Protective effect of vitamin E and vitamin C alone and in combination on testicular damage induced by sodium metabisulphite in rats: A stereological study
AbstractThe existing investigation was directed to consider the protective role of vitamin C and E alone and in combination on sodium metabisulphite ‐induced damage on testicular. Experimental animals were received sodium metabisulphite (520 mg/kg) alone and in combination with vitamin E (100 mg/kg), vitamin C (100 mg/kg) and vitamin E + C, while the control groups received 0.9% saline solution and olive oil (the solvent of the vitamin E) . Finally, the changes in the testis histology were examined stereologically. Lipid peroxidation was assessed through the measurement of malondialdehyde (MDA) levels in testis tiss...
Source: Andrologia - November 26, 2018 Category: Urology & Nephrology Authors: Shiva Zare, Mohammad Hossein Dabbaghmanesh, Ali Noorafshan, Farhad Koohpeyma, Marzieh Bakhshayeshkaram, Nima Montazeri ‐Najafabady Tags: ORIGINAL ARTICLE Source Type: research

Therapeutic options in male genital tract inflammation
AbstractChronic inflammatory conditions of the genital tract are still unsatisfactorily recognised in the workup of male infertility due to inappropriate definitions and inconsistent diagnostic criteria. The most popular term used for description of both, infections and inflammation in the genital tract is MAGI (male accessory gland infection). In asymptomatic patients, the diagnosis is primarily based on leucocytospermia (i.e., more than 1 million peroxidase ‐positive leucocytes per ml ejaculate), although ongoing infections should be identified and distinguished from post‐infectious or non‐infectious inflammatory d...
Source: Andrologia - November 26, 2018 Category: Urology & Nephrology Authors: Gerhard Haidl, Friederike Haidl, Jean ‐Pierre Allam, Hans‐Christian Schuppe Tags: INVITED REVIEW Source Type: research

Testicular spermatozoon is superior to ejaculated spermatozoon for intracytoplasmic sperm injection to achieve pregnancy in infertile males with high sperm DNA damage
AbstractThe purpose of this study was to compare the clinical outcome of testicular spermatozoon versus ejaculated spermatozoon in the treatment of infertile males with high sperm DNA damage, referred as sperm DNA fragmentation index (DFI), that attending intracytoplasmic sperm injection (ICSI) programme in terms of clinical pregnancy, births delivered as the primary and pregnancy loss and embryo fertilisation as the secondary outcome. A total of 102 males fulfilling the inclusion criteria were enrolled in the present study. Of the 102 males, 61 infertile males underwent testicular spermatozoon combined with ICSI while the...
Source: Andrologia - November 26, 2018 Category: Urology & Nephrology Authors: Jiyue Zhang, Huiying Xue, Fenglong Qiu, Jixiang Zhong, Jing Su Tags: ORIGINAL ARTICLE Source Type: research

Hypoxia pathway has more impact than inflammation pathway on etiology of infertile men with varicocele
This study aimed to compare main molecular markers of hypoxia (HIF1 ‐α and P53) and inflammation (TLR‐2, TLR‐4 and TNF‐α) pathways between infertile men with varicocele and fertile individuals. Sperm parameters such as sperm concentration, motility and morphology were assessed according to World Health Organization (Laboratory manual for the examination an d processing of human semen. Geneva, Switzerland, 2010) guideline in 20 infertile men with grade II or III varicocele, and 20 fertile men candidate of family balancing. In addition, sperm DNA fragmentation and molecular markers involved in hypoxia and inflammat...
Source: Andrologia - November 26, 2018 Category: Urology & Nephrology Authors: Rana Ghandehari ‐Alavijeh, Marziyeh Tavalaee, Dina Zohrabi, Shaqayeq Foroozan‐Broojeni, Homayoun Abbasi, Mohammad H. Nasr‐Esfahani Tags: ORIGINAL ARTICLE Source Type: research

Abolition of prenatal lipopolysaccharide ‐induced reproductive disorders in rat male offspring by fulvestrant
AbstractDuring prenatal and early postnatal periods of development, multiple environmental factors have profound and long ‐lasting effects on the immune and reproductive functions. The aim of this study was to investigate the effects of maternal lipopolysaccharide (LPS) exposure (50 mg/kg, i.p.) at day 12 of pregnancy and estradiol antagonist treatment (fulvestrant, 1.5 mg/kg, s.c. in neck) at postnatal days 5–14 (PND5–14) with high estradiol levels on reproductive parameters in adult rat males. Serum steroid concentrations were measured in male offspring at PND80 by ELISA. Body, testis weights and ano‐genital di...
Source: Andrologia - November 26, 2018 Category: Urology & Nephrology Authors: Marina S. Izvolskaia, Victoria S. Sharova, Vasilina M. Ignatiuk, Svetlana N. Voronova, Liudmila A. Zakharova Tags: ORIGINAL ARTICLE Source Type: research

Effect of platelet ‐derived growth factor‐BB on gap junction and connexin43 in rat penile corpus cavernosum smooth muscle cells
Abstract We explored whether platelet ‐derived growth factor (PDGF)‐BB regulates corpus cavernosum smooth muscle cell gap junctions and can ameliorate erectile dysfunction and how it modulates connexin43 (CX43) after bilateral cavernous neurectomy. Primary cultured rat corpus cavernosum smooth muscle cells were treated with PDGF‐B B with or without a PDGFR inhibitor, Akt siRNA or the depletion or promotion of β‐catenin. PDGF‐BB improved CCSMCs gap junction coupling and increased CX43 and PDGFRβ expression; inhibition of PDGFR activity down‐regulated CX43 and decreased Akt and nuclear β‐catenin. Knockdown o...
Source: Andrologia - November 23, 2018 Category: Urology & Nephrology Authors: Fan Zhao, Junfeng Yan, Jianfeng Zhao, Bing Shi, Miaoyong Ye, Xiaojun Huang, Bo Yu, Bodong Lv, Wenjie Huang Tags: ORIGINAL ARTICLE Source Type: research

The protective role of melatonin and curcumin in the testis of young and aged rats
AbstractWe aimed to investigate the effect of melatonin and curcumin treatment on oxidative stress, apoptosis, and histology of testicular tissue in our study. Four groups were formed using young (4  months old,n = 6) and aged (20–22 months old,n = 18) male Wistar albino rats: (a) Young control (1% ethanol:phosphate‐buffered saline [PBS], subcutaneously [s.c.]); (b) Aged control (CTL;n = 6, 1% ethanol:PBS, s.c.); (c) Aged Melatonin (MLT;n = 6, 10 mg/kg, s.c.); (d) Aged Curcumin (CUR;n = 6, 30 mg/kg, i.p.). At the end of 21 days, the rats were sacrificed, and testicular tissues were removed. Malondialdehy...
Source: Andrologia - November 22, 2018 Category: Urology & Nephrology Authors: Saide Murato ğlu, Ozen S. Akarca Dizakar, Arzu Keskin Aktan, Suna Ömeroğlu, Kazime Gonca Akbulut Tags: ORIGINAL ARTICLE Source Type: research

Seminal human papillomavirus originates from the body surface and is not a frequent aetiological factor in azoospermia
AbstractHuman papillomavirus (HPV) DNA has been detected in the testis tissue of 6.5% of 185 men with non ‐obstructive azoospermia (NOA). Others have suggested that seminal HPV originates from contamination from the genital skin and mucosa. One hundred unselected azoospermic men and 43 normal men undergoing vasectomy were recruited. Testicular biopsies for HPV examination were collected from all the m en. Additionally, the normal men undergoing vasectomy delivered a semen sample and had a swab for HPV examination taken from the genital skin before vasectomy. A piece of each Vas deferens obtained during the vasectomy was ...
Source: Andrologia - November 22, 2018 Category: Urology & Nephrology Authors: Jens Fedder, Dorthe Ørnskov, Birte Engvad, Thomas Kielsgaard Kristensen, Mads Lomholt, Niels Marcussen, Marianne Waldström Tags: ORIGINAL ARTICLE Source Type: research

Tocotrienol ‐rich fraction supplementation prevents foetal loss in females mated with corticosterone‐treated male Sprague–Dawley rats
This study examined whether tocotrienol supplementation to corticosterone ‐treated male rats could prevent foetal loss in females upon their mating. Epididymides of adult male Sprague–Dawley (SD) rats with proven fertility were surgically separated at the testis‐caput junction. Twenty‐four hours post‐surgery, these animals received for 7 days either: tocopherol ‐stripped corn oil (Control), corticosterone 25 mg/kg s.c. (CORT), CORT 25 mg/kg s.c. and tocotrienol‐rich fraction (TRF) 100 mg/kg orally (CORT + TRF) or TRF 100 mg/kg orally (TRF). On day 8, males were cohabited with proestrus females. A sperm...
Source: Andrologia - November 20, 2018 Category: Urology & Nephrology Authors: Noor Azean Anis Abd Aziz, Amar Chatterjee, Rita Chatterjee, Damayanthi Durairajanayagam Tags: ORIGINAL ARTICLE Source Type: research

The use of diffusion ‐weighted MR imaging in the functional assessment of the testes of patients with clinical varicocele
AbstractWe aimed to evaluate the use of diffusion ‐weighted imaging (DWI) in the assessment of the varicocele effect on testicular parenchyma and spermatogenesis, with estimation of apparent diffusion coefficient (ADC) value changes in the testicular parenchyma. We prospectively evaluated 30 consecutive patients (18 patients with bilateral varico cele and 12 patients with unilateral varicocele) and 10 healthy controls. US and DWI were performed to all patients. A total of 80 testes were included, which divided into three groups: group A: testes ipsilateral to the varicocele (n = 48, 60%); group B: testes contralateral ...
Source: Andrologia - November 20, 2018 Category: Urology & Nephrology Authors: Sally Emad ‐Eldin, Abdullah M. A. Salim, Manal Halim Wahba, Amr Tharwat Elahwany, Omar Abdelaziz Tags: ORIGINAL ARTICLE Source Type: research

Oxidative stress ‐mediated alterations on sperm parameters in male Wistar rats exposed to 3G mobile phone radiation
In conclusion, exposure to mobile phone radiations induces oxidative stress in male Wistar rats which may lead to alteration in sperm parameters and affects their fertility. (Source: Andrologia)
Source: Andrologia - November 20, 2018 Category: Urology & Nephrology Authors: Rohit Gautam, Kumari Vandana Singh, Jayprakash Nirala, Nina Nancy Murmu, Ramovatar Meena, Paulraj Rajamani Tags: ORIGINAL ARTICLE Source Type: research

LY294002, a PI3K pathway inhibitor, prevents leptin ‐induced adverse effects on spermatozoa in Sprague‐Dawley rats
In conclusion, LY294002 prevents leptin‐induced changes in rat sperm parameters, suggesting the potential role of the PI3K signalling pathway in the adverse effects of leptin on sperm param eters. (Source: Andrologia)
Source: Andrologia - November 19, 2018 Category: Urology & Nephrology Authors: Amir Hafidz Md Mokhtar, Ifrah Alam Malik, Noor Azean Anis Abd Aziz, Fayez A. Almabhouh, Damayanthi Durairajanayagam, Harbindar Jeet Singh Tags: ORIGINAL ARTICLE Source Type: research

Effect of phosphodiesterase type 5 inhibitors on prostate cancer risk and biochemical recurrence after prostate cancer treatment: A systematic review and meta ‐analysis
AbstractRecent studies have examined the impact of phosphodiesterase type 5 inhibitors (PDE5 ‐Is) use on the risk of prostate cancer, and biochemical recurrence (BCR) in prostate cancer patients, but the results were inconsistent. A meta‐analysis was conducted to assess the associations with all published studies. Databases (PubMed, Web of Science and MEDLINE) were retrieved to identify relevant studies which explored the impact of PDE5‐Is use on the risk of prostate cancer, and BCR in prostate cancer patients. The summary results along with 95% confidence intervals (CIs) were calculated. Nine articles were eligible ...
Source: Andrologia - November 16, 2018 Category: Urology & Nephrology Authors: Yougen Wu, Xiaofeng Qu, Yang Wang, Ju Xia, Yuting Gu, Qingqing Qian, Yang Hong Tags: INVITED REVIEW Source Type: research

Modulatory effects of methanolic fruit fraction of Pedalium murex on sulphasalazine ‐induced male reproductive disruption
In conclusion, the results suggest thatMfPm showed a significant modulatory effect against SSZ induced male reproductive disruption via possible mode of action such as spermatogenic and androgenic nature, therefore, justifying the traditional use of this plant in the treatment of reproductive disruption. (Source: Andrologia)
Source: Andrologia - November 14, 2018 Category: Urology & Nephrology Authors: Mahima Sharma, Dharmendra Arya, Kiran Bhagour, Radhey S. Gupta Tags: ORIGINAL ARTICLE Source Type: research

Orchidopexy for bilateral undescended testes: A multicentre study on its effects on fertility and comparison of two fixation techniques
AbstractTo evaluate fertility potential after orchidopexy for bilateral undescended testis and compare two surgical fixation techniques for effect on fertility. Men older than 22  years who had either tunica albuginea orchidopexy (TAO) or “no‐touch” technique (NTO) in childhood for bilateral undescended testis (BUDT) were selected. Participants filled out a questionnaire followed by physical examination, had testicular ultrasound, blood sample and semen analysis. Stat istical testing was performed using general linear modelling. Sixty‐seven out of 166 individuals responded. Forty‐nine completed the questionnaire...
Source: Andrologia - November 8, 2018 Category: Urology & Nephrology Authors: Mick Uijldert, Andreas Mei ßner, Caroline F. Kuijper, Sjoerd Repping, Tom P. V. M. de Jong, Rafal J. Chrzan Tags: ORIGINAL ARTICLE Source Type: research