Alterations in mitochondrial function and energy metabolism-related properties in thyroid cancer stem cells
This study aimed at testing the abnormalities in mitochondrial function and energy/metabolism-related phenotypes in thyroid cancer stem cells (TCSCs). TCSCs were isolated and identified from MDA-T32 thyroid carcinoma cell line. The mitochondrial mass and mitochondrial arrangement, amount of mitochondrial DNA (mtDNA), mitochondrial membrane potential (MMP), oxygen/glucose consumption, and intracellular concentrations of reactive oxygen species (ROS) and ATP levels were examined. Perinuclear mitochondrial distribution, low amount of mtDNA and oxygen/glucose consumption, high MMP, and low intracellular ROS and ATP concentrati...
Source: Acta Biochim Pol - November 26, 2021 Category: Biochemistry Authors: Yu Ren Hongyu Liang Xiao Wang Zhongwei Cao Yuzhen Ma Xiaoling Liu Source Type: research

Alterations in mitochondrial function and energy metabolism-related properties in thyroid cancer stem cells
This study aimed at testing the abnormalities in mitochondrial function and energy/metabolism-related phenotypes in thyroid cancer stem cells (TCSCs). TCSCs were isolated and identified from MDA-T32 thyroid carcinoma cell line. The mitochondrial mass and mitochondrial arrangement, amount of mitochondrial DNA (mtDNA), mitochondrial membrane potential (MMP), oxygen/glucose consumption, and intracellular concentrations of reactive oxygen species (ROS) and ATP levels were examined. Perinuclear mitochondrial distribution, low amount of mtDNA and oxygen/glucose consumption, high MMP, and low intracellular ROS and ATP concentrati...
Source: Acta Biochim Pol - November 26, 2021 Category: Biochemistry Authors: Yu Ren Hongyu Liang Xiao Wang Zhongwei Cao Yuzhen Ma Xiaoling Liu Source Type: research

Alterations in mitochondrial function and energy metabolism-related properties in thyroid cancer stem cells
This study aimed at testing the abnormalities in mitochondrial function and energy/metabolism-related phenotypes in thyroid cancer stem cells (TCSCs). TCSCs were isolated and identified from MDA-T32 thyroid carcinoma cell line. The mitochondrial mass and mitochondrial arrangement, amount of mitochondrial DNA (mtDNA), mitochondrial membrane potential (MMP), oxygen/glucose consumption, and intracellular concentrations of reactive oxygen species (ROS) and ATP levels were examined. Perinuclear mitochondrial distribution, low amount of mtDNA and oxygen/glucose consumption, high MMP, and low intracellular ROS and ATP concentrati...
Source: Acta Biochim Pol - November 26, 2021 Category: Biochemistry Authors: Yu Ren Hongyu Liang Xiao Wang Zhongwei Cao Yuzhen Ma Xiaoling Liu Source Type: research

Alterations in mitochondrial function and energy metabolism-related properties in thyroid cancer stem cells
This study aimed at testing the abnormalities in mitochondrial function and energy/metabolism-related phenotypes in thyroid cancer stem cells (TCSCs). TCSCs were isolated and identified from MDA-T32 thyroid carcinoma cell line. The mitochondrial mass and mitochondrial arrangement, amount of mitochondrial DNA (mtDNA), mitochondrial membrane potential (MMP), oxygen/glucose consumption, and intracellular concentrations of reactive oxygen species (ROS) and ATP levels were examined. Perinuclear mitochondrial distribution, low amount of mtDNA and oxygen/glucose consumption, high MMP, and low intracellular ROS and ATP concentrati...
Source: Acta Biochim Pol - November 26, 2021 Category: Biochemistry Authors: Yu Ren Hongyu Liang Xiao Wang Zhongwei Cao Yuzhen Ma Xiaoling Liu Source Type: research

The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy
CONCLUSION: We can state that the activity of class I alcohol dehydrogenase isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cells destruction during this disease and is comparable with the value of other markers.PMID:34817951 | DOI:10.18388/abp.2020_5841 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 24, 2021 Category: Biochemistry Authors: Joanna Piechota Wojciech Jelski Karolina Orywal Barbara Mroczko Source Type: research

The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy
CONCLUSION: We can state that the activity of class I alcohol dehydrogenase isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cells destruction during this disease and is comparable with the value of other markers.PMID:34817951 | DOI:10.18388/abp.2020_5841 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 24, 2021 Category: Biochemistry Authors: Joanna Piechota Wojciech Jelski Karolina Orywal Barbara Mroczko Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Comparison of photodynamic efficiency of cholesterol, selected cholesterol esters, metabolites and oxidation products on lipid peroxidation processes
Acta Biochim Pol. 2021 Nov 15. doi: 10.18388/abp.2020_5994. Online ahead of print.ABSTRACTCholesterol (Ch) is one of the most important components of biological membranes, which has a significant impact on their biophysical properties. As a key component of lipid membranes, Ch along with other unsaturated lipids present in a biological membrane undergoes oxidation reaction during oxidative stress. Cholesterol oxidation products, cholesteryl esters and metabolites are also localise in lipid membranes, where they may modify membrane properties. In this work the impact of cholesterol, selected cholesteryl esters, cholesterol ...
Source: Acta Biochim Pol - November 15, 2021 Category: Biochemistry Authors: Monika Burakowska Tadeusz Sarna Anna M Pawlak Source Type: research

Bioactive compounds from Lactarius deterrimus interfere with the invasive potential of gastric cancer cells
Acta Biochim Pol. 2021 Nov 14. doi: 10.18388/abp.2020_5915. Online ahead of print.ABSTRACTStomach cancer is the 4th most common cancer diagnosed worldwide. Despite intensive research on its etiopathology, its treatment strategies have not changed in the last 50 years. Mushrooms have recently attracted much attention as the source of bioactive compounds that can potentially complement cancer therapies. Here, we extracted a phenolic fraction from Lactarius deterrimus and analyzed its composition and bioactivity against the gastric cancer (AGS) cells. The complexity of L. deterrimus compounds was revealed by an HPLC assay, an...
Source: Acta Biochim Pol - November 14, 2021 Category: Biochemistry Authors: Kamila Kr ól Maciej Pude łek Gracjana Krzysiek-M ączka Mateusz Wierdak Bo żena Muszyńska Katarzyna Su łkowska-Ziaja Agata Krakowska Damian Ryszawy Jaros ław Czyż Source Type: research

On Dolly and the scandalous nature of life sciences and Where bioethics really begins
Acta Biochim Pol. 2021 Nov 14. doi: 10.18388/abp.2020_5950. Online ahead of print.ABSTRACT25 years ago, Dolly the sheep and the cloning issue stood in the focus of widespread and heated societal and ethical discussions that, for the bigger part, were not rational. In the aftermath of Dolly, in Europe bioethics was established as a discipline that is hyper-sceptical critic of science. Bioethics seen from the point of view of science is nebulous to many researchers, such as Lewis Wolpert, who called bioethics "a gross load of nonsense". It appears that the image of science in bioethics and society has as much suffe...
Source: Acta Biochim Pol - November 14, 2021 Category: Biochemistry Authors: Gregor Becker Source Type: research

Towards understanding the novel adhesin function of Candida albicans phosphoglycerate mutase at the pathogen cell surface: some structural analysis of the interactions with human host extracellular matrix proteins
In this study, we demonstrated tight binding of C. albicans Gpm1 to the candidal cell surface, thus suggesting that the readsorption of soluble Gpm1 from the external environment could be a likely mechanism leading to the presence of this moonlighting protein on the pathogen surface. Several putative Gpm1-binding receptors on the yeast surface were identified. The affinities of Gpm1 to human vitronectin (VTR) and fibronectin (FN) were characterized with surface plasmon resonance measurements, and the dissociation constants of the complexes formed were determined to be in the order of 10-8 M. The internal Gpm1 sequence moti...
Source: Acta Biochim Pol - November 14, 2021 Category: Biochemistry Authors: Dorota Satala Aleksandra Zelazna Grzegorz Satala Michal Bukowski Marcin Zawrotniak Maria Rapala-Kozik Andrzej Kozik Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Silencing ferritin alleviates atherosclerosis in mice via regulating the expression levels of matrix metalloproteinases and interleukins
This study was conducted to investigate the roles of ferritin in atherosclerosis. The mouse model of atherosclerosis was established by feeding ApoE knockout mice with a high-fat diet. The mice were then treated with ferritin-overexpressing and -silencing constructs, and assessed for interleukins (ILs) and matrix metalloproteinases (MMPs) levels using ELISA and Western blot analysis. After being fed with a high-fat diet, the ApoE knockout mice developed pro-atherogenic lipid profiles with elevated total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C). They also showed increased atheroscl...
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Mei Zheng Lizhuo Li Yuqian Liu Yun Liang Xiaoyong Qi Source Type: research

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis
In conclusion, corylin sensitized TAM-resistant cells to TAM treatment by inhibiting OAS1 expression and modulating the OAS1/miR-22-3p/SIRT1 axis.PMID:34731560 | DOI:10.18388/abp.2020_5663 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Li Che Hongru Yang Daijie Wang Shourong Liu Source Type: research

Identification of key genes involved in Brg1 mutation-induced cataract using bioinformatics analyses with publicly available microarray data
CONCLUSIONS: The Brg1 mutation affected expression of various genes in mice, such as HSP90ab1, Polr2e, Cdc20, and Polr2c. These genes may have some effects on the occurrence and development of cataract, and may serve as potential therapeutic targets for the cataract treatment.PMID:34731561 | DOI:10.18388/abp.2020_5632 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Chen Li Jianqing Li Peirong Lu Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608 (Source: Acta Biochim Pol)
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research