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Cancer: Bone Cancers

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Total 366 results found since Jan 2013.

The tetraspanin CD81 mediates the growth and metastases of human osteosarcoma
ConclusionBased on our findings we conclude that inhibition of CD81 suppresses intracellular signaling and reduces tumorigenesis and lung metastasis in osteosarcoma cells.
Source: Cellular Oncology - September 6, 2019 Category: Cancer & Oncology Source Type: research

AUF1 positively controls angiogenesis through mRNA stabilization-dependent up-regulation of HIF-1 α and VEGF-A in human osteosarcoma.
AUF1 positively controls angiogenesis through mRNA stabilization-dependent up-regulation of HIF-1α and VEGF-A in human osteosarcoma. Oncotarget. 2019 Aug 06;10(47):4868-4879 Authors: Al-Khalaf HH, Aboussekhra A Abstract Osteosarcoma is the most common malignant bone tumor in children, adolescents, and young adults. This pleiomorphic tumor depends on new blood vessel development, also known as angiogenesis, for tumor growth and metastasis. Therefore, it's of utmost importance to identify the key genes and pathways that regulate this pro-metastatic process in order to develop more efficient therapies. H...
Source: Oncotarget - August 28, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Targeting clusterin induces apoptosis, reduces growth ability, invasion and mediates sensitivity to chemotherapy in human cancer in human osteosarcoma cells.
CONCLUSIONS: Overexpression of sCLU was significantly correlated with metastasis and chemosensitivity in osteosarcoma cells. The described sCLU-specific siRNA that can potently silence sCLU gene expression may thus prove valuable agents during antitumor therapy. PMID: 31433751 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - August 20, 2019 Category: Biotechnology Authors: Wang X, Yu Y, Zang L, Zhang P, Ma J, Chen D Tags: Curr Pharm Biotechnol Source Type: research

i-Fect Delivers circRNA and miRNA
Blocks Bone Cancer PainAltered expression of circular RNA (circRNA) is recognized as a contributor to malignant pain where microRNA (miRNA) exerts an essential effect. Researchers used ouri-FectTMTransfection Kit to knock them down. Zhongqi Zhang, Xiaoxia Zhang, Yanjing Zhang, Jiyuan Li, Zumin Xing. Yiwen Zhang.Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model. Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model. Journal of Molecular Neuroscience. pp 1 –10Intrathecal Administration of miRNA and circRN...
Source: Neuromics - August 4, 2019 Category: Neuroscience Tags: Bone Cancer Pain circRNA iFect miRNA Transfection Transfection Reagents Source Type: news

MicroRNA-29a suppresses the invasion and migration of osteosarcoma cells by regulating the SOCS1/NF- κB signalling pathway through negatively targeting DNMT3B.
In conclusion, miR‑29a promoted the apoptosis, and inhibited the invasion, migration and EMT process of OS cells via inhibition of the SOCS1/NF‑κB signalling pathway by directly targeting DNMT3B. PMID: 31364725 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - July 23, 2019 Category: Molecular Biology Authors: Gong HL, Tao Y, Mao XZ, Song DY, You D, Ni JD Tags: Int J Mol Med Source Type: research

Kmt2c modulates migration and invasion processes in osteosarcoma cell lines
In this study we investigated the role of KMT2C (a chromatin-modifying and remodelling protein) in osteosarcoma progression through cell migration and invasion assays in osteosarcoma primary and metastatic cell lines. Wound healing and transwell assays were used to detect changes of cell migration and matrigel assay was used to evaluate changes of cell invasion in primary and metastatic osteosarcoma cell lines after KMT2C siRNA transfection. We found that primary osteosarcoma cell lines showed the highest capacity of migration before mRNA KMT2C silencing and the highest capacity of invasion after mRNA KMT2C silencing; on t...
Source: Pathology Research and Practice - July 13, 2019 Category: Pathology Source Type: research

AAV-mediated siRNA against TRPV1 reduces nociception in a rat model of bone cancer pain.
Conclusions: Knockdown of TRPV1 effectively ameliorated mechanical allodynia and thermal hyperalgesia induced by TCI. Our data demonstrated that modulate the expression of TRPV1 in the spinal cord could be a potential therapeutic approach for bone cancer pain. PMID: 31296147 [PubMed - as supplied by publisher]
Source: Neurological Research - July 13, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Down-regulation of RAC2 by small interfering RNA restrains the progression of osteosarcoma by suppressing the Wnt signaling pathway.
Abstract Osteosarcoma (OS) is the most common primary malignancy of bone and is characterized by a high malignant and metastatic potential. Microarray-based differentially expressed gene screening determined RAC2 as the candidate gene related to OS. Highly expressed RAC2 and activated Wnt signaling pathway were determined in OS tissues using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot analysis. The OS cells were transfected with siRNA-RAC2 or treated with BIO (activator of Wnt pathway), whereby the effects of siRNA-RAC2 on cell proliferation, invasion, cycle and apoptosi...
Source: International Journal of Biological Macromolecules - July 2, 2019 Category: Biochemistry Authors: Xia P, Gao X, Shao L, Chen Q, Li F, Wu C, Zhang W, Sun Y Tags: Int J Biol Macromol Source Type: research

Upregulated TTYH2 expression is critical for the invasion and migration of U2OS human osteosarcoma cell lines.
Abstract Ion channels have recently emerged as stable biomarkers and anticancer targets particularly when the applications of the currently available therapeutic regimens are limited, as in case of osteosarcoma, a malignant bone tumor. Here, we evaluated the expression of TTYH2, a presumably calcium-activated chloride channel, in a human osteosarcoma cell line U2OS. We used small-interfering RNA (siRNA)-mediated gene silencing to demonstrate the downregulation in the expression of TTYH2 that resulted in the decrease in the invasion and migration, but not proliferation, of U2OS cells. The expression levels of Slug ...
Source: Biochemical and Biophysical Research communications - June 19, 2019 Category: Biochemistry Authors: Moon DK, Bae YJ, Jeong GR, Cho CH, Hwang SC Tags: Biochem Biophys Res Commun Source Type: research

Furowanin A Exhibits Anti-proliferative and Pro-apoptotic Activities by Targeting Sphingosine Kinase 1 in Osteosarcoma.
This study is designed to evaluate the efficacy of Fur A against OS. The effect of Fur A on cell viability was assessed by Cell Counting Kit-8 (CCK-8) assay. Western blotting and quantitative real-time PCR (qRT-PCR) were performed to determine the protein and mRNA level of sphingosine kinase 1 (SphK1), respectively. To validate the role of SphK1 in the pro-apoptotic activity of Fur A, overexpressing SphK1 vector and siRNA targeting SphK1 were utilized to transfect OS cells. Moreover, a OS xenograft murine model was used to analyze the therapeutic efficacy of Fur A in vivo. Fur A treatment led to a dose-dependent decrease i...
Source: Anatomical Record - June 13, 2019 Category: Anatomy Authors: Wei K, Sun H, Chen X, Chen Q, Li Y, Wu H Tags: Anat Rec (Hoboken) Source Type: research

BTF3 Silencing Inhibits the Proliferation of Osteosarcoma Cells
Osteosarcoma (OS) is one of the bone malignancy cancers with poor prognosis in the early stages worldwide. Basic transcription factor 3 (BTF3) is associated with the development of several types of cancer. The present study aimed to evaluate the role of BTF3 in OS. Silencing of BTF3 was achieved by using stable lentivirus transfection of siRNA targeting BTF3 in the human OS cell line Saos-2. Cell viability and colony-forming ability were measured using methyl-thaizolyl-tetrazolium (MTT) and colony formation assays, respectively. Propidium iodide staining and flow cytometry was used to detect the progression of the cell cyc...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Liu, Lin Jiang, Wanchun Wang, Tao Jiang Tags: Research Paper Source Type: research

Upregulation of miR‑95-3p inhibits growth of osteosarcoma by targeting HDGF
Publication date: Available online 10 June 2019Source: Pathology - Research and PracticeAuthor(s): Xiwei Liu, Wei Ma, Jianbing Ma, Lin Xiao, Dingjun HaoAbstractOsteosarcoma is the most common bone malignancy and miR-95-3p plays an important role in multiple cancers. The purpose of this study was to explore the effect and potential mechanism of miR-95-3p on the growth of osteosarcoma. In vitro, the osteosarcoma cell lines, SAOS-2 and U2OS cells, were transfected with miR-95-agomir to assess the role of miR-95-3p in proliferation and apoptosis of osteosarcoma cells. We determined that overexpression of miR-95-3p significantl...
Source: Pathology Research and Practice - June 11, 2019 Category: Pathology Source Type: research

LncRNA NKILA inhibits invasion and migration of osteosarcoma cells via NF- κB/Snail signaling pathway.
CONCLUSIONS: NKILA was lowly expressed in osteosarcoma tissues. In addition, high expression of NKILA could suppress the migration and invasion of osteosarcoma cells by inhibiting the NF-κB/Snail signaling pathway. PMID: 31173281 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 9, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Long noncoding RNA NORAD regulates cancer cell proliferation and migration in human osteosarcoma by endogenously competing with miR ‐199a‐3p
In this study, we evaluated the expressions and functions of a long noncoding RNA (lncRNA), Noncoding RNA activated by DNA damage (NORAD) in human osteosarcoma. NORAD expressions were evaluated by qRT ‐PCR in in vitro osteosarcoma cell lines and in vivo clinical specimens. SiRNA‐induced NORAD downregulation was conducted in Saos‐2 and 143B cells, and the functional effects of NORAD downregulation on osteosarcoma cells were evaluated by CCK‐8 proliferation assay, 24‐well transwell invasi on assay and in vivo tumor explant assay, respectively. The possibility of NORAD endogenously competing microRNA target, hsa‐m...
Source: IUBMB Life - June 5, 2019 Category: Research Authors: Xuming Wang, Jilong Zou, Hongjun Chen, Peng Zhang, Zhiyuan Lu, Zhitao You, Jiabing Sun Tags: RESEARCH COMMUNICATION Source Type: research