Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case –control study
AbstractPurposeThe purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED.MethodsOur prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie ’s disease, or decompensated systemic illnesses. ED was evaluated by the validated Arabic version of the abbreviated five-item form of the International Index Of Erectile Function and confirmed by penile duplex. Serum FA level was assayed u...
Source: International Urology and Nephrology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Vaginoplasty and creating labia minora in children with disorders of sex development
ConclusionsIn infant and young child, when it is difficult to make use of complete urogenital mobilization, the mucosa of the prepuce can be an alternative to create a neovagina, its histological constitution is identical to a vaginal wall, and it does not prevent to have a good labia minora. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 13, 2018 Category: Urology & Nephrology Source Type: research

Mini-percutaneous nephrolithotomy for pediatric complex renal calculus disease: one-stage or two-stage?
AbstractObjectivesTo compare two different treatment strategies, one-stage and two-stage multi-tract mini-percutaneous nephrolithotomy (mt-mPCNL), for pediatric complex renal calculus disease.MethodsBetween the period of July 2016 and July 2018, a total of 36 children aged 15  years and younger, with complex renal calculi disease, who underwent total ultrasound-guided mt-mPCNL by a single experienced urologist were enrolled in our study. All patients were assigned either to Group 1 (n = 18) who received one-stage mt-mPCNL or Group 2 (n = 18) who received planned two-stage mt-mPCNL.ResultsTh...
Source: International Urology and Nephrology - December 12, 2018 Category: Urology & Nephrology Source Type: research

The miRNA-184 drives renal fibrosis by targeting HIF1AN in vitro and in vivo
AbstractProgressive renal fibrosis is the last phase of chronic kidney disease and results in renal failure. Micro-RNA has been demonstrated as important agent to drive organ fibrosis. However, the precise mechanisms are not fully understood. Here, we found miRNA-184 as a critical mediator to promote the renal fibrosis by targeting HIF1AN. In Vivo, miRNA-184 expression levels remarkably increased both in patients ’ serum and in unilateral ureteral obstruction kidneys, as well as induced the expression of COL1A1 and COL3A1. Furthermore, transfection of NRK49F cells with miRNA-184 mimics down-regulated HIF1AN, transfec...
Source: International Urology and Nephrology - December 10, 2018 Category: Urology & Nephrology Source Type: research

Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement
ConclusionsElevated serum PEDF aggravates the development of proteinuria and renal dysfunction by inducing F-actin arrangement, foot process fusion, and apoptosis of podocytes in both normal and diabetic mice, and this effect may be mediated by activation of the RhoA/ROCK1 pathway. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 7, 2018 Category: Urology & Nephrology Source Type: research

A study on the clinical application of a patented perfusion and suctioning platform and ureteral access sheath in the treatment of large ureteral stones below L4 level
AbstractPurposeThe purpose of the study was to evaluate the efficacy and safety of a patented perfusion and suctioning platform and ureteral access sheath in the treatment of large ureteral stones ( ≥ 1.5 cm) below L4 level.MethodsWe recruited 122 patients with large ureteral stones below L4 level at our hospital from December 2014 to June 2017. The patients were randomly divided into the study and control groups. Multiple operative and perioperative parameters were compared between the two groups.ResultsThe study group had shorter operation time, less cases of postoperative fever, lower serum levels of PCT,...
Source: International Urology and Nephrology - December 7, 2018 Category: Urology & Nephrology Source Type: research

Urine proteomic profiling in patients with nephrolithiasis and cystinuria
ConclusionWe provide proteomic evidence of impaired endocytosis, dysregulation of actin and myosin cytoskeleton, and inflammation in CYS. Endosomal transport proteins were down-regulated mainly through defective CHMP. These findings may contribute to further understanding of the pathogenesis of CYS, potentially affecting its management. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 5, 2018 Category: Urology & Nephrology Source Type: research

The effect of chronic kidney disease on lipid metabolism
AbstractThe major cause of death among chronic kidney disease patients is cardiovascular diseases. Cardiovascular and kidney disease are interrelated and increase the severity of each other. Dyslipidemia is one the major causes of cardiovascular disease among chronic kidney disease patients along with diabetes and hypertension. The relationship between dyslipidemia and chronic kidney disease is reciprocal. Dyslipidemia is known to be a risk factor for chronic kidney disease and chronic kidney disease causes major alterations on lipoprotein profile, defined as the “dyslipidemic profile” of chronic kidney disease...
Source: International Urology and Nephrology - December 5, 2018 Category: Urology & Nephrology Source Type: research

A modification with threading cannula needle-assisted 4-point suspension fixation for retroperitoneal laparoscopic pyeloplasty in children with ureteropelvic junction obstruction: a cohort study in single center
AbstractPurposeTo evaluate the effect and safety of modifying a threading cannula needle-assisted suspension fixation in retroperitoneal laparoscopic dismembered pyeloplasty (LDP) for children with congenital ureteropelvic junction obstruction (UPJO).MethodsBetween December 2012 and December 2017, 45 children (
Source: International Urology and Nephrology - December 5, 2018 Category: Urology & Nephrology Source Type: research

The effects of oxytocin on penile tissues in experimental priapism model in rats
This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia –reperfusion injury developed after priapism.MethodsForty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. In Group 2, a rat model of priapism was constructed and maintained for 1 h. In Group 3, reperfusion was ensured for 30 min following priapism. Rats in Group 4 rats were given oxytocin 30 min before the induction of reperfusion following priapism. All rats were penect omized, and adequate amounts of blood sample were drawn. Inflammation, vasocong...
Source: International Urology and Nephrology - December 4, 2018 Category: Urology & Nephrology Source Type: research

Relationship between serum sclerostin, vascular sclerostin expression and vascular calcification assessed by different methods in ESRD patients eligible for renal transplantation: a cross-sectional study
ConclusionsThe two methods, namely CT and pathology, to evaluate VC were highly consistent. Serum sclerostin was an independent determinant of positive expression of vessel sclerostin and VC in ESRD patients eligible for RT. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 4, 2018 Category: Urology & Nephrology Source Type: research

The other side of the coin in renal replacement therapies: the burden on caregivers
ConclusionCaregiver burden was found highest in HD group. Educational, social, and psychological support interventions may be considered for caregivers. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 4, 2018 Category: Urology & Nephrology Source Type: research

How do lupus glomerulonephritis and its treatment affect the renal reserve?
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 4, 2018 Category: Urology & Nephrology Source Type: research

The predictive value of malnutrition for functional and cognitive status in elderly hemodialysis patients
ConclusionThe study confirms the important correlation between malnutrition and cognitive/functional impairment and confirms that malnutrition scores could be useful in predicting depression and physical dependance in elderly dialysis patients. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 4, 2018 Category: Urology & Nephrology Source Type: research

Patterns and predictors of depression treatment among adults with chronic kidney disease and depression in ambulatory care settings in the United States
ConclusionsDepression treatment was recorded in approximately half of US ambulatory care visits involving adults with CKD and depression from 2014 to 2015. Further research is warranted to determine how to appropriately manage treatment of depression in adults with CKD. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 4, 2018 Category: Urology & Nephrology Source Type: research

Evaluating the associations between urinary excretion of magnesium and that of other components in calcium stone-forming patients
ConclusionsIn a routine dietary habit, since rich sources of magnesium contain a high amount of oxalate at the same time, it is not surprising that magnesium level in 24-h urinalysis showed a direct association with 24-h urine oxalate. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 4, 2018 Category: Urology & Nephrology Source Type: research

Case report of inguinal metastasis of epididymal malignant mesothelioma
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 3, 2018 Category: Urology & Nephrology Source Type: research

Foreskin reconstruction at the time of single-stage hypospadias repair: is it a safe procedure?
AbstractIntroductionForeskin reconstruction (FR) is a recognised, yet debated, option for patients undergoing single-stage hypospadias repair (HR).MethodsWe evaluated the incidence of complications after single-stage HR in our institution. This is a retrospective review of all single-stage HR. Patients were classified into group 1 (circumcision) and group 2 foreskin reconstruction (FR). Urethroplasty and foreskin complications were recorded. Statistics used are as follows: Mann –Whitney test to compare age at operation and length of follow-up (FU); Chi-Square test to analyse the incidence of urethral complications an...
Source: International Urology and Nephrology - December 1, 2018 Category: Urology & Nephrology Source Type: research

Penile lymphedeme: a very rare complication due to bilateral subinguinal varicocelectomy
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 1, 2018 Category: Urology & Nephrology Source Type: research

Kidney fibrosis induced by various irrigation pressures in mouse models of mild and severe hydronephrosis
ConclusionCompared with mild hydronephrosis, renal fibrosis in severe hydronephrosis is more severe and its tolerance to perfusion pressure is lower. These changes may be related to the TGF- β signalling pathway. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 27, 2018 Category: Urology & Nephrology Source Type: research

Effect of pregnancy on the cholinergic responses of the bladder: role of acetylcholinesterase
ConclusionsUrinary bladder dysfunction during pregnancy might be due to augmentation of acetylcholinesterase effect. This will lead to the decrease in response to cholinergic stimuli. New pharmaceutical drugs specifically affecting the enzyme in the bladder can help in avoiding the unpleasant urinary symptoms during pregnancy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 26, 2018 Category: Urology & Nephrology Source Type: research

Transvesical laparoendosopic single-site surgery as a valuable option to remove eroded materials from the bladder: single-center experience and a review of the literature
ConclusionsThe T-LESS technique for removal of eroded meshes is a safe and effective method. The precise access to the bladder minimizes morbidity, and suturing the bladder wall defects may reduce the risk of recurrence. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 26, 2018 Category: Urology & Nephrology Source Type: research

Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions
ConclusionThe results showed profound therapeutic effect of PnO-DBS on voiding functions and bladder control on TBI rats. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 24, 2018 Category: Urology & Nephrology Source Type: research

The phosphodiesterase type 4 inhibitor roflumilast suppresses inflammation to improve diabetic bladder dysfunction in rats
ConclusionsOral treatment with roflumilast in diabetic rats improves bladder function and inhibits the expression of inflammatory factors in DSM tissue, indicating that PDE4 is a potential therapeutic target for DBD. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 24, 2018 Category: Urology & Nephrology Source Type: research

Feasibility of a novel technique using 3-dimensional modeling and augmented reality for access during percutaneous nephrolithotomy in two different ex-vivo models
ConclusionsThis novel device, which uses software-based mathematical calculation, 3D modeling and AR, seems to ensure a correct access point and angle for PCNL. Further research is required to test its accuracy and safety in humans. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 24, 2018 Category: Urology & Nephrology Source Type: research

Effects of sleep disorders and sedative –hypnotic medications on health-related quality of life in dialysis patients
AbstractPurposeSleep disorders are very common among dialysis patients, leading patients to frequently take sedative –hypnotic medications; however, the effects of sleep disorders and the use of such drugs on health-related quality of life (HRQOL) have rarely been investigated.MethodsThe Pittsburgh Sleep Quality Index and Short Form-12 were used to assess sleep quality and patient health situations, respectively. Logistic regression was employed to identify factors associated with deterioration of the mental component summary (MCS) score and the physical component summary (PCS) score.ResultsA total of 461 patients un...
Source: International Urology and Nephrology - November 22, 2018 Category: Urology & Nephrology Source Type: research

Total parenteral nutrition versus early enteral nutrition after cystectomy: a meta-analysis of postoperative outcomes
This study aimed to systematically summarize and analyze the current evidence regarding the effect of total parenteral nutrition (TPN) versus early enteral nutrition (EEN) on postoperative outcomes of cystectomy.MethodsA comprehensive search of online databases was conducted to identify comparative studies on the postoperative outcomes of patients receiving TPN and EEN after cystectomy. Our subsequent meta-analysis followed the PRISMA Protocol and the Cochrane Handbook.ResultsFive studies with 556 participants were included for meta-analysis. EEN was shown to have a significant effect on reducing the overall complications ...
Source: International Urology and Nephrology - November 21, 2018 Category: Urology & Nephrology Source Type: research

Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India
AbstractPurposeCKD patients after kidney transplantation continue to suffer from elevated CV events which may be related to low vitamin D and its adverse impact on vascular function. The prevalence of vitamin D deficiency in North Indian kidney transplantation patients and its impact on vascular and bone biomarkers is unknown which this study investigated.MethodsNon-diabetic, stable,>  6 months post-kidney transplantation patients, not on vitamin D supplementation, were recruited after informed consent. Data on demographics, anthropometrics and treatment were collected. Blood samples were stored at −&t...
Source: International Urology and Nephrology - November 19, 2018 Category: Urology & Nephrology Source Type: research

Management of anxiety and depression in haemodialysis patients: the role of non-pharmacological methods
AbstractAnxiety and depression in patients undergoing haemodialysis can be reduced by a variety of treatment methods, including pharmacological therapy, cognitive-behavioural therapy, regular exercise and relaxation techniques, such as Benson ’s relaxation method and acupressure treatment. Additionally, intradialytic exercise training programmes have a positive effect on patients’ physical and psychological functioning. Moreover, social support from family and social environment, spirituality and religiosity, tele- nursing programmes and participation in network support groups frequently lead to a reduction of ...
Source: International Urology and Nephrology - November 19, 2018 Category: Urology & Nephrology Source Type: research

Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats
AbstractPurposeThe present study was designed to further investigate the protective effect of astaxanthin (AST) on contrast-induced acute kidney injury (CI-AKI) in rats and the relationship between SIRT1-p53 pathway and astaxanthin.Methods40 adult male Sprague Dawley (SD) rats were randomly divided into five groups (n = 8/group): control (CON), normal rats treated with AST (AST), CM-treated (CM), CM rats treated with isoform of nitric oxide synthase (iNOS) inhibitor (iNOS + CM), and CM rats treated with AST (AST + CM). Serum creatinine (Scr) and blood urea nitrogen (BUN) values wer...
Source: International Urology and Nephrology - November 19, 2018 Category: Urology & Nephrology Source Type: research

Prevalence of pulmonary hypertension in peritoneal dialysis patients: a meta-analysis
AbstractPurposeRecent epidemiological evidence indicates an association between peritoneal dialysis (PD) patients and pulmonary hypertension (PH). However, the true prevalence of PH associated with PD has not been well described. So we conducted a meta-analysis to summarize the point prevalence of PH in adults with PD.MethodsPubMed, EMBASE, the Cochrane Collaboration, and the reference lists of relevant articles were searched to identify eligible studies. We used a random-effect meta-analysis model to estimate the prevalence of PH. We also performed sensitivity analyses and assessments of publishing bias.ResultsFourteen ob...
Source: International Urology and Nephrology - November 19, 2018 Category: Urology & Nephrology Source Type: research

The effect of overactive bladder treatment with anticholinergics on female sexual function in women: a prospective observational study
AbstractPurposeThe aim of the study was to determine the effect of anticholinergics used for overactive bladder treatment on the sexual function of women.MethodsBetween January 2016 and August 2018, over 18  years old, 216 sexual active women with OAB and 165 healthy women as control group were prospectively enrolled in the study. Five different anticholinergics were used for the treatment. Female Sexual Function Index (FSFI), eight-item overactive bladder awareness tool (OAB-V8), and Beck Depression Inventory form were completed before and after 3 months. Baseline and post-treatment scores were compared with a c...
Source: International Urology and Nephrology - November 17, 2018 Category: Urology & Nephrology Source Type: research

Influence of symptomatic pseudoaneurysms on postoperative renal function after partial nephrectomy: results of a matched pair analysis
ConclusionPatients treated with TAE after PN show an additional risk for an impairment of renal function over time. Hence, those patients should explicitly be informed about possible consequences and closely monitored by nephrologists. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 12, 2018 Category: Urology & Nephrology Source Type: research

Urine can speed up the re-epithelialization process of prostatic urethra wounds by promoting the proliferation and migration of prostate epithelial cells
AbstractObjectivesThe present study aimed to investigate the influence of urine on re-epithelialization in canine prostatic urethra after prostatectomy and explore possible causes.MethodWe established two groups of prostatic canine models. The first group contained urine that canines underwent the surgery by two-micron laser resection of the prostate-tangerine technique (TmLRP-TT), and no transurethral catheter was required. The second group was without urine that canines accepted the surgery by TmLRP-TT add ureter skin ostomy urine bypass. Histopathology of re-epithelialization of repair in trauma in canine prostatic uret...
Source: International Urology and Nephrology - November 7, 2018 Category: Urology & Nephrology Source Type: research

Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin
ConclusionsThe present study showed that CYP-induced cystitis in mice is a model of visceral hyperalgesia affecting detrusor contractions, not urethral activations. The technique of using EUS  EMG to evaluate the drug effects on urethral activities is novel and useful for future investigations. Gabapentin can be as a potential treatment for detrusor overactivity and PBS/IC. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - November 1, 2018 Category: Urology & Nephrology Source Type: research

Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients
AbstractPurposeCardiovascular diseases are the leading causes of mortality in chronic kidney disease. Spondin-2 (SP-2), an intrinsic cardio-protective factor, prevents maladaptive remodeling. We aimed to determine the relation between serum SP-2 levels and cardiac morphology along with inflammatory parameters in hemodialysis (HD) patients.MethodThe study comprised a total of 95 patients (61 females) receiving HD treatment three times a week for at least 6  months, and a control group consisting of age and gender matched 62 subjects (34 females). SP-2 levels were determined by ELISA. Echocardiography, 24-h ambulatory b...
Source: International Urology and Nephrology - October 29, 2018 Category: Urology & Nephrology Source Type: research

Serum endocan and circadian heart rate variability in non-dialysis stage 5 chronic kidney disease patients
AbstractBackgroundChronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that elevated heart rate (HR) is a risk factor for cardiovascular mortality. We investigated the link between serum endocan and circadian heart rate variability in non-dialysis stage 5 CKD patients.MethodsIn a cross-sectional study, we enrolled 54 prevalentn non-dialysis stage 5 CKD patients (32 males, aged 48.2  ± 14.92 years). HR was measured with an automatic system. Serum endocan level was analyzed by ELISA.ResultsNight/day HR ratio ...
Source: International Urology and Nephrology - October 29, 2018 Category: Urology & Nephrology Source Type: research

Clinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patients
AbstractPurposeThe current study was conducted to determine the effects of coenzyme Q10 (CoQ10) supplementation on glycemic control and markers of lipid profiles risk in diabetic hemodialysis (HD) patients.MethodsThis randomized, double blind, placebo-controlled clinical trial was performed among 60 diabetic HD patients. Subjects were randomly allocated into two groups to take either 120  mg/day of CoQ10 supplements or placebo (n = 30 each group) for 12 weeks.ResultsAfter 12 weeks of intervention, CoQ10 supplementation, compared with the placebo, resulted in a significant decrease in serum insulin concen...
Source: International Urology and Nephrology - October 29, 2018 Category: Urology & Nephrology Source Type: research

Atypical haemolytic uremic syndrome: when multiple etiologies meet
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 29, 2018 Category: Urology & Nephrology Source Type: research

Acute renal infarction in Turkey: a review of 121 cases
ConclusionsOur study is the second largest series published on renal infarction in the literature. More detailed studies are needed to determine the etiological causes of acute renal infarction occurring in patients. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 29, 2018 Category: Urology & Nephrology Source Type: research

Characteristics and risk factors of postoperative acute kidney injury in ICU patients
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 29, 2018 Category: Urology & Nephrology Source Type: research

Effects of parathyroidectomy on blood bone markers and heart rate variability in patients with stage 5 chronic kidney disease
ConclusionsCirculating bone markers are correlated with HRV in CKD 5 patients and PTX can improve decreased HRV, which are associated with corrected bone markers in severe SHPT patients. Thus, we propose that PTH increases sympathetic tone and both high circulating PTH levels and sympathetic hyperactivity increase bone turnover, and that the products of bone turnover influence HRV. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 25, 2018 Category: Urology & Nephrology Source Type: research

Effect of high-fat diet-induced obesity on the small-conductance Ca 2+ -activated K + channel function affecting the contractility of rat detrusor smooth muscle
ConclusionsReduced expression and activity of SK channels in the DSM contribute to obesity-related OAB, indicating that SK channels are a potential therapeutic target for OAB. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 25, 2018 Category: Urology & Nephrology Source Type: research

The creatinine/cystatin C ratio provides effective evaluation of muscle mass in kidney transplant recipients
AbstractIntroductionMeasuring muscle mass is an important step in detecting sarcopenia. The evaluation of sarcopenia is also important for kidney transplant recipients. Methods for estimating muscle mass have been established using computed tomography or magnetic resonance imaging, which are considered the gold standards. But these methods are invasive and costly, and there is a need for a more practical and simple method using blood samples from kidney transplant recipients.MethodsThe study population was 62 patients who underwent kidney transplantation at Kansai Medical University Hospital, and were evaluated from August...
Source: International Urology and Nephrology - October 25, 2018 Category: Urology & Nephrology Source Type: research

A comparison between 2017 FAS and 2012 CKD-EPI equations: a multi-center validation study in Chinese adult population
AbstractBackgroundThe recent guidelines recommend using the estimated glomerular filtration rate (eGFR) to evaluate renal function. There are two reported full-age-spectrum (FAS) equations in 2017, which are based on serum cystatin C concentrations with or without accompanying serum creatinine level (FASCr –Cys or FASCys). We compared the performance and assessed the applicability of the new FAS equation with the 2012 CKD-EPI (CKD-EPICys and CKD-EPICr –Cys) equation in Chinese subjects.MethodsA total of 1184 patients, mean aged 55.06  year who underwent99mTc-DTPA GFR measurements (rGFR) from four hospitals...
Source: International Urology and Nephrology - October 24, 2018 Category: Urology & Nephrology Source Type: research

Need for upper urinary tract stenting in cases of ureteral orifice injury during laser enucleation of the prostate
AbstractIntroductionBenign prostatic hyperplasia (BPH) can be associated with marked intravesical protrusion, placing ureteral orifices at risk for injury during bladder outlet procedures.AimTo determine whether ureteral stenting is necessary in cases of ureteral orifice injury during laser enucleation.Materials and methodsRetrospective study included 465 patients with bladder outlet obstruction (IPSS  >  20, Qmax 
Source: International Urology and Nephrology - October 22, 2018 Category: Urology & Nephrology Source Type: research

Recovery of urinary function after robotic-assisted laparoscopic prostatectomy versus radical perineal prostatectomy for early-stage prostate cancer
AbstractIntroductionRobotic-assisted laparoscopic prostatectomy (RALP) has largely replaced open radical prostatectomy in many centers. Radical perineal prostatectomy (RPP) is another less invasive approach that has not been widely adopted. RPP offers excellent exposure of the urinary sphincter and bladder neck that may provide good urinary function outcomes. We evaluate urinary function after RALP and RPP.MethodsRetrospective review of a prospective radical prostatectomy database was performed. Urinary modules from the Expanded Prostate Cancer Index Composite —Urinary Function (EPIC-UF) questionnaire were used to de...
Source: International Urology and Nephrology - October 16, 2018 Category: Urology & Nephrology Source Type: research

MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats
AbstractDefective renal salt and water excretion, together with increased salt intake, frequently contributes to hypertension. Recent studies indicate that Ste20 family kinases, such as proline-alanine-rich Ste20-related kinase (SPAK) and oxidative stress-response protein 1 (OSR1), are regulators of cell volume, ion transport, and hypertension. The aim of this study was to investigate whether mammalian sterile 20-like protein kinase 3 (MST3), which is also a stress-regulated kinase, is involved in the development of hypertension. MST3 expression was compared in Wistar-Kyoto (WKY) and spontaneously hypertensive rat (SHR) ki...
Source: International Urology and Nephrology - October 16, 2018 Category: Urology & Nephrology Source Type: research

Five microRNAs in serum as potential biomarkers for prostate cancer risk assessment and therapeutic intervention
ConclusionThis study identified possible PCa tumor markers to more accurately predict the occurrence, progression, and prognosis of PCa, and which could be used in the development of tumor drug therapy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 15, 2018 Category: Urology & Nephrology Source Type: research

Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment
ConclusionThe circadian rhythms have influence in the renal physiology, pathophysiology, and pharmacology, and these data should be taken into account in clinical nephrology practice. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 15, 2018 Category: Urology & Nephrology Source Type: research