Erratum
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Tags: Erratum Source Type: research

Authors' Reply
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Salam, S., Khwaja, A., Eastell, R. Tags: Letter to the Editor Source Type: research

Novel Approaches for Assessment of Bone Turnover in CKD: Is New Always Better?
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Gosmanova, E. O., Gosmanov, A. R. Tags: Letter to the Editor Source Type: research

A New Criterion for Pediatric AKI Based on the Reference Change Value of Serum Creatinine
Background Current definitions of AKI do not take into account serum creatinine’s high variability in children. Methods We analyzed data from 156,075 hospitalized children with at least two creatinine tests within 30 days. We estimated reference change value (RCV) of creatinine on the basis of age and initial creatinine level in children without kidney disease or known AKI risk, and we used these data to develop a model for detecting pediatric AKI on the basis of RCV of creatinine. We defined pediatric AKI according to pediatric reference change value optimized for AKI in children (pROCK) as creatinine increase beyo...
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Xu, X., Nie, S., Zhang, A., Jianhua, M., Liu, H.-P., Xia, H., Xu, H., Liu, Z., Feng, S., Zhou, W., Liu, X., Yang, Y., Tao, Y., Feng, Y., Chen, C., Wang, M., Zha, Y., Feng, J.-H., Li, Q., Ge, S., Chen, J., He, Y., Teng, S., Hao, C., Liu, B.-C., Tang, Y., W Tags: Clinical Research Source Type: research

Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease
Conclusions We developed a noninvasive immunohistochemical method to detect MUC1fs that, after further validation, may be useful in the future for diagnostic testing. Production of the MUC1fs protein may be central to the pathogenesis of ADTKD-MUC1. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Zivna, M., Kidd, K., Pristoupilova, A., Baresova, V., DeFelice, M., Blumenstiel, B., Harden, M., Conlon, P., Lavin, P., Connaughton, D. M., Hartmannova, H., Hodanova, K., Stranecky, V., Vrbacka, A., Vyletal, P., Zivny, J., Votruba, M., Sovova, J., Hulkova Tags: Clinical Research Source Type: research

Association of Ambulatory Blood Pressure with All-Cause and Cardiovascular Mortality in Hemodialysis Patients: Effects of Heart Failure and Atrial Fibrillation
Conclusions This study provides evidence for the U-shaped association between peripheral ambulatory SBP or PP and mortality in patients on hemodialysis. Furthermore, it suggests that underlying cardiac disease can explain the opposite direction of associations. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Mayer, C. C., Matschkal, J., Sarafidis, P. A., Hagmair, S., Lorenz, G., Angermann, S., Braunisch, M. C., Baumann, M., Heemann, U., Wassertheurer, S., Schmaderer, C. Tags: Clinical Research Source Type: research

Acute Declines in Renal Function during Intensive BP Lowering and Long-Term Risk of Death
Background During intensive BP lowering, acute declines in renal function are common, thought to be hemodynamic, and potentially reversible. We previously showed that acute declines in renal function ≥20% during intensive BP lowering were associated with higher risk of ESRD. Here, we determined whether acute declines in renal function during intensive BP lowering were associated with mortality risk among 1660 participants of the African American Study of Kidney Disease and Hypertension and the Modification of Diet in Renal Disease Trial. Methods We used Cox models to examine the association between percentage decline in eGFR (
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Ku, E., Ix, J. H., Jamerson, K., Tangri, N., Lin, F., Gassman, J., Smogorzewski, M., Sarnak, M. J. Tags: Clinical Research Source Type: research

Race, Ethnicity, and End-of-Life Care in Dialysis Patients in the United States
Background End-of-life care is a prominent consideration in patients on maintenance dialysis, especially when death appears imminent and quality of life is poor. To date, examination of race- and ethnicity-associated disparities in end-of-life care for patients with ESRD has largely been restricted to comparisons of white and black patients. Methods We performed a retrospective national study using United States Renal Data System files to determine whether end-of-life care in United States patients on dialysis is subject to racial or ethnic disparity. The primary outcome was a composite of discontinuation of dialysis and ...
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Foley, R. N., Sexton, D. J., Drawz, P., Ishani, A., Reule, S. Tags: Clinical Epidemiology Source Type: research

EGF Receptor-Dependent YAP Activation Is Important for Renal Recovery from AKI
Conclusions This study shows that EGFR-PI3K-Akt–dependent YAP activation plays an essential role in mediating epithelial cell regeneration during kidney recovery from AKI. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Chen, J., You, H., Li, Y., Xu, Y., He, Q., Harris, R. C. Tags: Basic Research Source Type: research

Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling
Conclusions MAGI1 interacts with nephrin-PBM with exquisite specificity. A newly developed, potent inhibitory peptide that blocks this interaction may be useful for future functional investigations in vivo. Our findings also provide possible explanations for the diseases caused by NPHS1 mutations. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Weng, Z., Shang, Y., Ji, Z., Ye, F., Lin, L., Zhang, R., Zhu, J. Tags: Basic Research Source Type: research

Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract
Conclusions We identified monogenic mutations in a known human CAKUT gene or CAKUT phenocopy gene as the cause of disease in 14% of the CAKUT families in this study. Whole-exome sequencing provides an etiologic diagnosis in a high fraction of patients with CAKUT and will provide a new basis for the mechanistic understanding of CAKUT. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: van der Ven, A. T., Connaughton, D. M., Ityel, H., Mann, N., Nakayama, M., Chen, J., Vivante, A., Hwang, D.-y., Schulz, J., Braun, D. A., Schmidt, J. M., Schapiro, D., Schneider, R., Warejko, J. K., Daga, A., Majmundar, A. J., Tan, W., Jobst-Schwan, T., H Tags: Basic Research Source Type: research

ABCC6 Deficiency Promotes Development of Randall Plaque
Conclusions The frequency of kidney stones and probably, Randall plaque is extremely high in patients with PXE, and Abcc6–/– mice provide a new and useful model in which to study Randall plaque formation. Our findings also suggest that pyrophosphate administration should be evaluated for the prevention of Randall plaque and kidney stones. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Letavernier, E., Kauffenstein, G., Huguet, L., Navasiolava, N., Bouderlique, E., Tang, E., Delaitre, L., Bazin, D., de Frutos, M., Gay, C., Perez, J., Verpont, M.-C., Haymann, J.-P., Pomozi, V., Zoll, J., Le Saux, O., Daudon, M., Leftheriotis, G., Martin, Tags: Basic Research Source Type: research

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin
Conclusions These data indicate that reduced phosphorylation of ACC after renal injury contributes to the development of TIF, and that phosphorylation of ACC is required for metformin’s antifibrotic action in the kidney. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Lee, M., Katerelos, M., Gleich, K., Galic, S., Kemp, B. E., Mount, P. F., Power, D. A. Tags: Basic Research Source Type: research

Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in Pkd1-Deficient Mice
Conclusions Interactions between macrophages and CLECs promote cyst growth. ARG1 is a key molecule involved in this process and is a potential therapeutic target to help delay ADPKD progression. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Yang, Y., Chen, M., Zhou, J., Lv, J., Song, S., Fu, L., Chen, J., Yang, M., Mei, C. Tags: Basic Research Source Type: research

Biallelic Expression of Mucin-1 in Autosomal Dominant Tubulointerstitial Kidney Disease: Implications for Nongenetic Disease Recognition
Conclusions Diagnosing ADTKD-MUC1 by molecular genetics is possible, but it is technically demanding and labor intensive. However, immunohistochemistry on kidney biopsy specimens is feasible for nongenetic diagnosis of ADTKD-MUC1 and therefore, a valid method to select families for further diagnostics. Our data are compatible with the hypothesis that specific molecular effects of MUC1-fs underlie the pathogenesis of this disease. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Knaup, K. X., Hackenbeck, T., Popp, B., Stoeckert, J., Wenzel, A., Büttner-Herold, M., Pfister, F., Schueler, M., Seven, D., May, A. M., Halbritter, J., Gröne, H.-J., Reis, A., Beck, B. B., Amann, K., Ekici, A. B., Wiesener, M. S. Tags: Basic Research Source Type: research

Efficient Gene Transfer to Kidney Mesenchymal Cells Using a Synthetic Adeno-Associated Viral Vector
Conclusions These studies establish a novel method for inducible knockout of floxed genes in mouse mesangium, pericytes, and perivascular fibroblasts and are the foundation for future gene therapy approaches to treat kidney fibrosis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Ikeda, Y., Sun, Z., Ru, X., Vandenberghe, L. H., Humphreys, B. D. Tags: Basic Research Source Type: research

Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure
Conclusions The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Kamburova, E. G., Wisse, B. W., Joosten, I., Allebes, W. A., van der Meer, A., Hilbrands, L. B., Baas, M. C., Spierings, E., Hack, C. E., van Reekum, F. E., van Zuilen, A. D., Verhaar, M. C., Bots, M. L., Drop, A. C. A. D., Plaisier, L., Seelen, M. A. J., Tags: Rapid Communication Source Type: research

Effects of Enzyme Replacement Therapy and Antidrug Antibodies in Patients with Fabry Disease
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Lenders, M., Brand, E. Tags: Review Source Type: research

What Is the Glomerular Ultrafiltration Barrier?
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Fissell, W. H., Miner, J. H. Tags: Perspective Source Type: research

A New Pediatric AKI Definition: Implications of Trying to Build the Perfect Mousetrap
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Goldstein, S. L. Tags: Editorials Source Type: research

MUC1 Makes Me Miserable
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Gale, D. P., Kleta, R. Tags: Editorials Source Type: research

This Month's Highlights
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Tags: This Month ' s Highlights Source Type: research

Erratum
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Tags: Errata Source Type: research

Detection of Splicing Abnormalities and Genotype-Phenotype Correlation in X-linked Alport Syndrome
Conclusions We report unpredictable atypical splicing in the COL4A5 gene in male patients with XLAS and reveal that renal prognosis differs significantly for patients with truncating versus nontruncating splicing abnormalities. Our results suggest that splicing modulation should be explored as a therapy for XLAS with truncating mutations. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Horinouchi, T., Nozu, K., Yamamura, T., Minamikawa, S., Omori, T., Nakanishi, K., Fujimura, J., Ashida, A., Kitamura, M., Kawano, M., Shimabukuro, W., Kitabayashi, C., Imafuku, A., Tamagaki, K., Kamei, K., Okamoto, K., Fujinaga, S., Oka, M., Igarashi, T., Tags: Clinical Research Source Type: research

C5b9 Formation on Endothelial Cells Reflects Complement Defects among Patients with Renal Thrombotic Microangiopathy and Severe Hypertension
Conclusions These observations point to complement defects as the key causative factor of ESRD and recurrent TMA after transplant in patients presenting with severe hypertension. Complement defects can be identified by measurements of complement activation on microvascular endothelial cells, which should substantially influence treatment and prognosis. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Timmermans, S. A. M. E. G., Abdul-Hamid, M. A., Potjewijd, J., Theunissen, R. O. M. F. I. H., Damoiseaux, J. G. M. C., Reutelingsperger, C. P., van Paassen, P., on behalf of the Limburg Renal Registry, Christiaans, Fung, Gelens, Kooman, Leunissen, Litjens Tags: Clinical Research Source Type: research

Early Proteinuria Lowering by Angiotensin-Converting Enzyme Inhibition Predicts Renal Survival in Children with CKD
Conclusions The early antiproteinuric effect of ACE inhibition is associated with long-term preservation of renal function in children with CKD. Proteinuria lowering should be considered an important target in the management of pediatric CKD. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: van den Belt, S. M., Heerspink, H. J. L., Gracchi, V., de Zeeuw, D., Wühl, E., Schaefer, F., on behalf of the ESCAPE Trial Group, Anarat, Bakkaloglu, Ozaltin, Peco-Antic, Querfeld, Gellermann, Sallay, Drozdz, Bonzel, Wingen, Zurowska, Balasz, Triv Tags: Clinical Research Source Type: research

The Prognostic Value of Histopathologic Lesions in Native Kidney Biopsy Specimens: Results from the Boston Kidney Biopsy Cohort Study
Conclusions Across a diverse group of kidney diseases, histopathologic lesions on kidney biopsy provide prognostic information, even after adjustment for proteinuria and eGFR. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Srivastava, A., Palsson, R., Kaze, A. D., Chen, M. E., Palacios, P., Sabbisetti, V., Betensky, R. A., Steinman, T. I., Thadhani, R. I., McMahon, G. M., Stillman, I. E., Rennke, H. G., Waikar, S. S. Tags: Clinical Research Source Type: research

Decline in Kidney Function among Apparently Healthy Young Adults at Risk of Mesoamerican Nephropathy
Conclusions Although Mesoamerican nephropathy is associated with agricultural work, other factors may also contribute to this disease. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Gonzalez-Quiroz, M., Smpokou, E.-T., Silverwood, R. J., Camacho, A., Faber, D., Garcia, B. L. R., Oomatia, A., Hill, M., Glaser, J., Le Blond, J., Wesseling, C., Aragon, A., Smeeth, L., Pearce, N., Nitsch, D., Caplin, B. Tags: Clinical Epidemiology Source Type: research

Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population
Conclusions The most significant association with childhood SSNS was detected in the HLA-DR/DQ region. Further HLA allele/haplotype analyses should enhance our understanding of molecular mechanisms underlying SSNS. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Jia, X., Horinouchi, T., Hitomi, Y., Shono, A., Khor, S.-S., Omae, Y., Kojima, K., Kawai, Y., Nagasaki, M., Kaku, Y., Okamoto, T., Ohwada, Y., Ohta, K., Okuda, Y., Fujimaru, R., Hatae, K., Kumagai, N., Sawanobori, E., Nakazato, H., Ohtsuka, Y., Nakanishi, Tags: Clinical Epidemiology Source Type: research

Failed Target Weight Achievement Associates with Short-Term Hospital Encounters among Individuals Receiving Maintenance Hemodialysis
Background Hospitalizations and 30-day readmissions are common in the hemodialysis population. Actionable clinical markers for near-term hospital encounters are needed to identify individuals who require swift intervention to avoid hospitalization. Aspects of volume management, such as failed target weight (i.e, estimated dry weight) achievement, are plausible modifiable indicators of impending adverse events. The short-term consequences of failed target weight achievement are not well established. Methods Statistically deidentified data were taken from a cohort of Medicare-enrolled, prevalent hemodialysis patients treated...
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Assimon, M. M., Wang, L., Flythe, J. E. Tags: Clinical Epidemiology Source Type: research

Dialysis versus Medical Management at Different Ages and Levels of Kidney Function in Veterans with Advanced CKD
Background Appropriate patient selection and optimal timing of dialysis initiation among older adults with advanced CKD are uncertain. We determined the association between dialysis versus medical management and survival at different ages and levels of kidney function. Methods We assembled a nationally representative 20% sample of United States veterans with eGFR
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Kurella Tamura, M., Desai, M., Kapphahn, K. I., Thomas, I.-C., Asch, S. M., Chertow, G. M. Tags: Clinical Epidemiology Source Type: research

Mechanisms Underlying Increased TIMP2 and IGFBP7 Urinary Excretion in Experimental AKI
Conclusions AKI-induced urinary TIMP2/IGFBP7 elevations are not due to stress-induced gene transcription. Rather, increased filtration, decreased tubule reabsorption, and proximal tubule cell TIMP2/IGFBP7 urinary leakage seem to be the most likely mechanisms. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Johnson, A. C. M., Zager, R. A. Tags: Basic Research Source Type: research

Somatic Mutations in Renal Cyst Epithelium in Autosomal Dominant Polycystic Kidney Disease
Conclusions These findings support a cellular recessive mechanism for cyst formation in ADPKD caused primarily by inactivating constitutional and somatic mutations of PKD1 or PKD2 in kidney cyst epithelium. The potential interactions of these genes with other ciliopathy- and cancer-related genes to influence ADPKD severity merits further evaluation. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Tan, A. Y., Zhang, T., Michaeel, A., Blumenfeld, J., Liu, G., Zhang, W., Zhang, Z., Zhu, Y., Rennert, L., Martin, C., Xiang, J., Salvatore, S. P., Robinson, B. D., Kapur, S., Donahue, S., Bobb, W. O., Rennert, H. Tags: Basic Research Source Type: research

GAPVD1 and ANKFY1 Mutations Implicate RAB5 Regulation in Nephrotic Syndrome
Conclusions Mutations in GAPVD1 and probably in ANKFY1 are novel monogenic causes of NS. The discovery of these genes implicates RAB5 regulation in the pathogenesis of human NS. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Hermle, T., Schneider, R., Schapiro, D., Braun, D. A., van der Ven, A. T., Warejko, J. K., Daga, A., Widmeier, E., Nakayama, M., Jobst-Schwan, T., Majmundar, A. J., Ashraf, S., Rao, J., Finn, L. S., Tasic, V., Hernandez, J. D., Bagga, A., Jalalah, S. M., Tags: Basic Research Source Type: research

The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes
Conclusions The ANLNR431C mutation causes multiple derangements in podocyte function through hyperactivation of PI3K/AKT/mTOR/p70S6K/Rac1 signaling. Our findings suggest that the benefits of calcineurin inhibition in FSGS may be due, in part, to the suppression of ANLN and mTOR. Moreover, these studies illustrate that rational therapeutic targets for familial FSGS can be identified through biochemical characterization of dysregulated podocyte phenotypes. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Hall, G., Lane, B. M., Khan, K., Pediaditakis, I., Xiao, J., Wu, G., Wang, L., Kovalik, M. E., Chryst-Stangl, M., Davis, E. E., Spurney, R. F., Gbadegesin, R. A. Tags: Basic Research Source Type: research

The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury
Conclusions We elucidated a novel mechanism that links TRPC6 activity to calpain-1 activation and through Talin-1 loss and possibly, calcineurin activation, the podocyte injury characterizing FSGS. Therefore, calpain-1 and/or TRPC6 inhibition could be future therapeutic options to treat patients with FSGS or other podocytopathies. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Verheijden, K. A. T., Sonneveld, R., Bakker-van Bebber, M., Wetzels, J. F. M., van der Vlag, J., Nijenhuis, T. Tags: Basic Research Source Type: research

A Controlled Increase in Dietary Phosphate Elevates BP in Healthy Human Subjects
Conclusions Increased phosphate intake (controlled for sodium) significantly increases SBP, DBP, and PR in humans with normal renal function, in part, by increasing sympathoadrenergic activity. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Mohammad, J., Scanni, R., Bestmann, L., Hulter, H. N., Krapf, R. Tags: Basic Research Source Type: research

Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections
Conclusions This study presents a novel and robust application of convolutional neural nets for the localization of glomeruli in healthy and damaged trichrome-stained whole-renal section mounts and lays the groundwork for automated glomerular injury scoring. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Bukowy, J. D., Dayton, A., Cloutier, D., Manis, A. D., Staruschenko, A., Lombard, J. H., Solberg Woods, L. C., Beard, D. A., Cowley, A. W. Tags: Basic Research Source Type: research

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response
Conclusions We present the first step toward incorporation of single-cell transcriptomics into kidney biopsy specimen interpretation, describe a heterogeneous immune response in mixed rejection, and provide a searchable resource for the scientific community. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Wu, H., Malone, A. F., Donnelly, E. L., Kirita, Y., Uchimura, K., Ramakrishnan, S. M., Gaut, J. P., Humphreys, B. D. Tags: Basic Research Source Type: research

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus
Conclusions Our study comprehensively characterized gene expression in individual glomerular cells and sets the stage for the dissection of glomerular function at the single-cell level in health and disease. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Karaiskos, N., Rahmatollahi, M., Boltengagen, A., Liu, H., Hoehne, M., Rinschen, M., Schermer, B., Benzing, T., Rajewsky, N., Kocks, C., Kann, M., Müller, R.-U. Tags: Rapid Communications Source Type: research

Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily
Conclusions Therapeutics developed on the basis of the mechanism of action of soluble CRIg may be effective for the treatment of C3G and should be explored clinically. (Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Wang, X., Van Lookeren Campagne, M., Katschke, K. J., Gullipalli, D., Miwa, T., Ueda, Y., Wang, Y., Palmer, M., Xing, G., Song, W.-C. Tags: Rapid Communications Source Type: research

Nephrotoxicity of Cancer Immunotherapies: Past, Present and Future
Nephrotoxicity from cancer therapies is common and increasingly encountered in clinical practice, such that the subfield of "onco-nephrology" has emerged. Conventional chemotherapeutic drugs and novel agents targeting specific genes/proteins are effective cancer therapies but suffer from a number of adverse kidney effects. An effective avenue of cancer treatment is immunotherapy, which uses drugs that augment immune system–mediated recognition and targeting of tumor cells. As such, leveraging the immune system to target malignant cells represents an important modality in eradicating cancer. IFN and high-dos...
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Perazella, M. A., Shirali, A. C. Tags: Review Source Type: research

Single-Cell Sequencing the Glomerulus, Unraveling the Molecular Programs of Glomerular Filtration, One Cell at a Time
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Kretzler, M., Menon, R. Tags: Perspective Source Type: research

Now or Later? Understanding Timing of Dialysis Initiation beyond IDEAL
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Rifkin, D. E. Tags: Editorials Source Type: research

Novel Approaches to Control of the Alternative Complement Pathway for the Treatment of C3 Glomerulopathies
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Daha, M. R., Seelen, M. Tags: Editorials Source Type: research

AI: What Have You Done for Us Lately?
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Torres, R., Olson, E. Tags: Editorials Source Type: research

Donald Seldin: A Transformative Leader in Medicine and Nephrology
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Authors: Alpern, R., Giebisch, G. Tags: Obituary Source Type: research

This Month's Highlights
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - July 31, 2018 Category: Urology & Nephrology Tags: This Month ' s Highlights Source Type: research

Erratum
(Source: Journal of the American Society of Nephrology : JASN)
Source: Journal of the American Society of Nephrology : JASN - June 29, 2018 Category: Urology & Nephrology Tags: Erratum Source Type: research