Query: siRNA

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Total 14362 results found since Jan 2013.

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
Publication date: Available online 5 October 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Giovanna Butera, Raffaella Pacchiana, Nidula Mullappilly, Marilena Margiotta, Stefano Bruno, Paola Conti, Chiara Riganti, Massimo DonadelliAbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated generally resulting in conformational changes of mutant p53 (mutp53) proteins, which acquire oncogenic functions triggering aggressiveness of cancers and alteration of energetic metabo...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 6, 2018 Category: Molecular Biology Source Type: research

MiR-223 promotes cardiomyocyte apoptosis by inhibiting Foxo3a expression.
CONCLUSIONS: MiR-223 is an important regulator of cardiomyocyte apoptosis under oxidative stress. Inhibition of the miR-223/Foxo3a signaling axis may be a potential therapeutic strategy for cardiac injuries. PMID: 30280799 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

SETD5-AS1 stimulates neuron death in stroke via promoting PTEN expression.
CONCLUSIONS: SETD5-AS1 is highly expressed in the ischemia-reperfusion injury model. SETD5-AS1 participates in the development of ischemic stroke by activating PTEN and inhibiting PI3K/AKT pathway. PMID: 30280788 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

DUSP facilitates RPMI8226 myeloma cell aging and inhibited TLR4 expression.
CONCLUSIONS: DUSP facilitates H2O2-induced aging of myeloma cell line RPMI8226 and suppresses TLR4 expression, which provides academic basis for clinical intervention. PMID: 30280787 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MicroRNA-23a induces apoptosis of hepatocarcinoma cell line MHCC97H via down-regulating KIAP: a mechanism study.
CONCLUSIONS: MicroRNA-23a inhibits growth and proliferation of MHCC97H cells, and induces apoptosis of MHCC97H cells via down-regulating KIAP. KIAP could be a potential therapeutic target for hepatocarcinoma treatment. PMID: 30280770 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

CRNDE impacts the proliferation of osteoclast by estrogen deficiency in postmenopausal osteoporosis.
CONCLUSIONS: We found that lncRNA CRNDE was closely related to the postmenopausal osteoporosis with estrogen deficiency. CRNDE may be involved in the development and progression of postmenopausal osteoporosis in the absence of estrogen and become a potential target for treating. PMID: 30280760 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Knockdown of DSPP inhibits the migration and invasion of glioma cells
In this study, we aimed to investigate the expression and biological function of DSPP in human glioma cells. We demonstrated through Western blot that DSPP is overexpressed in glioma tissues comparing to normal brain tissues. To investigate the role of DSPP in glioma carcinogenesis, we reduced the DSPP expression by small interfering RNA (siRNA) and found that DSPP silencing significantly inhibited the migration and invasion of glioma cells, the critical characteristics of glioma. Furthermore, we showed that DSPP down-regulation significantly decreased the activation of the AKT/mTOR/p70S6K pathway in glioma cells. Taken to...
Source: Pathology Research and Practice - October 5, 2018 Category: Pathology Source Type: research

Biglycan gene connects metabolic dysfunction with brain disorder
Publication date: Available online 3 October 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Zhe Ying, Hyae Ran Byun, Qingying Meng, Emily Noble, Guanglin Zhang, Xia Yang, Fernando Gomez-PinillaAbstractDietary fructose is a major contributor to the epidemic of diabetes and obesity, and it is an excellent model to study metabolic syndrome. Based on previous studies that Bgn gene occupies a central position in a network of genes in the brain in response to fructose consumption, we assessed the capacity of Bgn to modulate the action of fructose on brain and body. We exposed male biglycan...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 5, 2018 Category: Molecular Biology Source Type: research

Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression
This study investigated the roles of α-adducin (ADD1) and γ-adducin (ADD3) in regulating migration and invasion of non-small cell lung cancer (NSCLC) cells. ADD1 was mislocalized, whereas ADD3 was markedly downregulated in NSCLC cells with the invasive mesenchymal phenotype. CRISPR/Cas9-mediated knockout of ADD1 and ADD3 in epithelial-type NSCLC and normal bronchial epithelial cells promoted their Boyden chamber migration and Matrigel invasion. Furthermore, overexpression of ADD1, but not ADD3, in mesenchymal-type NSCLC cells decreased cell migration and invasion. ADD1-overexpressing NSCLC cells demonstrated increased ad...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 5, 2018 Category: Molecular Biology Source Type: research

Senescence marker protein 30 protects intestinal epithelial cells against inflammation-induced cell death by enhancing Nrf2 activity
Publication date: December 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1864, Issue 12Author(s): Jieun Choo, Gwangbeom Heo, Su Jin Kim, Yunna Lee, Akihito Ishigami, Naoki Maruyama, Hae Young Chung, Eunok ImAbstractSenescence marker protein 30 (SMP30) is a calcium-binding protein whose expression decreases during senescence. SMP30 deficiency increases susceptibility to cytokine-induced apoptosis in the liver and to radiation-induced apoptosis in the small intestine. Furthermore, colonic epithelial cell death is associated with the severity of colitis. Therefore, in the present study, ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 5, 2018 Category: Molecular Biology Source Type: research

AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats
In conclusion, our data provides evidence that Mas activation with AVE reduces oxidative stress injury and neuronal apoptosis through Mas/PKA/p-CREB/UCP-2 pathway after SAH. Furthermore, our study indicates that Mas may be a novel therapeutic treatment target in early brain injury of SAH.Graphical abstract
Source: Redox Biology - October 5, 2018 Category: Biology Source Type: research

Identification, characterisation and preliminary functional analysis of IRAK-M in grass carp (Ctenopharyngodon idella)
Publication date: Available online 2 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Pengfei Chu, Libo He, Denghui Zhu, Liangming Chen, Rong Huang, Lanjie Liao, Yongming Li, Zuoyan Zhu, Yaping WangAbstractInterleukin-1 receptor-associated kinase (IRAK) family members play important roles in myeloid differentiation primary response 88 (MyD88)-dependent toll-like receptor (TLR) signaling, the crucial innate immune pathway in vertebrates. In the present study, the IRAK family gene IRAK-M (also called IRAK3) from grass carp (Ctenopharyngodon idella) was cloned and characterised. IRAK-M was mainly enriched in the sple...
Source: Fish and Shellfish Immunology - October 5, 2018 Category: Biology Source Type: research

Long Non-Coding RNA ZEB1-Antisense 1 Affects Cell Migration and Invasion of Cervical Cancer by Regulating Epithelial-Mesenchymal Transition via the p38MAPK Signaling Pathway
Conclusion: Inhibition of ZEB1-AS1 can block the p38MAPK signaling pathway, ultimately restricting the EMT and suppressing cell migration and invasion of cervical cancer cells.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - October 5, 2018 Category: OBGYN Source Type: research

Novel ABCA1 peptide agonists with antidiabetic action
Publication date: Available online 2 October 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Salman Azhar, Stefanie Bittner, Jie Hu, Wen-Jun Shen, Yuan Cortez, Xiao Hao, Han Lu, Jens O. Lagerstedt, Fredric B. Kraemer, Jan O. JohanssonAbstractPreviously, apoE-derived ABCA1 agonist peptides have been shown to possess anti-atherosclerotic and possibly antidiabetic properties. Here we assessed the in vitro and in vivo actions of a second generation of ABCA1 peptide agonists, CS6253 and T6991-2, on glucose homeostasis. The results show that these two peptides improve glucose tolerance in a prediabetic diet-induced ob...
Source: Molecular and Cellular Endocrinology - October 5, 2018 Category: Endocrinology Source Type: research

Oxidative stress-elicited YY1 potentiates antioxidative response via enhancement of NRF2-driven transcriptional activity: A potential neuronal defensive mechanism against ischemia/reperfusion cerebral injury
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Wei Liu, Qingdong Guo, Haikang ZhaoAbstractCerebral ischemia challenge evokes an adaptive defensive system through the induction of antioxidant enzymes. Many of such antioxidant enzymes are regulated essentially by the nuclear factor erythroid 2-related factor-2 (NRF2). Compelling evidence supports that targeting NRF2 signaling is a promising therapeutic strategy to alleviate post-I/R brain injury, but the molecular mechanisms underlying this strategy have yet to be elucidated. Herein, we show that the expression of transcription fac...
Source: Biomedicine and Pharmacotherapy - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

A novel hybrid of 3-benzyl coumarin seco-B-ring derivative and phenylsulfonylfuroxan induces apoptosis and autophagy in non-small-cell lung cancer
ConclusionThese findings raise a rationale that this 3-benzyl coumarin seco-B-ring derivative and phenylsulfonylfuroxan hybrid could be a promising candidate for developing as a therapeutic agent toward NSCLC, and the combination therapy through PI3K/Akt/mTOR signaling pathway may result in optimized treatment outcomes.Graphical Abstract
Source: Phytomedicine - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Tetraspanin 1 inhibits TNF α-induced apoptosis via NF-κB signaling pathway in alveolar epithelial cells
ConclusionsWe conclude that TSPAN1 mediated apoptosis resistance of alveolar epithelial cells by regulating the NF- κB pathway. TSPAN1 may be a potential therapeutic target for pulmonary fibrosis or acute lung injury.
Source: Inflammation Research - October 5, 2018 Category: Research Source Type: research

Withdrawal: Antioncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis. Withdrawals/Retractions
This article has been withdrawn by the authors. The corresponding author identified some issues and brought them to the attention of the Journal. The following issues were discovered in the article. The GAPDH immunoblot in Fig. 5A was reused in Figs. 1H, 2F, 2I, 3B, 3G, and 5B. The ESR spectrum from BEAS-2B cells in Fig. 2A was previously published in Son et al. ((2014) J. Biol. Chem. 289, 28660–28675) without attribution. The BEAS-2B image in Fig. 2C was reused in Fig. 6A as control siRNA. The GAPDH immunoblot from Fig. 3A was previously published in Fig. 4A of Son et al. ((2014) J. Biol. Chem. 289, 28660–28675), repr...
Source: Journal of Biological Chemistry - October 5, 2018 Category: Chemistry Authors: Young-Ok Son, Poyil Pratheeshkumar, Ram Vinod Roy, John Andrew Hitron, Lei Wang, Sasidharan Padmaja Divya, Mei Xu, Jia Luo, Gang Chen, Zhuo Zhang, Xianglin Shi Tags: Withdrawals/Retractions Source Type: research

Fra-2 is a novel candidate drug target expressed in the podocytes of lupus nephritis.
In this study, we evaluated the expression and mechanism of Fos-related antigen 2 (Fra-2) in LN. The results showed that Fra-2 was significantly increased in kidney biopsies of LN patients compared with healthy controls and other kidney disease in glomerular podocytes. The MRL/lpr mouse strain is a murine model of lupus, and it was used to study the mechanisms of Fra-2 in LN. The results showed that Fra-2 was expressed in the glomerular podocytes. We investigated the effects of inflammatory stimuli on Fra-2 protein expression in the glomerular podocytes, and found that interferon gamma was most effective at increasing Fra-...
Source: Clinical Immunology - October 5, 2018 Category: Allergy & Immunology Authors: Xu C, Miao Y, Pi Q, Zhu S, Li F Tags: Clin Immunol Source Type: research

Effect of aquaporin 3 knockdown by RNA interference on antrum formation in sheep secondary follicles cultured in vitro.
In conclusion, ovine secondary follicles can be successfully transfected during in vitro culture, and siRNA-mediated attenuation of AQP3 gene reduced antrum formation of secondary follicles. PMID: 30289102 [PubMed - as supplied by publisher]
Source: Zygote - October 5, 2018 Category: Reproduction Medicine Authors: Paz MP, de Sousa FGC, Alves BG, Lobo CH, Sales AD, Tavares KCS, de Sá NAR, Guerreiro DD, Maside C, Rocha RMP, Bertolini LR, Bordignon V, de Figueiredo JR, Rodrigues APR Tags: Zygote Source Type: research

Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia
Conclusion: The crosstalk between sema4D and Met could transactivate Met to promote trophoblast cell invasion and differentiation, and decreased expression of sema4D and Plexin-B1 may be responsible for the deficiency in Met signalling and the development of preeclampsia.
Source: Journal of Hypertension - October 4, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Mechanistic aspects Source Type: research

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights
Publication date: December 2018Source: Materials Today Communications, Volume 17Author(s): Kumar Janakiraman, Venkateshwaran Krishnaswami, Vijaya Rajendran, Subramanian Natesan, Ruckmani KandasamyAbstractRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8, and IL-10...
Source: Materials Today Communications - October 4, 2018 Category: Materials Science Source Type: research

IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
Publication date: 2 October 2018Source: Cell Reports, Volume 25, Issue 1Author(s): Sinu P. John, Jing Sun, Rebecca J. Carlson, Binh Cao, Clinton J. Bradfield, Jian Song, Margery Smelkinson, Iain D.C. FraserSummaryActivation of the TLR4 signaling pathway by lipopolysaccharide (LPS) leads to induction of both inflammatory and interferon-stimulated genes, but the mechanisms through which these coordinately activated transcriptional programs are balanced to promote an optimal innate immune response remain poorly understood. In a genome-wide small interfering RNA (siRNA) screen of the LPS-induced tumor necrosis factor α (TNF-...
Source: Cell Reports - October 4, 2018 Category: Cytology Source Type: research

Upregulation of P21-Activated Kinase 1 (PAK1)/CREB Axis in Squamous Non-Small Cell Lung Carcinoma
Conclusion: These results suggest a novel mechanism whereby the PAK1 –CREB axis drives carcinogenesis of squamous-cell carcinomas, and have important implications in the development of targeted therapeutics for squamous-cell lung cancer.Cell Physiol Biochem 2018;50:304 –316
Source: Cellular Physiology and Biochemistry - October 4, 2018 Category: Cytology Source Type: research

Reduced retromer function results in the accumulation of amyloid-beta oligomers
Publication date: December 2018Source: Molecular and Cellular Neuroscience, Volume 93Author(s): Anna Ansell-Schultz, Juan F. Reyes, My Samuelsson, Martin HallbeckAbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive loss of multiple cognitive functions. Accumulation of amyloid beta oligomers (oAβ) play a major role in the neurotoxicity associated with the disease process. One of the early affected brain regions is the hippocampus, wherein a reduction of the vacuolar protein sorting-associated protein 35 (VPS35), the core protein comprising the retromer complex involved in cellular...
Source: Molecular and Cellular Neuroscience - October 4, 2018 Category: Neuroscience Source Type: research

Expression of Duplex shRNAs through a Lentiviral Vector against Cellular and Viral Genes Inflicts Sustained Inhibition of Hepatitis C Virus Replication
Conclusion: A lentiviral vector-based delivery system is a “single-shot” therapeutic strategy. It can express duplex shRNA for long-term synergistic inhibition of HCV and qualify as a promising therapeutic approach for sustained inhibition of HCV replication.Intervirology
Source: Intervirology - October 4, 2018 Category: Virology Source Type: research

Hairpin-structured probe conjugated nano-graphene oxide for the cellular detection of connective tissue growth factor mRNA.
This report introduces a fluorescent probe that targets a potential abnormal scar biomarker (connective tissue growth factor (CTGF) mRNA) in skin fibroblasts. This probe is constructed of hairpin-structured probes (HPs) targeting CTGF mRNA and the nano-graphene oxide (nano-GO) base. The HPs are non-covalently absorbed on the surface of nano-GO, which pre-quenches the fluorescence of HPs. Close proximity of complementary CTGF mRNA would lead to preferential HP hybridization and dissociation from nano-GO, which restores the fluorescence signal from HPs. Utilizing this probe, we can distinguish abnormal fibroblasts derived fr...
Source: Analytica Chimica Acta - October 4, 2018 Category: Chemistry Authors: Wang M, Wiraja C, Wee M, Yeo D, Hu L, Xu C Tags: Anal Chim Acta Source Type: research

Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma
In conclusion, TSA elicits a synergistic cytotoxic response in combination with chemotherapy via targeting the Raf/MEK/ERK pathway. TSA elicits synergistic cytotoxic response in combination with three DNA-damaging drugs (cisplatin, gemcitabine, and doxorubicin). Activated Raf/MEK/ERK pathway is involved in chemoresistant mechanism of UC. Combining chemotherapeutic agents with HDAC inhibitor (TSA) or with targeting Raf/MEK/ERK pathway is promising to c ircumvent chemoresistance in UCs.
Source: Journal of Molecular Medicine - October 4, 2018 Category: Molecular Biology Source Type: research

LncRNA Gm15290 promotes cell proliferation and invasion in lung cancer through directly interacting with and suppressing the tumor suppressor miR-615-5p.
In this study, we investigated the role of lncRNA Gm15290 in the proliferation and invasion of non-small cell lung cancer (NSCLC) cells. First, we found that lncRNA Gm15290 was markedly upregulated in tumor tissues from NSCLC patients and NSCLC cell lines, compared with adjacent normal tissues and normal lung cell line HBE respectively. Then, different concentrations of pcDNA-Gm15290 expression vector and Gm15290 siRNA were respectively transfected into A549 NSCLC cells. Our results showed that overexpression of Gm15290 significantly increased the proliferation and invasion of A549 cells and suppressed cell apoptosis. Knoc...
Source: Bioscience Reports - October 4, 2018 Category: Biomedical Science Authors: Dong Y, Huo X, Sun R, Liu Z, Huang M, Yang S Tags: Biosci Rep Source Type: research

Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1/miR-214/HSP27 axis.
CONCLUSION: Zhenbao Pill regulated TUG1/miR-214/HSP27 signaling pathway to reduce Treg cell proportion and thus relieve acute spinal cord injury. PMID: 30287503 [PubMed - as supplied by publisher]
Source: Bioscience Reports - October 4, 2018 Category: Biomedical Science Authors: He Y, Li M, Lv B, Huan Y, Liu B, Wang D, Yu H, Zhang L, Shi Z Tags: Biosci Rep Source Type: research

A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancer.
In this study, the antitumor activity of a novel selenonucleoside (4'-selenofuranosyl-2,6-dichloropurine, LJ-2618), a third-generation nucleoside, and its plausible mechanisms of action in paclitaxel-resistant prostate cancer (PC-3-Pa) cells were investigated. The established PC-3-Pa cells exhibited over 100-fold resistance against paclitaxel compared to the paclitaxel-sensitive PC-3 cells. LJ-2618, however, effectively inhibited the proliferation of both cell lines with similar IC50 values in vitro. In PC-3-Pa cells, the activated PI3K/Akt signaling pathway was suppressed by LJ-2618 treatment. In addition, Skp2 was found ...
Source: Biochemical Pharmacology - October 4, 2018 Category: Drugs & Pharmacology Authors: Byun WS, Jin M, Yu J, Kim WK, Song J, Chung HJ, Jeong LS, Lee SK Tags: Biochem Pharmacol Source Type: research

Modified Ginseng Extract Induces Apoptosis in HepG2 Cancer Cells by Blocking the CXCL8-Mediated Akt/Nuclear Factor-Formula: see textB Signaling Pathway.
Abstract The cytokine C-X-C motif chemokine ligand 8 (CXCL8) is produced in the tumor microenvironment and has an important role in cancer pathogenesis. CXCL8 activates the nuclear factor (NF)-[Formula: see text]B signaling. However, the role of NF-[Formula: see text]B inactivation in apoptosis induced by negative regulation of CXCL8 remains unclear. Here, we assessed the effects of MRGX on the transcriptional activity of NF-[Formula: see text]B and the expression of tumor necrosis factor (TNF)-[Formula: see text]-stimulated target genes in liver cancer cells. Furthermore, we found that modified regular ginseng ex...
Source: The American Journal of Chinese Medicine - October 4, 2018 Category: Complementary Medicine Authors: Cui ZY, Jo E, Jang HJ, Hwang IH, Lee KB, Yoo HS, Park SJ, Jung MK, Lee YW, Jang IS Tags: Am J Chin Med Source Type: research

Implication of SLIT3-ROBO1/ROBO2 in granulosa cell proliferation, differentiation and follicle selection in the prehierarchical follicles of hen ovary.
Abstract The SLIT/ROBO pathway has been implicated in prehierarchical follicular development of hen ovary by an intrafollicular autocrine and/or paracrine fashion. SLIT3, one of the key components of the SLIT/ROBO family, serves as a ligand that potentially interacts with the four receptors, ROBO1, ROBO2, ROBO3 and ROBO4. But the exact roles and regulatory mechanism of SLIT3 in chicken ovarian follicle development remain largely unclear. The present study was conducted to investigate the potential roles and molecular regulation of SLIT3 in granulosa cell (GC) proliferation, differentiation and follicle selection w...
Source: Cell Biology International - October 4, 2018 Category: Cytology Authors: Xu R, Qin N, Xu X, Sun X, Chen X, Zhao J Tags: Cell Biol Int Source Type: research

Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma
In conclusion, TSA elicits a synergistic cytotoxic response in combination with chemotherapy via targeting the Raf/MEK/ERK pathway. TSA elicits synergistic cytotoxic response in combination with three DNA-damaging drugs (cisplatin, gemcitabine, and doxorubicin). Activated Raf/MEK/ERK pathway is involved in chemoresistant mechanism of UC. Combining chemotherapeutic agents with HDAC inhibitor (TSA) or with targeting Raf/MEK/ERK pathway is promising to c ircumvent chemoresistance in UCs.
Source: Journal of Molecular Medicine - October 4, 2018 Category: Molecular Biology Source Type: research

Nicotinamide mononucleotide alleviates Aluminum induced bone loss by inhibiting the TXNIP-NLRP3 inflammasome.
Abstract Aluminum (Al) recognized as a persistent environmental contaminant is associated with bone diseases. Nicotinamide mononucleotide (NMN) is an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis widely used to replenish NAD+. Increasing evidences demonstrated that replenishment of NAD+ can protect against bone loss. However, the potentially protective effects of NMN against Al-induced bone impairment and the underlying mechanisms remain unknown. In the present study, we sought to investigate the protective effects of NMN on Al-induced bone damages and elucidate the potential mechanisms. We...
Source: Toxicology and Applied Pharmacology - October 4, 2018 Category: Toxicology Authors: Liang H, Gao J, Zhang C, Li C, Wang Q, Fan J, Wu Z, Wang Q Tags: Toxicol Appl Pharmacol Source Type: research

The long non-coding RNA MALAT1 is increased in renal ischemia-reperfusion injury and inhibits hypoxia-induced inflammation.
CONCLUSION: The expression of MALAT1 is increased in renal ischemia-reperfusion injury. It is likely that MALAT1 inhibits the hypoxia-induced inflammatory response through the NF-κB pathway. PMID: 30277425 [PubMed - in process]
Source: Renal Failure - October 3, 2018 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Taurolidine promotes cell apoptosis by enhancing GRIM ‑19 expression in liver cancer.
Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncol Rep. 2018 Sep 18;: Authors: Li F, Qi J, Qin C, Fu Z, Ren W Abstract Taurolidine (TRD) is a substance derived from the amino sulfonic acid taurine, which was originally used to treat peritonitis and catheter‑associated bloodstream infections, due to its antimicrobial and anti‑inflammatory properties. A recent study reported the anticancer function of TRD in malignant tumors; however, the effects and mechanisms of TRD in liver cancer remain unclear. The present study aimed to investigate the effects and mecha...
Source: Oncology Reports - October 3, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1
ConclusionsHydrogen peroxide upregulated the expression of FUNDC1 through the activation of ERK1/2 signal to trigger a mitophagic response, giving laryngeal cancer cells a befit for survival. These findings suggested that FUNDC1 might be a potential target for the treatment of laryngeal cancer accompanied with high lipid peroxidation status.
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

The association of neuronal stress with activating transcription factor 3 in dorsal root ganglion of in vivo and in vitro models of bortezomib-induced neuropathy.
This study exhibited important mechanistic insight into how BTZ induces neurotoxicity through the activation of ATF3 resulting in intracellular oxidative stress, mitochondrial dysfunction, cell apoptosis, and ER stress and provided a novel potential therapeutic target by blocking ATF3 signaling. PMID: 30289077 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - October 3, 2018 Category: Cancer & Oncology Authors: Yin Y, Qi X, Qiao Y, Liu H, Yan Z, Li H, Liu Z Tags: Curr Cancer Drug Targets Source Type: research

USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway.
In conclusion, these results suggest that USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway. PMID: 30281322 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - October 3, 2018 Category: Cytology Authors: Chen Q, Hang Y, Zhang T, Tan L, Li S, Jin Y Tags: Am J Physiol Cell Physiol Source Type: research

The Importance of CYP19A1 in Estrogen Receptor-Positive Cholangiocarcinoma
In this study, we investigated the expressions of CYP19A1 and estrogen-related proteins in CCA tissues (n = 74; 51 males and 23 females) using immunohistochemistry. The results showed that CYP19A1 was overexpressed in CCA cells compared with that in normal bile duct cells in the adjacent tissues. High expression of CYP19A1 was correlated with the metastatic status of the patients. High CYP19A1 expr ession was also positively correlated with GPR30 expression. Correlation between high CYP19A1 expression in the tumor tissues and shorter survival time was more prominent in male than in female CCA patients. To elucidate fur...
Source: Hormones and Cancer - October 3, 2018 Category: Cancer & Oncology Source Type: research

TREM-1 Attenuates RIPK3 Mediated Necroptosis in Hyperoxia Induced Lung Injury in Neonatal Mice.
Abstract Hyperoxia-induced injury to the developing lung, impaired alveolarization and dysregulated vascularization are critical factors in the pathogenesis of bronchopulmonary dysplasia (BPD); however, mechanisms for hyperoxia-induced development of BPD are not fully known. Here we show that the triggering receptor expressed on myeloid cells 1 (TREM-1) is upregulated in hyperoxia-exposed neonatal mice lungs as well as in tracheal aspirates (TA) and lungs of human neonates with respiratory distress syndrome (RDS) and BPD as an adaptive response to survival in hyperoxia. Inhibition of TREM-1 function using siRNA ap...
Source: American Journal of Respiratory Cell and Molecular Biology - October 3, 2018 Category: Molecular Biology Authors: Syed MA, Shah D, Das P, Andersson S, Pryhuber G, Bhandari V Tags: Am J Respir Cell Mol Biol Source Type: research

Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1
ConclusionsHydrogen peroxide upregulated the expression of FUNDC1 through the activation of ERK1/2 signal to trigger a mitophagic response, giving laryngeal cancer cells a befit for survival. These findings suggested that FUNDC1 might be a potential target for the treatment of laryngeal cancer accompanied with high lipid peroxidation status.
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

A Mesenchymal stem cell line (B10) increases angiogenesis in a rat MCAO model.
Abstract A human mesenchymal stem cell line (B10) transplantation has been shown to improve ischemia-induced neurological deficits in animal stroke models. To understand the underlying mechanism, we have investigated the effects of B10 transplantation on cerebral angiogenesis in a rat middle cerebral artery occlusion (MCAO) model. B10 cells were transplanted intravenously 24 h after MCAO. Immunofluorescence staining results showed that compared to PBS-groups, vWF positive vessel and endoglin positive new vessels were increased in B10-transplanted MCAO groups in the lesion areas. The mRNA of angiogenesis factors ...
Source: Experimental Neurology - October 3, 2018 Category: Neurology Authors: Sheikh AM, Yano S, Mitaki S, Haque MA, Yamaguchi S, Nagai A Tags: Exp Neurol Source Type: research

QRICH1 Mutations cause a Chondrodysplasia with Developmental Delay.
This article is protected by copyright. All rights reserved. PMID: 30281152 [PubMed - as supplied by publisher]
Source: Clinical Genetics - October 3, 2018 Category: Genetics & Stem Cells Authors: Lui JC, Jee YH, Lee A, Yue S, Wagner J, Donnelly DE, Vogt KS, Baron J Tags: Clin Genet Source Type: research

The Importance of CYP19A1 in Estrogen Receptor-Positive Cholangiocarcinoma
In this study, we investigated the expressions of CYP19A1 and estrogen-related proteins in CCA tissues (n = 74; 51 males and 23 females) using immunohistochemistry. The results showed that CYP19A1 was overexpressed in CCA cells compared with that in normal bile duct cells in the adjacent tissues. High expression of CYP19A1 was correlated with the metastatic status of the patients. High CYP19A1 expr ession was also positively correlated with GPR30 expression. Correlation between high CYP19A1 expression in the tumor tissues and shorter survival time was more prominent in male than in female CCA patients. To elucidate fur...
Source: Hormones and Cancer - October 3, 2018 Category: Cancer & Oncology Source Type: research

Specific expression of lncRNA RP13-650J16.1 and TCONS_00023979 in prostate cancer.
CONCLUSION: Collectively, our findings demonstrated that RP13-650J16.1 might be an oncogene and TCONS_00023979 might be an anti-oncogene in PCa. PMID: 30279207 [PubMed - as supplied by publisher]
Source: Bioscience Reports - October 2, 2018 Category: Biomedical Science Authors: Zhou X, Chen Q, Wang H, Zhang C, Fu B, Wang G Tags: Biosci Rep Source Type: research

Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA Genetics
Ribosome biogenesis is a multistep process, during which mistakes can occur at any step of pre-rRNA processing, modification, and ribosome assembly. Misprocessed rRNAs are usually detected and degraded by surveillance machineries. Recently, we identified a class of antisense ribosomal siRNAs (risiRNAs) that down-regulate pre-rRNAs through the nuclear RNAi pathway. To...
Source: Proceedings of the National Academy of Sciences - October 2, 2018 Category: Science Authors: Chengming Zhu, Qi Yan, Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng, Shouhong Guang Tags: Biological Sciences Source Type: research

ASAP Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.8b00388
Source: Molecular Pharmaceutics - October 1, 2018 Category: Drugs & Pharmacology Authors: Lu Xue, Nita J. Maihle, Xiaolin Yu, Shou-Ching Tang, Hong Yan Liu Source Type: research

MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD.
In conclusion, miR-301b plays an oncogenic role in TNBC possibly by downregulating CYLD and subsequently activating NF-κB p65, and this may provide a novel therapeutic approach for TNBC. PMID: 30269739 [PubMed - as supplied by publisher]
Source: BMB Reports - October 1, 2018 Category: Biochemistry Authors: Song H, Li D, Wu T, Xie D, Hua K, Hu J, Deng X, Ji C, Deng Y, Fang L Tags: BMB Rep Source Type: research