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Specialty: Urology & Nephrology
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Total 430 results found since Jan 2013.
Synbindin Downregulation Participates in Slit Diaphragm Dysfunction
CONCLUSION: Synbindin participates in maintaining foot processes and slit diaphragm as a downstream molecule of SV2B-mediated vesicle transport. Synbindin downregulation participates in slit diaphragm dysfunction. Synbindin can be an early marker to detect podocyte injury.PMID:34515036 | DOI:10.1159/000517975
Source: American Journal of Nephrology - September 13, 2021 Category: Urology & Nephrology Authors: Veniamin Ivanov Yoshiyasu Fukusumi Ying Zhang Hidenori Yasuda Meiko Kitazawa Hiroshi Kawachi Source Type: research
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury
Am J Physiol Renal Physiol. 2021 Aug 2. doi: 10.1152/ajprenal.00673.2020. Online ahead of print.ABSTRACTThe relevance of primary cilia shortening in kidney disease and its pathomechanism are largely unknown. Tubular damage in acute kidney injury (AKI) is strongly associated with mitochondrial dysfunction. Thus, we investigated the interaction between primary cilia and mitochondria in cisplatin-induced AKI mouse models. We observed that the expression of intraflagellar transport 88 (IFT88), a ciliary maintenance protein, was decreased in the renal cortex following tubular damage due to cisplatin-induced AKI. This result was...
Source: Am J Physiol Renal P... - August 2, 2021 Category: Urology & Nephrology Authors: Rie Fujii Sho Hasegawa Hiroshi Maekawa Tsuyoshi Inoue Kentaro Yoshioka Rie Uni Yoichiro Ikeda Masaomi Nangaku Reiko Inagi Source Type: research
Actin-related protein (Arp) 2/3 complex plays a critical role in the aquaporin-2 exocytotic pathway
Am J Physiol Renal Physiol. 2021 Jun 28. doi: 10.1152/ajprenal.00015.2021. Online ahead of print.ABSTRACTThe trafficking of proteins such as aquaporin-2 (AQP2) in the exocytotic pathway requires an active actin cytoskeleton network, but the mechanism is incompletely understood. Here, we show that the actin-related protein (Arp) 2/3 complex, a key factor in actin filament branching and polymerization, is involved in the shuttling of aquaporin-2 (AQP2) between the trans Golgi network (TGN) and the plasma membrane. Arp2/3 inhibition (using CK-666) or siRNA knockdown blocks vasopressin induced AQP2 membrane accumulation, and i...
Source: Am J Physiol Renal P... - June 28, 2021 Category: Urology & Nephrology Authors: Chen-Chung Steven Liu Pui W Cheung Anupama Dinesh Noah Baylor Theodor C Paunescu Anil V Nair Richard Bouley Dennis Brown Source Type: research
