Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.

In conclusion, deletion of exon 9 from Cul3 generates a protein that is itself ubiquitin ligase-defective, but also capable of enhanced autophagocytic KLHL3 degradation, thereby exerting dominant-negative effects on the WT-allele. PMID: 29897280 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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árquez MÁ, Baranda-Tovar FM PMID: 31834325 [PubMed - in process]
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
, Jacobo-García K, Cossio-Aranda J Abstract Heart failure (HF) is a syndrome characterized basically by a circulatory deficit to cover the metabolic and energetic demands of the body. This condition has a broad spectrum in its clinical presentation, affects the quality of life significantly, impacts the family/social environment, and generates a great demand for health services. The purpose of this research is to report the situational diagnose of patients with HF in Mexico. We evaluated 292 patients, 70.2% were men. Average age was 56.7 ± 14.3 years. Ischemic heart disease is the main etiology (98 p...
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
Publication date: January 2020Source: Pregnancy Hypertension, Volume 19Author(s): Rui Liu, Chan Wei, Qiang Ma, Weimin WangAbstractBackgroundThe present study aims to explore the possible mechanisms of Hippo-YAP1 signaling pathway in the development of severe preeclampsia (sPE).MethodsA total of 14 pregnancies complicated with severe preeclampsia as well as 14 healthy pregnancies were involved in this research from Department of Obstetrics, the First Affiliated Hospital of Xi’An Jiaotong University, from 15th March 2016 to 15th March 2018. The mRNA levels of YAP1, TAZ, MST1 and MST2 were tested via the RT-qPCR in the ...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: Available online 13 December 2019Source: Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyAuthor(s): Jerónimo Lazos, Eugenia Rodríguez Marco, Mabel Brunotto, Rene Panico, Eduardo PiemonteAbstractObjectiveOral venous varicosities (OV) are a common condition, increasing its incidence with age. They are also mentioned in association with several medical conditions, but the evidence is scarce and inconsistent. The aim was to describe OV clinical features and to analyze the association with medical conditions.MethodsAn observational, cross-sectional study was carried out in the O...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
Publication date: Available online 14 December 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Alessandra Feraco, Vincenzo Marzolla, Angelo Scuteri, Andrea Armani, Massimiliano CaprioOver the past decade, several studies have shown that activity of extra-renal mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue function, and cardiomyocyte contraction. In mice, abnormal activation of MR in the vasculature and in adipose tissue favors the occurrence of several components of the metabolic syndrome (MetS), such as hypertension, obesity, and glucose intolerance. Accordingly, high...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
One of the advantages of practicing clinical medicine, and seeing patients daily for many years, is you develop your own long-term study regarding certain medical health issues. In the area of hypertension, I have been taught by the best since my internship with pioneers such as Eliseo Perez Stable and Barry Materson at the University […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Cardiology Source Type: blogs
ze Li Blood pressure is an extremely important blood hemodynamic parameter. The pulse wave contains abundant blood-pressure information, and the convenience and non-invasivity of its measurement make it ideal for non-invasive continuous monitoring of blood pressure. Based on combined photoplethysmography and electrocardiogram signals, this study aimed to extract the waveform information, introduce individual characteristics, and construct systolic and diastolic blood-pressure (SBP and DBP) estimation models using the back-propagation error (BP) neural network. During the model construction process, the mean impact valu...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
We report the case of a falcotentorial meningioma presenting only with binocular, horizontal diplopia in an otherwise healthy sixty-two-year old male. Review of the established literature highlights a lack of consensus regarding management of this extremely rare pineal region tumor. Complete surgical resection ultimately remains the ideal therapeutic option but surgical excision continues to bear serious risk of neurologic and ophthalmic morbidity, including hemianopia and cortical visual impairment. We advocate that a multidisciplinary approach focusing on patient values is critical in treatment of these uncommon lesions....
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: Despite differences between adults with SCI and adults with CVD in several demographic and health-related measures, the overall similarity in PARs for SCI and CVD suggests potential benefits from using effective CVD interventions to address SCI. PMID: 31835014 [PubMed - in process]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
We present an unusual case of indapamide-induced hyponatremia and hypokalemia complicated by cardiac arrhythmia. The adverse drug reaction was reversible and non-life-threatening, but this case serves as a reminder that careful evaluation and constant monitoring are necessary when prescribing diuretics. PMID: 31827736 [PubMed]
Source: American Family Physician - Category: Primary Care Authors: Tags: Malays Fam Physician Source Type: research
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