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Ethanol lock is effective on reducing the incidence of tunneled catheter-related bloodstream infections in hemodialysis patients: a systematic review and meta-analysis
ConclusionsOur meta-analysis suggests that ethanol lock is effective on reducing the incidence of CRBSI in hemodialysis patients with tunneled central venous catheters. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 17, 2018 Category: Urology & Nephrology Source Type: research

The association of serum angiogenic growth factors with renal structure and function in patients with adult autosomal dominant polycystic kidney disease
We report here the relationship of serum angiopoietin-1 (Ang-1), Ang-2, and vascular endothelial growth factor (VEGF) with total kidney volume (TKV), total cyst volume (TCV), and renal failure in adult ADPKD patients at various stages of CKD.MethodsThis cross-sectional study was conducted with 50 patients diagnosed with ADPKD and a control group of 45 age-matched healthy volunteers. In patient group, TKV and TCV were determined with upper abdominal magnetic resonance imaging, whereas in controls, TKV was determined with ultrasonography according to ellipsoid formula. Renal function was assessed with serum creatinine, estim...
Source: International Urology and Nephrology - April 13, 2018 Category: Urology & Nephrology Source Type: research

Factors influencing efficacy endpoints in clinical trials for new oral medicinal treatments for overactive bladder: a systematic literature review and meta-analysis
ConclusionsWe identified that change from baseline in the mean number of incontinence episodes in 24  h should serve as a relatively stable endpoint. In contrast, we identified factors influencing other endpoints, and the identified factors should be taken into account when planning and conducting future clinical trials. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 12, 2018 Category: Urology & Nephrology Source Type: research

Diversity of the midstream urine microbiome in adults with chronic kidney disease
AbstractPurposeTo examine the characteristics of the midstream urine microbiome in adults with stage 3 –5 non-dialysis-dependent chronic kidney disease (CKD).MethodsPatients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR]    50% reads) by the generaCorynebacterium (n = 11),Staphylococcus (n = 9),Streptococcus (n = 7),Lactobacillus (n = 7),Gardnerella (n = 7),Prevotella (n = 4),Escherichia_Shigella (n = 3), andEnterobacteriaceae (n = 2); the rest lacked a dominant g...
Source: International Urology and Nephrology - April 12, 2018 Category: Urology & Nephrology Source Type: research

Sagittal abdominal diameter and Framingham risk score in non-dialysis chronic kidney disease patients
AbstractBackgroundChronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that abdominal obesity is a risk factor for cardiovascular mortality. We investigated the link between sagittal abdominal diameter (SAD) and Framingham risk score in non-dialysis CKD patients.MethodsIn a cross-sectional study, we enrolled 307 prevalent non-dialysis CKD patients (175 males, aged 50.7  ± 17.04 years). SAD and Framingham risk score were measured.ResultsFramingham cardiovascular disease risk score was independently predicted by SAD (P 
Source: International Urology and Nephrology - April 12, 2018 Category: Urology & Nephrology Source Type: research

Discontinuation of antiviral prophylaxis increased the risk of hepatitis B virus reactivation in glomerulonephritis patients under immunotherapy: a real-life observation
ConclusionsDiscontinuation of antiviral prophylaxis increased the risk of HBV reactivation in HBsAg-positive patients under immunotherapy for glomerulonephritis. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 11, 2018 Category: Urology & Nephrology Source Type: research

Determination of NF- κB and RANKL levels in peripheral blood osteoclast precursor cells in chronic kidney disease patients
ConclusionIn conclusion, vitamin D3 and iPTH levels seem to be important parameters for evaluating the early stages of ROD. The lack of statistically significant differences in the levels of sRANKL and NF- κB suggests that these parameters are not sufficient in the evaluation of bone metabolism in the early stages of renal failure. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 11, 2018 Category: Urology & Nephrology Source Type: research

Psoriasis and risk of incident chronic kidney disease and end-stage renal disease: a systematic review and meta-analysis
ConclusionA significantly increased risk of incident CKD and ESRD among patients with psoriasis compared with individuals without psoriasis was demonstrated in this study. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 11, 2018 Category: Urology & Nephrology Source Type: research

Silymarin and celecoxib ameliorate experimental varicocele-induced pathogenesis: evidences for oxidative stress and inflammation inhibition
AbstractBackgroundThe present study was done to investigate the ameliorative effect of silymarin (SMN) and celecoxib (CEL) on varicocele (VCL)-induced detrimental impact in testicular tissue.MethodsMatureWistar rats were divided into control and test groups. Following VCL induction, the animals in test group were subdivided into non-treated VCL-induced, SMN-treated (50  mg/kg, orally), CEL-treated (10 mg/kg) and SMN + CEL-treated groups. Following 60 days, testicular total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (G...
Source: International Urology and Nephrology - April 5, 2018 Category: Urology & Nephrology Source Type: research

Treatment dose and the elimination rates of electrolytes, vitamins, and trace elements during continuous veno-venous hemodialysis (CVVHD)
ConclusionClinically relevant loss of folic acid, vitamin B12, zinc, inorganic phosphate, and magnesium was not observed for differently used dialysis doses of CVVHD, and the loss was covered sufficiently by daily recommended nutritional supplementation. Increased loss of ionized calcium for higher dialysis doses occurred during citrate CVVHD. Therefore, a strict protocol must maintain calcium homeostasis to avoid calcium depletion. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 2, 2018 Category: Urology & Nephrology Source Type: research

Elevated visceral obesity quantified by CT is associated with adverse postoperative outcome of laparoscopic radical nephrectomy for renal clear cell carcinoma patients
ConclusionsElevated visceral obesity by VFA is associated with increased surgical complexity, postoperative morbidity, postoperative stay and hospitalization expenses for RCCC patients and may be superior to BMI for renal cancer outcome assessment. VFA may be a useful index for the evaluation and calculation of RCCC aggressiveness. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 2, 2018 Category: Urology & Nephrology Source Type: research

A care bundle to improve perioperative mitomycin use in non-muscle-invasive bladder cancer
ConclusionCompliance rates of intravesical chemotherapy in NMIBC can improve by devising care bundles to modify team behaviour. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 2, 2018 Category: Urology & Nephrology Source Type: research

Collectins in urinary tract and kidney diseases
AbstractThe innate immune system serves as the frontline defense against invading pathogens and initiates an inflammatory response to microorganisms. Collectins are C-type lectins that are structurally characterized by a collagen-like sequence and a carbohydrate recognition domain. Moreover, they are widely expressed throughout the body and are involved in the innate immunity against a variety of pathogens, regulating inflammation, and protecting the lungs from pathogens. Recently, two classical collectins, surfactant protein A (SP-A) and surfactant protein D (SP-D), as well as novel collectin 11, were found present in uri...
Source: International Urology and Nephrology - March 30, 2018 Category: Urology & Nephrology Source Type: research

Estrogen therapy in patients with prostate cancer: a contemporary systematic review
ConclusionsDES might be similarly effective to other forms of ADT on advanced PCa patients, with potential important roles. Intriguingly, the burden of severe cardiovascular toxicity is mainly related to old-fashioned doses of 5.0 and 3.0  mg. Modern PCa hormonal knowledge warrants stout high-quality prospective randomized trials in the low-dose 1 mg DES scenario. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 29, 2018 Category: Urology & Nephrology Source Type: research

The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease
AbstractPurposeSeveral studies investigated the association between the estimated glomerular filtration rate (eGFR) and the concentration of high-density lipoproteins (HDL) in patients without severely damaged kidney function. As results of those studies were inconclusive and contradictory, we wanted to investigate this association in multiple cardiovascular disease (CVD) risk patients without severe kidney disease or renal failure.MethodsWe enrolled a cohort of 187 patients with intermediate and high CVD risk without severe renal disease. We grouped them based on their eGFR into: group 1 ( ≥ 30 
Source: International Urology and Nephrology - March 28, 2018 Category: Urology & Nephrology Source Type: research

Mesenchymal stem cells alleviate acute kidney injury by down-regulating C5a/C5aR pathway activation
ConclusionsThe present study indicates that hBM-MSCs alleviate AKI via suppressing C5a/C5aR-NF- κB pathway activation. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 28, 2018 Category: Urology & Nephrology Source Type: research

Health-related quality of life in end-stage renal disease patients: the effects of starting dialysis in the first year after the transition period
This study firstly aimed to compare HRQOL between CKD-5 non-dialysis and prevalent dialysis patients in a cross-sectional analysis and to assess longitudinal changes over 1  year after the dialysis initiation. Secondly, the correlation between HRQOL and physical activity (PA) was explored.MethodsCross-sectional 44 CKD-5 non-dialysis, 29 prevalent dialysis, and 20 healthy controls were included. HRQOL was measured by Short Form-36 questionnaires to measure physical and mental domains of health expressed by the physical component summary (PCS) and mental component summary (MCS) scores. PA was measured by a SenseWear &tr...
Source: International Urology and Nephrology - March 26, 2018 Category: Urology & Nephrology Source Type: research

Prevalence of pulmonary hypertension in patients with chronic kidney disease without dialysis: a meta-analysis
AbstractPurposeRecent epidemiological evidence attempts to demonstrate the risk of pulmonary hypertension (PH) among patients with chronic kidney disease (CKD) without dialysis, but prevalence estimates of PH in CKD without dialysis vary widely in the existing studies. This meta-analysis was to summarize the point prevalence of PH in adults with CKD without dialysis.MethodsPubMed, EMBASE, the Cochrane Collaboration, and the reference lists of relevant articles were searched to identify eligible studies. We used a random-effect meta-analysis model to estimate the prevalence of PH. Associations were tested in subgroups and m...
Source: International Urology and Nephrology - March 26, 2018 Category: Urology & Nephrology Source Type: research

Comparison of Vela and holmium laser enucleation of the prostate: a retrospective clinical trial with a 12-month follow-up
ConclusionSimilarly as the holmium laser, the Vela laser is a potent, safe, efficient durable and surgical treatment option for minimally invasive surgery in patients with BPH-induced LUTS. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 24, 2018 Category: Urology & Nephrology Source Type: research

Prevalence, pathophysiological mechanisms and factors affecting urolithiasis
AbstractThe formation of urinary stone, urolithiasis, is one the oldest known disease affecting human throughout different civilizations and times. The exact pathophysiological mechanism of urolithiasis is not yet clear, as these calculi are of various types and too complex for simple understanding. A single theory cannot explain its formation; therefore, different theories are presented in various times for its explanation like free particle, fixed particle, Randall ’s plaque theory. In addition, various factors and components are identified that play an important role in the formation of these urinary calculi. In t...
Source: International Urology and Nephrology - March 22, 2018 Category: Urology & Nephrology Source Type: research

Recommendations for urological follow-up of patients with neurogenic bladder secondary to spinal cord injury
ConclusionIndividuals with neurogenic lower urinary tract dysfunction are at increased risk of multiple complications. Nevertheless, proper follow-up after SCI improves the prognosis for these patients and their quality of life. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 22, 2018 Category: Urology & Nephrology Source Type: research

Effect of pregnancy on cooling tone and rhythmic contractions of the rat urinary bladder
ConclusionsPregnancy increases cooling-induced contraction in pregnant rat urinary preparations and its rhythmic contractions including amplitude and frequency than non-pregnant rat. Rhythmic contractions are myogenic in nature and highly extracellular calcium dependent. They may play a crucial role in urinary bladder overactivity and incontinence during pregnancy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 22, 2018 Category: Urology & Nephrology Source Type: research

Research progress of percutaneous nephrolithotomy
AbstractPercutaneous nephrolithotomy (PCNL) is generally accepted as the gold standard treatment for the treatment of large kidney stones (>  2 cm). For nearly 40 years, with the continuous progress of technology and the constant updating of ideas, PCNL has made great progress. In this review, we discuss the current research progress, recent advancement and hot spot of the whole process of PCNL including anesthesia, position, punctur e, dilation, lithotripsy approaches, perfusate, tube placement, hospitalization time, drug, treatment of residual stones, prognosis judgment and operation evaluation by sum...
Source: International Urology and Nephrology - March 19, 2018 Category: Urology & Nephrology Source Type: research

Value of electronic alerts for acute kidney injury in high-risk wards: a pilot randomized controlled trial
AbstractPurposeTo investigate the application value of “electronic alerts” (“e-alerts”) for acute kidney injury (AKI) among high-risk wards of hospitals.MethodsA prospective, randomized, controlled study was conducted. We developed an e-alert system for AKI and ran the system in intensive care units and divisions focusing on cardiovascular disease. The e-alert system diagnosed AKI automatically based on serum creatinine levels. Patients were assigned randomly to an e-alert group (467 patients) or non-e-alert group (408 patients). Only the e-alert group could receive pop-up messages.ResultsThe sensit...
Source: International Urology and Nephrology - March 19, 2018 Category: Urology & Nephrology Source Type: research

The importance of Oxalobacter formigenes and oxalic acid in the pathogenesis of chronic kidney disease
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 19, 2018 Category: Urology & Nephrology Source Type: research

Tonsillitis exacerbates renal injury in IgA nephropathy through promoting Th22 cells chemotaxis
ConclusionsTonsil infection may aggravate the renal pathological lesions of IgAN by exacerbating Th22 cell accumulation. Our data suggested a collaboration between HMC and Th22 cells in IgAN with tonsillitis underlying the effects of CCL20, CCL22, and CCL27. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 16, 2018 Category: Urology & Nephrology Source Type: research

Additional treatments, satisfaction, symptoms and quality of life in women 1  year after vaginal and abdominal pelvic organ prolapse repair
AbstractObjectivesTo evaluate additional treatments, symptoms, satisfaction and quality of life 1  year after vaginal and abdominal pelvic organ prolapse (POP) repair.MethodsAdult women enrolled in a prospective POP database were reviewed. Baseline and outcomes data 1  year after surgery were collected including the Pelvic Floor Distress Inventory (PFDI) and mailed surveys. Data were analyzed with descriptive statistics, Fisher’s exact tests andt tests.ResultsOf 222 women, 147 (66%) had vaginal and 75 (34%) had abdominal repair. Vaginal group patients were older (64.1 vs. 59.7  years;p = ...
Source: International Urology and Nephrology - March 16, 2018 Category: Urology & Nephrology Source Type: research

MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma
AbstractIntroductionCurrently, there is no accurate diagnostic molecular biomarker for renal cell carcinoma (RCC). The aim of this study was to assess the expression of microRNA-15a (miR-15a) in urine of patients with RCC and to evaluate its potential as a diagnostic molecular biomarker.Materials and methodsIn total, 67 patients with solid renal tumors were enrolled: clear-cell RCC (ccRCC,n  =  22), papillary RCC (pRCC,n  =  16), chromophobe RCC (chRCC,n  =  14), oncocytoma (n  =  8), papillary adenoma (n  =  2) and angiomyolipoma (n  =  5)...
Source: International Urology and Nephrology - March 16, 2018 Category: Urology & Nephrology Source Type: research

Effect of varicocele repair on sperm DNA fragmentation: a review
AbstractVaricocele, the leading cause of male infertility, can impair sperm quality and fertility via various oxidative stress mechanisms. An imbalance between excessive reactive oxygen species production and antioxidant protection causes alterations in nuclear and mitochondrial sperm DNA, thus rendering a subset of varicocele men less fertile. In particular, sperm DNA fragmentation is usually elevated in men with clinical varicocele in both abnormal and normal semen parameters by the current World Health Organization criteria. In this review, we discuss the evidence concerning the association between varicocele, oxidative...
Source: International Urology and Nephrology - March 14, 2018 Category: Urology & Nephrology Source Type: research

Effect of socio-demographic factors on endogenous biomarkers (cystatin C and creatinine) among elderly chronic kidney disease patients: a cross-sectional study
AbstractPurposeCreatinine is normally used to evaluate kidney function among elderly patients in clinical practice, which has been reported to be affected by socio-demographic factors like BMI and age. Cystatin C a newly introduced biomarker may be more efficient in identifying kidney function in obese and aged CKD patients. The aim of the current study was to assess the effect of BMI on endogenous biomarkers (cystatin C and creatinine) among elderly CKD patients in Malaysia, a first such study in the country.MethodsThe current study was conducted at the Hospital University Sains Malaysia, Kelantan. A total of 300 elderly ...
Source: International Urology and Nephrology - March 13, 2018 Category: Urology & Nephrology Source Type: research

Does sex matter? A matched pairs analysis of neuromodulation outcomes in women and men
AbstractAimsTo evaluate whether baseline symptoms and outcomes are influenced by gender in a matched cohort undergoing neuromodulation.MethodsPatients in our prospective neuromodulation database that had a tined lead placed were reviewed. Those that had implantable pulse generator (IPG) placed were matched on age and urologic diagnosis. History, voiding diaries, satisfaction, Interstitial Cystitis Symptom/Problem Index (ICSIPI), and overactive bladder symptom severity (OABq ss)/health-related quality of life (HRQOL) preimplant and over 3  years were evaluated using descriptive statistics, repeated measures, and matche...
Source: International Urology and Nephrology - March 13, 2018 Category: Urology & Nephrology Source Type: research

Implementation and evaluation of structured nephrology morbidity and mortality conferences: a quality education report
ConclusionsThe implementation of regularly scheduled M&MCs at an academic nephrology program, using a structured model, identified preventable health-systems issues and cognitive errors. Approximately one-half of the cases reviewed generated actions for health care delivery improvement. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 12, 2018 Category: Urology & Nephrology Source Type: research

Disparities in early mortality among chronic kidney disease patients who transition to peritoneal dialysis and hemodialysis with and without catheters
ConclusionAmong a diverse CKD population who transitioned to ESRD, we observed considerable differences in early mortality risk among PD, HD with fistula/graft, and HD with catheter patients. The identification of patient-specific and clinical environmental factors related to high early mortality may provide insights for managing advanced stages of CKD and shared decision making. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 12, 2018 Category: Urology & Nephrology Source Type: research

Calcimimetics versus parathyroidectomy: What is preferable?
Abstract Secondary hyperparathyroidism (SHPT) is common among patients with end-stage renal disease (ESRD). SHPT is associated with high-turnover bone disease, interstitial and vascular calcifications, cardiovascular morbidity and mortality. The pharmacological management of SHPT has progressed in recent years. The introduction of targeted therapies, such as selective vitamin D receptors activators and calcium-sensing receptor modulators, offers an increased opportunity to adequately control elevated parathyroid hormone (PTH), especially in patients with chronic kidney disease under dialysis treatment. Calcimimetic medic...
Source: International Urology and Nephrology - March 12, 2018 Category: Urology & Nephrology Source Type: research

Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion
ConclusionsThese findings suggest that CXCL3 autocrine/paracrine pathways are involved in the development of prostate cancer by regulating the expression of the target genes that are related to the progression of malignancies. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 9, 2018 Category: Urology & Nephrology Source Type: research

Effects of combined treatment of tadalafil and tamsulosin on bladder dysfunction via the inhibition of afferent nerve activities in a rat model of bladder outlet obstruction
ConclusionsThese results suggest that the combination therapy of tadalafil and tamsulosin can induce the additive inhibitory effects on urinary frequency compared with monotherapy, more likely via inhibition of the afferent limb of micturition reflex rather than the efferent function as evidenced by the increases in threshold pressures and intercontraction intervals without affecting bladder contractile function. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 8, 2018 Category: Urology & Nephrology Source Type: research

Principles of quantitative water and electrolyte replacement of losses from osmotic diuresis
AbstractOsmotic diuresis results from urine loss of large amounts of solutes distributed either in total body water or in the extracellular compartment. Replacement solutions should reflect the volume and monovalent cation (sodium and potassium) content of the fluid lost. Whereas the volume of the solutions used to replace losses that occurred prior to the diagnosis of osmotic diuresis is guided by the clinical picture, the composition of these solutions is predicated on serum sodium concentration and urinary sodium and potassium concentrations at presentation. Water loss is relatively greater than the loss of sodium plus ...
Source: International Urology and Nephrology - March 6, 2018 Category: Urology & Nephrology Source Type: research

Benefit of an operating vehicle preventing peritonitis in peritoneal dialysis patients: a retrospective, case –controlled study
ConclusionOperating vehicle might help to reduce PD-related peritonitis by preventing contamination during bag exchange. Further studies are still needed to demonstrate the protective role of the operating vehicle in preventing peritonitis. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Silencing of CXCL12 performs a protective effect on C5b-9-induced injury in podocytes
ConclusionsAll data suggested that silencing of CXCL12 had a protective effect on podocyte injury, which may be through inhibiting CXCL12/STAT3 signaling pathway. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

Epidermal growth factor receptor function in the human urothelium
ConclusionsEGFr modulates urothelial proliferation and the formation of the three-dimensional structure of the urothelium possibly by interfering with occludin. The present data also show a cell culture technique enabling phenotypically normal urothelial cells to form epithelial structures in contrast to malignant urothelial cells. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 5, 2018 Category: Urology & Nephrology Source Type: research

The impact of donor and recipient weight incompatibility on renal transplant outcomes
This study assessed the impact of donor body weight (DBW) to recipient body weight (RBW) ratio on allograft function and survival.MethodsA total of 898 deceased donor renal transplant recipients were included in the study. Patients were divided into quartiles depending on the ratio of DBW/RBW: Q1 ( ≤ 0.88), Q2 (0.89–1.00), Q3 (1.01–1.22) and Q4 (>  1.22). Donor and recipient characteristics were obtained from the national kidney transplant service database. Serum creatinine and estimated glomerular filtration rate (eGFR) at 1 and 5 years after transplant were compared.ResultsQ4 patients had a hi...
Source: International Urology and Nephrology - March 1, 2018 Category: Urology & Nephrology Source Type: research

LPS ameliorates renal ischemia/reperfusion injury via Hsp27 up-regulation
ConclusionAdministration of LPS produces protective effects against renal IRI via Hsp27 up-regulation. Preconditional Hsp27 up-regulation might have a great potential for the treatment of renal IRI via ameliorating apoptosis. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 1, 2018 Category: Urology & Nephrology Source Type: research

The relationship between female sexual function index domains and premature ejaculation
AbstractPurposeThe aim of this prospective, observational study was to investigate the relationship between premature ejaculation (PE) and female sexual response cycle, using the female sexual function index (FSFI). The FSFI evaluates female sexual function in six domains: desire, arousal, lubrication, orgasm, satisfaction, and pain.MethodsAll men were considered to have PE if they fulfilled the criteria of the second Ad Hoc International Society for Sexual Medicine (ISSM) Committee. All men were also assessed by the Premature Ejaculation Diagnostic Tool (PEDT) and intravaginal ejaculatory latency time (IELT) using stopwat...
Source: International Urology and Nephrology - March 1, 2018 Category: Urology & Nephrology Source Type: research

TURP in the era of UroLift
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 1, 2018 Category: Urology & Nephrology Source Type: research

Primary androgen deprivation therapy as monotherapy in unfavourable intermediate- and high-risk localised prostate cancer: a Singaporean single-centre perspective
ConclusionFor clinically localised unfavourable intermediate-risk and high-risk PCa, starting pADT within 12  months of diagnosis is not associated with improved 5-year all-cause mortality or PCSM compared to patients treated conservatively with no therapy and should be discouraged due to lack of mortality benefit. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - February 28, 2018 Category: Urology & Nephrology Source Type: research

Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease
This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients.Materials and methodsSeventy-one non-dialysis CKD patients with low vitamin D (serum 25(OH)D  
Source: International Urology and Nephrology - February 26, 2018 Category: Urology & Nephrology Source Type: research

Epidemiological characteristics of and risk factors for patients with postoperative acute kidney injury: a multicenter prospective study in 30 Chinese intensive care units
ConclusionRisk factors for AKI in ICU patients after different types of surgery were identified. This might be the first step to reduce the high incidence of AKI after surgery. The presence of AKI in ICU patients was associated with higher mortality after most types of surgery, but not after neurosurgery.Trial registrationChiCTR-ONC-11001875. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - February 26, 2018 Category: Urology & Nephrology Source Type: research

Coercion, dissatisfaction, and social stigma: an ethnographic study of compensated living kidney donation in Iran
This article updates the qualitative research on Iran reported in the 2012 article by Tong et al. “The experiences of commercial kidney donors: thematic synthesis of qualitative research” (Tong et al. in Transpl Int 25:1138–1149,2012). The basic approach used in the Tong et al. article is applied to a more recent and more comprehensive study of Iranian  living organ donors, providing a clearer picture of what compensated organ donation is like in Iran since the national government began regulating compensated donation. Iran is the only country in the world where kidney selling is legal, regulated, an...
Source: International Urology and Nephrology - February 26, 2018 Category: Urology & Nephrology Source Type: research

A1AR-mediated renal protection against ischemia/reperfusion injury is dependent on HSP27 induction
ConclusionsActivation of A1AR produces renoprotective effects via HSP27 induction. It suggests that preconditional HSP27 activation might have a great potential for the treatment of renal IRI. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - February 26, 2018 Category: Urology & Nephrology Source Type: research

Transurethral en bloc resection with bipolar button electrode for non-muscle invasive bladder cancer
ConclusionsThe current results demonstrated that transurethral en bloc resection with bipolar button electrode is an effective, feasible, and safe treatment for NMIBC. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - February 24, 2018 Category: Urology & Nephrology Source Type: research