Letters Published in the June Issue.
Authors: Moon HS PMID: 32615670 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Robotic Sacrocolpopexy for Treatment of Apical Compartment Prolapse.
Authors: Ko KJ, Lee KS Abstract Abdominal sacrocolpopexy is the gold-standard treatment for apical compartment prolapse, as it is more effective and durable than the transvaginal approach. In the current era of minimally invasive surgery, laparoscopic sacrocolpopexy techniques have been described, but have not gained popularity due to their complexity and steep learning curves. To overcome this problem, robotic sacrocolpopexy was introduced, and has shown equivalent outcomes and safety compared to open and laparoscopic sacrocolpopexy based on findings that have been accumulated over 15 years. PMID: 32615671 [Pu...
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Management of Urinary Incontinence With Underactive Bladder: A Review.
Authors: Cho KJ, Kim JC Abstract Urinary incontinence is caused by storage function failure, while underactive bladder (UAB) is caused by a decline in detrusor contractility and voiding dysfunction. As the treatment mechanisms for incontinence and UAB are contrary to each other, it is difficult to treat both incontinence and UAB, and the patient's quality of life can be further degraded. Conventional midurethral sling (MUS), such as transobturator tape or retropubic MUS, introduces a risk of postoperative voiding dysfunction in stress urinary incontinence with UAB. However, there have been several reports about the...
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Managing Urological Disorders in Multiple Sclerosis Patients: A Review of Available and Emerging Therapies.
Authors: Bientinesi R, Gandi C, Bassi P Abstract Multiple sclerosis (MS) is a progressive neurological autoimmune disease with a diverse range of urological symptomatology, and most MS patients experience 1 or more moderate to severe urinary symptoms, as well as bladder and/or sexual disorders. Urologists play the director's role in evaluating and treating these patients. Therefore, identifying the proper evaluation tools and the most suitable therapeutic options for specific patients requires a thorough understanding of this disease process. PMID: 32615673 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Differential Effects of Alpha 1-Adrenoceptor Antagonists on the Postsynaptic Sensitivity: Using Slice Patch-Clamp Technique for Inhibitory Postsynaptic Current in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats.
CONCLUSION: Naftopidil-induced GABA/glycine-mediated outward currents in a subset of SG neurons prepared from the L6- S1 level of rat spinal cord. The results indicated that α1-adrenoceptor antagonists, particularly naftopidil, induce neural suppression (in part) by mediating hyperpolarization. The response is associated with glycinergic and/or GABAergic neural transmission. Naftopidil may suppress the micturition reflex and improve urinary storage symptoms as a subsidiary effect resulting from hyperpolarization in SG neurons of the spinal cord. PMID: 32615674 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Effect of Alpha 1-Adrnoceptor Antagonists on Postsynaptic Sensitivity in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats Using Slice Patch-Clamp Technique for mEPSC.
CONCLUSION: Alpha1-adrenoceptor antagonists changed the amplitudes of mEPSCs in a subset of SG neurons in slices prepared from the L6-S1 levels of rat spine. Although the α1-adrenoceptor antagonists generated inward or outward currents in the SG neurons, different rates of response were observed with each antagonist. These results are important for understanding the mechanisms of action (at the spinal level) of α1-adrenoceptor antagonists for the storage symptoms of male LUTS. PMID: 32615675 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Repetitive Transcranial Magnetic Stimulation for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Prospective Pilot Study.
CONCLUSION: rTMS for patients with CP/CPPS seemed to be well tolerated, at least moderately effective in pain reduction, and might be of interest in patients with chronic pelvic pain resistant to conventional treatment. These findings remain to be confirmed by a randomized trial. PMID: 32615676 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Is There a Correlation Between Beh ├žet Disease and Lower Urinary Tract Symptoms?
CONCLUSION: LUTS were highly prevalent in patients with BD, and the severity and current activity of BD were correlated with frequency, nocturia, urgency, and urinary incontinence. Therefore, a urological evaluation of patients with BD in whom the activity and severity of the disease is elevated should be carried out comprehensively and patients should be managed accordingly. PMID: 32615677 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Daily Pad Usage Versus the International Consultation on Incontinence Questionnaire Short Form for Continence Assessment Following Radical Prostatectomy.
Authors: Tienza A, Graham PL, Robles JE, Diez-Caballero F, Rosell D, Pascual JI, Patel MI, Mungovan SF Abstract PURPOSE: Continence assessment is an essential component of follow-up after radical prostatectomy (RP). Several methods exist to assess the severity of urinary incontinence (UI). Our study examined the relationship and degree of agreement between International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) scores and the number of pads used in a 24-hour period in the assessment of UI following RP. METHODS: Continence was prospectively assessed in 746 men from a Spanish urology clinic ...
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Efficacy and Safety of Naftopidil in Patients With Neurogenic Lower Urinary Tract Dysfunction: An 8-Week, Active-Controlled, Stratified-Randomized, Double-Blind, Double-Dummy, Parallel Group, Noninferiority, Multicenter Design.
This study was conducted as an 8-week, active-controlled, stratified-randomized, double-blind, double-dummy, parallel group, noninferiority, and multicenter clinical trial. After 2 weeks of screening, eligible subjects were randomly assigned to receive naftopidil (25 mg for 1 week followed by 75 mg for 7 weeks) or tamsulosin (0.2 mg for 8 weeks). Primary endpoint was a change of International Prostatic Symptom Score (IPSS) total score after 8 weeks of treatment. RESULTS: One hundred ninety-four subjects with neurogenic LUTD were included into this trial. There were no differences between the 2 groups in baseline charac...
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Clinical Factors Associated With the Feeling of Incomplete Bladder Emptying in Women With Little Postvoided Residue.
CONCLUSION: Female patients with the feeling of incomplete emptying who have insignificant PVR volume exhibited severe voiding symptoms and low quality of life. The treatment strategy should be focused on improving the minimum volume of voids and shortening the time to Qmax. PMID: 32615680 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Equality, Inclusion, and Diversity in Healthcare During the COVID-19 Pandemic.
Authors: Kim J PMID: 32615681 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Commentary on "The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method".
Commentary on "The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method". Int Neurourol J. 2020 Jun;24(2):182-184 Authors: Lee SJ PMID: 32615682 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Commentary on "Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials".
Commentary on "Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials". Int Neurourol J. 2020 Jun;24(2):185-186 Authors: Beloy IC, González MG, Argibay IS PMID: 32615683 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Reply to Commentary on "Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials".
Reply to Commentary on "Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials". Int Neurourol J. 2020 Jun;24(2):187-188 Authors: Zhou Z, Cui Y PMID: 32615684 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Neural Repair and Tissue Regeneration.
Authors: Kim CJ PMID: 32482051 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Stem Cell Therapy for Neurogenic Bladder After Spinal Cord Injury: Clinically Possible?
Authors: Kim SJ, Cho YS, Park JM, Na YG, Kim KH Abstract Neurogenic bladder (NB) after spinal cord injury (SCI) is a common complication that inhibits normal daily activities and reduces the quality of life. Regrettably, the current therapeutic methods for NB are inadequate. Therefore, numerous studies have been conducted to develop new treatments for NB associated with SCI. Moreover, a myriad of preclinical and clinical trials on the effects and safety of stem cell therapy in patients with SCI have been performed, and several studies have demonstrated improvements in urodynamic parameters, as well as in sensory an...
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Dexmedetomidine Improves Locomotor Function and Alleviates Thermal Hyperalgesia Following Sciatic Nerve Crush Injury in Rats.
CONCLUSION: Dexmedetomidine may be used as a potential new treatment drug for recovery of locomotion and control of pain in peripheral nerve injury. PMID: 32482053 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Cdk5 Phosphorylation of STAT3 in Dorsal Root Ganglion Neurons Is Involved in Promoting Axonal Regeneration After Peripheral Nerve Injury.
CONCLUSION: Our study demonstrated that Cdk5 activity induced from DRG neurons after SNI increased phosphorylation of STAT3. The activation of Cdk5-STAT3 pathway may be involved in promoting axonal regeneration in the peripheral nerve after injury. PMID: 32482054 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Treadmill Exercise Improves Motor Function and Short-term Memory by Enhancing Synaptic Plasticity and Neurogenesis in Photothrombotic Stroke Mice.
CONCLUSION: Treadmill exercise improved motor function and short-term memory through increasing synaptic plasticity and neurogenesis in photothrombotic stroke mice. Treadmill exercise can be used as an effective treatment strategy to improve brain function related to stroke. PMID: 32482055 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Swimming Exercise Ameliorates Symptoms of MOG-Induced Experimental Autoimmune Encephalomyelitis by Inhibiting Inflammation and Demyelination in Rats.
CONCLUSION: The results of this experiment suggest the possibility of swimming exercise in urological diseases that are difficult to treat. Swimming exercises can be considered for relief of symptom in incurable multiple sclerosis. PMID: 32482056 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Effect of Glycyrrhizic Acid on Scopolamine-Induced Cognitive Impairment in Mice.
CONCLUSION: Our results suggest that glycyrrhizic acid has a neuroprotective effect on cognitive function in scopolamine-induced cognitive impairment. PMID: 32482057 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Combination Therapy With Polydeoxyribonucleotide and Pirfenidone Alleviates Symptoms of Acute Respiratory Distress Syndrome in Human Lung Epithelial A549 Cells.
CONCLUSION: The combination therapy with PDRN and pirfenidone exerted stronger therapeutic effect against lipopolysaccharide and TGF-β-induced ARDS environment compared to the PDRN monotherapy or pirfenidone monotherapy. The excellent therapeutic effect of combination therapy with PDRN and pirfenidone on ARDS was shown by promoting the rapid anti-inflammatory effect and inhibiting the fibrotic processes. PMID: 32482058 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - June 4, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Covid-19.
COVID-19. Int Neurourol J. 2020 Mar;24(1):1 Authors: Kim KH PMID: 32252179 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Improvement Based on Conventional Wisdom and New Idea.
Authors: Kim SJ PMID: 32252180 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Underactive Bladder; Review of Progress and Impact From the International CURE-UAB Initiative.
Authors: Chancellor MB, Bartolone SN, Lamb LE, Ward E, Zwaans BMM, Diokno A Abstract There is a significant need for research and understanding of underactive bladder (UAB). The International Congress of Urologic Research and Education on Aging UnderActive Bladder (CURE-UAB) was organized by Doctors Michael Chancellor and Ananias Diokno in order to address these concerns. CURE-UAB was supported, in part, by the US National Institute of Aging and National Institute of Diabetes Digestive and Kidney. Since 2014, there have been 5 successful CURE-UAB congresses. They have brought together diverse stakeholders in the UA...
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Robotic Simple Prostatectomy: Why and How?
In conclusion, RSP can be recommended as a safe and effective minimally invasive treatment for large BPH. PMID: 32252182 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Effect of the Sodium-Glucose Cotransporter 2 Inhibitor, Dapagliflozin, on Genitourinary Infection in an Animal Model of Type 2 Diabetes.
Authors: Choi JB, Yoo JM, Lee YJ, Kim JW, Lee SJ, Kim HY, Lee DS, Ko SH, Choe HS Abstract PURPOSE: To investigate the effect of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, on inflammatory cytokines of urogenital tissue in a rat model of type 2 diabetes (T2DM) to infer pharmaceutical influence of dapagliflozin on genitourinary infection or inflammation. METHODS: Study animals were divided into the following 4 groups of 10 animals each: (1) the Otsuka Long-Evans Tokushima Fatty (OLETF)-DA group treated with dapagliflozin at 1.0 mg/kg/day, (2) the OLETF-VO group treated with voglibose at 0.6 mg/kg/d...
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Pioglitazone Alters the Proteomes of Normal Bladder Epithelial Cells but Shows No Tumorigenic Effects.
Authors: Shahid M, Kim M, Yeon A, Jin P, Kim WK, You S, Kim J Abstract PURPOSE: Pioglitazone, an antihyperglycemic drug, is widely used in diabetes mellitus patients with insulin resistance. Although pioglitazone is known to have a potential link to bladder cancer (BC), there have been contradictory results. This present study is designed to understand the regulatory mechanisms that drive the effects of pioglitazone on the bladder epithelial cells. METHODS: Labeled liquid chromatography-tandem mass spectrometry-based proteomics profiling characterized the global proteomes of normal human bladder epithelial cell...
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method.
CONCLUSION: Our findings lend credence to the hypothesis that Lactobacilli are important members of the healthy urine microbiome. Our data also suggest that the microbiomes of the urethra and bladder differ from one another. In conclusion, urine collection method results in different 16S-based NGS data, likely due to the sensitivity of NGS methods enabling detection of urethral bacteria present in voided but not catheterized urine specimens. PMID: 32252185 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Clinical and Urodynamic Predictors of the Q-Tip Test in Women With Lower Urinary Tract Symptoms.
Authors: Wu CJ, Ting WH, Lin HH, Hsiao SM Abstract PURPOSE: The Q-tip test is used to measure urethral hypermobility and can predict surgical outcomes. However, certain factors may affect the reliability of this test. Our aim was to identify independent clinical and urodynamic predictors of the results of the Q-tip test. METHODS: Between January 2014 and June 2019, 176 consecutive women with lower urinary tract symptoms who underwent the Q-tip test and urodynamic studies were included in this retrospective study. RESULTS: Multivariable regression analysis revealed that age (regression coefficient, -0.55), p...
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Intravesical Loss of OnabotulinumtoxinA During Endoscopic Intradetrusor Injection - A Multicenter Experience.
CONCLUSION: The endoscopic injection of onaBTA marked by MB into the bladder wall is associated with minimal intravesical loss of the agent, representing less than 3% of the administered dose of MB. This may reflect the amount of the onaBTA detected in the irrigation fluid. PMID: 32252187 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Korean Translation and Linguistic Validation of Urgency and Overactive Bladder Questionnaires.
CONCLUSION: In this study, the panel produced a successful linguistic validation of Korean versions of multiple OAB questionnaires, which can be utilized to evaluate the severity and treatment outcomes of OAB. PMID: 32252188 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Translation and Linguistic Validation of the Korean Version of the Wisconsin Stone Quality of Life Questionnaire.
CONCLUSION: The present study demonstrated that, despite language differences, translation and linguistic validation of the KWISQOL were successfully performed. This K-WISQOL could be useful tools for treatment plan and patient care. PMID: 32252189 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Role of Transcutaneous Electrical Nerve Stimulation in Treating Children With Overactive Bladder From Pooled Analysis of 8 Randomized Controlled Trials.
CONCLUSION: TENS had a remarkable effect on the improvement of urodynamic indexes and objective OAB symptoms without a significant increase in VAS scores for children with OAB. PMID: 32252190 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

At the End of the Year 2019.
Authors: Kim KH PMID: 31905271 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Influence of Circadian Disruption Associated With Artificial Light at Night on Micturition Patterns in Shift Workers.
Authors: Kim SJ, Kim JW, Cho YS, Chung KJ, Yoon H, Kim KH Abstract Shift workers often experience problems associated with circadian disruption associated with artificial light at night and nocturia is commonly noted in night-shift workers. Nocturia associated with circadian disruption is due to increased urine production of the kidney and decreased storage function of the bladder. A recent discovery of peripheral clock genes in the bladder and their role in contractile property of the bladder support that micturition is closely related to the circadian rhythm. Moreover, there are clinical studies showed that shift...
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Artificial Urinary Sphincter for Postradical Prostatectomy Urinary Incontinence - Is It the Best Option?
Authors: Ha YS, Yoo ES Abstract Male stress urinary incontinence (SUI) can undoubtedly reduce quality of life and promote personal distress and psychosocial alienation. The frequency of postprostatectomy urinary incontinence (PPI) counts on the characterization of urinary incontinence and the periods of patient follow-up. Operational therapeutics, for instance, urethral male slings and artificial urinary sphincters, are well-chosen as adequate and secure surgeries for male SUI in men with continual PPI when conservative treatment is ineffective. Over the former 2 decades, surgery has progressed regarding both opera...
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats.
CONCLUSION: Although naftopidil did not directly act on the interval between spontaneous contractions of the urinary bladder, the plasma collected from rats administered naftopidil, with changing levels of monoamines and amino acids, may suppressed shortening the interval. PMID: 31905274 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Do Failure of Posterior Tibial Nerve Stimulation Precludes to Use Sacral Neuromodulation in Patient With Overactive Bladder?
CONCLUSION: SNM might improve OAB symptoms in most patients who experienced no or poor efficacy with TPTNS. History of failed TPTNS should not preclude the use of SNM in OAB patients. PMID: 31905275 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

A Prospective, Multicenter, Open-Label Study of Dose Escalation Therapy in Male Patients With Nocturia Refractory to 0.2-mg Tamsulosin Monotherapy.
CONCLUSION: Dose escalation may yield a significant improvement of nocturia in>20% of patients, and may be especially helpful in patients with lower sodium levels and urge incontinence. PMID: 31905276 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Needle Placement: A Guide to Predictable Sensory and Motor Responses Based on Variations in Needle Placement During Sacral Neuromodulation Procedures.
CONCLUSION: By considering the 3-dimensional spatial trajectory of the S3 nerve, and following this presented guide, the most optimal lead placement with consistently reproducible outcomes that include S3 motor and sensory response on all 4 leads at less than, or equal to, 2 volts can be achieved and can potentially maximize the life of the device while potentially affording patients a more successful outcome. PMID: 31905277 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Comparison of Ultrasound-Guided Transgluteal and Finger-Guided Transvaginal Pudendal Nerve Block Techniques: Which One is More Effective?
CONCLUSION: The TV-PNI may be an alternative to US-guidance technique as a safe, simple, effective approach in pudendal nerve blocks. PMID: 31905278 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

The Effects of Intradetrusor BoNT-A Injections on Vesicoureteral Reflux in Children With Myelodysplasia.
Authors: Toprak T, Danacioglu YO, Verit A Abstract PURPOSE: We retrospectively evaluated the efficacy of botulinum neurotoxin A (BoNT-A) on vesicoureteral reflux (VUR), continence status, and urodynamic parameters in children with myelodysplasia who were not responsive to standard conservative therapy. METHODS: The study included 31 children (13 boys, 18 girls) with a mean age of 9.2±2.3 years (range, 5-14 years) with myelodysplasia, retrospectively. All children were fully compatible with clean intermittent catheterization (CIC) and did not respond to the maximum tolerable anticholinergic dose. All chil...
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Therapeutic Endoscopic Treatment Plus Maintenance Dimethyl Sulfoxide Therapy Prolongs Recurrence-Free Time in Patients With Hunner Type Interstitial Cystitis: A Pilot Study.
Authors: Otsuka A, Suzuki T, Matsushita Y, Watanabe H, Tamura K, Motoyama D, Ito T, Sugiyama T, Miyake H Abstract PURPOSE: To evaluate whether hydrodistention with fulguration of Hunner lesions (HD/FUL) plus maintenance dimethyl sulfoxide (DMSO) therapy prolongs the recurrence-free time in patients with Hunner type interstitial cystitis (IC). METHODS: The study enrolled patients with Hunner type IC who required repeat HD/FUL due to recurrence of IC symptoms after the first HD/FUL at our institution. All patients received a second HD/FUL plus maintenance DMSO therapy. The maintenance DMSO therapy was performed e...
Source: International Neurourology Journal - January 8, 2020 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Molecular and Cellular Substrates of Neuroinflammation in Alzheimer Disease and Depression.
Authors: Im HI PMID: 31795602 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - December 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

The Far-Reaching Effects of Neuroinflammation.
Authors: Kim JW PMID: 31795603 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - December 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease.
Authors: Yang SH Abstract Alzheimer disease (AD) is a neurodegenerative disorder characterized by the loss of neuronal cells and the progressive decline of cognitive function. The major pathological culprit of AD is aggregation of amyloid-β (Aβ) and hyperphosphorylation of tau, eventually leading to progressive neuronal cell death and brain atrophy. However, the detailed molecular and cellular mechanisms underlying AD development as a result of neuronal cell death are little known. Although several hypotheses have been proposed regarding the development of AD, increasingly many studies suggest that the pa...
Source: International Neurourology Journal - December 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Inflammation as the Potential Basis in Depression.
Authors: Maeng SH, Hong H Abstract There is growing evidence of the association between inflammation and stress-related disorders including depression. The positive correlation between the increased levels of inflammatory cytokines observed in patients with other diseases and the byproduct of the depressive symptoms may be caused by chronic stress. Increased neuroinflammatory responses are capable of activating microglia and astrocytes, which leads to release pro-inflammatory cytokines. Moreover, elevated levels of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 are causally...
Source: International Neurourology Journal - December 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Methyl-CpG Binding Protein 2 in Alzheimer Dementia.
Authors: Kim B, Choi Y, Kim HS, Im HI Abstract Despite decades of research on Alzheimer disease, understanding the complexity of the genetic and molecular interactions involved in its pathogenesis remains far from our grasp. Methyl-CpG Binding Protein 2 (MeCP2) is an important epigenetic regulator enriched in the brain, and recent findings have implicated MeCP2 as a crucial player in Alzheimer disease. Here, we provide comprehensive insights into the pathophysiological roles of MeCP2 in Alzheimer disease. In particular, we focus on how the alteration of MeCP2 expression can impact Alzheimer disease through risk gen...
Source: International Neurourology Journal - December 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research