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Specialty: Urology & Nephrology
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Total 430 results found since Jan 2013.
Actin-related protein (Arp) 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway
Am J Physiol Renal Physiol. 2021 Jun 28. doi: 10.1152/ajprenal.00015.2021. Online ahead of print.ABSTRACTThe trafficking of proteins such as aquaporin-2 (AQP2) in the exocytotic pathway requires an active actin cytoskeleton network, but the mechanism is incompletely understood. Here, we show that the actin-related protein (Arp) 2/3 complex, a key factor in actin filament branching and polymerization, is involved in the shuttling of aquaporin-2 (AQP2) between the trans Golgi network (TGN) and the plasma membrane. Arp2/3 inhibition (using CK-666) or siRNA knockdown blocks vasopressin induced AQP2 membrane accumulation, and i...
Source: Am J Physiol Renal P... - June 28, 2021 Category: Urology & Nephrology Authors: Chen-Chung Steven Liu Pui W Cheung Anupama Dinesh Noah Baylor Theodor C Paunescu Anil V Nair Richard Bouley Dennis Brown Source Type: research
ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research
Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma
CONCLUSIONS: The present study confirms over-expression of CA9 in UC and for the first time shows a correlation with molecular subtypes. However, CA9 expression showed no association with the outcome of patients with muscle invasive bladder cancer and inhibition of CA9 did not lead to a consistent inhibition of tumor growth. Based on these data, CA9 exhibits a role neither as a predictive or prognostic marker nor as a therapeutic target in invasive UC.PMID:34083096 | DOI:10.1016/j.urolonc.2021.04.011
Source: Urologic Oncology - June 4, 2021 Category: Urology & Nephrology Authors: Tilman Todenh öfer Ewan A Gibb Roland Seiler Alireza Kamyabi J örg Hennenlotter Paul McDonald Igor Moskalev Craig Stewart Jian Gao Ladan Fazli Shoukat Dedhar Arnulf Stenzl Htoo Zarni Oo Peter C Black Source Type: research
Vitamin D protects glomerular mesangial cells from high glucose-induced injury by repressing JAK/STAT signaling
ConclusionVitamin D (VD) treatment inhibits the function of HG on fibronectin production through regulating JAK/STAT pathway. These results provide direct evidences that VD protects glomerular mesangial cells from high glucose-induced injury through repressing JAK/STAT signaling, which has the potential for clinical DN treatment.
Source: International Urology and Nephrology - May 3, 2021 Category: Urology & Nephrology Source Type: research
Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress
Ren Fail. 2021 Dec;43(1):556-565. doi: 10.1080/0886022X.2021.1902821.ABSTRACTAldosterone exerts an enormous function on proximal tubular cells (PTC) senescence, which is a common pathomechanism contributing to renal dysfunction. Numerous studies have shown that oxidative stress is deeply involved in the pathophysiologic processes of chronic kidney diseases. The study aims to investigate whether autophagy could regulate the process of senescence through oxidative stress in PTC both in vivo and ex vivo. Our results suggested that aldosterone treatment increased the senescence and oxidative stress as evidenced by increased pe...
Source: Renal Failure - March 24, 2021 Category: Urology & Nephrology Authors: Jing-Yuan Cao Li-Lu Ling Wei-Jie Ni Hong-Lei Guo Min Yang Source Type: research
