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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
Abstract Lithium, given to bipolar disorder patients, causes nephrogenic diabetes insipidus (Li-NDI), a urinary concentrating defect. Li-NDI is due to downregulation of principal cell AQP2 expression, which coincides with principal cell proliferation. The metabolic effect of lithium on principal cells, however, is unknown and investigated here. Earlier, we have shown that the carbonic anhydrase (CA) inhibitor acetazolamide attenuated Li-induced downregulation in mouse collecting duct (mpkCCD) cells. Of the eight CAs present in mpkCCD cells, siRNA and drug treatments showed that downregulation of CA9 and to some ex...
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Alsady M, de Groot T, Kortenoeven MLA, Carmone C, Neijman K, Bekkenkamp-Grovenstein M, Engelke U, Wevers R, Baumgarten R, Korstanje R, Deen PMT Tags: Am J Physiol Renal Physiol Source Type: research

Resveratrol Ameliorates Contrast Induced Nephropathy Through the Activation of SIRT1-PGC-1 α-Foxo1 Signaling in Mice
Conclusion: Resveratrol attenuated CIN by modulating renal oxidative stress and apoptosis through activation of SIRT1-PGC-1 α-FoxO1 signaling.Kidney Blood Press Res 2017;42:641 –653
Source: Kidney and Blood Pressure Research - October 16, 2017 Category: Urology & Nephrology Source Type: research

High Uric Acid-Induced Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via the TLR4/NF-kB Signaling Pathway.
CONCLUSIONS: UA can induce EMT in renal tubular epithelial cells by the activation of the TLR4/NF-κB signaling pathway, and the targeted intervention of the TLR4/NF-κB signaling pathway might effectively inhibit UA-induced renal interstitial fibrosis mediated by EMT. PMID: 29017152 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - October 10, 2017 Category: Urology & Nephrology Authors: Liu H, Xiong J, He T, Xiao T, Li Y, Yu Y, Huang Y, Xu X, Huang Y, Zhang J, Zhang B, Zhao J Tags: Am J Nephrol Source Type: research

UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury
Uncoupling protein-2 (UCP2) plays critical roles in energy metabolism and cell survival. Previous investigations showed that UCP2 regulated the production of extracellular matrix and renal fibrosis. However, little is known about UCP2 in acute kidney injury (AKI). Here, we used Ucp2 knockout mice to investigate the role of UCP2 in an AKI model generated by renal ischemia-reperfusion (I/R) injury. The Ucp2 global knockout mice were born and grew normally without kidney histological abnormality or renal dysfunction. Compared with littermates, deletion of Ucp2 exacerbated I/R-induced AKI whereas increase of UCP2 by conjugated...
Source: AJP: Renal Physiology - October 1, 2017 Category: Urology & Nephrology Authors: Zhou, Y., Cai, T., Xu, J., Jiang, L., Wu, J., Sun, Q., Zen, K., Yang, J. Tags: RESEARCH ARTICLE Source Type: research

Regulation of PDZ domain-containing 1 (PDZK1) expression by hepatocyte nuclear factor-1{alpha} (HNF1{alpha}) in human kidney
In the renal proximal tubule the secretion and reabsorption of glomerularly filtrated compounds is realized by a functional network of uptake and efflux transporters. The activity and localization of several transporters expressed at the apical tubular membrane are regulated by the membrane-associated protein PDZ domain-containing 1 (PDZK1). We aimed to characterize the transcriptional regulation of this modulator of renal transport. Coexpression analyses of PDZK1 and putative regulators were performed using human kidney samples. Protein and mRNA expression of PDZK1 in renal proximal tubule epithelial cells after adenovira...
Source: AJP: Renal Physiology - October 1, 2017 Category: Urology & Nephrology Authors: Prestin, K., Hussner, J., Ferreira, C., Seibert, I., Breitung, V., Zimmermann, U., Meyer zu Schwabedissen, H. E. Tags: RESEARCH ARTICLE Source Type: research

Contribution of myo-inositol oxygenase in age: rage mediated renal tubulo-interstitial injury in the context of diabetic nephropathy.
CONTRIBUTION OF MYO-INOSITOL OXYGENASE IN AGE: RAGE MEDIATED RENAL TUBULO-INTERSTITIAL INJURY IN THE CONTEXT OF DIABETIC NEPHROPATHY. Am J Physiol Renal Physiol. 2017 Sep 20;:ajprenal.00434.2017 Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS Abstract Advanced glycation end products (AGEs) play a role in pathogenesis of diabetic nephropathy (DN). Myo-inositol Oxygenase (MIOX) has been implicated in tubulo-interstitial injury in the context of DN. We investigated the effect of AGEs on MIOX expression and delineated mechanisms that lead to tubulo-interstitial injury. Status of MIOX, RAGE and relevant ...
Source: Am J Physiol Renal P... - September 20, 2017 Category: Urology & Nephrology Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS Tags: Am J Physiol Renal Physiol Source Type: research

The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells
ConclusionsWe demonstrated that the time‐dependent gene expressions, including clock genes, mechano‐sensors, and ARMM, were reproducible in UCs. These findings demonstrated that UCs have the potential to progress research into the circadian functions of the lower urinary tract regulated by clock genes.
Source: Neurourology and Urodynamics - September 1, 2017 Category: Urology & Nephrology Authors: Tatsuya Ihara, Takahiko Mitsui, Yuki Nakamura, Mie Kanda, Sachiko Tsuchiya, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Yuri Hirayama, Keisuke Shibata, Eiji Shigetomi, Yoichi Shinozaki, Mitsuharu Yoshiyama, Atsuhito Nakao, Masayuki Takeda, Schuichi Ko Tags: ORIGINAL BASIC SCIENCE ARTICLE Source Type: research

MicroRNA-200a Inhibits Transforming Growth Factor β1-Induced Proximal Tubular Epithelial-Mesenchymal Transition by Targeting β-Catenin
Conclusions: miRNA-200a inhibits TGF β1-induced EMT by directly targeting β-catenin in proximal tubule epithelial cells.Nephron
Source: Nephron - August 17, 2017 Category: Urology & Nephrology Source Type: research

Role for reactive oxygen species in flow-stimulated inner medullary collecting duct endothelin-1 production
Inner medullary collecting duct (IMCD)-derived endothelin-1 (ET-1) is stimulated by volume expansion, in part through augmented luminal flow, whereupon it can elicit natriuresis and diuresis. Since flow can alter nitric oxide (NO) and reactive oxygen species (ROS), both of which can affect collecting duct salt transport, we asked whether NO and/or ROS mediate flow-stimulated IMCD ET-1. Mouse IMCD3 cells were exposed to flow, and ET-1/GAPDH mRNA was assessed. A shear stress of 10 dyn/cm2 for 1 h increased ET-1 mRNA by fourfold compared with no flow (ET-1 flow response). Global NO synthase (NOS) inhibition [NG-nitro-l-argini...
Source: AJP: Renal Physiology - August 10, 2017 Category: Urology & Nephrology Authors: Wheatley, W., Kohan, D. E. Tags: RESEARCH ARTICLE Source Type: research

(Pro)renin Receptor Is an Amplifier of Wnt/{beta}-Catenin Signaling in Kidney Injury and Fibrosis
The (pro)renin receptor (PRR) is a transmembrane protein with multiple functions. However, its regulation and role in the pathogenesis of CKD remain poorly defined. Here, we report that PRR is a downstream target and an essential component of Wnt/β-catenin signaling. In mouse models, induction of CKD by ischemia-reperfusion injury (IRI), adriamycin, or angiotensin II infusion upregulated PRR expression in kidney tubular epithelium. Immunohistochemical staining of kidney biopsy specimens also revealed induction of renal PRR in human CKD. Overexpression of either Wnt1 or β-catenin induced PRR mRNA and protein expre...
Source: Journal of the American Society of Nephrology : JASN - July 31, 2017 Category: Urology & Nephrology Authors: Li, Z., Zhou, L., Wang, Y., Miao, J., Hong, X., Hou, F. F., Liu, Y. Tags: Basic Research Source Type: research

Loss of the Protein Cystathionine β-Synthase During Kidney Injury Promotes Renal Tubulointerstitial Fibrosis
Conclusions: These findings establish CBS as a novel inhibitor in renal fibrosis and as a new therapeutic target in patients with chronic kidney disease.Kidney Blood Press Res 2017;42:428 –443
Source: Kidney and Blood Pressure Research - July 27, 2017 Category: Urology & Nephrology Source Type: research

Regulation of PDZ domain containing 1 (PDZK1) Expression by Hepatocyte Nuclear Factor 1 alpha (HNF1 α) in Human Kidney.
Regulation of PDZ domain containing 1 (PDZK1) Expression by Hepatocyte Nuclear Factor 1 alpha (HNF1α) in Human Kidney. Am J Physiol Renal Physiol. 2017 Jul 19;:ajprenal.00650.2016 Authors: Prestin K, Hussner J, Ferreira C, Seibert I, Breitung V, Zimmermann U, Meyer Zu Schwabedissen HE Abstract In the renal proximal tubule the secretion and reabsorption of glomerularly filtrated compounds is realized by a functional network of uptake and efflux transporters. The activity and localization of several transporters expressed at the apical tubular membrane is regulated by the membrane associated protein PD...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Prestin K, Hussner J, Ferreira C, Seibert I, Breitung V, Zimmermann U, Meyer Zu Schwabedissen HE Tags: Am J Physiol Renal Physiol Source Type: research

TNF- α Deficiency Prevents Renal Inflammation and Oxidative Stress in Obese Mice
Conclusion: These findings suggest that TNF- α plays an important role in the HFD induced kidney damage, and targeting TNF-α and/or its receptors could be a promising therapeutic regimen for progressive nephropathy.Kidney Blood Press Res 2017;42:416 –427
Source: Kidney and Blood Pressure Research - July 6, 2017 Category: Urology & Nephrology Source Type: research

{beta}-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis
In this study we investigated the role of β-arrestins in regulating extracellular matrix (ECM) synthesis in renal fibrosis. The rat kidney fibroblast cell line (NRK-49F) was treated with the β-arrestin biased agonist [1-sar, 4, 8-ile]angiotensin II (SII), which does not initiate AT1R-G protein signaling. The cells were transfected with recombinant adenoviruses expressing β-arrestin-2 gene or small-interfering RNA (siRNA) targeting β-arrestin-2. The unilateral ureteral obstruction (UUO) model was used in vivo. mRNA and protein levels of β-arrestin-2, not β-arrestin-1, were significantly upregul...
Source: AJP: Renal Physiology - July 1, 2017 Category: Urology & Nephrology Authors: Wang, Y., Huang, J., Liu, X., Niu, Y., Zhao, L., Yu, Y., Zhou, L., Lu, L., Yu, C. Tags: RESEARCH ARTICLE Source Type: research

Store operated calcium entry suppressed tgf β1-smad3 signaling pathway in glomerular mesangial cells.
STORE OPERATED CALCIUM ENTRY SUPPRESSED TGFβ1-SMAD3 SIGNALING PATHWAY IN GLOMERULAR MESANGIAL CELLS. Am J Physiol Renal Physiol. 2017 Jun 21;:ajprenal.00483.2016 Authors: Chaudhari S, Li W, Wang Y, Jiang H, Ma Y, Davis ME, Zuckerman JE, Ma R Abstract Our previous study demonstrated that the abundance of extracellular matrix proteins was suppressed by store-operated Ca2+ entry in mesangial cells (MCs). The present study was conducted to investigate the underlying mechanism focused on the transforming growth factor beta 1 (TGFβ1) - Smad3 pathway, a critical pathway for ECM expansion in diabetic kidney...
Source: Am J Physiol Renal P... - June 21, 2017 Category: Urology & Nephrology Authors: Chaudhari S, Li W, Wang Y, Jiang H, Ma Y, Davis ME, Zuckerman JE, Ma R Tags: Am J Physiol Renal Physiol Source Type: research