Pd03-07 rna interference of hepatic lactate dehydrogenase reduces urinary oxalate in a mouse model of primary hyperoxaluria type 1

Endogenous oxalate synthesis primarily occurs via lactate dehydrogenase (LDH) activity in the liver. Liver specific RNAi therapeutics are currently in clinical trials for a number of diseases. Previous work using RNAi against liver glycolate oxidase demonstrated reduction of urinary oxalate in the Agxt knock out mouse, a model for primary hyperoxaluria Type 1 (PH1). Our objective was to evaluate the effects of siRNA knock down of liver LDHA in wild type (Wt) and PH1 mouse model (Agxt knock out (KO)).
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Stone Disease: Basic Research & Pathophysiology I Source Type: research