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Comment on “The prevalence and influencing factors of frailty in patients with chronic kidney disease: a systematic review and meta-analysis”
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 6, 2023 Category: Urology & Nephrology Source Type: research

Alteration of the maximal renal water excretion capacity with kidney function and age in human
This study shows a decrease in maximal urinary dilution capacity and free water clearance with CKD and age, without gender difference. These alterations are mild but must be considered when a significant water intake is required or in the case of hyponatremia. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 4, 2023 Category: Urology & Nephrology Source Type: research

Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
ConclusionResults suggest that AP can exhibit therapeutic effects against CP-induced testicular toxicity. It can be concluded that AP may be a potential molecule to abolish reproductive toxicity after chemotherapy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 3, 2023 Category: Urology & Nephrology Source Type: research

The clinical and imaging features of eosinophilic cystitis in children: a case series study
ConclusionThe clinical and imaging manifestations of EC in children have relative characteristics; when urologist and radiologist confronted with similar cases, EC should be considered. The final diagnosis depends on pathological biopsy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 2, 2023 Category: Urology & Nephrology Source Type: research

Comment on “Association of statin use after renal replacement therapy with mortality in patients with dialysis-requiring acute kidney injury”
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - October 2, 2023 Category: Urology & Nephrology Source Type: research

Comparison of the Charlson comorbidity index, the modified Charlson comorbidity index, and the recipient risk score in prediction of the graft and patient survival among renal graft recipients: historical cohort in a single center
ConclusionThe mCCI-KT index followed by the CCI index provided the best model in predicting the 10-year patient survival; however, they were poor in predicting graft survival and this model can be used for better stratifying transplant candidates prior to surgery. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

Incidence of urological tumors in Down ’s syndrome: a systematic review and meta-analysis
ConclusionThere was a very low incidence of urological tumors in people with Down ’s syndrome. Testis tumor was the most frequently described in all cohorts and within a normal distribution range. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

The WNT/ β-catenin system in chronic kidney disease-mineral bone disorder syndrome
ConclusionsThe WNT/ β-catenin signaling pathway is a potential therapeutic target for CKD-MBD. Small molecular compounds that target the components or regulatory molecules of the pathway may provide a promising approach to treat CKD-MBD. However, more research is needed to identify safe and effective compounds and to determine the optimal dosages and treatment regimens. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

Establishment of a new predictive model for the recurrence of upper urinary tract stones
ConclusionThe nomogram model can effectively evaluate the recurrence risk of upper urinary stones, especially suitable for stone postoperative patients, to help reduce the possibility of postoperative stone recurrence. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

Tenascin-C promotes the proliferation and fibrosis of mesangial cells in diabetic nephropathy through the β-catenin pathway
ConclusionTNC is upregulated in DN and induces MC proliferation and fibrosis through the β-catenin pathway. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

Diagnostic utility of serum and urine biomarkers in idiopathic membranous nephropathy: a systematic review and meta-analysis
ConclusionsThis meta-analysis shows that PLA2R-AB and THSD7A-AB are of important diagnostic value for IMN. More studies are needed in the future to reveal the diagnostic value of LIMP-2 and circRNAs for IMN. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

Sanjin Paishi Decoction improves the imbalance of gut microbiota and regulates MAPK signaling pathway to inhibit calcium oxalate stones in rats
ConclusionThe mechanism of SJPSD inhibition of calcium oxalate stone injury in rats may be related to the inhibition of the MAPK signaling pathway and regulation of gut microbiota imbalance. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

The prognostic value of estimated glomerular filtration rate on admission for death within 30  days among COVID-19 inpatients using fractional polynomial and spline smoothing
ConclusionThere is a non-linear and asymmetric relationship between eGFR and death within 30  days among COVID-19 inpatients. Kidney function can be measured in COCID-19 patients on admission to know better understanding about prognosis of the patients. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

Reno-protective effects of perioperative dexmedetomidine in kidney transplantation: a systematic review and meta-analysis of randomized controlled trials
ConclusionAlthough there is no difference between DEX and placebo regarding reducing DGF and acute rejection after kidney transplantation, there may be some evidence that it has reno-protective benefits because we found statistically significant improvement in the short-term serum creatinine and blood urea nitrogen levels. More trials are required to investigate the long-term reno-protective effects of DEX. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research

Does renal failure worsen radiation cystitis following radical prostatectomy?
ConclusionEnd-stage renal failure is associated with the risk and severity of radiation cystitis in patients receiving postoperative radiation therapy. Knowledge of the potential morbidity of this complication in this population could guide physicians and patients as they evaluate risks and benefits prior to selecting adjuvant or salvage radiation therapy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research