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Cancer: Bone Cancers

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Total 366 results found since Jan 2013.

lncRNA JPX modulates malignant progress of osteosarcoma through targeting miR-33a-5p and PNMA1 regulatory loop
In this study, we found that lncRNA JPX was up-regulated in OS tissues and cells. We subsequently examined the functional role of JPX in OS cells through knocked-down JPX by using siRNA. JPX down-regulation was observed to suppress OS cell proliferation, migration and invasion. Furthermore, it was verified that JPX acts as a sponge for miR-33a-5p, and that JPX regulated OS cell proliferation, migration and invasion through miR-33a-5p. Moreover, down-regulation of miR-33a-5p in OS contributed to PNMA1 upregulation, and PNMA1 depletion inhibited OS cell proliferation, migration and invasion in vitro. Taken together, our data...
Source: Translational Oncology - September 6, 2022 Category: Cancer & Oncology Authors: Wei Xiong Dan Liu Xi Chen Leiting Liu Weihong Xiao Source Type: research

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research

GSE154529 Identification of ALKBH5 targets in osteosarcoma by methyl RNA immunoprecipitation MeRIP-seq
Contributors : Pooja Yadav ; Manjeet Rao ; Yidong Chen ; Zhao LaiSeries Type : OtherOrganism : Homo sapiensTo identify potential target mRNAs that are demethylated by ALKBH5, meRIP-seq with a m6A antibody was conducted in 143B osteosarcoma cells transfected with scrambled or ALKBH5-siRNA.
Source: GEO: Gene Expression Omnibus - June 28, 2022 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

Cancer combination therapies by silencing of CTLA ‐4, PD‐L1, and TIM3 in osteosarcoma
ConclusionOur findings suggest that triple blockade of CTLA-4, PD-L1, and TIM3 is an effective strategy for inhibiting tumor cell progression and migration in OS, which requires large-scale clinical investigations to be translated into broad therapeutic applicability for OS patients.
Source: IUBMB Life - May 31, 2022 Category: Research Authors: Amin Daei Sorkhabi, Aila Sarkesh, Ali Fotouhi, Hossein Saeedi, Leili Aghebati ‐Maleki Tags: RESEARCH COMMUNICATION Source Type: research

Analysis of the function and mechanism of DIRAS1 in osteosarcoma
CONCLUSIONS: Taken together, our findings illustrated that DIRAS1 regulated by METTL3 and METTL14 can obviously modulate the malignant behaviors of osteosarcoma cells by inactivating ERK pathway.PMID:35413492 | DOI:10.1016/j.tice.2022.101794
Source: Tissue and Cell - April 12, 2022 Category: Cytology Authors: Huan Liu Weibin Shu Tianyue Liu Qingsong Li Mingzhi Gong Source Type: research