Macroscopic somatic clonal expansion in morphologically normal human urothelium
In this study, we investigated somatic clonal events in morphologically normal human urothelium (MNU; epithelium lining the bladder and ureter) and identified macroscopic clonal expansions. Aristolochic acid (AA), a natural herb-derived compound, was a major mutagenic driving factor in MNU. AA drastically accelerates mutation accumulation and enhances clonal expansion. Mutations in MNU were widely observed in chromatin remodeling genes such as KMT2D and KDM6A but rarely in TP53, PIK3CA, and FGFR3. KMT2D mutations were found to be common in urothelial cells, regardless of whether the cells experience exogenous mutagen expos...
Source: ScienceNOW - September 30, 2020 Category: Science Authors: Li, R., Du, Y., Chen, Z., Xu, D., Lin, T., Jin, S., Wang, G., Liu, Z., Lu, M., Chen, X., Xu, T., Bai, F. Tags: Genetics, Medicine, Diseases r-articles Source Type: news
The toxicity and safety of traditional Chinese medicines: please treat with rationality - Cai P, Qiu H, Qi F, Zhang X.
For a long time, many people have believed that traditional Chinese medicines (TCMs) are safe because they derive from natural products. However, this belief has been greatly challenged in recent years especially after some reports on aristolochic acid inv... (Source: SafetyLit)
Source: SafetyLit - October 2, 2019 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
Herb Tied to'Remarkable' Number of Liver Cancers in Asia Herb Tied to'Remarkable' Number of Liver Cancers in Asia
Aristolochic acid, an herbal compound found in many traditional medicines that has been previously linked to kidney failure and urinary tract cancers, is now implicated in liver cancer.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 25, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Traditional Chinese medicine could cause liver cancer
Scientists said the danger stems from chemicals called aristolochic acids, derived from the woody vines of Aristolochia plants. The report was published in Science Translational Medicine. (Source: the Mail online | Health)
Source: the Mail online | Health - October 19, 2017 Category: Consumer Health News Source Type: news
Scientists reveal herbal remedies containing aristolochic acid may cause liver cancer
(Duke-NUS Medical School) Mutational signatures reveal high burdens of AA-related mutations in Asian liver cancers, with Taiwan most intensely affected. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 18, 2017 Category: Cancer & Oncology Source Type: news
Safety concerns of herbal products and traditional Chinese herbal medicines: dehydropyrrolizidine alkaloids and aristolochic acid - Stegelmeier BL, Brown AW, Welch KD.
In many countries, including the United States, herbal supplements, tisanes and vegetable products, including traditional Chinese medicines, are largely unregulated and their content is not registered, monitored or verified. Consequently, potent plant toxi... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 22, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Herbs and hazards: risk of Aristolochic acid nephropathy in Iran - Ardalan MR, Khodaie L, Nasri H, Jouyban A.
Herbs are usually considered as inherently harmless products. Nonetheless, various renal injuries have been reported in association with several herbs. The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. Aristolochic acid i... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 24, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
The connection between kidney cancer and the use of aristolochic acid
There is aan apparent link between exposure to aristolochic acid and incidence of kidney cancer, particularly in Romania.10/30/2014 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - October 30, 2014 Category: Cancer & Oncology Source Type: news
Kidney cancer in Central Europe
(European Molecular Biology Laboratory) Large-scale DNA and RNA sequencing of renal cell carcinoma patients in Europe reveals primary causes of kidney cancer vary between populations. Findings provide insights into the genetic architecture of clear-cell renal-cell carcinoma. Association between cancer incidence and exposure to aristolochic acid -- an ingredient in some herbal remedies -- has implications for public health, particularly in Romania. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2014 Category: Cancer & Oncology Source Type: news
Study sheds light on genetic architecture of kidney cancer
(McGill University) A new study on a large cohort of kidney cancer patients in Europe sheds light on the genetic architecture of the disease -- and reveals an apparent link between exposure to aristolochic acid and incidence of kidney cancer, particularly in Romania. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2014 Category: Cancer & Oncology Source Type: news
A renaissance in herbal medicine identification: from morphology to DNA - Chen S, Pang X, Song J, Shi L, Yao H, Han J, Leon C.
Numerous adverse reactions have arisen following the use of inaccurately identified medicinal plant ingredients, resulting in conditions such as aristolochic acid nephropathy and herb-induced poisoning. This problem has prompted increased global concern ov... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 8, 2014 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Scientists unravel cancers linked to herbal remedies
A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid...08/15/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - August 15, 2013 Category: Cancer & Oncology Source Type: news
Scientists unravel cancers linked to herbal remedies containing Aristolochic Acid, a natural compound found in Aristolochia plants
A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid (AA), a natural product of Aristolochia plants traditionally used in some Asian herbal remedies for weight loss and slimming... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 14, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Geneticists confirm herbal remedy carcinogen
In a study that identifies the striking genetic changes caused by a herb compound, scientists have found a direct link between aristolochic acid - used in a traditional herbal remedy - and upper urinary tract cancers. The researchers say their findings also show the power of genome-wide sequencing, the method they used to find the compound's mutation signature, to spot individual exposure to carcinogens. They write about their work in an August 7th online issue of Science Translational Medicine... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 12, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Singapore scientists unravel cancers linked to herbal remedies
(SingHealth) A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid, a natural product of Aristolochia plants traditionally used in some Asian herbal remedies for weight loss and slimming. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 12, 2013 Category: Global & Universal Source Type: news
