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Cancer: Bone Cancers
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Total 366 results found since Jan 2013.
Analysis of the function and mechanism of DIRAS1 in osteosarcoma
CONCLUSIONS: Taken together, our findings illustrated that DIRAS1 regulated by METTL3 and METTL14 can obviously modulate the malignant behaviors of osteosarcoma cells by inactivating ERK pathway.PMID:35413492 | DOI:10.1016/j.tice.2022.101794
Source: Tissue and Cell - April 12, 2022 Category: Cytology Authors: Huan Liu Weibin Shu Tianyue Liu Qingsong Li Mingzhi Gong Source Type: research
Knocking down Siglec-15 in osteosarcoma cells inhibits proliferation while promoting apoptosis and pyroptosis by targeting the Siglec-15/STAT3/Bcl-2 pathway
CONCLUSIONS: In this study, we demonstrated that the ablation of Siglec-15 in osteosarcoma inhibited proliferation and promoted apoptosis and pyroptosis by targeting the Siglec-15/STAT3/Bcl-2 pathway.PMID:35398779 | DOI:10.1016/j.advms.2022.03.001
Source: Advances in Medical Sciences - April 10, 2022 Category: Biomedical Science Authors: Keliang Song Jinfeng Ma Yang Gao Yan Qu Chongmin Ren Peng Yan Bingxin Zheng Bin Yue Source Type: research
MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites RESEARCH
The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Because super-enhancers are frequently dysregulated in cancer, we hypothesized that MYC preferentially invades into super-enhancers and alters the cancer genome organization. To that end, we performed ChIP-seq, RNA-seq, circular chromosome conformation capture (4C-seq), and Spike-in Quantitative Hi-C (SIQHiC) on the U2OS osteosarcoma ce...
Source: Genome Research - April 8, 2022 Category: Genetics & Stem Cells Authors: See, Y. X., Chen, K., Fullwood, M. J. Tags: RESEARCH Source Type: research
Targeting podoplanin for the treatment of osteosarcoma
CONCLUSIONS: Targeting PDPN with a neutralizing antibody against PDPN-CLEC-2 without ADCC and CDC is a novel therapeutic strategy for PDPN-positive OS.PMID:35381070 | DOI:10.1158/1078-0432.CCR-21-4509
Source: Clinical Cancer Research - April 5, 2022 Category: Cancer & Oncology Authors: Ai Takemoto Satoshi Takagi Takao Ukaji Nobuhiko Gyobu Mamoru Kakino Miho Takami Asami Kobayashi Marie Lebel Tokuichi Kawaguchi Minoru Sugawara Kazue Tsuji-Takayama Kenji Ichihara Yuki Funauchi Keisuke Ae Seiichi Matsumoto Yoshiya Sugiura Kengo Takeuchi Te Source Type: research
TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway
Oncol Lett. 2022 May;23(5):143. doi: 10.3892/ol.2022.13262. Epub 2022 Mar 11.ABSTRACTThe present study aimed to investigate the significance of targeting protein for Xenopus kinesin-like protein 2 (TPX2) expression in osteosarcoma. First, the TPX2 expression and survival analysis data were evaluated from The Cancer Genome Atlas (TCGA) database. Next, reverse transcription-quantitative PCR was used to explore the expression of TPX2 in osteosarcoma tissues. The observed potential target relationship between TPX2 and microRNA (miR)-29c-3p was verified using TargetScan and luciferase reporter assays. Kaplan-Meier survival anal...
Source: Oncology Letters - March 28, 2022 Category: Cancer & Oncology Authors: Dongsheng Zhu Xiangfei Xu Ming Zhang Tong Wang Source Type: research
GABPB1-AS1 Promotes the Development of Osteosarcoma by Targeting SP1 and Activating the Wnt/ < em > β < /em > -Catenin Pathway
This study suggested that GABPB1-AS1 plays a carcinogenic role in OS through the SP1/Wnt/β-catenin signaling pathway through competitive binding and inhibition of miR-199a-3p.PMID:35342417 | PMC:PMC8956396 | DOI:10.1155/2022/8468896
Source: Journal of Oncology - March 28, 2022 Category: Cancer & Oncology Authors: Jingyang Chen Meiru Bian Lingxiao Pan Chengdong Liu Hanshi Yang Source Type: research
TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway
Oncol Lett. 2022 May;23(5):143. doi: 10.3892/ol.2022.13262. Epub 2022 Mar 11.ABSTRACTThe present study aimed to investigate the significance of targeting protein for Xenopus kinesin-like protein 2 (TPX2) expression in osteosarcoma. First, the TPX2 expression and survival analysis data were evaluated from The Cancer Genome Atlas (TCGA) database. Next, reverse transcription-quantitative PCR was used to explore the expression of TPX2 in osteosarcoma tissues. The observed potential target relationship between TPX2 and microRNA (miR)-29c-3p was verified using TargetScan and luciferase reporter assays. Kaplan-Meier survival anal...
Source: Oncology Letters - March 28, 2022 Category: Cancer & Oncology Authors: Dongsheng Zhu Xiangfei Xu Ming Zhang Tong Wang Source Type: research
Local anesthetic levobupivacaine inhibits stemness of osteosarcoma cells by epigenetically repressing MAFB though reducing KAT5 expression
In this study, we identified that the treatment of levobupivacaine suppressed proliferation of osteosarcoma cells in vitro. The tumor xenograft analysis showed that levobupivacaine significantly repressed the osteosarcoma cell growth in the nude mice. The treatment of levobupivacaine improved the apoptosis rate and attenuated invasion and migration abilities of osteosarcoma cells. The sphere formation capabilities of osteosarcoma cells were repressed by levobupivacaine. The protein levels of Sox-2, Oct3/4, and Nanog were inhibited by the treatment of levobupivacaine in osteosarcoma cells. Regarding mechanism, we identified...
Source: Aging - March 25, 2022 Category: Biomedical Science Authors: Zhan Wang Yuxin Song Hui Zhang Yang Yang Suifeng Zhang Wenji Wang Source Type: research
