Filtered By:
Cancer: Bone Cancers

This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 366 results found since Jan 2013.

Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer.
Abstract The tropomyosin-related kinase B (TrkB) receptor is a member of the neurotrophic tyrosine kinase receptors family and, together with the brain-derived neurotrophic factor (BDNF), plays an important role in the development of breast cancer, lung cancer, neuroblastoma, colorectal cancer, leukemia, cervical cancer, gallbladder cancer, gastric cancer, kidney cancer, Ewing's sarcoma, esophageal cancer, and head and neck cancer. Overexpression of these two factors has been associated with increased processes involved in carcinogenesis, such as invasion, migration, epithelial-mesenchymal transition (EMT), angiog...
Source: Cytokine - September 6, 2020 Category: Molecular Biology Authors: Serafim Junior V, Fernandes GMM, Oliveira-Cucolo JG, Pavarino EC, Goloni-Bertollo EM Tags: Cytokine Source Type: research

Receptor Tyrosine Kinases in Osteosarcoma: 2019 Update.
Authors: Greenfield EM, Collier CD, Getty PJ Abstract The primary conclusions of our 2014 contribution to this series were as follows: Multiple receptor tyrosine kinases (RTKs) likely contribute to aggressive phenotypes in osteosarcoma and, therefore, inhibition of multiple RTKs is likely necessary for successful clinical outcomes. Inhibition of multiple RTKs may also be useful to overcome resistance to inhibitors of individual RTKs as well as resistance to conventional chemotherapies. Different combinations of RTKs are likely important in individual patients. AXL, EPHB2, FGFR2, IGF1R, and RET were identified as pr...
Source: Advances in Experimental Medicine and Biology - August 13, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Long noncoding RNA ERICD interacts with ARID3A via E2F1 and regulates migration and proliferation of osteosarcoma cells.
Abstract Long noncoding RNA (lncRNA) dysregulation is known to be taking part in majority of cancers, including osteosarcoma. In one of our previous studies, we showed that lncRNA MEG3 is being regulated by microRNA-664a (miR-664a) suppresses the migratory potential of osteosarcoma cells (U-2OS). We now report a novel lncRNA, namely, ERICD, which is linked to the transcription factor AT-rich interaction domain 3A (ARID3A) in U-2OS cells. We show that ARID3A binds to ERICD and indirectly interacts with each other via the E2F transcription factor 1 (E2F1). Furthermore, small interfering RNA (siRNA)-mediated knockdow...
Source: Cell Biology International - August 3, 2020 Category: Cytology Authors: Arman K, Saadat KASM, Igci YZ, Bozgeyik E, Ikeda MA, Cakmak EA, Arslan A Tags: Cell Biol Int Source Type: research

SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer
Conclusion: This study presented a bone-cancer dual-targeting biomimetic nanodelivery system for bone metastatic CRPC.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jiyuan Chen, Zhenjie Wu, Weihong Ding, Chengwu Xiao, Yu Zhang, Shen Gao, Yuan Gao, Weimin Cai Tags: Research Paper Source Type: research

miR-487a performs oncogenic functions in osteosarcoma by targeting BTG2 mRNA.
In this study, we elucidated the involvement of miR-487a in OS and the underlying molecular mechanisms. We found that miR-487a was upregulated in OS clinical samples and cell lines. Knockdown of miR-487a suppressed OS cell growth and invasion and induced apoptosis; however, overexpression of miR-487a promoted OS cell growth and invasion. Accordingly, downregulation of miR-487a significantly suppressed tumor growth of OS xenografts in vivo. Furthermore, B-cell translocation gene 2 (BTG2) mRNA was found to be a novel target of miR-487a. Knockdown of BTG2 using small interfering RNA (siRNA) recapitulated the oncogenic effects...
Source: Acta Biochimica et Biophysica Sinica - May 12, 2020 Category: Biochemistry Authors: Gu Z, Wu S, Xu G, Wu W, Mao B, Zhao S Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway.
CONCLUSIONS IL-33 was highly expressed in human osteosarcoma cells. Down-regulation of IL-33 reduced cell viability and EMT of osteosarcoma cells, and induced cell apoptosis through activation of the PI3K/AKT signaling pathway. PMID: 32312946 [PubMed - in process]
Source: Medical Science Monitor - April 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Upregulated LEPRE1 correlates with poor outcome and its knockdown attenuates cells proliferation, migration and invasion in osteosarcoma
In conclusion, leucine proline-enriched proteoglycan 1 might function as an important therapeutic factor in human osteosarcoma through regulating the PI3K/AKT signaling pathway.
Source: Anti-Cancer Drugs - March 14, 2020 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2
ConclusionOverall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment.
Source: Biomedicine and Pharmacotherapy - February 9, 2020 Category: Drugs & Pharmacology Source Type: research

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
CONCLUSION: Overall, our study revealed that METTL3 functions as an oncogene in the growth and invasion of osteosarcoma by regulating ATAD2, suggesting a potential therapeutic target for osteosarcoma treatment. PMID: 32044716 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 6, 2020 Category: Drugs & Pharmacology Authors: Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J Tags: Biomed Pharmacother Source Type: research

HOTAIR Promotes Cisplatin Resistance of Osteosarcoma Cells by Regulating Cell Proliferation, Invasion, and Apoptosis via miR-106a-5p/STAT3 Axis.
Abstract Osteosarcoma (OS) is a common primary malignant bone tumor among adolescences, and the emergence of multidrug resistance poses a huge challenge for clinical treatment of OS. LncRNA HOTAIR (HOX antisense intergenic RNA) has been reported to be associated with many malignancies, including OS. However, the underlying mechanisms of HOTAIR involved in drug resistance in OS are obscure. Our study showed that HOTAIR was upregulated in cisplatin (DDP)-resistant OS tissues and cells. HOTAIR knockdown decreased the DDP resistance, drug resistance-related gene expression, cell proliferation, and invasion and promote...
Source: Cell Transplantation - December 31, 2019 Category: Cytology Authors: Guo J, Dou D, Zhang T, Wang B Tags: Cell Transplant Source Type: research

IL-6 Promotes Cancer Stemness and Oncogenicity in U2OS and MG-63 Osteosarcoma Cells by Upregulating the OPN-STAT3 Pathway
Conclusions: IL-6 mediates promotion of osteosarcoma spheroid stemness by activating OPN/STAT3 signaling.
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chuan Zhang, Kun Ma, Wu-Yin Li Tags: Research Paper Source Type: research

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway.
CONCLUSIONS Orai1 activates the Ras-Rac1-WAVE2 signaling pathway to promote metastasis of osteosarcoma. Abnormal expression or function of Orai1 may be an important cause of osteosarcoma metastasis. PMID: 31796725 [PubMed - in process]
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Knockdown of Ski decreases osteosarcoma cell proliferation and migration by suppressing the PI3K/Akt signaling pathway.
In this study, firstly the differential expression of Ski in OS tissues and osteochondroma tissues was detected, and the expression of Ski in both human OS cell lines (MG63 and U2OS) and normal osteoblasts (hFoB1.19) was then detected. The results demonstrated that Ski expression was significantly upregulated in both human OS tissues and cell lines. The results led us to hypothesize that Ski may play an essential role in the pathological process of OS. Thus, Ski specific small interfere RNA (Ski‑siRNA) was used. The results revealed that OS cell proliferation was markedly inhibited following the knockdown of Ski, which w...
Source: International Journal of Oncology - November 13, 2019 Category: Cancer & Oncology Authors: Zhao X, Fang Y, Wang X, Yang Z, Li D, Tian M, Kang P Tags: Int J Oncol Source Type: research

Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion
AbstractOsteosarcoma is a highly malignant tumor. The molecular mechanism of its occurrence and development has not yet been clarified. Current studies have found that noncoding RNAs, such as circular RNAs (circRNAs) and microRNAs (miRNAs), play important regulatory roles in the progression of diseases. Our previous studies have shown that miR-19b is an oncogene in osteosarcoma. Further studies have shown that circ_ANKIB1 has binding sites for miR-19b, and both molecules were generally upregulated in osteosarcoma cells. RIP assay, RNA pull down, and dual-luciferase reporter gene assay showed that circ_ANKIB1 could directly...
Source: Human Cell - October 29, 2019 Category: Cytology Source Type: research

Expression and significance of Annexin A3 in the osteosarcoma cell lines HOS and U2OS.
Authors: Zeng X, Wang S, Gui P, Wu H, Li Z Abstract Annexin A3 (ANXA3) is highly expressed in different types of cancers, but the impact of ANXA3 in bone tumors is still not clear. In the present study, the expression of ANXA3 in osteosarcoma cells was first confirmed by cellular immunofluorescence. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis were used to detect the expression of ANXA3 in osteoblasts in the osteosarcoma cell lines U2OS and HOS. Furthermore, small interfering (si)‑RNA were transfected into U2OS and HOS cells via a liposome‑mediated method....
Source: Molecular Medicine Reports - September 17, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research