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Safety concerns of herbal products and traditional Chinese herbal medicines: dehydropyrrolizidine alkaloids and aristolochic acid - Stegelmeier BL, Brown AW, Welch KD.
In many countries, including the United States, herbal supplements, tisanes and vegetable products, including traditional Chinese medicines, are largely unregulated and their content is not registered, monitored or verified. Consequently, potent plant toxi... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 22, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Herbs and hazards: risk of Aristolochic acid nephropathy in Iran - Ardalan MR, Khodaie L, Nasri H, Jouyban A.
Herbs are usually considered as inherently harmless products. Nonetheless, various renal injuries have been reported in association with several herbs. The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. Aristolochic acid i... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 24, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

The connection between kidney cancer and the use of aristolochic acid
There is aan apparent link between exposure to aristolochic acid and incidence of kidney cancer, particularly in Romania.10/30/2014 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - October 30, 2014 Category: Cancer & Oncology Source Type: news

Study sheds light on genetic architecture of kidney cancer
(McGill University) A new study on a large cohort of kidney cancer patients in Europe sheds light on the genetic architecture of the disease -- and reveals an apparent link between exposure to aristolochic acid and incidence of kidney cancer, particularly in Romania. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2014 Category: Cancer & Oncology Source Type: news

Kidney cancer in Central Europe
(European Molecular Biology Laboratory) Large-scale DNA and RNA sequencing of renal cell carcinoma patients in Europe reveals primary causes of kidney cancer vary between populations. Findings provide insights into the genetic architecture of clear-cell renal-cell carcinoma. Association between cancer incidence and exposure to aristolochic acid -- an ingredient in some herbal remedies -- has implications for public health, particularly in Romania. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2014 Category: Cancer & Oncology Source Type: news

A renaissance in herbal medicine identification: from morphology to DNA - Chen S, Pang X, Song J, Shi L, Yao H, Han J, Leon C.
Numerous adverse reactions have arisen following the use of inaccurately identified medicinal plant ingredients, resulting in conditions such as aristolochic acid nephropathy and herb-induced poisoning. This problem has prompted increased global concern ov... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 8, 2014 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Scientists unravel cancers linked to herbal remedies
A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid...08/15/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - August 15, 2013 Category: Cancer & Oncology Source Type: news

Scientists unravel cancers linked to herbal remedies containing Aristolochic Acid, a natural compound found in Aristolochia plants
A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid (AA), a natural product of Aristolochia plants traditionally used in some Asian herbal remedies for weight loss and slimming... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 14, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Geneticists confirm herbal remedy carcinogen
In a study that identifies the striking genetic changes caused by a herb compound, scientists have found a direct link between aristolochic acid - used in a traditional herbal remedy - and upper urinary tract cancers. The researchers say their findings also show the power of genome-wide sequencing, the method they used to find the compound's mutation signature, to spot individual exposure to carcinogens. They write about their work in an August 7th online issue of Science Translational Medicine... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 12, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Singapore scientists unravel cancers linked to herbal remedies
(SingHealth) A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid, a natural product of Aristolochia plants traditionally used in some Asian herbal remedies for weight loss and slimming. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 12, 2013 Category: Global & Universal Source Type: news

Birthwort herb implicated in upper urinary tract cancers
Genomic sequencing experts at Johns Hopkins partnered with pharmacologists at Stony Brook University to reveal a striking mutational signature of upper urinary tract cancers caused by aristolochic acid, a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments such as arthritis, gout and inflammation. Their discovery is described in the journal Science Translational Medicine. Aristolochic [pronounced a-ris-to-lo-kik] acid is found in the plant family "Aristolochia," a vine known widely as birthwort, and while the U.S... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 9, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Scientists use genome sequencing to prove herbal remedy causes upper urinary tract cancers
(Johns Hopkins Medicine) Genomic sequencing experts at Johns Hopkins partnered with pharmacologists at Stony Brook University to reveal a striking mutational signature of upper urinary tract cancers caused by aristolochic acid, a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments such as arthritis, gout and inflammation. Their discovery is described in the Aug. 7 issue of Science Translational Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 7, 2013 Category: Global & Universal Source Type: news