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Specialty: Urology & Nephrology
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Total 430 results found since Jan 2013.
(Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/ β-catenin pathways in glomerulonephritis.
(Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/β-catenin pathways in glomerulonephritis.
Am J Physiol Renal Physiol. 2020 Aug 24;:
Authors: Urushihara M, Kondo S, Kinoshita Y, Ozaki N, Jamba A, Nagai T, Fujioka K, Hattori T, Kagami S
Abstract
(Pro)renin receptor ((P)RR) has multiple functions, but its regulation and role in the pathogenesis in glomerulonephritis (GN) are poorly defined. The aims of this study were to determine the effects of direct renin inhibition (DRI) and demonstrate the role of (P)RR on the progression of crescentic GN. Anti-glomerular basement membrane (G...
Source: Am J Physiol Renal P... - August 23, 2020 Category: Urology & Nephrology Authors: Urushihara M, Kondo S, Kinoshita Y, Ozaki N, Jamba A, Nagai T, Fujioka K, Hattori T, Kagami S Tags: Am J Physiol Renal Physiol Source Type: research
Protein Disulfide Isomerase Inhibition Impairs Keap1/Nrf2 Signaling and Mitochondrial Function and Induces Apoptosis in Renal Proximal Tubular Cells.
Abstract
Renal proximal tubular apoptosis plays a critical role in kidney health and disease. However, cellular molecules that trigger renal apoptosis remain elusive. Here, we evaluated the effect of inhibiting protein disulfide isomerase (PDI), a critical thioredoxin chaperone protein, on apoptosis, and the underlying mechanisms in human renal proximal tubular (HK2) cells. HK2 cells were transfected with PDI specific siRNA in the absence and presence of an antioxidant tempol. PDI siRNA transfection resulted in a decrease of ~70% in PDI protein expression and enzyme activity. PDI inhibition increased caspase-3 act...
Source: Am J Physiol Renal P... - August 23, 2020 Category: Urology & Nephrology Authors: Pokkunuri ID, Lokhandwala MF, Banday AA Tags: Am J Physiol Renal Physiol Source Type: research
Role of promoting inflammation of Kr üppel-like factor 6 in acute kidney injury.
CONCLUSION: These results suggest that (1) KLF6 might be a novel biomarker for early diagnosis of AKI and (2) KLF6 may play a role in promoting inflammation in AKI.
PMID: 32698645 [PubMed - in process]
Source: Renal Failure - July 24, 2020 Category: Urology & Nephrology Tags: Ren Fail Source Type: research
‘Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway’
ConclusionsThis is the first evidence that SNAI1 and SNAI2 are involved in human spermatogenesis, with independent functions. These outcomes demonstrate that SNAI1 and SNAI2 inhibition leads to loss of migratory and viability capacities in seminoma cells. These findings show the potential for therapeutic treatments targeting SNAIL or BMP4 signalling for patients with metastatic testicular germ cell tumours.
Source: Andrology - June 11, 2020 Category: Urology & Nephrology Authors: Diana J. Micati,
Karthika Radhakrishnan,
Julia C. Young,
Ewa Rajpert ‐De Meyts,
Gary R. Hime,
Helen E. Abud,
Kate L. Loveland Tags: ORIGINAL ARTICLE Source Type: research
Apalutamide in combination with autophagy inhibitors improves treatment effects in prostate cancer cells.
CONCLUSIONS: These data demonstrate that treatment with ARN-509 leads to increased autophagy levels in LNCaP cells. Furthermore, in combination with autophagy inhibitors, ARN-509 provided a significantly elevated antitumor effect, thus providing a new therapeutic approach potentially translatable to patients.
PMID: 32466878 [PubMed - as supplied by publisher]
Source: Urologic Oncology - May 24, 2020 Category: Urology & Nephrology Authors: Eberli D, Kranzbühler B, Mortezavi A, Sulser T, Salemi S Tags: Urol Oncol Source Type: research
Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway
ConclusionsThis is the first evidence that SNAI1 and SNAI2 are involved in human spermatogenesis, with independent functions. These outcomes demonstrate that SNAI1 and SNAI2 inhibition leads to loss of migratory and viability capacities in seminoma cells. These findings show the potential for therapeutic treatments targeting SNAIL or BMP4 signalling for patients with metastatic testicular germ cell tumours.
Source: Andrology - May 21, 2020 Category: Urology & Nephrology Authors: Diana J. Micati,
Karthika Radhakrishnan,
Julia C. Young,
Ewa Rajpert ‐De Meyts,
Gary R. Hime,
Helen E. Abud,
Kate L. Loveland Tags: ORIGINAL ARTICLE Source Type: research
The contrasting roles of Dysferlin during tumor progression in renal cell carcinoma.
CONCLUSION: DYSF mRNA and protein expression are opposingly involved in tumor progression of ccRCC. DYSF could be used as a prognostic biomarker to predict survival of patients with ccRCC.
PMID: 32430251 [PubMed - as supplied by publisher]
Source: Urologic Oncology - May 16, 2020 Category: Urology & Nephrology Authors: Cox A, Zhao C, Tolkach Y, Nettersheim D, Schmidt D, Kristiansen G, Hauser S, Müller SC, Ritter M, Ellinger J Tags: Urol Oncol Source Type: research
Ablation of Gsa impairs renal tubule proliferation after injury via CDK2/Cyclin E.
In conclusion, Gsa is required for tubular epithelial cell regeneration during kidney repair after AKI. The loss of Gsa impairs renal tubular epithelial cell regeneration by blocking the Raf-MEK-ERK pathway.
PMID: 32036696 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - February 9, 2020 Category: Urology & Nephrology Authors: Liu L, Deng Y, Cai Y, Lu P, Guo Y, Zhang C, Li Q, Zhang T, Han M, Xu G Tags: Am J Physiol Renal Physiol Source Type: research
High glucose and TGF- β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells.
High glucose and TGF-β1 reduce expression of endoplasmic reticulum-resident selenoprotein S and selenoprotein N in human mesangial cells.
Ren Fail. 2019 Nov;41(1):762-769
Authors: Huang F, Guo Y, Wang L, Jing L, Chen Z, Lu S, Fu R, Tian L
Abstract
There are seven endoplasmic reticulum (ER)-resident selenoproteins in human body and they can regulate the inflammation, oxidative stress, and ER stress. We established transforming growth factor-β1 (TGF-β1) or high glucose (HG) induced human mesangial cells (HMCs) fibronectin expression model in vitro. Next, the expression changes of seven ER-resident sel...
Source: Renal Failure - December 29, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Cholesterol accumulation, lipid droplet formation, and steroid production in Leydig cells: Role of translocator protein (18 ‐kDa)
ConclusionThese results support the conclusion that FGIN ‐1‐27 stimulates steroid formation by increasing TSPO‐mediated cholesterol translocation into the inner mitochondria for steroidogenesis, as well as into the cytosol for lipid droplet formation. FGIN‐1‐27 also increased steroid formation at least in part by inducing the conversion of chole steryl ester located in lipid droplets to cholesterol, thus making available more substrate for steroid formation.
Source: Andrology - December 8, 2019 Category: Urology & Nephrology Authors: Jin ‐Yong Chung,
Haolin Chen,
Vassilios Papadopoulos,
Barry Zirkin Tags: ORIGINAL ARTICLE Source Type: research
Cholesterol Accumulation, Lipid Droplet Formation and Steroid Production in Leydig Cells: Role of Translocator Protein (18 ‐kDa)
ConclusionThese results support the conclusion that FGIN ‐1‐27 stimulates steroid formation by increasing TSPO‐mediated cholesterol translocation into the inner mitochondria for steroidogenesis, as well as into the cytosol for lipid droplet formation. FGIN‐1‐27 also increased steroid formation at least in part by inducing the conversion of chole steryl ester located in lipid droplets to cholesterol, thus making available more substrate for steroid formation.
Source: Andrology - November 17, 2019 Category: Urology & Nephrology Authors: Jin ‐Yong Chung,
Haolin Chen,
Vassilios Papadopoulos,
Barry Zirkin Tags: ORIGINAL ARTICLE Source Type: research
The miR-15a-5p-XIST-CUL3 regulatory axis is important for sepsis-induced acute kidney injury.
Conclusion: The miR-15a-5p-XIST-CUL3 regulatory axis was related to the pathogenesis of sepsis-induced AKI. Highlights Totally, 31 miRNAs were dysregulated between disease and control groups. MiR-15a-5p, miR-15b-5p, and miR-16-5p were involved in mTOR signaling pathway. MiR-16-5p and miR-29b-3p were implicated in PI3K-Akt signaling pathway. The miR-15a-5p-XIST-CUL3 axis was critical for sepsis-induced AKI.
PMID: 31658856 [PubMed - in process]
Source: Renal Failure - October 30, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research
The inhibition of Nrf2 accelerates renal lipid deposition through suppressing the ACSL1 expression in obesity-related nephropathy.
Conclusions: The Nrf2 is inhibited in ORN, resulting more ROS production and oxidative stress. Increased oxidative stress will suppress the expression of ACSL1, which could increase the intracellular FFA and TG contents, ultimately leading to renal lipid deposition in renal tubulars and accelerating the development of ORN.
PMID: 31488013 [PubMed - in process]
Source: Renal Failure - September 7, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research
MAL protein stabilizes luminal membrane PLC β3 and negatively regulates ENaC in mouse cortical collecting duct cells.
MAL protein stabilizes luminal membrane PLCβ3 and negatively regulates ENaC in mouse cortical collecting duct cells.
Am J Physiol Renal Physiol. 2019 Jul 31;:
Authors: Tuna KM, Liu BC, Yue Q, Ghazi ZM, Ma HP, Eaton DC, Alli AA
Abstract
Abnormally high epithelial sodium channel (ENaC) activity in the aldosterone sensitive distal nephron and collecting duct leads to hypertension. Mal is a lipid-raft-associated protein that has been previously shown to regulate NKCC2 (Na-K -2Cl co-transporter) and aquaporin-2 in the kidney, but it is not known whether it regulates renal ENaC. ENaC activity is positively...
Source: Am J Physiol Renal P... - July 30, 2019 Category: Urology & Nephrology Authors: Tuna KM, Liu BC, Yue Q, Ghazi ZM, Ma HP, Eaton DC, Alli AA Tags: Am J Physiol Renal Physiol Source Type: research
p53-cyclophilin D mediates renal tubular cell apoptosis in ischemia-reperfusion-induced acute kidney injury.
Abstract
Ischemia-reperfusion-induced acute kidney injury (IR-AKI) favors mitochondrial permeability transition pore (mPTP) opening and subsequent cell death. Cyclophilin D (CypD) is an essential component of the mPTP, and recent findings implicate the p53-CypD complex in cell death. To evaluate the role of p53-CypD following IR-AKI, we tested the hypothesis that the p53-CypD complex mediates renal tubular cell apoptosis in IR-AKI via mPTP opening. The expression of p53 and cleaved caspase-3 was significantly increased in rats subjected to IR-AKI compared with the normal control and sham-operated control. The unde...
Source: Am J Physiol Renal P... - July 23, 2019 Category: Urology & Nephrology Authors: Yang H, Li R, Zhang L, Zhang S, Dong W, Chen Y, Wang W, Li C, Ye Z, Zhao X, Li Z, Wu Y, Zhang M, Liu S, Dong Z, Liang X Tags: Am J Physiol Renal Physiol Source Type: research
