A case of idiopathic membranous nephropathy and psoriasis vulgaris
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 10, 2021 Category: Urology & Nephrology Source Type: research

Miniaturized percutaneous Nephrolithotomy without antibiotic prophylaxis: a single institution experience
ConclusionPatients with negative preoperative UC, a none-staghorn stone and no history of recurrent UTI or infectious stones may not need routine antibiotic prophylaxis prior to mPCNL. A prospective validation is warranted. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 3, 2021 Category: Urology & Nephrology Source Type: research

Effectiveness of fibroblast growth factor 23 lowering modalities in chronic kidney disease: a systematic review and meta-analysis
ConclusionsThe present meta-analysis demonstrated that non-calcium-based phosphate binders including sevelamer, lanthanum, and iron-based phosphate binders, iron supplements, calcimimetics, hemoperfusion, and preservation of RRF could effectively reduce FGF23 in CKD patients. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 2, 2021 Category: Urology & Nephrology Source Type: research

The efficacy of manipulation as a treatment for myofascial pelvic pain
AbstractObjectiveTo evaluate the effect of myofascial manipulation by observing the changes in pelvic floor myofascial scores and electromyography (EMG) data before and after treatment.MethodsA total of 106 patients with myofascial pelvic pain (MFPP) were enrolled in a treatment group, and 50 healthy women were enrolled in a control group. The changes in the pelvic floor EMG data in the two groups were monitored by using Myo Trac before and after treatment. Pelvic trigger points and their distribution in the MFPP patients were examined using a finger pressure test. The visual analogue scale was used to assess the severity ...
Source: International Urology and Nephrology - April 2, 2021 Category: Urology & Nephrology Source Type: research

Proton-pump inhibitors associated with decreased urinary citrate excretion
AbstractIntroductionProton-pump inhibitors (PPIs) may increase the risk of kidney stone formation, but the mechanism has not been elucidated. There is a paucity of literature evaluating the effects of PPIs on urinary metabolites and urine pH.MethodsWe performed a retrospective review of nephrolithiasis patients treated at our institution and compared patients who were taking PPIs to those who were  not at the time of their 24-h urine collections. Hierarchical multivariate linear regression was used to evaluate the independent relationship between PPI use and urinary mineral composition.ResultsWe identified 301 co...
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

The EPIC-26 domain scores after radical prostatectomy are associated with the personality trait of neuroticism
This study examines the levels of self-reported adverse effects (AEs) after robot-assisted radical prostatectomy (RALP) in Norwegian men with high or low levels of neuroticism. Neuroticism is also compared to relevant factors concerning their associations with various AEs.MethodsAmong 982 men who had RALP at Oslo University Hospital, Radiumhospitalet between 2005 and 2010, 79% responded to a mailed questionnaire in 2011. They rated AEs by completing the EPIC-26 questionnaire, and neuroticism on the Eysenck Personality Questionnaire (EPQ). Men with  
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

Preoperative Wilms tumor rupture in children
ConclusionContrast-enhanced computed tomography (CT) and ultrasonography (US) are of major value in the diagnosis of preoperative tumor rupture,  and immediate surgery or delayed surgery are available therapeutic methods. The treatment plan was based on patients’ general conditions, tumor size, position and impairment degree of tumor rupture, extent of invasion and experience of a multidisciplinary team (including surgeon and anesthesiolo gists). In our experience, for ruptured preoperative tumor diagnosed with stage III, the criteria for immediate surgery are as follows: tumor not acrossing the midline, tumor w...
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

Experimental autoimmune prostatitis: different antigens induction and antigen-specific therapy
ConclusionsPE-induced model is the most commonly used, while T2- or p25-model could serve as a promising CP/CPPS model. Antigen-specific therapy in CP/CPPS deserves further study. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

Autoantibodies against phospholipase A2 receptor in Brazilian patients with glomerular diseases
ConclusionsAnti-PLA2R showed high specificity and PPV for the diagnosis of primary MN in Brazilian patients. There was a strong correlation between disease activity and positive anti-PLA2R. This biomarker represents an important diagnostic tool for primary MN and may contribute to the monitoring of disease activity in such patients. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

The effect of anemia on the efficacy and safety of treating chronic hepatitis C infection with direct-acting antivirals in patients with chronic kidney disease
AbstractBackground/AimChronic hepatitis-C infection is a great health burden in Egypt. The effect of anemia on the efficacy and safety of direct-acting anti-viral (DAA) therapies for those with chronic-kidney disease (CKD) has not been evaluated.Patients/MethodsThis single-center retrospective study included 235 renal patients: i.e., 70-CKD patients not on hemodialysis (42 with anemia, 28 without); 40 hemodialysis patients (16 anemic; 24 non-anemic), and 125 kidney-transplant (KTx) recipients (40 anemic; 85 non-anemic). Anemia was defined by a hemoglobin level    30 mL/min/1.73 m2 received sofosbuvir/dac...
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

COVID-19 pandemic impact on clinical outcomes of patients with obstructive pyelonephritis
ConclusionDuring the COVID-19 pandemic, patients with acute obstructive pyelonephritis presented later for evaluation at the ER, had higher disease severity and longer hospital length of stay when compared to the pre-COVID group of patients with the same pathology. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

Tumor cell PD-L1 expression is a strong predictor of unfavorable prognosis in immune checkpoint therapy-naive clear cell renal cell cancer
AbstractBackgroundPD-L1 expression predicts response to immune checkpoint inhibitors in renal cell carcinomas (RCC), but has also been suggested to be linked to poor patient outcome.MethodsWe analyzed PD-L1 in  >  1400 RCC in a tissue microarray format by immunohistochemistry. Results were compared with histological tumor type, parameters of cancer aggressiveness, and intratumoral CD8+ cytotoxic cells.ResultAt a cut-off level of 5% PD-L1 positive tumor cells, PD-L1 positivity was seen in 6.3% of 633 clear cell RCC (ccRCC), 18.2% of 165 papillary RCC, 18.8% of 64 chromophobe RCC, and 41.7% of 103 oncoc...
Source: International Urology and Nephrology - April 1, 2021 Category: Urology & Nephrology Source Type: research

Pittsburgh Sleep Quality Index score predicts all-cause mortality in Chinese dialysis patients
ConclusionsPSQI score can be used as a predictor of all-cause mortality in dialysis patients, and those with PSQI  >  7 were associated with increased odds of mortality. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 31, 2021 Category: Urology & Nephrology Source Type: research

A systematic review for the efficacy of coenzyme Q10 in patients with chronic kidney disease
ConclusionsOur systematic review demonstrated that CoQ10 supplementation might have promising effects on oxidative stress. This work provided some clues that CoQ10 supplementation might have the potential to improve inflammation levels, glucose metabolism, cardiac structure, and cardiac biomarkers. However, the effects of CoQ10 supplementation should be confirmed in larger high-quality studies. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 29, 2021 Category: Urology & Nephrology Source Type: research

Pretreatment morning urine osmolality and oral desmopressin lyophilisate treatment outcome in patients with primary monosymptomatic enuresis
AbstractPurposeTo determine the association between urine osmolality (Uosm) in patients with primary monosymptomatic enuresis (PMNE) and response to desmopressin (dDAVP) lyophilisate.MethodsThis was a prospective cohort study that included 419 children with enuresis seen in outpatient clinic between October 2017 and October 2019. Patient workup included symptom checklist, 48  h frequency/volume chart, kidney and bladder ultrasound, uroflow, urinalysis and culture, spot urine Ca/creatinine, and first-morning Uosm. Patients   814 mOsm/kg) might be suggestive of an alternative treatment to dDAVP lyophi...
Source: International Urology and Nephrology - March 27, 2021 Category: Urology & Nephrology Source Type: research

Assessment of health-related quality of life and its determinants in the pre-dialysis patients with chronic kidney disease
ConclusionsThis study shows that the overall HRQoL of the participants was high, though a considerable proportion of them had poor HRQoL, while the discomfort and symptoms dimension was the most impacted. Being educated, unemployed, and self-employed were significantly and independently associated with poor overall HRQoL. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 26, 2021 Category: Urology & Nephrology Source Type: research

Platelet-to-lymphocyte ratio and prediction of progressive IgA nephropathy: myth or fact?
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 26, 2021 Category: Urology & Nephrology Source Type: research

Rhein protects 5/6 nephrectomized rat against renal injury by reducing inflammation via NF- κB signaling
ConclusionThese findings provide evidence that Rhein protect against renal injury, and NF- κB signaling pathway is involved in this protective effect. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 25, 2021 Category: Urology & Nephrology Source Type: research

Application of ultrasound during electrode implantation for sacral neuromodulation in patients with neurogenic bladder secondary to spinal cord disease: a retrospective study
ConclusionUltrasound can be applied to safely place lead electrode for sacral neuromodulation and leads to no radiation exposure to the patient, surgeon, and operating room staff and a shortened operating time while maintaining the same efficacy as X-ray. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 20, 2021 Category: Urology & Nephrology Source Type: research

Outcomes of a single trigone-only vs. 20 trigone-sparing injections of OnabotulinumtoxinA for refractory overactive bladder (OAB)
AbstractPurposeTo compare the safety and durability of a single intravesical trigonal-only versus 20 trigone-sparing injections of OnabotulinumtoxinA (BTA) for refractory OAB.MethodsA chart review of all idiopathic OAB patients treated with BTA from January 2016 to December 2018 was performed. Outcomes measures included: inter-injection interval, post-void residual (PVR), urinary tract infections (UTI), urinary retention requiring catheterization, and procedure time (min). Statistical analyses were performed using independent sample t-tests.ResultsBaseline characteristics were comparable for the two groups, data on 69 trea...
Source: International Urology and Nephrology - March 19, 2021 Category: Urology & Nephrology Source Type: research

microRNA-29b prevents renal fibrosis by attenuating renal tubular epithelial cell –mesenchymal transition through targeting the PI3K/AKT pathway
ConclusionOur findings suggested that miR-29b significantly prevented tubulointerstitial injury in mouse model of UUO by attenuating renal tubular epithelial cell –mesenchymal transition via repressing PI3K/AKT signaling pathway. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 19, 2021 Category: Urology & Nephrology Source Type: research

Outcomes of death and prolonged renal insufficiency in ethylene glycol poisoned patients
ConclusionsCompared with survivors, patients who died or had prolonged kidney injury were more likely to exhibit clinical signs such as coma, seizures, and acidosis. Hemodialysis and antidote should be started early and continued until acidosis is corrected. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 18, 2021 Category: Urology & Nephrology Source Type: research

Antibiotic dosing adjustments in hospitalized patients with chronic kidney disease: a retrospective chart review
ConclusionOur study revealed a high frequency of guideline-discordant antibiotic dosing in patients with CKD. This dosing error is preventable by increasing awareness of prescribing physicians and collaborating with clinical pharmacists. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 18, 2021 Category: Urology & Nephrology Source Type: research

Cardiovascular implantable electronic devices and native arteriovenous fistula in hemodialysis patients: novel perspectives
AbstractThe benefits from cardiovascular implantable electronic devices (CIED) implantation in hemodialysis (HD) patients are still far to be thoroughly defined, especially on primary prevention. In addition, CIED placement is not a risk-free procedure, because it could be followed by a not negligible burden of complications that could compromise the health and the vascular access of HD patients. In fact, the arteriovenous fistula (AVF) dysfunction following CIED implantation is usually due to a hemodynamically significant alteration of blood flow. This condition could lead to a potential decrease of dialysis efficacy and ...
Source: International Urology and Nephrology - March 16, 2021 Category: Urology & Nephrology Source Type: research

Greenlight laser photoselective vaporization vs open simple prostatectomy: long-term functional outcomes after treatment of large volume prostates ( & gt;  80 cc)
AbstractPurposeTo compare long-term outcomes between photoselective vaporization (PVP) and Open simple prostatectomy (OSP) for prostates  >  80 cc.MethodsMen operated either by PVP or OSP for BPH  >  80 cc were included in two expert centres. Functional and uroflowmetric outcomes were assessed pre- and postoperatively. Data were collected prospectively in the PVP group and retrospectively in the OSP group and compared at long-term follow-up. Complications and re-intervention rates were used as main outcomes.Results332 men underwent surgery: 132 PVP were performed in a fist expert...
Source: International Urology and Nephrology - March 16, 2021 Category: Urology & Nephrology Source Type: research

Kidney transplantation from donation after circulatory death using abdominal normothermic oxygenated circulation: are the outcomes equivalent?
This study aims to determine the outcomes of kidney transplantation from DCD after abdominal normothermic oxygenated circulation (ANOR) support.MethodsFrom January 2016 to December 2018, 58  kidneys were implanted from uncontrolled DCD after ANOR support. We performed an observational prospective study, assessing graft function and cumulative incidence of surgical complications. A descriptive analysis was conducted. Potential determinants of the outcomes were evaluated, including don or and receptor gender and age, and warm and cold ischemia times. Regression coefficients (β) and odds ratio (OR) were calcula...
Source: International Urology and Nephrology - March 15, 2021 Category: Urology & Nephrology Source Type: research

Kidney biopsy findings in vancomycin-induced acute kidney injury: a pooled analysis
ConclusionsAcute tubular necrosis and tubulointerstitial nephritis represent the main histological patterns of vancomycin-induced acute kidney injury. The presence of fibrosis in the context of interstitial inflammation may be linked to lower recovery rates and worse long-term renal outcomes. A novel cast nephropathy obstructive mechanism has been suggested, necessitating further confirmation. Large-scale studies should define the exact indications of kidney biopsy in cases with suspected vancomycin nephrotoxicity. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 14, 2021 Category: Urology & Nephrology Source Type: research

Biomechanics of the urinary bladder: spontaneous contraction activity and micromotions related to accommodation
ConclusionLocalized contractile activity and MMs that change the plastic elongated state of varying bladder regions are biomechanically effective in the active accommodation of detrusor pressure to changes in bladder volume. According to this concept, autonomous bladder wall activity as a source of nerve activity, also is crucial for active accommodation. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 13, 2021 Category: Urology & Nephrology Source Type: research

Effect of l -carnitine supplementation on renal anemia in patients on hemodialysis: a meta-analysis
AbstractBackgroundl-carnitine is an amino acid derivative that is thought to be helpful for treating renal anemia in hemodialysis patients. However, the mechanism remains to be fully elucidated.MethodsA literature search was performed on PubMed, Embase, and Cochrane Central Register of Controlled Trials to identify randomized controlled trials (RCTs) and conduct a meta-analysis for investigating the effect ofl-carnitine in the treatment of renal anemia in participants receiving hemodialysis.ResultsA total of 18 eligible trials with 1090 participants were included in this study.l-carnitine can significantly increase plasma ...
Source: International Urology and Nephrology - March 13, 2021 Category: Urology & Nephrology Source Type: research

Improving glomerular filtration rate estimation by semi-supervised learning: a development and external validation study
AbstractBackgroundAccurate estimating glomerular filtration rate (GFR) is crucial both in clinical practice and epidemiological survey. We incorporated semi-supervised learning technology to improve GFR estimation performance.MethodsAASK [African American Study of Kidney Disease and Hypertension], CRIC [Chronic Renal Insufficiency Cohort] and DCCT [Diabetes Control and Complications Trial] studies were pooled together for model development, whereas MDRD [Modification of Diet in Renal Disease] and CRISP [Consortium for Radiological Imaging Studies of Polycystic Kidney Disease] studies for model external validation.A total o...
Source: International Urology and Nephrology - March 12, 2021 Category: Urology & Nephrology Source Type: research

Comment on “Prognostic value of immunological profile based on CD8+ and FoxP3+ T lymphocytes in the peritumoral and intratumoral subsites for renal cell carcinoma”
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 12, 2021 Category: Urology & Nephrology Source Type: research

Solute-free water excretion and electrolyte-free water excretion are better  terms than solute-free water clearance and electrolyte-free water clearance
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 9, 2021 Category: Urology & Nephrology Source Type: research

Incidence of death from kidney diseases among cancer patients: a US population-based analysis
ConclusionThe risk of death from kidney diseases is increasing among cancer survivors recently. Nephrologists should be actively involved in certain facets of cancer treatment, and provide effective nephrology care, especially for elderly patients with black race, higher grade, and poorer disease stage. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 8, 2021 Category: Urology & Nephrology Source Type: research

Discovery of potential biomarkers in acute kidney injury by ultra-high-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF –MS)
Conclusion2-S-glutathionyl glutathione acetate, 5-l-Glutamyl-taurine, andl-Phosphoarginine were associated with AKI patients, which could be selected as potential biomarkers to predicate AKI disease. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 8, 2021 Category: Urology & Nephrology Source Type: research

Prognostic performance of clinical assessment tools following hip fracture in patients with chronic kidney disease
ConclusionPatients with advanced CKD and severe frailty have a high mortality risk following hip fracture. The Clinical Frailty Scale is an excellent prognostic tool for mortality in this setting and could be easily incorporated into routine clinical practice. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 8, 2021 Category: Urology & Nephrology Source Type: research

The role of Elabela in kidney disease
AbstractElabela, also known as Toddler or Apela, is a recently discovered hormonal peptide containing 32 amino acids. Elabela is a ligand of the apelin receptor (APJ). APJ is a G protein-coupled receptor widely expressed throughout body, and together with its cognate ligand, apelin, it plays an important role in various physiological processes including cardiovascular functions, angiogenesis and fluid homeostasis. Elabela also participates in embryonic development and pathophysiological processes in adulthood. Elabela is highly expressed in undifferentiated embryonic stem cells and regulates endoderm differentiation and ca...
Source: International Urology and Nephrology - March 8, 2021 Category: Urology & Nephrology Source Type: research

Revised ISN/RPS 2018 classification of lupus renal pathology predict clinical remission
ConclusionThe study identified baseline GFR, anti-DNA titer, cellular crescent, and high chronicity index according to revised ISN/RPS 2018 classification as important predictors of renal response after induction therapy in proliferative lupus nephritis. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 8, 2021 Category: Urology & Nephrology Source Type: research

Thyroid hormone status in patients with impaired kidney function
AbstractPurposeWe aimed to investigate the prevalence of thyroid hormone abnormalities and the relationship between free triiodothyronine (fT3), thyroid stimulating hormone (TSH) and free thyroxine (fT4) serum levels with kidney function and proteinuria in 4108 subsequent patients admitted to a Nephrology Clinic at a tertiary Medical Centre.MethodsAll patients were categorized based on their estimated glomerular filtration rate (eGFR) as follows: normal —eGFR ≥ 60 ml/min, mild kidney impairment—30 ≤ eGFR 
Source: International Urology and Nephrology - March 8, 2021 Category: Urology & Nephrology Source Type: research

Chronic kidney disease progression in aged patients
In this study, we investigated the progression of CKD and related factors in aged patients.MethodsThis was a retrospective study including 334 patients over 80  years of age that were diagnosed with stage 3–4 CKD at our CKD clinic. CKD progression was assessed as an annual decline in the estimated glomerular filtration rate (eGFR). Comorbidities were globally categorized with the Charlson comorbidity index (CCI), but diabetes mellitus, hypertension, and cardiac morbidities were evaluated separately. Patients were grouped as either ‘progression to end-stage renal disease (ESRD)’ or ‘others&rsquo...
Source: International Urology and Nephrology - March 7, 2021 Category: Urology & Nephrology Source Type: research

COVID-19 in hemodialysis patients: a single-center experience in Istanbul
ConclusionMortality of COVID-19 in HD patients is high and follow up of certain laboratory parameters can help to predict the prognosis of the patients. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Iterative renal transplantation: our experience on third transplants
AbstractPurposeTo report our experience on third kidney transplantation, analyzing the complications and graft survival rates as compared to previous transplants.MethodsRetrospective study of third renal transplants performed at our center. Outcomes were compared with a cohort of first and second transplants.ResultsOf a total of 4143, we performed 72 third transplants in 46 men and 26 women with an average age of 46  years and mean time on dialysis of 70 months. Thirty-seven patients were hypersensitized [panel-reactive antibody (PRA) >  50%]. They were all from deceased donors, with a mean cold ...
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Pilot health technology assessment study: organizational and economic impact of remote monitoring system for home automated peritoneal dialysis
ConclusionIn our pilot report, the RPM system allowed the accurate assessment of daily APD sessions to suggest significative organizational and economic advantages, and both patients and healthcare providers reported good subjective experiences in terms of safety and quality of follow-up. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Using iron-based phosphate binders in phosphate reduction and anemia improvement in patients receiving dialysis: a meta-analysis of randomized controlled trials
ConclusionFC was associated with the control of hyperphosphatemia and the improvement of anemia. However, PA21 did not show superiority for alleviating anemia compared with the active treatment. Other IBPBs, such as fermagate and SBR759, remained poorly understood due to the limited number of studies. Further trials are required to assess the effect of IBPBs on the risk of cardiovascular events and all-cause mortality. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Study of early complications associated with peritoneal dialysis catheters: an analysis of the New Zealand Peritoneal Dialysis Registry data
ConclusionsImprovements in PDC insertion techniques and reduction in infection rates may result in improvements in long-term PD technique survival. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Predictive value of preprocedural albuminuria for contrast-induced nephropathy non-recovery in patients undergoing percutaneous coronary intervention
AbstractObjectiveThe present study investigated the predictive value of albuminuria for contrast-induced nephropathy (CIN) non-recovery in patients undergoing percutaneous coronary intervention (PCI).MethodsWe retrospectively enrolled 550 consecutive patients inflicted with CIN after PCI and reassessing kidney function among 1  week–12 months between January 2012 and December 2018. Patients were stratified into three groups according to urine albumin: negative group (urine dipstick negative), trace group (urine dipstick trace) and positive group (urine dipstick ≥ 1 +). The primary ou...
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Association of metabolic equivalent of task (MET) score in length of stay in hospital following radical cystectomy with urinary diversion: a multi-institutional study
AbstractPurposeThe Metabolic equivalent of task (MET) score is used in patients ’ preoperative functional capacity assessment. It is commonly thought that patients with a higher MET score will have better postoperative outcomes than patients with a lower MET score. However, such a link remains the subject of debate and is yet unvalidated in major urological surgery. This stu dy aimed to explore the association of patients’ MET score with their postoperative outcomes following radical cystectomy.MethodsWe used records-linkage methodology with unique identifiers (Community Health Index/hospital number) and e...
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Prevalence of non-alcoholic fatty liver disease among patients with non-diabetic chronic kidney disease detected by transient elastography
AbstractPurposeNon-alcoholic fatty liver disease (NAFLD) shares a close relationship with cardiovascular morbidity and mortality. The purpose of this study is to evaluate the frequency of NAFLD in the patients with non-diabetic chronic kidney disease (CKD).MethodsThis cross-sectional study included 80 patients with non-diabetic CKD, of which, 50 patients were on hemodialysis (HD) and 30 patients had CKD stage G3 –5 not on dialysis. These patients were randomly selected from Ain Shams University Hospitals, Cairo, Egypt. Patients with diabetes mellitus, obesity, alcohol intake, viral hepatitis, or drug-induced liver st...
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats
AbstractBackgroundAcute kidney injury (AKI), secondary to renal ischemia/reperfusion (I/R), is a serious problem associated with high mortality. The pathophysiology of AKI after renal I/R involves peroxynitrite production; hence, scavenging this metabolite may rescue AKI. Entacapone is a catechol-O-methyl transferase (COMT) inhibitor which elicits antioxidant activity by scavenging peroxynitrite. Therefore, we hypothesized that the peroxynitrite scavenging activity of entacopone protects against AKI after renal I/R injury in rats.MethodsMale Wistar rats were given either entacapone or a well-known peroxynitrite scavenger (...
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Outcomes of arteriovenous fistula in elderly patients on maintenance haemodialysis
AbstractBackgroundThe optimal vascular  access strategy in elderly patients receiving haemodialysis (HD) remains controversial. We aim to report the outcomes of arteriovenous fistula (AVF) in elderly patients initiated on maintenance HD in our centre.MethodsMedical records of 688 incident patients initiated on HD from 2010 to 2012 in a tertiary centre were retrospectively reviewed. Patients ’ characteristics and AVF outcomes were compared among those 
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research

Association of fetuin-A levels and left ventricular diastolic dysfunction in patients on haemodialysis
ConclusionA decrease in the serum fetuin-A level is associated with an increased risk of LVDD in patients on haemodialysis. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 6, 2021 Category: Urology & Nephrology Source Type: research