‘Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway’

ConclusionsThis is the first evidence that SNAI1 and SNAI2 are involved in human spermatogenesis, with independent functions. These outcomes demonstrate that SNAI1 and SNAI2 inhibition leads to loss of migratory and viability capacities in seminoma cells. These findings show the potential for therapeutic treatments targeting SNAIL or BMP4 signalling for patients with metastatic testicular germ cell tumours.

Source: Andrology - June 11, 2020 Category: Urology & Nephrology Authors: Diana J. Micati, Karthika Radhakrishnan, Julia C. Young, Ewa Rajpert ‐De Meyts, Gary R. Hime, Helen E. Abud, Kate L. Loveland Tags: ORIGINAL ARTICLE Source Type: research