Cyclophilin A/CD147 signaling induces the epithelial-to-mesenchymal transition and renal fibrosis in chronic allograft dysfunction by regulating p38 MAPK signaling

CONCLUSIONS: Our study reported the positive relationship of CyPA-CD147 signaling with renal allograft dysfunction. The in vitro study suggested that CyPA-CD147 signaling induce the development of the EMT process by p38 MAPK signaling, thus contributing to renal allograft fibrosis and CAD.PMID:36203223 | DOI:10.1080/0886022X.2022.2126788

Source: Renal Failure - October 6, 2022 Category: Urology & Nephrology Authors: Xuzhong Liu Zhiwang Tang Xi Jiang Tianwei Wang Lun Zhao Zongyuan Xu Kun Liu Source Type: research