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Immunohistochemical expression of CD117/KIT, HER2, and Er β in schistosomal and non-schistosomal urothelial carcinoma of Egyptian patients
AbstractBladder carcinoma is an endemic problem in Egypt with schistosomiasis being an additional risk factor. Due to gender disparities, Er β investigation and its role in modulating chemosensitivity are studied. CD117/KIT expression is also considered since the emergence of the targets of the tyrosine kinase inhibitor imatinib mesylate (Gleevec). HER2 is one of the established therapeutic targets in many cancers. We aimed to investiga te CD117/KIT immunoexpression in schistosomal and non-schistosomal urothelial carcinoma of Egyptian patients and its relationship with HER2 and Erβ expressions, correlating it with pertin...
Source: International Urology and Nephrology - June 20, 2023 Category: Urology & Nephrology Source Type: research

The association of normal-range serum phosphorus with immunoglobulin A nephropathy progression: a retrospective cohort study
ConclusionsRelatively higher serum phosphorus levels within the normal range were significantly associated with the progression of IgA nephropathy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 19, 2023 Category: Urology & Nephrology Source Type: research

Review of self-efficacy assessment scales for geriatric patients with urinary incontinence
In this study, we reviewed the self-efficacy assessment tools for geriatric patients with urinary incontinence, to provide a reference for related research. It is important to accurately assess the self-efficacy of patients with geriatric UI to effectively enhance their level of self-efficacy, so that patients with geriatric UI can avail early help and quickly reintegrate with family and society. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 18, 2023 Category: Urology & Nephrology Source Type: research

Activation of the adenosine A1 receptor in the lumbosacral spinal cord improves bladder overactivity in rats with cystitis induced by cyclophosphamide
ConclusionThe findings of this study suggest that intrathecal administration of the adenosine A1 receptor agonist CCPA alleviates CYP-induced bladder overactivity. Furthermore, our results indicate that the adenosine A1 receptor in the lumbosacral spinal cord may be a promising target for treatment of bladder overactivity. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 18, 2023 Category: Urology & Nephrology Source Type: research

Comparison of unilateral and bilateral microdissection testicular sperm extraction (MD-TESE) in patients with non-obstructive azoospermia: a prospective study
ConclusionsIn our study, it was determined that there was no significant difference between the groups in terms of sperm availability in patients with NOA. Considering the operative time and complication rates of bilateral MD-TESE in patients diagnosed with NOA and the possible MD-TESE procedures that may be performed later, we believe that unilateral MD TESE is a more preferable procedure for the patient and surgeon in this patient group. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 18, 2023 Category: Urology & Nephrology Source Type: research

Based on functional and histopathological correlations: is diffusion kurtosis imaging valuable for noninvasive assessment of renal damage in early-stage of chronic kidney disease?
ConclusionDKI shows potential in non-invasive and multi-parameter quantitative assessment of renal damage in early-stage of CKD patients and provide additional information for changes in renal function and histopathology. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 16, 2023 Category: Urology & Nephrology Source Type: research

Knowledge mapping of UMOD of English published work from 1985 to 2022: a bibliometric analysis
ConclusionsThe number of UMOD-related articles has steadily increased over the past decades Current UMOD studies focused on Biological relevance of the UMOD to kidney function and potential applications in the risk of CKD mechanisms, these might provide ideas for further research in the UMOD field. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 15, 2023 Category: Urology & Nephrology Source Type: research

Bladder perforation as a complication of transurethral resection of bladder tumors: the predictors, management, and its impact in a series of 1570 at a tertiary urology institute
ConclusionsThe overall incidence of bladder perforation is 10%; however, 86% required only prolongation of urethral catheter. Bladder perforation did not affect the probability for tumor recurrence, tumor progression nor radical cystectomy. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 15, 2023 Category: Urology & Nephrology Source Type: research

The effect of adding Montelukast to oxybutynin on daily urination in children with pollakiuria: a randomized clinical trial
ConclusionThe results of this study showed that adding montelukast to oxybutynin has a significant decrease in frequency of daily urination in patients with pollakiuria, although further studies are recommended in this area. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 14, 2023 Category: Urology & Nephrology Source Type: research

Association between oxidative balance score and urinary incontinence in females: results from the national health and nutrition examination survey in 2005 –2018
ConclusionAmong females, the higher the OBS, the lower the prevalence of UI. Therefore, dietary and lifestyle-related antioxidant therapy for females with UI should receive attention and be subject to further investigation. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 14, 2023 Category: Urology & Nephrology Source Type: research

Thiazide prescriptions are not associated with lower urolithiasis: a Japanese epidemiologic study
(Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 13, 2023 Category: Urology & Nephrology Source Type: research

Effect of ureteral stricture in transplant kidney and choice of treatment on long-term graft survival
ConclusionThe ureteral stricture has a negative correlation with the long-term survival rate of the transplant kidney, the curative rate and long-term effect of open surgery are the best, stricture recurrence rate of luminal surgery is high, and it may require multiple operations in the future, the MCA is a new breakthrough and innovation in the treatment of ureteral stricture. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 12, 2023 Category: Urology & Nephrology Source Type: research

Nomogram for predicting the biochemical recurrence of prostate cancer after neoadjuvant androgen deprivation therapy
ConclusionsWe constructed and validated a nomogram to predict the risk of BCR in PCa patients after nADT. This nomogram is a complement to the existing risk stratification systems for PCa, which could have marked implications for clinical decision-making for PCa patients after nADT. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 12, 2023 Category: Urology & Nephrology Source Type: research

Sufentanil inhibits Pin1 to attenuate renal tubular epithelial cell ischemia –reperfusion injury by activating the PI3K/AKT/FOXO1 pathway
ConclusionSufentanil reduced Pin1 expression through activation of the PI3K/AKT/FOXO1 signaling to suppress cell apoptosis, oxidative stress and inflammation in renal tubular epithelial cells during RIRI development. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 10, 2023 Category: Urology & Nephrology Source Type: research

Exploring the characteristics of gut microbiome in patients of Southern Fujian with hypocitraturia urolithiasis and constructing clinical diagnostic models
ConclusionGMB disorder may be involved in the occurrence and clinical characteristics of HCU by influencing genetic and metabolic pathways. The new microbiome-clinical indicator diagnostic model is effective. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - June 9, 2023 Category: Urology & Nephrology Source Type: research