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Total 366 results found since Jan 2013.

APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
J Radiat Res. 2023 Mar 20:rrad007. doi: 10.1093/jrr/rrad007. Online ahead of print.ABSTRACTAprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA 5'-end, which arises from abortive ligation by DNA ligases. It is also reported that APTX physically binds to XRCC1 and XRCC4, suggesting its involvement in DNA single-strand break repair (SSBR) and DNA double-strand break repair (DSBR) via non-homologous end joining pathway. Al...
Source: Cell Research - March 20, 2023 Category: Cytology Authors: Rikiya Imamura Mizuki Saito Mikio Shimada Junya Kobayashi Masamichi Ishiai Yoshihisa Matsumoto Source Type: research

Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway
In conclusion, prognosis-related VDAC1 can affect osteosarcoma cells' proliferative activity and apoptosis level. The MAPK signaling pathway mediates VDAC1 regulation of osteosarcoma cell development.PMID:36871636 | DOI:10.1016/j.ygeno.2023.110595
Source: Genomics - March 5, 2023 Category: Genetics & Stem Cells Authors: Xu Cai Shaihong Zhu Source Type: research

Synergistic treatment of osteosarcoma with biomimetic nanoparticles transporting doxorubicin and siRNA
ConclusionDOX/siSUR-PLGA@MSCM NPs can show improved therapeutic effects in osteosarcoma patients due to the combination of a chemotherapeutic drug and gene therapy based on their good tumor targeting and biosafety.
Source: Frontiers in Oncology - January 23, 2023 Category: Cancer & Oncology Source Type: research

Molecules, Vol. 28, Pages 97: Alpha Ketoglutarate Downregulates the Neutral Endopeptidase and Enhances the Growth Inhibitory Activity of Thiorphan in Highly Aggressive Osteosarcoma Cells
sińska Since natural substances are widely explored as epigenetic modulators of gene expression and epigenetic abnormalities are important causes of cancerogenesis, factors with pro-tumor activities subjected to epigenetic control, e.g., neutral endopeptidase (NEP, neprilysin), are promising anticancer targets for potential therapies acting via epigenetic regulation of gene expression. Alpha-ketoglutarate (AKG) is a naturally occurring co-substrate for enzymes involved in histone and DNA demethylation with suggested anti-cancer activity. Hence, we investigated a potential effect of AKG on the NEP expression in cells d...
Source: Molecules - December 22, 2022 Category: Chemistry Authors: Magdalena Mizerska-Kowalska Adrianna S ławińska-Brych Emilia Niedziela Viktor Brodovskiy Barbara Zdzisi ńska Tags: Article Source Type: research

DEPDC1 as a crucial factor in the progression of human osteosarcoma
ConclusionsCollectively, this study demonstrated thatDEPDC1 is a critical driver in the promotion of osteosarcoma progression and results in poor patient prognosis. Genetically targeting or pharmacologically inhibitingDEPDC1 may serve as a promising strategy for treating human osteosarcoma.
Source: Cancer Medicine - December 7, 2022 Category: Cancer & Oncology Authors: Lin Shen, Han Li, Ronghan Liu, Chendan Zhou, Morgan Bretches, Xuan Gong, Laitong Lu, Ying Zhang, Kai Zhao, Bin Ning, Shang ‐You Yang, Aijun Zhang Tags: RESEARCH ARTICLE Source Type: research

The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma
Autophagy. 2022 Nov 30:1-18. doi: 10.1080/15548627.2022.2150003. Online ahead of print.ABSTRACTChemotherapy is an important treatment modality for osteosarcoma (OS), but the development of chemoresistance limits the therapeutic efficacy of OS and results in a poor prognosis. Thus, a better understanding of the mechanisms underlying chemoresistance in OS is essential. We previously demonstrated that COPS3/CSN3 (COP9 signalosome subunit 3) functions as an oncogene to promote OS cells lung metastasis, which is closely related to chemoresistance. Here, we showed that COPS3 was significantly upregulated in OS tissues with poor ...
Source: Autophagy - December 1, 2022 Category: Cytology Authors: Jianfang Niu Taiqiang Yan Wei Guo Wei Wang Tingting Ren Yi Huang Zhiqing Zhao Yiyang Yu Chenglong Chen Qingshan Huang Jingbing Lou Lei Guo Source Type: research

Acetylshikonin induces apoptosis of human osteosarcoma U2OS cells by triggering ROS-dependent multiple signal pathways
In this study, we attempted to investigate the anti-cancer potential of acetylshikonin towards osteosarcoma U2OS cells. The effects of acetylshikonin towards the treatment of U2OS cells showed that decreased cell proliferation and inhibited migration ability of cells which are experimentally assessed via wide range of assays including MTT, WST-1, cell counting, colony formation assays, wound healing assay and gelatin zymography assay. We also observed that early apoptosis and late apoptosis were increased through fluorescence-activated cell sorter (FACS) analysis. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP n...
Source: Toxicology in Vitro - November 21, 2022 Category: Toxicology Authors: Hyo Sun Cha Han Ki Lee See-Hyoung Park Myeong Jin Nam Source Type: research

P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling
CONCLUSION: These findings suggest that targeting the microglial P2X7R activated NLRP3/IL-1beta signaling pathway could serve as a potential strategy for BCP treatment.PMID:36375190
Source: Pain Physician - November 14, 2022 Category: Anesthesiology Authors: Ping Wu Xiaoqi Wu Guohua Zhou Yin Wang Xiaojun Liu Run Lv YanSong Liu Qingping Wen Source Type: research

FOXO3a-dependent up-regulation of HSP90 alleviates cisplatin-induced apoptosis by activating FUNDC1-mediated mitophagy in hypoxic osteosarcoma cells
In conclusion, our findings suggest that hypoxia alleviates CDDP-induced apoptosis by activating mitophagy through the FOXO3a/HSP90/Ulk1/FUNDC1 signaling pathway in OS cells.PMID:36270475 | DOI:10.1016/j.cellsig.2022.110500
Source: Cellular Signalling - October 21, 2022 Category: Cytology Authors: Dian Lu Rui Liu Yuting Zhou Zhenbo Zhang Xiuqin Jiang Jinjin Xu Airong Su Zhenzhen Hu Source Type: research