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Cancer: Bone Cancers

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Total 366 results found since Jan 2013.

Parathyroid hormone type 1 receptor regulates osteosarcoma K7M2 Cell growth by interacting with angiotensinogen.
This study aimed to determine the interactions between parathyroid hormone type 1 receptor (PTHR1) and angiotensinogen (AGT) and the effects of these agents on osteosarcoma (OS). We constructed a stably transfected mouse OS K7M2 cell line (shPTHR1- K7M2) using shRNA and knocked down AGT in these cells using siRNA-AGT. The transfection efficiency and expression of AGT, chemokine C-C motif receptor 3 (CCR3), and chemokine (C-C motif) ligand 9 (CCL9) were determined using real-time quantitative PCR. Cell viability and colony formation were assessed using Cell Counting Kit-8 and crystal violet staining, respectively. Cell apop...
Source: J Cell Mol Med - January 28, 2021 Category: Molecular Biology Authors: Li S, Liu F, Pei Y, Dong Y, Shang Y Tags: J Cell Mol Med Source Type: research

Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter
CONCLUSION: knockdown of 91 H suppressed the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter in vitro and in vivo. Thus, 91 H may serve as a new target for the treatment of osteosarcoma.PMID:33499776 | PMC:PMC7844445 | DOI:10.1177/1533033821990006
Source: Technology in Cancer Research and Treatment - January 27, 2021 Category: Cancer & Oncology Authors: Suoli Cheng Jianping Zheng Xueqin Liu Jiandang Shi Fan Gong Xu Zhang Changhao Liu Cuiyun Liu Source Type: research

The Long Noncoding RNA RP11-728F11.4 Promotes Atherosclerosis.
CONCLUSIONS: RP11-728F11.4 promotes atherosclerosis, with an influence on cholesterol homeostasis and proinflammatory molecule production, thus representing a potential therapeutic target. PMID: 33406853 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 6, 2021 Category: Cardiology Authors: Dong XH, Lu ZF, Kang CM, Li XH, Haworth KE, Ma X, Lu JB, Liu XH, Fang FC, Wang CS, Ye JH, Zheng L, Wang Q, Ye S, Hu YW Tags: Arterioscler Thromb Vasc Biol Source Type: research

Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter.
CONCLUSION: knockdown of 91 H suppressed the tumorigenesis of osteosarcoma via inducing methylation of CDK4 promoter in vitro and in vivo. Thus, 91 H may serve as a new target for the treatment of osteosarcoma. PMID: 33499776 [PubMed - in process]
Source: Technology in Cancer Research and Treatment - January 1, 2021 Category: Cancer & Oncology Authors: Cheng S, Zheng J, Liu X, Shi J, Gong F, Zhang X, Liu C, Liu C Tags: Technol Cancer Res Treat Source Type: research

Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion.PMID:33334789
Source: Annals of Clinical and Laboratory Science - December 18, 2020 Category: Laboratory Medicine Authors: Zhengming Yang Jianjun Qian Wei Yu Minfei Yang Bin Liu Huimin Tao Source Type: research

Cancers, Vol. 12, Pages 3781: Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms
We examined the effects of combining the novel thiosemicarbazones, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), or its analog, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), with the standard chemotherapies, celecoxib (CX), etoposide (ETO), or temozolomide (TMZ). These combinations were analyzed for synergism to inhibit proliferation of three pediatric tumor cell-types, namely osteosarcoma (Saos-2), medulloblastoma (Daoy) and neuroblastoma (SH-SY5Y). In terms of mechanistic dissection, this study discovered novel thiosemicarbazone targets not previously identified and which are importa...
Source: Cancers - December 15, 2020 Category: Cancer & Oncology Authors: Silvia Paukovcekova Jan Skoda Jakub Neradil Erika Mikulenkova Petr Chlapek Jaroslav Sterba Des R. Richardson Renata Veselska Tags: Article Source Type: research

LncRNA-TMPO-AS1 promotes apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1.
CONCLUSIONS: TMPO-AS1 can function as a diagnostic and prognostic marker for osteosarcoma. LncRNA-TMPO-AS1 can promote apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1, which is a potent treatment option for osteosarcoma. PMID: 33215415 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - November 22, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells.
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion. PMID: 33334789 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - November 1, 2020 Category: Laboratory Medicine Authors: Yang Z, Qian J, Yu W, Yang M, Liu B, Tao H Tags: Ann Clin Lab Sci Source Type: research

Downregulation of CDC20 suppressed cell proliferation, induced apoptosis, triggered cell cycle arrest in osteosarcoma cells, and enhanced chemosensitivity to cisplatin.
In this study, we aim to explore the role of CDC20 in two independent human OS cell lines' biological phenotype and chemotherapy sensitivity. We applied multiple approaches to measure cell growth, cell cycle, and apoptosis with or without deregulation or overexpression of CDC20. We found that the downregulation of CDC20 by siRNA or apcin suppressed cell proliferation, induced apoptosis, and triggered cell cycle arrest. Consistently, overexpression of CDC20 in normal cells promoted cell growth, inhibited apoptosis. What's more, the additional treatment of siCDC20 or apcin achieved better anticancer effects than that of cisp...
Source: Neoplasma - October 30, 2020 Category: Cancer & Oncology Authors: Gao Y, Guo C, Fu S, Cheng Y, Song C Tags: Neoplasma Source Type: research

Thrombospondin-2 stimulates MMP-9 production and promotes osteosarcoma metastasis via the PLC, PKC, c-Src and NF- κB activation.
Thrombospondin-2 stimulates MMP-9 production and promotes osteosarcoma metastasis via the PLC, PKC, c-Src and NF-κB activation. J Cell Mol Med. 2020 Oct 06;: Authors: Liu JF, Chen PC, Chang TM, Hou CH Abstract Osteosarcoma is an extremely common primary bone malignancy that is highly metastatic, with most deaths resulting from pulmonary metastases. The extracellular matrix protein thrombospondin-2 (TSP-2) is key to many biological processes, such as inflammation, wound repair and tissue remodelling. However, it is unclear as to what biological role TSP-2 plays in human metastatic osteosarcoma. The im...
Source: J Cell Mol Med - October 5, 2020 Category: Molecular Biology Authors: Liu JF, Chen PC, Chang TM, Hou CH Tags: J Cell Mol Med Source Type: research