Filtered By:
Specialty: Urology & Nephrology

This page shows you your search results in order of date. This is page number 14.

Order by Relevance | Date

Total 430 results found since Jan 2013.

lncRNA CCAT1 promotes bladder cancer cell proliferation, migration and invasion
Conclusion: CCAT1 plays an oncogenic role in urothelial carcinoma of the bladder. In addition, CCAT1 may be a potential therapeutic target in this cancer.
Source: International Braz J Urol - June 27, 2019 Category: Urology & Nephrology Source Type: research

Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure
Conclusion: We are the first to verify UII induces mice skeletal muscle atrophy associated with enhanced skeletal muscle autophagy and inhibited FNDC5 expression in chronic renal failure.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - June 25, 2019 Category: Urology & Nephrology Source Type: research

Preconditioning of adipose ‐derived stem cells by phosphodiesterase‐5 inhibition enhances therapeutic efficacy against diabetes‐induced erectile dysfunction
ConclusionsAdipose ‐derived stem cell therapy could serve as an alternate approach for diabetes‐induced erectile dysfunction, albeit with a long onset period.In vitro preconditioning of adipose ‐derived stem cells could accelerate the functional and structural recoveryin vivo, indicating that preconditioning by inhibition of phosphodiesterase type 5 may improve adipose ‐derived stem cells therapy following diabetes‐induced erectile dysfunction.
Source: Andrology - June 18, 2019 Category: Urology & Nephrology Authors: J. Yang, Z. Yu, Y. Zhang, G. ‐H. Zang, L. Zhuan, Z. Tang, Y. Liu, T. Wang, S.‐G. Wang, J.‐H. Liu Tags: Original Article Source Type: research

Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Conclusions: Niban protein is involved in apoptosis regulation in HK-2 cells, and most likely via caspase-dependent pathway. PMID: 31163002 [PubMed - in process]
Source: Renal Failure - June 5, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Cadmium regulates von Willebrand factor and occludin expression in glomerular endothelial cells of mice in a TNF- α-dependent manner.
CONCLUSIONS: These results suggest that TNF-α acts to balance homeostasis of glomerular endothelium after Cd treatments. PMID: 31057027 [PubMed - in process]
Source: Renal Failure - May 8, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Loss of reticulocalbin 2 lowers blood pressure and restrains angiotensin II-induced hypertension in vivo.
Abstract Hypertension affects over one billion people worldwide and increases risk for heart failure, stroke and chronic kidney disease. Despite high prevalence and devastating impact, its etiology still remains poorly understood for most hypertensive cases. Rcn2, encoding reticulocalbin 2, is a candidate gene for atherosclerosis we previously demonstrated in mice. Here we identified Rcn2 as a novel regulator of blood pressure in mice. Rcn2 was dramatically upregulated in arteries undergoing structural remodeling. Deletion of Rcn2 lowered basal blood pressure and attenuated angiotensin II-induced hypertension in C...
Source: Am J Physiol Renal P... - April 2, 2019 Category: Urology & Nephrology Authors: Li J, Cechova S, Wang L, Isakson BE, Le T, Shi W Tags: Am J Physiol Renal Physiol Source Type: research

Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy.
CONCLUSION: We identified and demonstrated that GM130 plays an important role in IgA1 O-glycans deficiency in IgAN patients, by negatively regulating C1GALT1 expression. We believe that this finding will provide theoretical foundations for a new mechanism of Gd-IgA1 production in IgAN patients. PMID: 30917363 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - March 26, 2019 Category: Urology & Nephrology Authors: Wang C, Ye M, Zhao Q, Xia M, Liu D, He L, Chen G, Peng Y, Liu H Tags: Am J Nephrol Source Type: research

Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells
Conclusion: Interestingly, cytosolic sensors of viral RNA were found to be involved in IL-6 production via TLR3 signaling in GECs. Regional activation of TLR3/IFN- β/ MDA5/RIG-I/IL-6 axis due to viral and “pseudoviral” infections is involved in innate immunity and inflammatory reactions in GECs. We believe this signaling pathway also plays a pivotal role in the development of some forms of GN.Kidney Blood Press Res 2019;44:62 –71
Source: Kidney and Blood Pressure Research - February 25, 2019 Category: Urology & Nephrology Source Type: research

RPS7 promotes cell migration through targeting epithelial-mesenchymal transition in prostate cancer.
CONCLUSIONS: RPS7 is a newly verified tumor promoter in PCa, and promotes cell migration by targeting epithelial-to-mesenchymal transition pathway. Thus, inhibition of RPS7-epithelial to-mesenchymal transition signaling might represent a prospective approach toward limiting prostate tumor progression. PMID: 30737160 [PubMed - as supplied by publisher]
Source: Urologic Oncology - February 5, 2019 Category: Urology & Nephrology Authors: Wen Y, An Z, Qiao B, Zhang C, Zhang Z Tags: Urol Oncol Source Type: research

Estrogen-Related Receptor α Mediates Puromycin Aminonucleoside-induced Mesangial Cell apoptosis and Inflammatory Injury.
Abstract Glomerular diseases are the leading causes of chronic kidney disease and mesangial cells (MCs) were demonstrated to be involved in the pathogenesis. Puromycin aminonucleoside (PAN) is a nephrotoxic drug that induced glomerular injury with elusive mechanisms. The present study is undertaken to investigate the role of PAN in MC apoptosis, as well as the underlying mechanism. Here we found that PAN induced MC apoptosis accompanied by the declined cell viability and enhanced inflammatory response. The apoptosis was further evidenced by the increments of BAX and Caspase-3 expression. In line with the apoptotic...
Source: Am J Physiol Renal P... - January 30, 2019 Category: Urology & Nephrology Authors: Gong W, Song J, Chen X, Li S, Yu J, Xia W, Ding G, Zhang Y, Jia Z, Zhang A, Huang S Tags: Am J Physiol Renal Physiol Source Type: research

Blockade of ERK1/2 by U0126 alleviates uric acid induced EMT and tubular cell injury in the rats with hyperuricemic nephropathy.
In this study, we showed that hyperuricemic injury induced EMT as characterized by down-regulation of E-cadherin and up-regulation of Vimentin and Snail1 in a rat model of HN. This was coincident with epithelial cells arrested at the G2/M phase of cell cycle, activation of Notch1/Jagged-1 and Wnt/β-catenin signaling pathways, and upregulation of matrix metalloproteinases 2 (MMP2) and MMP9. Administration of U0126, a selective inhibitor of ERK1/2, blocked all these responses. U0126 was also effective in inhibiting renal tubular cell injury as shown by decreased expression of lipocalin-2 (Lcn2) and kidney injury molecule-1 ...
Source: Am J Physiol Renal P... - January 16, 2019 Category: Urology & Nephrology Authors: Tao M, Shi Y, Tang L, Wang Y, Fang L, Jiang W, Lin T, Qiu A, Zhuang S, Liu N Tags: Am J Physiol Renal Physiol Source Type: research

Identification of NFAT5 as a transcriptional regulator of the EDN1gene in collecting duct.
Abstract The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na+and water reabsorption. Recent studies suggest that IMCD ET-1 production is enhanced by extracellular hypertonicity as can occur during high salt intake. While NFAT5 has been implicated in the IMCD ET-1 hypertonicity response, no studies in any cell type have identified NFAT5 as a transcriptional regulator of the EDN1gene; the currently study examined this using a mouse IMCD cell line (IMCD3). Media hypertonicity increased IMCD3 ET-1 mRNA in a dose- and time-dependent ...
Source: Am J Physiol Renal P... - January 9, 2019 Category: Urology & Nephrology Authors: Lakshmipathi J, Wheatley W, Kumar A, Mercenne G, Rodan AR, Kohan DE Tags: Am J Physiol Renal Physiol Source Type: research

Effect of platelet ‐derived growth factor‐BB on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells
Abstract We explored whether platelet ‐derived growth factor (PDGF)‐BB regulates corpus cavernosum smooth muscle cell gap junctions and can ameliorate erectile dysfunction and how it modulates connexin43 (CX43) after bilateral cavernous neurectomy. Primary cultured rat corpus cavernosum smooth muscle cells were treated with PDGF‐B B with or without a PDGFR inhibitor, Akt siRNA or the depletion or promotion of β‐catenin. PDGF‐BB improved CCSMCs gap junction coupling and increased CX43 and PDGFRβ expression; inhibition of PDGFR activity down‐regulated CX43 and decreased Akt and nuclear β‐catenin. Knockdown o...
Source: Andrologia - November 23, 2018 Category: Urology & Nephrology Authors: Fan Zhao, Junfeng Yan, Jianfeng Zhao, Bing Shi, Miaoyong Ye, Xiaojun Huang, Bo Yu, Bodong Lv, Wenjie Huang Tags: ORIGINAL ARTICLE Source Type: research

Mammalian Target of Rapamycin Complex 1 Activation Disrupts the Low-Density Lipoprotein Receptor Pathway: A Novel Mechanism for Extracellular Matrix Accumulation in Human Peritoneal Mesothelial Cells.
Abstract Peritoneal fibrosis (PF) is characterized by progressive extracellular matrix (ECM) accumulation. Increasing evidence has suggested that ECM synthesis was increased in human peritoneal mesothelial cells (HPMCs) under high-glucose conditions, but the effects of high-glucose peritoneal dialysis solution (PDS) on ECM synthesis have not been fully elucidated. The aim of this study was to explore the potential mechanisms of high-glucose PDS-induced production of ECM in HPMCs. HPMCs were stimulated by high-glucose PDS. The activity of mammalian target of rapamycin complex 1 (mTORC1) was inhibited by rapamycin...
Source: American Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Authors: Liu J, Zhu W, Jiang CM, Feng Y, Xia YY, Zhang QY, Xu PF, Zhang M Tags: Am J Nephrol Source Type: research

Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia
Conclusion: AT1-AA induced podocyte damage in a dose-dependent manner. The underlying mechanism might involve activation of the TRPC6 –calcium/calcineurin pathway. This study provides new details regarding podocyte injury and the mechanism underlying the generation of proteinuria in pre-eclampsia.Kidney Blood Press Res 2018;43:1666 –1676
Source: Kidney and Blood Pressure Research - October 31, 2018 Category: Urology & Nephrology Source Type: research