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Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
Conclusions/interpretationWe provide the first account of epigenetic changes in diabetic corneas including dual inhibition ofWNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing stimulator that can be targeted to improve wound healing and stem cells in the diabetic cornea.Data availabilityThe DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328).Graphical Abstract
Source: Diabetologia - September 1, 2023 Category: Endocrinology Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
Ultrathin SU-8 membrane for highly efficient tunable cell patterning and massively parallel large biomolecular delivery
This study presents a novel and efficient technique that enables massively parallel high throughput cell patterning and precise delivery of small to large biomolecules into patterned cells. The innovative cell patterning device proposed in this study is a standalone, ultrathin 3D SU-8 micro-stencil membrane, with a thickness of 10 μm. It features an array of micro-holes ranging from 40 μm to 80 μm, spaced apart by 50 μm to 150 μm. By culturing cells on top of this SU-8 membrane, the technique achieves highly efficient cell patterns varying from single-cell to cell clusters on a Petri dish. Utilizing this technique, we...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Pallavi Shinde Ashwini Shinde Srabani Kar Kavitha Illath Moeto Nagai Fan-Gang Tseng Tuhin Subhra Santra Source Type: research
Exosomal circRNA-001264 promotes AML immunosuppression through induction of M2-like macrophages and PD-L1 overexpression
Int Immunopharmacol. 2023 Aug 30;124(Pt A):110868. doi: 10.1016/j.intimp.2023.110868. Online ahead of print.ABSTRACTExosomes can help to effectively regulate the crosstalk between cancer cells and normal cells in the tumor microenvironment. They also regulate cancer cell proliferation and apoptosis by virtue of their cargo molecules. Transmission electron microscopy (TEM) together with differential ultracentrifugation served for verifying the presence of exosomes. In vivo and in vitro assays served for determining the role of exosomal circ_001264. RNA pull-down and dual-luciferase reporter assays assisted in the classifica...
Source: International Immunopharmacology - September 1, 2023 Category: Allergy & Immunology Authors: Ashuai Du Qinglong Yang Xiaoying Sun Qiangqiang Zhao Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
