Ablation of Gsa impairs renal tubule proliferation after injury via CDK2/Cyclin E.

In conclusion, Gsa is required for tubular epithelial cell regeneration during kidney repair after AKI. The loss of Gsa impairs renal tubular epithelial cell regeneration by blocking the Raf-MEK-ERK pathway.
PMID: 32036696 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - February 9, 2020 Category: Urology & Nephrology Authors: Liu L, Deng Y, Cai Y, Lu P, Guo Y, Zhang C, Li Q, Zhang T, Han M, Xu G Tags: Am J Physiol Renal Physiol Source Type: research