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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Correlations between forkhead box D1 expression and clinicopathological characteristics of patients with bladder cancer and influence on biological behaviors of bladder cancer cells
CONCLUSIONS: FOXD1 is highly expressed in bladdercancer tissues and cells, being closely associatedwith the development and progression of bladder cancer.It facilitates the proliferation, migration and invasionof cells and carcinogenesis. FOXD1 may be a newtarget for bladder cancer therapy.PMID:35435161
Source: Archivos Espanoles de Urologia - April 18, 2022 Category: Urology & Nephrology Authors: Fuke Wang Junfeng Yang Source Type: research

Requirement of Na+/H+ exchanger NHE1 for vasopressin-induced osteogenic signaling and calcification in human aortic smooth muscle cells
Conclusion: Vasopressin stimulates NHE1 expression and ROS generation, an effect dependent on SGK1 and required for vasopres sin-induced stimulation of osteogenic signaling and calcification of VSMCs.
Source: Kidney and Blood Pressure Research - March 25, 2022 Category: Urology & Nephrology Source Type: research

Endoplasmic reticulum stress mediates parathyroid hormone-induced apoptosis in vascular smooth muscle cells
Ren Fail. 2022 Dec;44(1):126-136. doi: 10.1080/0886022X.2022.2027248.ABSTRACTVascular calcification is one of the most common complications of chronic kidney disease (CKD), which is closely associated with increased mortality and morbidity rates of CKD patients. It has been reported that increased parathyroid hormone (PTH) aggravates vascular calcification in CKD patients. However, the direct role of PTH in vascular smooth muscle cells (VSMCs) is less elucidated. Here, we present evidence that PTH promotes apoptosis of VSMCs and endoplasmic reticulum (ER) stress participates in this process. Human aorta vascular smooth mus...
Source: Renal Failure - February 17, 2022 Category: Urology & Nephrology Authors: Shuzhong Duan Xinpan Chen Yingjie Liu Weikang Guo Wenhu Liu Source Type: research

Role of (Pro)Renin Receptor in Cyclosporin A-Induced Nephropathy
Am J Physiol Renal Physiol. 2022 Jan 24. doi: 10.1152/ajprenal.00332.2021. Online ahead of print.ABSTRACTCalcineurin inhibitors (CNIs) such as cyclosporin A (CsA) have been widely used to improve graft survival following solid-organ transplantation. However, the clinical use of CsA is often limited by its nephrotoxicity. The present study tested the hypothesis that activation of (pro)renin receptor (PRR) contributes to CsA-induced nephropathy by activating the renin-angiotensin system (RAS). Renal injury in male Sprague-Dawley rats was induced by a low-salt diet combined with CsA as evidenced by elevated plasma creatinine ...
Source: Am J Physiol Renal P... - January 24, 2022 Category: Urology & Nephrology Authors: Jiajia Hu Yandan Tan Yanting Chen Shiqi Mo Brittin Hekking Jiahui Su Min Pu Aihua Lu J David Symons Tianxin Yang Source Type: research