Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma

CONCLUSIONS: The present study confirms over-expression of CA9 in UC and for the first time shows a correlation with molecular subtypes. However, CA9 expression showed no association with the outcome of patients with muscle invasive bladder cancer and inhibition of CA9 did not lead to a consistent inhibition of tumor growth. Based on these data, CA9 exhibits a role neither as a predictive or prognostic marker nor as a therapeutic target in invasive UC.PMID:34083096 | DOI:10.1016/j.urolonc.2021.04.011

Source: Urologic Oncology - June 4, 2021 Category: Urology & Nephrology Authors: Tilman Todenh öfer Ewan A Gibb Roland Seiler Alireza Kamyabi J örg Hennenlotter Paul McDonald Igor Moskalev Craig Stewart Jian Gao Ladan Fazli Shoukat Dedhar Arnulf Stenzl Htoo Zarni Oo Peter C Black Source Type: research