Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Exposed to Hypoxic Environment is Regulated by Caveolin-1-dependent AMPK Activity

CONCLUSIONS: We suggest a new finding for the first time that AMPK activation can regulate Hif-1α induction as well as Hif-1α-induced Cav-1 expression, and the inhibitory effect of anti-apoptotic pathway on the exposure of RT4 cells to hypoxic environment is due to Cav-1-dependent AMPK activity.PMID:33752282 | DOI:10.5213/inj.2040444.222
Source: International Neurourology Journal - Category: Urology & Nephrology Authors: Source Type: research