019 Category: Urology & Nephrology Source Type: research

Recent Insights into Kidney Injury and Repair from Transcriptomic Analyses
Injured tubular epithelium exhibits cellular plasticity in that it can dedifferentiate, reenter the cell cycle, and subsequently either redifferentiate or adopt a chronically injured phenotype. Although some nephrogenic genes are reexpressed during injury and repair, developmental pathways are only partially recapitulated and the process is more accurately viewed as an entirely new program intrinsic to the regenerative response to injury. Recent advances in our understanding of the molecular circuitry underpinning epithelial plasticity have come from bulk, cell-specific, and single-cell transcriptomic analyses. These resul...
Source: Nephron - May 21, 2019 Category: Urology & Nephrology Source Type: research

Criteria for Living Donation from Marginal Donors: One, No One, and One Hundred Thousand
Context: The increasing need for kidney grafts has led to a progressive expansion in the selection criteria for deceased and living donors (LDs). While concerns regarding the use of organs from suboptimal deceased donors relate to the quality of the graft, donation from “marginal” LDs may pose potential harm to the donor.Subject of Review: Living kidney donation is a safe procedure, but is associated with a small risk of end-stage kidney disease in the long- term. When elderly subjects and those with comorbidities are considered, long-term post-donation data are missing, making decisions regarding donation from...
Source: Nephron - May 20, 2019 Category: Urology & Nephrology Source Type: research

Acute Kidney Injury in Kidney Transplants: New Insights
Delayed allograft function (DGF) is defined as dialysis treatment in the kidney transplant recipient in the first week following transplantation. With the demand for kidney transplants growing and the supply limited, as well as implementation of a national allocation scheme for deceased donor kidneys, rates of DGF remain high, on average, 30% for recipients of deceased donor kidneys. DGF is associated with inferior allograft outcomes, and there are no FDA-approved therapies to mitigate this disorder. There is renewed interest in this therapeutic arena, and there are several recent clinical trials that have considered inter...
Source: Nephron - May 16, 2019 Category: Urology & Nephrology Source Type: research

Importance of Genetic Diagnostics in Adult-Onset Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte and glomerulus injury. FSGS can be primary and secondary to other diseases or due to a genetic cause. Strikingly, genetic causes for adult-onset FSGS are often overlooked, likely because identifying patients with genetic forms of FSGS based on clinical presentation and histopathology is difficult. Yet diagnosing genetic FSGS does not only have implications for prognostication and therapy but also for family and family planning. In this case series, we present 3 adult patients who presented with advanced renal disease with the histological pictu...
Source: Nephron - May 16, 2019 Category: Urology & Nephrology Source Type: research

Comparison of Salt Intake in Children to that of their Parents
Conclusions: In 91% of children aged 10 –15 years, daily salt intake was higher than recommended. Also, children’s salt consumption was closer to that of their mothers than that of their fathers, ­possibly because of closeness in dietary habits with their mothers.Nephron (Source: Nephron)
Source: Nephron - May 8, 2019 Category: Urology & Nephrology Source Type: research

Targeting Acute Kidney Injury: Can an Innovative Approach to Existing and Novel Biomarkers Shift the Paradigm?
Acute kidney injury (AKI) continues to be an epidemic problem among hospitalized patients. Diagnostic stasis has, in part, contributed to the poor outcomes associated with AKI. Incorporation of newer diagnostic methodology, longitudinal assessment of markers of AKI alone and in combination may improve appreciation of patient risk and the speed of recognition, augment the precision of diagnosis, and target management.Nephron (Source: Nephron)
Source: Nephron - May 7, 2019 Category: Urology & Nephrology Source Type: research

Transforming Growth Factor- β in the Acute Kidney Injury to Chronic Kidney Disease Transition
Transforming growth factor- β (TGF-β) is a key profibrotic growth factor that is activated in acute kidney injury (AKI) and associated with cellular responses that lead to the development of chronic kidney disease (CKD). The persistently injured, de-differentiated tubular epithelial cell is an important mediator of the trans ition from AKI to CKD. TGF-β signaling may perpetuate proximal tubule injury through de-differentiation, cell cycle arrest, and increased susceptibility to apoptosis. In addition, TGF-β signaling promotes macrophage chemotaxis, endothelial injury, and myofibroblast differentiation a...
Source: Nephron - May 5, 2019 Category: Urology & Nephrology Source Type: research

Development and Internal Validation of a Prediction Model to Estimate the Probability of Left-Ventricular Diastolic Dysfunction in Stable Maintenance Hemodialysis Patients without Clinical Heart Failure
Conclusions: A model using routinely available simple clinical record data and laboratory tests can accurately predict the risk of LVDD in stable MHD patients. The Model and its cutoff values may be useful for early diagnosis and intervention of LVDD.Nephron (Source: Nephron)
Source: Nephron - May 5, 2019 Category: Urology & Nephrology Source Type: research

Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins
Conclusion: Integrin-mediated pathways can facilitate the spontaneous accumulation of ECM during fibroblast: epithelial cell interactions, and this direct renal co-culture assay system could provide a translational in vitro assay for investigating novel pathways involved in the pro-ECM response and the screening of renal anti-fibrotic agents.Nephron (Source: Nephron)
Source: Nephron - May 5, 2019 Category: Urology & Nephrology Source Type: research

Metabolic Stress Resistance in Acute Kidney Injury: Evidence for a PPAR-Gamma-Coactivator-1 Alpha-Nicotinamide Adenine Dinucleotide Pathway
Acute kidney injury (AKI) is estimated to affect 3 –10% of all hospitalized adults in the United States, making it one of the most common inpatient diagnoses. Despite this staggering incidence, most individuals exposed to AKI stressors, such as intravenous radiocontrast or cardiopulmonary bypass, do not develop AKI. In fact, whereas animal models of ischemia, sepsis, or nephrotoxicity suggest near-uniform responses to stressors, the natural history of stressed patients is highly heterogeneous. Recent studies of mitochondrial perturbations underlying experimental and human AKI suggest a conserved metabolic contributio...
Source: Nephron - May 5, 2019 Category: Urology & Nephrology Source Type: research

Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions
Sepsis-associated acute kidney injury (S-AKI) significantly worsens patient prognosis, and recent evidence suggests that the injury process begins early and may be sustained by therapies used to treat the sepsis (e.g., fluids resuscitation, antibiotics). While efforts to develop less-injurious treatments are making progress, some degree of secondary injury is to be expected. So too is the inevitable nature of organ injury, which is often present at the time the patient seeks medical attention. We recently found that most patients presenting with septic shock and developing AKI had evidence of kidney damage at the time of, ...
Source: Nephron - April 25, 2019 Category: Urology & Nephrology Source Type: research

Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?
The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Effects of RAAS antagonists are variable in chronic or acute conditions. The aim of this review is to discuss the renal and systemic effects of the RAAS, and its modulation, in...
Source: Nephron - April 18, 2019 Category: Urology & Nephrology Source Type: research

The Role of Uric Acid in Acute Kidney Injury
Studies have demonstrated the presence of a strong association between serum uric acid (SUA) and acute kidney injury (AKI) consistently across several disease models. Exposure to SUA at different time periods and concentrations has reliably resulted in AKI whether assessed by conventional or novel biomarkers or by kinetic estimated glomerular filtration rate (KeGFR) engineered for non-steady dynamic states. In experimental models, moderate hyperuricemia was associated with an absence of intrarenal crystals, manifestation of tubular injury, macrophage infiltration, and increased expression of inflammatory mediators that wer...
Source: Nephron - April 17, 2019 Category: Urology & Nephrology Source Type: research

Effect of Furosemide under Hyperchloremic Acidosis on Intraoperative Oliguria and Acute Kidney Injury in Patients with Normal Renal Function
Conclusions: In surgery patients under hyperchloremic acidosis, furosemide (0.1 mg/kg) resolved intraoperative oliguria and reduced the incidence of postoperative acute kidney injury.Nephron (Source: Nephron)
Source: Nephron - April 16, 2019 Category: Urology & Nephrology Source Type: research

Consequences of Glomerular Hyperfiltration: The Role of Physical Forces in the Pathogenesis of Chronic Kidney Disease in Diabetes and Obesity
Background: Glomerular hyperfiltration (GH) is a hallmark of renal dysfunction in diabetes and obesity. Recent clinical trials demonstrated that SGLT2 inhibitors are renoprotective, possibly by abating hyperfiltration. The present review considers the current evidence for a cause-to-effect relationship between hyperfiltration-related physical forces and the development of chronic kidney disease (CKD).Summary: Glomerular hyperfiltration is associated with glomerular and tubular hypertrophy. Hyperfiltration is mainly due to an increase in glomerular capillary pressure, which increases tensile stress applied to the capillary ...
Source: Nephron - April 16, 2019 Category: Urology & Nephrology Source Type: research

Making Procurement Biopsies Important Again for Kidney Transplant Allocation
In this study, procurement biopsies were frozen and read by on-call pathologists, often with no specific training in renal pathology, while reperfu sion sections were paraffin embedded and scored by experienced renal pathologists at Columbia University, New York, NY, USA. This methodological difference per se represents an obvious explanation for the poor concordance between the 2 assessments. Use of wedge biopsies in procurement samples versus core-needle samples in reperfusion biopsies may further account for the discrepancies between scores even in seemingly objective measurements, such as the percentage of glomeruloscl...
Source: Nephron - April 3, 2019 Category: Urology & Nephrology Source Type: research

Contents Vol. 141, 2019
Nephron 2019;141:I –0 (Source: Nephron)
Source: Nephron - April 3, 2019 Category: Urology & Nephrology Source Type: research

Erratum
Nephron 2019;142:1 (Source: Nephron)
Source: Nephron - April 3, 2019 Category: Urology & Nephrology Source Type: research

Maintenance Haemodialysis in the Edward Francis Small Teaching Hospital in the Gambia
Maintenance haemodialysis is the most common form of renal replacement therapy treatment in Sub-Saharan Africa. In spite of this, there is a general inadequacy for patients receiving this form of therapy due to lack of materials, human resources and funding from the governments. This form of treatment is relatively new in the Gambia compared to many West African countries, but there is also an enormous challenge on the part of the government to ensure that the citizens benefit from this form of therapy. Inadequate finances and human resources are making it difficult for the Gambia government to achieve this objective. It i...
Source: Nephron - April 3, 2019 Category: Urology & Nephrology Source Type: research

Hematuria Alone or in Combination with Proteinuria Is a Harbinger of Poor Prognosis in Patients with Non-Hodgkin Lymphoma
Conclusions: In patients with hematuric NHL, systemic inflammation is likely to develop to such a great extent that kidney damage occurs. Therefore, the presence of hematuria, alone or especially in combination with proteinuria, predicts a poor prognosis of NHL.Nephron (Source: Nephron)
Source: Nephron - March 31, 2019 Category: Urology & Nephrology Source Type: research

A Clinical Score to Predict Severe Acute Kidney Injury in Chinese Patients after Cardiac Surgery
Conclusion: We developed and validated a practical risk prediction model for SAKI after cardiac surgery based on routinely available perioperative clinical and laboratory data. The prediction model can be easily applied at the bedside and provides a simple and interpretable estimation of risk.Nephron (Source: Nephron)
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Predicting Risk of Recurrent Acute Kidney Injury: A Systematic Review
Background: Although the epidemiology of acute kidney injury (AKI) has been well described, less is known about recurrent AKI (r-AKI). We undertook a systematic review to identify incidence, risk factors, and outcomes of r-AKI.Methods: MEDLINE, EMBASE, CINAHL, Cochrane, Web of Science were searched, from inception to December 2017, for quantitative studies on adults with AKI, where follow-up included ­reporting of r-AKI. Two reviewers independently identified studies and assessed study quality.Summary: From 2,824 citations, 10 cohort studies met inclusion criteria (total patientsn = 538,667). There were 2 distinct set ...
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Hyperosmolality, High Blood Pressure, and Decreased Estimated Glomerular Filtration Rate in US Adolescents, National Health and Nutrition Examination Survey 1999 –2012
Conclusion: Among adolescents in a nationally representative survey, hypernatremia and hyperosmolality were associated with high SBP and decreased eGFR. These findings may support the hypothesis that an imbalance of salt and water contribute to hypertension and CKD.Nephron (Source: Nephron)
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Hemolytic Uremic Syndrome in an Infant with Primary Hyperoxaluria Type II: An Unreported Clinical Association
A 6-month-old boy presented with acute renal failure, thrombocytopenia, and severe non-immune hemolytic anemia. Infection by Shiga-like toxin-producingEscherichia coli and other causes of microangiopathic hemolysis were ruled out, leading to a diagnosis of atypical hemolytic uremic syndrome (aHUS). Neither pathogenic variants in HUS-associated genes nor anti-factor H antibodies were identified. Copy number variation analysis uncovered 4 copies of complement factor H related genes,CFHR1-CFHR4, conceivably leading to higher than normal levels of the corresponding proteins. However, this abnormality was also found in the heal...
Source: Nephron - March 21, 2019 Category: Urology & Nephrology Source Type: research

Mother and Child Reunion in “Hypertensive” End-Stage Renal Disease: Will They Complement Each Other?
We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation, indicating atypical hemolytic uremic syndrome (HUS). The pathogenic variant inCD46 was also found in the mother who donated the kidney, indicating that the TMA occurred on the background of atypical HUS instead of severe hypertension. The patient died from disseminated cancer originated in the mother ’s kidney. Knowledge of the genetic background would have prevent...
Source: Nephron - March 14, 2019 Category: Urology & Nephrology Source Type: research

Salidroside Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis by Inhibiting the Hypoxia-Inducible Factor-1 α Expression Through Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
Conclusions: In summary, SAL ameliorates FSGS mainly by inhibiting the expression of HIF-1 α through PI3K/Akt pathway, which might offer an array of hope for ameliorating FSGS.Nephron (Source: Nephron)
Source: Nephron - March 7, 2019 Category: Urology & Nephrology Source Type: research

Serum miR-192 Is Related to Tubulointerstitial Lesion and Short-Term Disease Progression in IgA Nephropathy
Conclusions: Lower serum miR-192 in IgA nephropathy patients indicates lower intrarenal miR-192 expression, more severe tubular atrophy, interstitial inflammation, and fibrotic tendency (with higher TGF- β and E-cadherin in renal miR-192). IgA nephropathy patients with higher serum miR-192 are less likely to have renal function decline over the course of 2 years.Nephron (Source: Nephron)
Source: Nephron - February 26, 2019 Category: Urology & Nephrology Source Type: research

Effect of Dapagliflozin Treatment on the Expression of Renal Sodium Transporters/Channels on High-Fat Diet Diabetic Mice
Conclusion: Our findings suggest that dapagliflozin treatment augments compensatory changes in the renal PT in diabetic mice.Nephron (Source: Nephron)
Source: Nephron - February 22, 2019 Category: Urology & Nephrology Source Type: research

Association of Thyrotropin Concentration with Chronic Kidney Disease in a Japanese General Population Cohort
Conclusions: Our data indicate that higher TSH concentrations are positively correlated with CKD prevalence and that  a high TSH concentration is a risk factor for CKD development.Nephron (Source: Nephron)
Source: Nephron - February 22, 2019 Category: Urology & Nephrology Source Type: research

Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction
Conclusion: Our data suggest that the activation of MR is involved in NLRP3/caspase-1 pathway-induced cell pyroptosis in the contralateral kidney of UUO model.Nephron (Source: Nephron)
Source: Nephron - February 21, 2019 Category: Urology & Nephrology Source Type: research

CD44-Positive Glomerular Parietal Epithelial Cells in a Mouse Model of Calcineurin Inhibitors-Induced Nephrotoxicity
Conclusion: CD44-positive (activated) PECs reflect extremely early podocyte injury in the progression of FSGS formation and may be a good marker for early detection of CNI-induced nephrotoxicity.Nephron (Source: Nephron)
Source: Nephron - February 20, 2019 Category: Urology & Nephrology Source Type: research

Burden, Access, and Disparities in Kidney Disease
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here, we highlight the need for strengthening basic infrastructure for kidney care services for early detec...
Source: Nephron - February 18, 2019 Category: Urology & Nephrology Source Type: research

Amelioration of Uremic Toxin Indoxyl Sulfate-Induced Osteoblastic Calcification by SET Domain Containing Lysine Methyltransferase 7/9 Protein
Conclusions: Our data demonstrated that SET7/9 downregulation and autophagy activation may be the key mechanism of IS-induced VC in CKD.Nephron (Source: Nephron)
Source: Nephron - February 15, 2019 Category: Urology & Nephrology Source Type: research

Reversal Unilateral Ureteral Obstruction: A Mice Experimental Model
Conclusion: This R-UUO model is an easy, reproducible and reliable method to assess kidney recovery after obstructive uropathy. In this setting, the use of this model may help to a better understanding of the process of kidney repair.Nephron (Source: Nephron)
Source: Nephron - February 15, 2019 Category: Urology & Nephrology Source Type: research