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Total 366 results found since Jan 2013.
MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites RESEARCH
The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Because super-enhancers are frequently dysregulated in cancer, we hypothesized that MYC preferentially invades into super-enhancers and alters the cancer genome organization. To that end, we performed ChIP-seq, RNA-seq, circular chromosome conformation capture (4C-seq), and Spike-in Quantitative Hi-C (SIQHiC) on the U2OS osteosarcoma ce...
Source: Genome Research - March 23, 2022 Category: Genetics & Stem Cells Authors: See, Y. X., Chen, K., Fullwood, M. J. Tags: RESEARCH Source Type: research
Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S
CONCLUSION: Taken together, our data reinforced the evidence that CD44 knockdown inhibited cell proliferation, migration and invasion of OS cells accompanied by altered expression of cathepsin S. These findings offer new clues for OS development and progression, suggesting CD44 as a potential therapeutic target for OS.PMID:35264209 | DOI:10.1186/s13018-022-03048-x
Source: Cell Research - March 10, 2022 Category: Cytology Authors: Lingwei Kong Hairu Ji Xintian Gan Sheng Cao Zhehong Li Yu Jin Source Type: research
MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites RESEARCH
The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. MYC overexpression leads to MYC binding at active enhancers, resulting in a global transcriptional amplification of active genes. Since superenhancers are frequently dysregulated in cancer, we hypothesized that MYC preferentially invades into superenhancers and alters the cancer genome organization. To that end, we performed ChIP-seq, RNA-seq, 4C-seq and SIQHiC (Spike-in Quantitative Hi-C) on the U2OS osteosarcoma cell line with tetracycline-inducible MYC. MYC ove...
Source: Genome Research - February 3, 2022 Category: Genetics & Stem Cells Authors: See, Y. X., Chen, K., Fullwood, M. J. Tags: RESEARCH Source Type: research
Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells
ConclusionsWe show that time-dependent changes induced by suppression of oncogenicEWSR1/FLI1 expression induces dormancy, with different subpopulation dynamics. Cells re-entering the proliferative cycle show enhanced stem-like characteristics, whereas those remaining dormant for prolonged periods appear to survive through autophagy. Cells with these characteristics identified in exponentially growing cell populations and in tumor xenografts may confer drug resistance and could potentially contribute to metastasis.
Source: Cellular Oncology - January 7, 2022 Category: Cancer & Oncology Source Type: research
Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy
This study provides a new reference to improve the efficacy of OS clinically.
Source: Frontiers in Pharmacology - December 20, 2021 Category: Drugs & Pharmacology Source Type: research
IRE1 α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma
In this study, we investigated the functions of endoplasmic reticulum (ER) stress activities in OS and elucidated whether ER stress inhibitors could exert antitumor effects. The expression of 84 key genes associated with unfolded protein response (UPR) was assessed in four OS cells (143B, MG63, U2OS and KHOS) by RT2 Profiler PCR Arrays. Based on results, we performed both siRNA and inhibitor assays focusing on IRE1 α-XBP1 and PERK pathways. All OS cell lines showed resistance to PERK inhibitors. Furthermore,ATF4 andEIF2A inhibition by siRNA did not affect the survival of OS cell lines. On the other hand, IRE1 α-XBP1 inhi...
Source: Hormones and Cancer - November 30, 2021 Category: Cancer & Oncology Source Type: research
MsrB1 Promotes Proliferation and Invasion of Colorectal Cancer Cells via GSK-3 β/β-catenin Signaling Axis
In conclusion, the oncogenic role and related mechanisms of MsrB1 in CRC discovered in our work determined the potential role of MsrB1 as a biomarker and may provide a new target for clinical therapy of CRC.PMID:34719306 | PMC:PMC8558597 | DOI:10.1177/09636897211053203
Source: Cell Transplantation - November 1, 2021 Category: Cytology Authors: Xiao-Yu Chen Sheng-Yong Yang Xiao-Jie Ruan Hong-Yue Ding Ning-Xi Wang Fang Liu Jia-Chu Li Yi Li Source Type: research
Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells
CONCLUSIONS: Our study found that ADD3 functioned as a tumor suppressor gene during osteosarcoma development. The abnormal upregulation of miR-23b-3p targeted the expression of ADD3 and resulted in accelerated osteosarcoma cell proliferation and migration. Thus, the miR-23b-3p/ADD3 axis contributes to the development of osteosarcoma and ADD3 is a key driver of malignancy.PMID:34632867 | DOI:10.1177/03008916211050687
Source: Tumori - October 11, 2021 Category: Cancer & Oncology Authors: Zhigang Suo Xiucai Ma Yueping Ding Yu Zhou Xiangguo Duan Le Fei Jianmin Song Huiqiang Ding Source Type: research
