Correlation of serum galectin-3 level with renal volume and function in adult polycystic kidney disease
AbstractPurposeThe decrease in kidney functions in autosomal dominant polycystic kidney disease (ADPKD) is strongly correlated with the severity and growth of kidney cysts. Total kidney volume (TKV) was shown to be an early marker of the severity of the disease and a predictor of reduction in kidney functions. New treatment approaches for ADPKD have led to a need for easily applicable strong biomarkers predicting progression of the disease. The profibrotic mediator of galectin-3 (Gal-3) is linked to development of renal fibrosis.MethodsThe study included 74 patients with ADPKD diagnosis and 40 healthy controls. The TKV of ...
Source: International Urology and Nephrology - April 22, 2019 Category: Urology & Nephrology Source Type: research

Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells
ConclusionsWe demonstrated that TRPC3 upregulation upon PC2 knockdown aggravated the mitochondrial abnormalities and cell proliferation by modulating mitochondrial calcium uptake. Targeting TRPC3 might be a promising target for ADPKD treatment. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 22, 2019 Category: Urology & Nephrology Source Type: research

Citrate versus heparin lock for prevention of hemodialysis catheter-related complications: updated systematic review and meta-analysis of randomized controlled trials
AbstractObjectiveTo provide updated evidence, we conducted a systematic review and meta-analysis to compare citrate lock with heparin in the prevention of hemodialysis catheter-related complications.MethodsA systematic review and meta-analysis of randomized controlled trials were obtained by searching PubMed, EMBASE, Ovid, Cochrane library, and the Web of Science databases. Primary outcomes were catheter-related bloodstream infections (CRBI), exit-site infections, bleeding events, catheter removal for poor flow, and thrombolytic treatment. Secondary outcomes were thrombocytopenia, access-related admission, and all-cause mo...
Source: International Urology and Nephrology - April 22, 2019 Category: Urology & Nephrology Source Type: research

Pentosidine in chronic hemodialysis patients: relation with arteriovenous fistula morphology and function
AbstractPurpose It has been suggested that advanced glycation end products (AGEs) are involved in atherogenesis, vascular calcification and remodeling, including neointimal hyperplasia, in renal and non-renal patients. Their relevance for arteriovenous fistula (AVF) function has been poorly studied to date, with only one clinical study addressing the issue of thrombosis of vascular access in relation to AGEs in dialysis patients. We aimed to evaluate the relationship between serum pentosidine and AVF morphology and function.MethodsEighty-eighth hemodialysis patients with patent native AVF were included. Ultrasound examin...
Source: International Urology and Nephrology - April 22, 2019 Category: Urology & Nephrology Source Type: research

Florid mesothelial hyperplasia of the tunica vaginalis: report of two cases with immunohistochemical findings
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 17, 2019 Category: Urology & Nephrology Source Type: research

The efficacy and safety of immunosuppressive agents plus steroids compared with steroids alone in the treatment of Henoch –Schönlein purpura nephritis: A meta-analysis
ConclusionAdministration of immunosuppressive agents combined with steroids may be a superior alternative for HSPN. Nevertheless, long-term, high-quality, large-sample, and  multicenter RCTs are required to make the results more convincing. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 15, 2019 Category: Urology & Nephrology Source Type: research

Acute kidney injury in patients with HELLP syndrome
AbstractPurposeTo evaluate the risk factors and renal prognosis of acute kidney injury (AKI) in patients with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.MethodsWomen with HELLP syndrome over a 15-year period at Peking Union Medical College Hospital, China, were retrospectively studied.ResultsA total of 108 patients with HELLP syndrome were included. Fifty-two (48.1%) patients were diagnosed with AKI (median serum creatinine, 139.72  µmol/L; range, 89.00–866.00); 11 (21.2%) required hemodialysis. The AKI group had significantly more multiparity (p = 0.034), hemo...
Source: International Urology and Nephrology - April 15, 2019 Category: Urology & Nephrology Source Type: research

Adjunction of tamsulosin or mirabegron before semi-rigid ureterolithotripsy improves outcomes: prospective, randomized single-blind study
ConclusionsTamsulosin or mirabegron use for 1  week before semi-rigid ureteroscope increases stone access and the stone-free rate. Tamsulosin or mirabegron can be used with safety and efficacy before ureteroscopy for ureteral stones. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 15, 2019 Category: Urology & Nephrology Source Type: research

Renal histopathology of prolonged acute kidney injury in HELLP syndrome: a case series and literature review
ConclusionsATN was the most common finding for persistent AKI in HELLP syndrome. Patients with ARCN or TMA with ATN may have the potential to develop chronic renal dysfunction. Renal biopsy should be performed in patients with prolonged AKI to determine the renal prognosis and guide the appropriate treatment. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 15, 2019 Category: Urology & Nephrology Source Type: research

A new modification of tubeless cutaneous ureterostomy following radical cystectomy
ConclusionsOur technique of single-site-modified cutaneous ureterostomy is a safe and simple surgical technique with similar postoperative complications rate and better catheter-free rate compared to standard cutaneous ureterostomy. We believe that this technique could be a method of choice not only for candidates for cutaneous ureterostomy but also for selected patients for ileal conduit. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 13, 2019 Category: Urology & Nephrology Source Type: research

Robot-assisted laparoscopic surgery for the management of post-renal transplant ureteric strictures
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 13, 2019 Category: Urology & Nephrology Source Type: research

Long-term oncological outcomes of cystic renal cell carcinoma according to the Bosniak classification
AbstractObjectivesTo evaluate the prognostic role of the Bosniak classification on the long-term oncological outcomes of cystic renal cell carcinomas.Material and methodIn a national multicentric retrospective study, we included patients treated surgically for localized cystic RCC from 2000 to 2010. Patients with a follow-up of less than 4  years, benign tumors, and ablative treatments were excluded. The primary outcome was disease-free survival.Results152 patients met the inclusion criteria: Bosniak II (6%), III (53%), IV (41%), with a median follow-up of 61 (12 –179) months. Characteristics of the population a...
Source: International Urology and Nephrology - April 12, 2019 Category: Urology & Nephrology Source Type: research

Salvage treatment for radio-recurrent prostate cancer: a review of literature with focus on recent advancements in image-guided focal salvage therapies
This article summarizes the outcomes of currently used salvage treatment options for radio-recurrent prostate cancer and focuses on recent advancements in image-guided focal salvage therapies. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 12, 2019 Category: Urology & Nephrology Source Type: research

Response to the letter to editor: need for upper urinary tract stenting in cases of ureteral orifice injury during laser enucleation of the prostate
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 12, 2019 Category: Urology & Nephrology Source Type: research

Renal hilar block predicts long-term success of renal auto-transplantation for loin pain hematuria syndrome
ConclusionsA MDT approach utilizing a RHB should be considered as a tool to select appropriate LPHS patients for RAT to achieve long-term success in reducing chronic pain and depression while increasing quality of life. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 11, 2019 Category: Urology & Nephrology Source Type: research

Hypomagnesemia is not an independent risk factor for mortality in Japanese maintenance hemodialysis patients
AbstractPurposeIt is unclear whether hypomagnesemia is an independent risk factor or innocent bystander for mortality in maintenance hemodialysis (MHD) patients. Thus, we studied associations between hypomagnesemia and all-cause as well as cardiovascular (CV) mortality in MHD patients.MethodsBaseline clinical characteristics and coronary artery calcium score (CACS) of 353 Japanese MHD patients were reviewed. Three-year survival rate and mortality risk factors were assessed.ResultsMedian (interquartile range) age, dialysis vintage, serum magnesium (Mg), serum albumin and CACS of the subjects were 68 (60 –78) years, 75...
Source: International Urology and Nephrology - April 11, 2019 Category: Urology & Nephrology Source Type: research

Morphologic changes after bladder neck intussusception in laparoscopic radical prostatectomy contribute to early postoperative continence
ConclusionsThe modified technique of bladder neck intussusception in laparoscopic radical prostatectomy prolongs the length of functional posterior urethra and is effective to improve postoperative early continence. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 8, 2019 Category: Urology & Nephrology Source Type: research

Prognostic impact of galectin-3 in chronic kidney disease patients: a systematic review and meta-analysis
ConclusionsOur meta-analysis suggests that high levels of galectin-3 may increase the risk of all-cause mortality and CV events in CKD patients, however, probably not a sensitive biomarker for outcomes in HD patients. Further studies were warranted to validate our findings. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 8, 2019 Category: Urology & Nephrology Source Type: research

Lactic acidosis due to metformin in type 2 diabetes mellitus and chronic kidney disease stage 3 –5: is it significant?
ConclusionMetformin can be safely used in CKD stage 3 and with regular measurement of plasma lactate in later stages. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 8, 2019 Category: Urology & Nephrology Source Type: research

Comments on the article entitled “Morphologic changes after bladder neck intussusception in laparoscopic radical prostatectomy contribute to early postoperative continence”
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 8, 2019 Category: Urology & Nephrology Source Type: research

Commentary to: “Morphologic changes after bladder neck intussusception in laparoscopic radical prostatectomy contribute to early postoperative continence”
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 8, 2019 Category: Urology & Nephrology Source Type: research

Magnetic resonance imaging characteristics and changes in hemostatic agents after partial nephrectomy
ConclusionsThe distinction of MLL causing bolster-related mass and granulomatosis tissue from relapse/recurrence can be made based on the change in mass size observed in the MR images and image characteristics. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 6, 2019 Category: Urology & Nephrology Source Type: research

Prognostic significance of maternal urinary carbohydrate antigen 19-9 for antenatal diagnosis of posterior urethral valve associated with fetal hydronephrosis
AbstractPurposeTo evaluate the predictive role of maternal urinary CA 19-9 as a non-invasive marker for diagnosing antenatal posterior urethral valve (PUV).MethodsA total of 40 women in the third pregnancy trimester were enrolled. Case group (group A) consisted of 20 women with a diagnosis of antenatal PUV. Twenty women with similar gestational age, fetal sex, normal US, and no history of congenital anomalies were chosen as a control group (group B). Maternal urine samples were collected and urinary CA 19-9 was measured in both groups. The correlations between maternal urinary CA 19-9 and APD (measured during pregnancy and...
Source: International Urology and Nephrology - April 6, 2019 Category: Urology & Nephrology Source Type: research

Do renal cell carcinoma patients with brain metastases still need nephrectomy?
ConclusionsPatients with high risk of BM (age 45 –65 years, tumor diameter>  10 cm, histologic type of ccRCC) should emphasize brain imaging screening during follow-up. Nephrectomy may bring survival advantages for RCC patients with BM. Nomogram model based on nephrectomy can helps predicting the 1-, 2- and 3-year survival rates. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 5, 2019 Category: Urology & Nephrology Source Type: research

Classification of non-gonococcal urethritis: a review
AbstractNon-gonococcal urethritis (NGU) is the most common disease of the genital tract in men. Recent studies have recommended avoiding the empiric antibiotic administrations that constitute the classical treatment approach in NGU and to aim toward treatment of causative pathogens. However, the classification of NGU agents remains controversial. In addition, the relevance of the commensalism ofMycoplasma hominis,Ureaplasma urealyticum,Ureaplasma parvum, andGardnerella vaginalis, which are among the opportunistic pathogens found in the urethral flora, has yet to be determined. Furthermore, there are certain pathogens on wh...
Source: International Urology and Nephrology - April 5, 2019 Category: Urology & Nephrology Source Type: research

Which treatment is best for patients with AJCC stage IV bladder cancer?
AbstractPurposeWe sought to identify the method that could obtain the best survival rate for AJCC stage IV bladder cancer (BCa) patients.MethodsPatients with AJCC stage IV BCa diagnosed between 2004 and 2015 were identified using the Surveillance, epidemiology and end results (SEER) database. Kaplan –Meier curves and log-rank test were used for overall survival (OS) and cancer-specific survival (CSS). Multivariable Cox regression was used to determine factors associated with all-cause mortality (ACM) and cancer-specific mortality (CSM).ResultsWe found that among the 11824 patients, the number of patients who received...
Source: International Urology and Nephrology - April 4, 2019 Category: Urology & Nephrology Source Type: research

Urothelial carcinoma of the upper urinary tract: preoperative pyuria is not correlated with bladder cancer recurrence and survival
ConclusionsPreoperative pyuria is unable to predict outcomes in a single-centre series of consecutive patients who were treated with RNU. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 1, 2019 Category: Urology & Nephrology Source Type: research

Uretero-iliac artery fistula: a challenge diagnosis for a life-threatening condition: monocentric experience and review of the literature
ConclusionsIn case of gross hematuria during ureteral stent change in female patients with history of previous pelvic surgery and radiation, UIAF must be suspected and immediately treated, since it represents a urological emergency. Angiography can be useful to confirm the diagnosis and endovascular treatment with vascular endoprosthesis is the best therapeutic option. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 30, 2019 Category: Urology & Nephrology Source Type: research

The clinical utility of prostate cancer heterogeneity using texture analysis of multiparametric MRI
ConclusionADC map mpMRI TA correlated negatively with GS, andT2 and post-contrast images with the D ’Amico risk score. These associations may allow for better assessment of disease prognosis and a non-invasive method of follow-up for patients on surveillance. Further, identifying clinically significant prostate cancer is essential to reduce harm from over-diagnosis and over-treatment. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 30, 2019 Category: Urology & Nephrology Source Type: research

Predictors for immediate recovery of continence following Retzius-sparing robot-assisted radical prostatectomy: a case –control study
ConclusionsRS-RARP hastens the recovery of urinary continence after surgery. Prostate volume and severe preoperative IPSS were independent adverse predictors of the return to immediate urinary continence. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 30, 2019 Category: Urology & Nephrology Source Type: research

Religiosity, spirituality and quality of life of dialysis patients: a systematic review
ConclusionsIn this systematic review, we synthesized the studies involving R/S assessment in dialysis patients and their benefit on QoL. R/S has a positive impact on most QoL parameters in 5D-CKD. We suggest that nephrology guidelines on palliative care and/or elderly should include specific recommendations on R/S support and opportunities for integrated specific therapies. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 27, 2019 Category: Urology & Nephrology Source Type: research

A systematic review of the long-term efficacy of low-intensity shockwave therapy for vasculogenic erectile dysfunction
ConclusionsLISWT may be a safe and acceptable potential ED treatment with demonstrated benefits at 6 months. There is some question regarding efficacy deterioration beyond this, but there is still a demonstrated benefit seen even at 12 months post treatment. However, quality of evidence remains low with larger multiinstitutional studies required, standardising confounders such as shockwave administration and oral medication use. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 22, 2019 Category: Urology & Nephrology Source Type: research

Intraoperative ICG-fluorescence imaging for robotic-assisted urologic surgery: current status and review of literature
ConclusionsAlthough it is not necessary to utilize fluorescence-enhanced surgery in all cases, the authors find the utilization of ICG-NIRF in complex and highly technical surgeries useful. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 22, 2019 Category: Urology & Nephrology Source Type: research

Uroprotective effect of ambroxol in cyclophosphamide-induced cystitis in mice
ConclusionThese results suggest that AMB pretreatment could improve CYP-induced HC via antioxidant and antiinflammatory activities. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 20, 2019 Category: Urology & Nephrology Source Type: research

Comparison of short-term complications between Onlay and Duckett urethroplasty and the analysis of risk factors
AbstractAimsTo compare the short-term complications between Onlay and Duckett urethroplasty and to analyze the various risk factors cause the complications.MethodsThe children with hypospadias who underwent treatment with Onlay or Duckett urethroplasty from November 2014 to June 2016 were followed up. The difference in complications between the two groups was analyzed. Moreover, a single-factor ANOVA was performed to analyze the length and curvature of the penis and the length of the urethral defect.Results40 patients were treated by Duckett, while 54 by Onlay. In comparison to the Onlay group, the Duckett group showed the...
Source: International Urology and Nephrology - March 20, 2019 Category: Urology & Nephrology Source Type: research

MiR-200a ameliorates peritoneal fibrosis and functional deterioration in a rat model of peritoneal dialysis
In conclusion, results from the present study suggest that treatment with miR-200a may represent a novel and effective therapy for PD-related PF. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 19, 2019 Category: Urology & Nephrology Source Type: research

Outcomes of hospital-acquired acute kidney injury in elderly patients: a single-centre study
ConclusionHAAKI is associated with increased morbidity and mortality in elderly patients. Associated co-morbid conditions predispose elderly patients to HAAKI. ICU admission, Oliguria, severity of renal failure, requirement of RRT, and initial SOFA score were strong predictors of survival of elderly patients with HAAKI. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 19, 2019 Category: Urology & Nephrology Source Type: research

What is the place of sclerostin in chronic kidney disease, atherosclerosis, and ageing?
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 19, 2019 Category: Urology & Nephrology Source Type: research

Why renal biopsy is crucial in monoclonal gammopathy of renal significance (MGRS)
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 19, 2019 Category: Urology & Nephrology Source Type: research

Treating symptoms to improve the quality of life in patients on chronic hemodialysis
AbstractHealth-related quality of life (HRQOL) in patients on chronic hemodialysis has not improved significantly in the last 20 years. This is largely due to their substantial symptom burden which is rarely assessed and treated in routine clinical practice. This is also consequence of the lack of an appropriate armamentarium for the treatments of such symptoms. Adequate studies on the causes and pathogenesis of the symptoms of hemodialysis patients are needed followed by high-quality studies on possible therapeutic pharmacological and non-pharmacological interventions. Patients on chronic hemodialysis deserve a better qua...
Source: International Urology and Nephrology - March 19, 2019 Category: Urology & Nephrology Source Type: research

Long-term anatomic and functional results of laparoscopic sacrocolpopexy: a prospective study
AbstractPurposeThe aim of our study was to assess the impact of laparoscopic sacrocolpopexy on pelvic symptoms, quality of life and sexual function in patients with symptomatic pelvic organ prolapse. Secondary goals included the assessment of anatomical correction, recurrence and complication rates.MethodsThis is a prospective, single-center study that included 82 patients between 2009 and 2016. A clinical evaluation took place before surgery, and was repeated at 3, 12, 36 and 60  months postoperatively. Patients routinely received an anterior prosthesis, associated with a posterior prosthesis in case of symptomatic r...
Source: International Urology and Nephrology - March 14, 2019 Category: Urology & Nephrology Source Type: research

Association of single nucleotide polymorphism in hsa-miR-499 and hsa-miR-196a2 with  the risk of prostate cancer
ConclusionOur findings supported thathsa-miR-499 gene polymorphism significantly increased susceptibility to PCa and may be considered as a potential prognostic biomarker in PCa patients. The findings suggested that no correlation betweenhsa-miR-196a2 gene polymorphism  and PCa susceptibility in an Iranian population. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 13, 2019 Category: Urology & Nephrology Source Type: research

Efficacy and safety of glucocorticoids for patients with IgA nephropathy: a meta-analysis
AbstractBackgroundThe efficacy and safety of glucocorticoids for the treatment of patients with IgA nephropathy (IgAN) remains controversial. The aim of the study is to perform a metaanalysis of randomized controlled trials to evaluate the efficacy and safety of glucocorticoids for patients with IgAN.MethodsWe searched PubMed, EMBASE and the Cochrane Library and article reference lists of Controlled Trials, and Clinical Trial Registries for randomized controlled trials comparing glucocorticoids with other non-immunosuppressive agents in patients with IgAN.ResultsThe present meta-analysis, including 10 RCTs and 791 patients...
Source: International Urology and Nephrology - March 6, 2019 Category: Urology & Nephrology Source Type: research

Regional trends in average years of potential life lost (AYPLL) secondary to prostate cancer deaths among Caucasians and African Americans treated by surgery or radiation
ConclusionsRacial disparity between AA and CA existed across the examined regions. It is more pronounced in advanced tumor grades. The differences were more significant in the last decade. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 6, 2019 Category: Urology & Nephrology Source Type: research

ISPD guideline-driven retraining, exit site care and decreased peritonitis: a single-center experience in Israel
ConclusionsEnforcement of an educational program and strict adherence to an exit site care protocol was associated with a significant decrease in peritonitis rates. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 5, 2019 Category: Urology & Nephrology Source Type: research

Evaluation of kidney biopsies in elderly patients
AbstractObjectiveThe renal parenchymal disease spectrum in geriatric patients is similar to that in younger patients and can be controlled by appropriate treatment. We evaluated the clinicopathological features of kidney biopsies from geriatric patients.Materials and methodsOne hundred nine native kidney biopsies from older patients (>  65 years old) obtained from 2005 to 2014 were evaluated retrospectively. The specimens were inspected by the same pathologist in the same laboratory by light microscopy and immunofluorescence.ResultsThe mean age of the patients was 72.4  ± 7.8 years ...
Source: International Urology and Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research

A simple modified open peritoneal dialysis catheter insertion procedure reduces the need for secondary surgery
AbstractBackgroundThe aim of this retrospective study was to assess the efficacy of a modified peritoneal dialysis catheter insertion technique for reducing the incidence of mechanical complications.MethodsWe conducted a retrospective analysis of clinical data of 346 patients undergoing peritoneal dialysis catheter insertion at our peritoneal dialysis center. The traditional procedure was performed in 157 patients (group A) and the modified procedure in 189 patients (group B). The double-polyester-cuff straight Tenckhoff catheter was used in all patients.ResultsAt the end of 1 year, tunnel inflammation was more common in g...
Source: International Urology and Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research

How to estimate renal function in patients with liver disease: choosing the most suitable equation
ConclusionThe CHINAcr-cys equation may be more suitable for the estimation of GFR in Chinese patients with CHB or compensated cirrhosis. INR, creatinine, NAG, and CysC are proper biomarkers for screening renal dysfunction in Chinese patients with CHB or compensated LC. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research

Effect of SGLT2 inhibitor on renal function in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
This study summarizes the evidence from randomized controlled trials (RCTs) to assess the effects of SGLT2 inhibitors on renal function and albuminuria in patients with type 2 diabetes.Materials/methodsWe searched PubMed, Web of Science, Cochrane Library and EMBASE for reports published up to March 2018 and included RCTs reporting estimated glomerular filtration rate (eGFR) and/or urine albumin/creatinine ratio (UACR) changes. Data extraction and assessment of research quality based on Cochrane risk biasing tools. Data were calculated to represent the standardized mean difference (SMD) for each study, and the SMDs with 95%...
Source: International Urology and Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research

Defining a clinically significant struvite stone: a non-randomized retrospective study
ConclusionsHigher struvite content is associated with a higher frequency of traditional urea splitting bacteria in urine culture, higher risk for postoperative SIRS, and higher recurrence rate. Struvite content greater than 25% can be used to define a clinically significant struvite stone. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - March 4, 2019 Category: Urology & Nephrology Source Type: research