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Total 40893 results found since Jan 2013.
Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
An aging-susceptible circadian rhythm controls cutaneous antiviral immunity
JCI Insight. 2023 Sep 19:e171548. doi: 10.1172/jci.insight.171548. Online ahead of print.ABSTRACTAged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP expression in skin and such circadian-control of AVPs was diminished by disruption of immune cell interleukin 27 signaling and deletion of Bmal1/Clock genes in mouse skins, as well as siRNA-mediated knockdown of CLOCK in ...
Source: Herpes - September 19, 2023 Category: Infectious Diseases Authors: Stephen Kirchner Vivian Lei Paul T Kim Meera Patel Jessica L Shannon David Corcoran Dalton Hughes Diana K Waters Kafui Dzirasa Detlev Erdmann J örn Coers Amanda S MacLeod Jennifer Y Zhang Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
Early Growth Response Gene-1 Deficiency Interrupts TGF β1 Signaling Activation and Aggravates Neurodegeneration in Experimental Autoimmune Encephalomyelitis Mice
This study demonstrated that Egr-1 was down-regulated at mRNA and protein levels in the central nervous system (CNS) of experimental autoimmune encephalomyelitis (EAE) mice. Egr-1 knockout exacerbated EAE progression in mice, as shown by increased disease severity and incidence; it also aggravated neuronal apoptosis, which was associated with weakened activation of the BDNF/TGF β 1/MAPK/Akt signaling pathways in the CNS of EAE mice. Consistently, Egr-1 siRNA promoted apoptosis but mitigated the activation of BDNF/TGFβ 1/MAPK/Akt signaling in SH-SY5Y cells. Our results revealed that Egr-1 is a crucial regulator of neurona...
Source: Neuroscience Bulletin - September 19, 2023 Category: Neuroscience Source Type: research
Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway
CONCLUSIONS: This study suggests that the downregulation of PP2 A could reduce AF cell apoptosis and degeneration via the p38/MAPK pathway. It also revealed that the inhibition of PP2 A is expected to be a therapeutic target for IVDD.PMID:37722489 | DOI:10.1016/j.bbadis.2023.166888
Source: Biochimica et Biophysica Acta - September 18, 2023 Category: Biochemistry Authors: Pengfei Zhu Xiexing Wu Li Ni Kai Chen Zhongchen Dong Jiacheng Du Fanchen Kong Yubo Mao Huaqiang Tao Miao Chu Haiqin Mao Huilin Yang Qinbai Liu Minfeng Gan Dechun Geng Source Type: research
Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus
CONCLUSION: Our findings reveal a mechanism which underlies the contribution of the fSNP rs8085824 on the SMD7 locus to CRC susceptibility.PMID:37721570 | DOI:10.1007/s00432-023-05402-w
Source: Clinical Colorectal Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Zhao Liu Yihan Zhao Hongli Song Huaxue Miao Yingying Wang Chuntian Tu Tianyun Fu Juliang Qin Bing Du Min Qian Hua Ren Source Type: research
NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species
Acta Biochim Pol. 2023 Sep 18. doi: 10.18388/abp.2020_6580. Online ahead of print.ABSTRACTNicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is an enzyme that regulates reactive oxygen species (ROS) generation, and its function in the development of chondrosarcoma remains unclear. In the present study, we studied NOX4 expression in chondrosarcoma by immunochemical examination, and analyzed the role of NOX4 in viability and apoptosis of human chondrosarcoma cell line SW1353 using NOX4 siRNA or NOX4 inhibitor GKT137831. NOX4 level significantly increased in tumor compared to that in para-carcinoma sample. The level...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Zheng Jun Wang Lei Fang Ce Ren Wen Tao Meng Xiang Hui Qing Ci Nan Source Type: research
Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus
CONCLUSION: Our findings reveal a mechanism which underlies the contribution of the fSNP rs8085824 on the SMD7 locus to CRC susceptibility.PMID:37721570 | DOI:10.1007/s00432-023-05402-w
Source: Clinical Colorectal Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Zhao Liu Yihan Zhao Hongli Song Huaxue Miao Yingying Wang Chuntian Tu Tianyun Fu Juliang Qin Bing Du Min Qian Hua Ren Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
NADPH oxidase 4 facilitates progression of chondrosarcoma via generation of reactive oxygen species
Acta Biochim Pol. 2023 Sep 18;70(3):685-692. doi: 10.18388/abp.2020_6580.ABSTRACTNicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is an enzyme that regulates reactive oxygen species (ROS) generation, and its function in the development of chondrosarcoma remains unclear. In the present study, we studied NOX4 expression in chondrosarcoma by immunochemical examination, and analyzed the role of NOX4 in viability and apoptosis of human chondrosarcoma cell line SW1353 using NOX4 siRNA or NOX4 inhibitor GKT137831. NOX4 level significantly increased in tumor compared to that in para-carcinoma sample. The levels of NOX4...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Zheng Jun Wang Lei Fang Ce Ren Wen Tao Meng Xiang Hui Qing Ci Nan Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1
Source: Mol Biol Cell - September 18, 2023 Category: Molecular Biology Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus
CONCLUSION: Our findings reveal a mechanism which underlies the contribution of the fSNP rs8085824 on the SMD7 locus to CRC susceptibility.PMID:37721570 | DOI:10.1007/s00432-023-05402-w
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Zhao Liu Yihan Zhao Hongli Song Huaxue Miao Yingying Wang Chuntian Tu Tianyun Fu Juliang Qin Bing Du Min Qian Hua Ren Source Type: research
Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway
CONCLUSIONS: This study suggests that the downregulation of PP2 A could reduce AF cell apoptosis and degeneration via the p38/MAPK pathway. It also revealed that the inhibition of PP2 A is expected to be a therapeutic target for IVDD.PMID:37722489 | DOI:10.1016/j.bbadis.2023.166888
Source: Biochimica et Biophysica Acta - September 18, 2023 Category: Biochemistry Authors: Pengfei Zhu Xiexing Wu Li Ni Kai Chen Zhongchen Dong Jiacheng Du Fanchen Kong Yubo Mao Huaqiang Tao Miao Chu Haiqin Mao Huilin Yang Qinbai Liu Minfeng Gan Dechun Geng Source Type: research
