A Message From the New Editor-in-Chief.
Authors: Moon HS PMID: 31607094 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Time for a New Start for the International Neurourology Journal.
Authors: Lee T PMID: 31607095 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

The Prospect of a New Smart Healthcare System: A Wearable Device-Based Complex Structure of Position Detecting and Location Recognition System.
Authors: Chung KJ, Kim J, Whangbo TK, Kim KH Abstract In upcoming fourth industrial revolution era, it is inevitable to address smart healthcare as not only scientist but also clinician. We have the task to plan and realize this through human imagination, creativity, and applicability for the clarification of the direction of the development and utilization of this technology. One thing that is clear is that it is important to understand what information is needed, how to interpret it, what will be the outcomes, and how to respond in artificial intelligence and Internet of Things era. Therefore, we would like to br...
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Sling Surgery for Male Urinary Incontinence Including Post Prostatectomy Incontinence: A Challenge to the Urologist.
Authors: Ko KJ, Kim SJ, Cho ST Abstract The management of postprostatectomy urinary incontinence (PPI) is still challenging for urologists. In recent decades, various kinds of male sling system have been developed and introduced; however, they have not yet shown as good a result as that of artificial urinary sphincter (AUS). However, a male sling is still in an important position because patients have a high demand for sling implantation, and it can allow the avoidance of the use of mechanical devices like AUS. Recently, the male sling has been widely used in mild-to-moderate PPI patients; however, there are no stu...
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Data-Driven Machine-Learning Quantifies Differences in the Voiding Initiation Network in Neurogenic Voiding Dysfunction in Women With Multiple Sclerosis.
CONCLUSION: Voiders and VD patients showed distinctly different FC in their Voiding Initiation Network. Machine-learning is able to identify brain centers contributing to these observed differences. Knowledge of these centers and their connectivity may allow phenotyping patients to centrally focused treatments such as cortical modulation. PMID: 31607098 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Neural Correlates of Urinary Retention in Lateral Medullary Infarction.
CONCLUSION: In patients with isolated LMI, we postulate that disruption of the descending pathway from the pontine micturition centre to the sacral spinal cord at the level of the lateral tegmentum results in urinary retention. PMID: 31607099 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease.
CONCLUSION: DO is almost universal in all patients with PD complaining of OAB symptoms (97.1%). However, a significant percentage of patients also had BOO (36.8%), DU (47%), and increased PVR (16.7%) indicating that neurogenic DO may not be the only cause of OAB symptoms in PD patients. PMID: 31607100 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Artificial Urinary Sphincter Cuff Size Predicts Outcome in Male Patients Treated for Stress Incontinence: Results of a Large Central European Multicenter Cohort Study.
Authors: Queissert F, Huesch T, Kretschmer A, Anding R, Kurosch M, Kirschner-Hermanns R, Pottek T, Olianas R, Friedl A, Pfitzenmaier J, Naumann CM, Wotzka C, Nyarangi-Dix J, Hoffmann T, Herrmann E, Obaje A, Rose A, Homberg R, Abdunnur R, Loertzer H, Bauer RM, Haferkamp A, Schrader AJ Abstract PURPOSE: The aim was to study the correlation between cuff size and outcome after implantation of an AMS 800 artificial urinary sphincter. METHODS: A total of 473 male patients with an AMS 800 sphincter implanted between 2012 and 2014 were analyzed in a retrospective multicenter cohort study performed as part of the Centra...
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Outcomes of Intradetrusor Onabotulinum Toxin A Therapy in Overactive Bladder Refractory to Sacral Neuromodulation.
CONCLUSION: BTXA appears effective for OAB refractory to SNM, although the success rate is lower compared to BTXA patients without SNM exposure. PMID: 31607102 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

The Effectiveness of Cystography-Measured Bladder Neck Elevation at Predicting the Return of Continence After Robot-Assisted Radical Prostatectomy.
Authors: Huh JS, Kim YJ, Kim SD, Park KK Abstract PURPOSE: To analyze the clinical parameters correlated with early recovery of urinary continence after radical prostatectomy, with a focus on urethral mobility during pelvic contraction at catheter removal. METHODS: We prospectively analyzed 67 patients who underwent prostatectomy for prostate cancer at Jeju National University Hospital from January 2015 to June 2018. At the time of catheter removal, a cystography was performed in 67 men (median age, 65 years; range, 55-76 years) who had undergone robot-assisted laparoscopic prostatectomy. The vertical length of...
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Assessment of Anticholinergic Use After Fading of BTX-A Effects in Refractory Idiopathic Overactive Bladder: A Prospective Blinded Randomized Trial.
Authors: Elbaset MA, Taha DE, El-Hefnawy AS, Zahran MH, Shokeir AA Abstract PURPOSE: To evaluate the efficacy and safety of re-treatment with anticholinergics on refractory idiopathic overactive bladder (OAB) previously treated with intravesical botulinum neurotoxin type A (BTX-A) injections. METHODS: One hundred patients were initially managed by intravesical injections of 100 IU of BTX-A. After the effects of BTX-A faded, patients were randomized into 2 groups: group A patients received solifenacin (10 mg) for 12 weeks (study group), while group B patients received placebo treatment for 12 weeks (control grou...
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Feasibility of Self-administered Neuromodulation for Neurogenic Bladder in Spinal Cord Injury.
CONCLUSION: This pilot trial suggests TTNS is feasible to be performed at home in people with chronic SCI. Participants were able to reduce anticholinergic medication dosage and anticholinergic side effects while maintaining continence, subsequently improving QoL scores. These results advocate for further randomized, controlled trials with longer duration and urodynamic evaluation to assess long-term efficacy. PMID: 31607105 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - October 16, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Treatment of Prostate Disease and Cognitive Problems.
Authors: Cho YS PMID: 31260607 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Time-Dependent Changes of Urethral Function in Diabetes Mellitus: A Review.
This article reviewed the current knowledge on time-course manifestation of diabetic urethral dysfunction (DUD), and explored an early intervention target to prevent the contribution of DUD to the progression of diabetes-induced impairment of the lower urinary tract (LUT). In the literature search through PubMed, key words used included "diabetes mellitus," "diabetic urethral dysfunction," and "diabetic urethropathy." Polyuria and hyperglycemia induced by diabetes mellitus (DM) can cause the time-dependent changes in functional and morphological manifestations of DUD. In the early stage, it pr...
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Emotional Stress Facilitates Micturition Reflex: Possible Inhibition by an α1-Adrenoceptor Blocker in the Conscious and Anesthetized State.
Emotional Stress Facilitates Micturition Reflex: Possible Inhibition by an α1-Adrenoceptor Blocker in the Conscious and Anesthetized State. Int Neurourol J. 2019 Jun;23(2):100-108 Authors: Hattori T, Sugaya K, Nishijima S, Kadekawa K, Ueda T, Yamamoto H Abstract PURPOSE: To test the hypothesis that naftopidil prolongs intercontraction intervals in rats undergoing chronic stress as observed in previous animal models, voiding behavior and bladder function were measured and analyzed. METHODS: Female Sprague-Dawley rats weighing 200-230 g were exposed to repeated variate stress (RVS) for 1 week, ...
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Effects of Acute Sacral Neuromodulation at Different Pulse Widths on Bladder Overactivity in Pigs.
This study evaluated the effects of stimulation using different pulse widths on the inhibition of bladder overactivity by sacral nerve stimulation (SNM) in pigs. METHODS: Implant-driven stimulators were used to stimulate the S3 spinal nerve in 7 pigs. Cystometry was performed by infusing normal saline (NS) or acetic acid (AA). SNM at pulse widths of 64 μsec to 624 μsec was conducted at the intensity threshold at which observable perianal and/or tail movement was induced. Multiple cystometrograms were performed to determine the effects of different pulse widths on the micturition reflex. RESULTS: AA-induced bl...
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus.
CONCLUSION: Short-term memory and spatial memory were affected by surgical and chemical castration via the PKA/CREB/BDNF and c-Raf/MEK/ERK signaling pathways. PMID: 31260611 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Do Lifestyle Factors Affect Lower Urinary Tract Symptoms? Results from the Korean Community Health Survey.
Authors: Kim KS, Jo JK, Lee JA, Choi BY, Moon HS Abstract PURPOSE: To evaluate the relationships between lower urinary tract symptoms (LUTS) and lifestyle factors (physical activity, smoking, alcohol consumption, body mass index, and stress) in Korean men. METHODS: We analyzed the survey results of South Korean men (n=64,439) who were 40 years of age or older among whom interviews were conducted using questionnaires. Trained interviewers performed face-to-face surveys using computer-assisted personal interviewing, the International Prostate Symptom Score (IPSS), and standard questions. We assessed the relations...
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

What Is the Effect of Body Mass Index on Subjective Outcome Following Vaginal Hysterectomy for Prolapse?
CONCLUSION: With increasing BMI, women are likely to report lower levels of satisfaction following prolapse surgery, despite reporting equivalent improvements in symptoms. BMI is known to affect how individuals perceive their general health and well-being with obese individuals reporting poorer levels of subjective health status. Women with obesity may perceive change in their condition after prolapse surgery differently to women of normal weight. Reduction of weight prior to prolapse surgery could be considered in obese women to improve subjective outcomes of surgery. PMID: 31260613 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Laparoscopic Sacrocolpopexy Plus Colporrhaphy With an Small Intestine Submucosa Graft Versus Total Pelvic Floor Reconstruction for Advanced Prolapse: A Retrospective Cohort Study.
Authors: Wang J, Wang X, Hua K, Chen Y Abstract PURPOSE: Transvaginal mesh (TVM) results in a greater anatomic cure but more complications. We aimed to compare laparoscopic sacrocolpopexy (LSC) plus colporrhaphy with the small intestine submucosa (SIS) graft versus TVM for advanced pelvic organ prolapse (POP). METHODS: Patients with advanced POP who underwent LSC plus colporrhaphy with the SIS graft or TVM at a center between September 2015 and November 2016 were studied. Anatomical outcomes were evaluated using POP quantification. Functional outcomes related to POP and sexual life were evaluated using the Pelv...
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Validity and Reliability of the Korean Version of the Women's Toileting Behavior Scale.
Authors: So A, De Gagne JC, Park S Abstract PURPOSE: The purpose of this study was to investigate the validity and reliability of the Korean version of the Toileting Behavior Scale (KTBS) to assess women's toileting behavior related to urinary elimination. METHODS: The original English version, the Toileting Behavior: Women's Elimination Behaviors scale, was translated into Korean with forward and backward translation. Examinations of internal consistency reliability, construct validity using exploratory factor analysis and confirmatory factor analysis, item convergent validity, and discriminant validity were c...
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Effect of Nocturnal Hypoxia on Nocturia in Patients With Obstructive Sleep Apnea.
Authors: Chung JH, Moon HS, Park SY, Kim KR, Cho SH, Kim YT Abstract PURPOSE: To identify the association between nocturia and obstructive sleep apnea (OSA), we compared results of polysomnography (PSG) with the presence or absence of nocturia in patients with suspected OSA. METHODS: Patients underwent PSG for suspected OSA. The International Prostate Symptom Score and quality of life (IPSS/QoL) questionnaire was evaluated to assess voiding symptoms that may affect sleep quality. The results of PSG were compared between patient groups with or without nocturia. RESULTS: In logistic regression analysis, age (...
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

The Association Between Obesity and the Nocturia in the U.S. Population.
CONCLUSION: This study reported that obesity was significant association with the prevalence of nocturia with dose-dependent manner, regardless of age, sex, hypertension, and DM after taking major confounding factors into account. PMID: 31260617 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - July 2, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Knowledge Knows No Boundaries.
Authors: Lee T PMID: 30943687 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

In Search of a New Prostate-Specific Antigen.
Authors: Kim JW PMID: 30943688 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

For Physicians Managing Voiding Dysfunction, Improving the Detection Rate of Early Prostate Cancer and Discrimination From Benign Prostatic Hyperplasia, in a Molecular Biomarker Aspects.
Authors: Kim WT, Yun SJ, Kim WJ Abstract Prostate cancer (CaP) is the most common cancer diagnosed among men in the United States and the fifth most common cancer among men in Korea. Unfortunately, the early stages of CaP may have no symptoms. Thus, early detection is very important and physicians managing voiding dysfunction must have awareness about CaP. The traditional tests used for early detection of CaP are the prostate-specific antigen (PSA) blood test and digital rectal examination. However, a high PSA level is not specific for CaP. Benign prostatic hyperplasia, prostatitis, urinary tract infection, and uri...
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Characterization on Responsiveness of Excitatory Synaptic Transmissions to α1-Adrenoceptor Blockers in Substantia Gelatinosa Neurons Isolated From Lumbo-Sacral Level in Rat Spinal Cords.
CONCLUSION: There was a difference in responsiveness in the frequency of mEPSCs to α1-adrenoceptor blockers, with the response to naftopidil being the greatest among the α1-adrenoceptor blockers. These data are helpful to understand the action mechanisms of α1-adrenoceptor blockers for male lower urinary tract symptoms in clinical usage. PMID: 30943690 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Analysis of Present Status for Surgery of Benign Prostatic Hyperplasia in Korea Using Nationwide Healthcare System Data.
CONCLUSION: Through the data of the National Health Insurance Service, we could apprehend the present status of BPH-related surgery in Korea. Then, we could know about the trend according to several factors and we think these results will be valuable as academic references as well. PMID: 30943691 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

A Korean Postmarketing Study Assessing the Effectiveness of OnabotulinumtoxinA for the Treatment of Neurogenic Detrusor Overactivity or Idiopathic Overactive Bladder Using a Validated Patient-Reported Outcome Measure.
CONCLUSION: Effectiveness and safety of onabotulinumtoxinA in Korea in a real-world setting was demonstrated. PMID: 30943692 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Risk Factors for Interstitial Cystitis in the General Population and in Individuals With Depression.
CONCLUSION: The incidence of IC was higher in individuals with depression. Subjects who developed IC had more chronic pain conditions, depression, malaise, and inflammatory disorders. PMID: 30943693 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

A Novel Technique of Morcellation Using a Pneumovesicum After Holmium Laser Enucleation of the Prostate in Complicated Situations: Our Initial Experience and Tips.
Authors: Tae BS, Jeon BJ, Choi H, Park JY, Bae JH Abstract PURPOSE: To describe our initial experience with a novel method of adenoma retrieval using a pneumovesicum (PNV) after Holmium laser enucleation of the prostate (HoLEP). METHODS: From January 2016 to April 2018, a total of 93 consecutive patients treated with HoLEP were enrolled in this study. For tissue morcellation, we used the PNV morcellation technique for an initial series of 21 patients and the conventional technique (Lumenis VersaCut) for a consecutive series of 72 patients. We compared efficiency and safety between the novel technique and the tr...
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Alpha-1 Adrenergic Receptor Blockers for the Treatment of Lower Urinary Tract Symptoms in Women: A Systematic Review and Meta-Analysis.
Authors: Kim DK, Lee JY, Jung JH, Kim JH, Hah YS, Hong CH, Cho KS Abstract PURPOSE: To assess the effectiveness of alpha-1 adrenergic receptor blockers (α1-blockers) in the treatment of female lower urinary tract symptoms (LUTS). METHODS: A literature search was conducted using the PubMed/MEDLINE, Embase, and Cochrane Library databases. Fourteen studies with 1,319 patients were ultimately included. The study comprised 2 analyses: a comparison of urinary symptom scores, maximal flow rate (Qmax), and postvoid residual (PVR) urine volume before and after α1-blocker administration in 8 prospective, open...
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Urodynamic and Bladder Diary Factors Predict Overactive Bladder-wet in Women: A Comparison With Overactive Bladder-dry.
Authors: Hsiao SM, Wu PC, Chang TC, Chen CH, Lin HH Abstract PURPOSE: To identify factors predicting the presence of overactive bladder syndrome (OAB)-wet, compared with OAB-dry. METHODS: Between September 2007 and September 2013, the medical records of 623 women with OAB who completed a 3-day bladder diary and underwent urodynamic studies in a medical center were retrospectively reviewed. OAB-wet was diagnosed in patients who complained of at least one episode of urgency incontinence in the previous month; otherwise, OAB-dry was diagnosed. Multivariable logistic regression analysis was used to predict the pres...
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Linguistic Validation of the Intermittent Self-catheterization Questionnaire for Patients With Neurogenic Bladder Who Perform Intermittent Catheterization for Voiding Dysfunction.
CONCLUSION: This study presents a successful linguistic validation of the Korean version of the ISC-Q, which could be a useful tool for evaluating treatment satisfaction in patients with neurogenic bladder performing CIC regularly. PMID: 30943697 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Application of Low-Cost, Easy-to-Use, Portable Biosensor Systems for Diagnosing Bladder Dysfunctions.
Authors: Myung NV, Jung S, Kim J PMID: 30943698 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - April 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

How to Interpret the Effects Shown in Animal Study.
Authors: Kim KH PMID: 30832460 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - March 7, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Mitochondrial Dysfunction as a Cause of Neurological Diseases.
Authors: Kim CJ PMID: 30832461 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - March 7, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease.
Authors: Tang J, Oliveros A, Jang MH Abstract Synapses are sites of high energy demand which are dependent on high levels of mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are key for maintenance of functional neurotransmission and this critical biological process is modulated by energy metabolism, mitochondrial distribution, mitochondrial trafficking, and cellular synaptic calcium flux. Synapse loss is presumed to be an early yet progressive pathological event in Alzheimer disease (AD), resulting in impaired cognitive function and memory loss which is particularly prevalent a...
Source: International Neurourology Journal - March 7, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death.
CONCLUSION: These findings document a protective role of Gadd45b against neuronal insults associated with global ischemia and identify Gadd45b as a potential therapeutic target for the amelioration of hippocampal neurodegeneration. PMID: 30832463 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - March 7, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Effects of Acute Exercise on Mitochondrial Function, Dynamics, and Mitophagy in Rat Cardiac and Skeletal Muscles.
CONCLUSION: A single bout of aerobic exercise may improve mitochondrial function (e.g., O2 respiration and Ca2+ retention capacity) in the heart and skeletal muscles without changes in mitochondrial dynamics or mitophagy. PMID: 30832464 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - March 7, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Treadmill Exercise Ameliorates Chemotherapy-Induced Muscle Weakness and Central Fatigue by Enhancing Mitochondrial Function and Inhibiting Apoptosis.
CONCLUSION: Apoptosis was enhanced and mitochondria function was deteriorated by DOX treatment, resulting in muscle weakness and central fatigue. Treadmill exercise suppressed apoptosis and prevented deterioration of mitochondria function in muscle, resulting in alleviation of muscle weakness and central fatigue during DOX therapy. PMID: 30832465 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - March 7, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway.
CONCLUSION: Treadmill exercise acts as the zeitgeber that improves memory function under the circadian rhythm disrupted conditions. PMID: 30832466 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - March 7, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

On Impact Factor.
Authors: Kim KH PMID: 30599491 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Applications of Basic Experimental and Clinical Research Using Biomarkers.
Authors: Ko IG Abstract PMID: 30599492 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Detecting Bladder Biomarkers for Closed-Loop Neuromodulation: A Technological Review.
Authors: Park E, Lee JW, Kang M, Cho K, Cho BH, Lee KS Abstract Neuromodulation was introduced for patients with poor outcomes from the existing traditional treatment approaches. It is well-established as an alternative, novel treatment option for voiding dysfunction. The current system of neuromodulation uses an open-loop system that only delivers continuous stimulation without considering the patient's state changes. Though the conventional open-loop system has shown positive clinical results, it can cause problems such as decreased efficacy over time due to neural habituation, higher risk of tissue damage, and l...
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Comprehensive MicroRNAome Analysis of the Relationship Between Alzheimer Disease and Cancer in PSEN Double-Knockout Mice.
CONCLUSION: Based on literature reviews, many of the miRNAs involved in Cancer pathways were found to be known tumorsuppressive miRNAs, and their target genes were known or putative oncogenes. In conclusion, the expression levels of known tumor-suppressive miRNAs increased at 7 and 18 months, in the PSEN dKO mouse model of AD, supporting the negative correlation between AD and cancer. PMID: 30599494 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin.
CONCLUSION: The effect of serotonin on contractile force, but not sensitivity, was potentiated in bladder strips from cats with FIC, and was dependent upon the presence of the mucosa in control and FIC groups. As atropine inhibited these effects of serotonin, we hypothesize that, serotonin enhances acetylcholine release from the mucosa of FIC cat bladder strips, which could account for the increased force generated. In summary, FIC augments the responsiveness of bladder to serotonin, which may contribute to the symptoms associated with this chronic condition. PMID: 30599495 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro.
CONCLUSION: The present study suggests that a high concentration of naftopidil reduces the amplitude of evoked EPSCs via a mechanism that apparently does not involve α1-adrenoceptors. Inhibition of evoked EPSCs may also contribute to suppression of the micturition reflex, together with nociceptive stimulation. PMID: 30599496 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Cell Versus Chemokine Therapy Effects on Cell Mobilization to Chronically Dysfunctional Urinary Sphincters of Nonhuman Primates.
Authors: Williams JK, Mariya S, Suparto I, Lankford SS, Andersson KE Abstract PURPOSE: A major question remaining in approaches to tissue engineering and organ replacement is the role of native mobilized native cells in the regeneration process of damaged tissues and organs. The goal of this study was to compare the cell mobilizing effects of the chemokine CXCL12 and cell therapy on the urinary sphincter of nonhuman primates (NHP) with chronic intrinsic urinary sphincter dysfunction. METHODS: Either autologous lenti-M-cherry labeled skeletal muscle precursor cells (skMPCs) or CXCL12 were injected directly into ...
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Urethral Pressure Measurement as a Tool for the Urodynamic Diagnosis of Detrusor Sphincter Dyssynergia.
CONCLUSION: Urethral pressure amplitude of>20 cm H2O during detrusor contraction occurred in 86% of patients with known DSD. Longer DSD episodes were associated with larger bladder capacity. Further studies exploring the relationship between urethral pressure measurements and bladder physiology could phenotype DSD as a measurable variable rather than a categorical observation. PMID: 30599498 [PubMed] (Source: International Neurourology Journal)
Source: International Neurourology Journal - January 4, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research