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Total 366 results found since Jan 2013.

Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhanced cancer therapy
Publication date: Available online 22 June 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Li Li, Run Zhang, Wenyi Gu, Zhi Ping Xu Sheet-like layered double hydroxide nanoparticles (LDH NPs) have showed great potentials in biomedical applications such as nanocarriers for drug and gene delivery, biosensors and imaging agents. However, target delivery of drugs and genes using LDH NPs to the desired tumor sites is a major challenge in cancer therapy. The aim of this study is to develop a functional LDH-based nanocomposite for target delivery of siRNA to cancer cells. Mannose as a targeting moiety wa...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 23, 2017 Category: Nanotechnology Source Type: research

Long Noncoding RNA GAS5 Suppresses Cell Growth and Epithelial –Mesenchymal Transition in Osteosarcoma by Regulating the miR‐221/ARHI Pathway
This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR‐221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real‐time PCR (RT‐qPCR). The underlying mechanism of GAS5 in osteosarcoma growth was analyzed via MTT, Transwell, RT‐qPCR, Western blot, dual‐luciferase reporter assay, RNA immunoprecipitation, and xenograft models after GAS5 overexpression. GAS5 and ARHI levels were significantly reduced, while miR‐221 increased, both in osteosarcoma tissues and cells. Overexpression of GAS5 su...
Source: Journal of Cellular Biochemistry - June 13, 2017 Category: Biochemistry Authors: Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan Tags: Article Source Type: research

Mir-150 Up-Regulates Glut1 and Increases Glycolysis in Osteosarcoma Cells
Conclusion: These data suggest that miR-150 is involved in regulation of glycolysis in osteosarcoma cells by influencing Glut1 expression. PMID: 28547952 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - May 28, 2017 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Long noncoding RNA GAS5 suppresses cell growth and epithelial ‐mesenchymal transition in osteosarcoma by regulating the miR‐221/ARHI pathway
This study explored the potential functions and mechanisms of GAS5 in the tumorigenesis of osteosarcoma. Here, the expression of GAS5, miR‐221 and aplasia Ras homologue member I (ARHI) was determined in osteosarcoma tissues and cells by Real‐time PCR (RT‐qPCR). The underlying mechanism of GAS5 in osteosarcoma growth was analyzed via MTT, Transwell, RT‐qPCR, Western blot, dual‐luciferase reporter assay, RNA immunoprecipitation, and xenograft models after GAS5 overexpression. GAS5 and ARHI levels were significantly reduced, while miR‐221 increased, both in osteosarcoma tissues and cells. Overexpression of GAS5 su...
Source: Journal of Cellular Biochemistry - May 18, 2017 Category: Biochemistry Authors: Kaishan Ye, Shuanke Wang, Haihong Zhang, Hua Han, Bing Ma, Wei Nan Tags: Article Source Type: research

Suppression of heat shock protein 70 by siRNA enhances the antitumor effects of cisplatin in cultured human osteosarcoma cells.
This study investigated whether small interfering RNA (siRNA)-mediated inhibition of Hsp70 expression in an osteosarcoma cell line would enhance sensitivity to cisplatin. The expression of Hsp70 with cisplatin treatment was observed by using Western blotting and real-time reverse transcription polymerase chain reaction (RT-PCR). Changes in the IC50 of cisplatin when Hsp70 was inhibited by siRNA were evaluated. Cisplatin's effectiveness in inducing apoptosis was assessed by assay of terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), caspase-3 activity, and mitochondrial membrane potential. Up-reg...
Source: Cell Stress and Chaperones - May 2, 2017 Category: Cytology Authors: Mori Y, Terauchi R, Shirai T, Tsuchida S, Mizoshiri N, Arai Y, Kishida T, Fujiwara H, Mazda O, Kubo T Tags: Cell Stress Chaperones Source Type: research

Effects of ZEB1 on regulating osteosarcoma cells via NF- κB/iNOS.
CONCLUSIONS: Inhibition of ZEB1 can facilitate osteosarcoma cell apoptosis and inhibit cell proliferation or invasion via down-regulating NF-kB/iNOS signal pathway. PMID: 28387915 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 8, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

A comprehensive mathematical model of drug release kinetics from nano-liposomes, derived from optimization studies of cationic PEGylated liposomal doxorubicin formulations for drug-gene delivery.
In conclusion, we have established a predictive mathematical model for the fine-tuning of controlled drug release from liposomal formulations, while creating functional drug-delivery liposomes with potential for siRNA co-delivery to increase specificity and efficacy. [Formula: see text]. PMID: 28376641 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - April 6, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Wnt/ β‐catenin Signaling Activates Expression of the Bone‐related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - March 28, 2017 Category: Biochemistry Authors: Oscar A. Vega, Claudia M.J. Lucero, Hector F. Araya, Sofia Jerez, Julio C. Tapia, Marcelo Antonelli, Flavio Salazar ‐Onfray, Facundo Las Heras, Roman Thaler, Scott M. Riester, Gary S. Stein, Andre J. van Wijnen, Mario A. Galindo Tags: Article Source Type: research

Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma.
CONCLUSIONS: The present study identifies a novel signaling involving SYK/c-MYC/MALAT1 as a promising therapeutic target for the treatment of EWS. PMID: 28336564 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - March 23, 2017 Category: Cancer & Oncology Authors: Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VK, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP Tags: Clin Cancer Res Source Type: research

Enhanced Stim1 expression is associated with acquired chemo-resistance of cisplatin in osteosarcoma cells
In this study, we showed that Stim1 expression was significantly increased in chemo-resistant osteosarcoma tissues compared with chemo-sensitivity tissues. Patients with Sitm1 expression exhibited poorer overall survival than Stim1-negative patients. Moreover, un-regulation of Stim1 expression and SOCE were also observed in cisplatin-resistant MG63/CDDP cells compared with their parental cells. Cisplatin treatment obviously reduced Stim1 expression and SOCE in cisplatin-sensitivity MG63 cells, but had no effects on MG63/CDDP cells. In addition, cisplatin resulted in a more pronounced increase of endoplasmic reticulum (ER) ...
Source: Human Cell - March 22, 2017 Category: Cytology Source Type: research

Hypoxia ‐induced proliferation of HeLa cells depends on epidermal growth factor receptor‐mediated arginase II induction
Abstract Solid tumors can often be hypoxic in regions, and cancer cells can respond to hypoxia with an increase in proliferation and a decrease in apoptosis, leading to a net increase in viable cell numbers. We have recently found that in an osteosarcoma cell line, hypoxia‐induced proliferation depends on arginase II induction. Epidermal growth factor receptor (EGFR) has been shown to mediate the hypoxia‐induced cellular proliferation in some cancer cell lines. We hypothesized that hypoxia‐induced proliferation of HeLa cells would depend on arginase II induction and that this induction of arginase II would occur thro...
Source: Physiological Reports - March 22, 2017 Category: Physiology Authors: Bhuvana A. Setty, Natasha Pillay Smiley, Caitlyn M. Pool, Yi Jin, Yusen Liu, Leif D. Nelin Tags: Original Research Source Type: research

CXCL5 Plays a Promoting Role in Osteosarcoma Cell Migration and Invasion in Autocrine- and Paracrine-Dependent Manners.
Authors: Dang H, Wu W, Wang B, Cui C, Niu J, Chen J, Chen Z, Liu Y Abstract CXCL5, a CXC-type chemokine, is an important attractant for granulocytic immune cells by binding to its receptor CXCR2. Recently, CXCL5/CXCR2 has been found to play an oncogenic role in many human cancers. However, the exact role of CXCL5 in osteosarcoma cell migration and invasion has not been revealed. Here we found that the protein expression of CXCL5 was significantly increased in osteosarcoma tissues compared with that in matched adjacent nontumor tissues. Moreover, the expression of CXCL5 was significantly associated with advanced cli...
Source: Oncology Research - March 10, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Effects of SOST Gene Silencing on Proliferation, Apoptosis, Invasion, and Migration of Human Osteosarcoma Cells Through the Wnt/ β-Catenin Signaling Pathway
AbstractOur study explored the effects ofSOST gene silencing on the proliferation, apoptosis, invasion, and migration of human osteosarcoma cells through Wnt/ β-catenin signaling pathway. Fresh tissues were obtained from 108 patients with osteosarcoma and 46 patients with osteochondroma. Human osteosarcoma cells (MG-63, U2-OS, HOS, and Saos-2) and normal osteoblast (hFoB1.19) were selected and cultured. Osteosarcoma cells were grouped randomly into the b lank group, the scrambled control group, and theSOST-siRNA group. Cell proliferation was determined by MTT assay. Cell cycle and apoptosis were tested by flow cytometry. ...
Source: Calcified Tissue International - February 27, 2017 Category: Orthopaedics Source Type: research

Transcription factor Oct4 promotes osteosarcoma by regulating lncRNA AK055347.
Authors: Fan H, Liu G, Zhao C, Li X, Yang X Abstract Osteosarcoma is the most common primary bone tumor in children and adolescents, typically presenting with a poor prognosis. Octamer-binding transcription factor 4 (Oct4) protein, encoded by the POU class 5 homeobox 1 gene, is important in maintaining self-renewal of pluripotent stem cells, and is closely associated with cancer. However, its role in osteosarcoma remains to be elucidated. The present study observed Oct4 was markedly increased in osteosarcoma cell lines and in human osteosarcoma tissue samples. Following Oct4 downregulation by small interfering RNA ...
Source: Oncology Letters - January 28, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

MicroRNA-21 Inhibits the Apoptosis of Osteosarcoma Cell Line SAOS-2 Via Targeting Caspase-8.
In conclusion, overexpression of miR-21 suppressed SAOS-2 cells apoptosis via directly targeting caspase-8. PMID: 28109080 [PubMed - as supplied by publisher]
Source: Oncology Research - January 22, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research