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Cancer: Bone Cancers
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Total 366 results found since Jan 2013.
DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway
Am J Cancer Res. 2021 Jun 15;11(6):3354-3374. eCollection 2021.ABSTRACTThe distal-less (dlx) homeobox transcription factors have been implicated roles in bone development. DLX5, in particular, was shown to play essential roles in osteoblast differentiation by targeting RUNX2, a master transcription factor for bone development. Interestingly, DLX5 has also been shown to play an oncogenic role in lung and other cancers, possibly via regulation of MYC expression. Given its dual roles in bone and cancer, this study aimed to investigate the effect of DLX5 on progression of osteosarcoma (OS), the primary bone cancer that is char...
Source: Cell Research - July 12, 2021 Category: Cytology Authors: Xiaojing Zhang Huiqin Bian Wei Wei Qian Wang Jinnan Chen Ruoxuan Hei Chen Chen Xuan Wu Haochun Yuan Junxia Gu Yaojuan Lu Cheguo Cai Qiping Zheng Source Type: research
Cancers, Vol. 13, Pages 3201: Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines
Conclusion: These novel findings demonstrated that STRAP plays a role in tumorigenesis and maintenance of neuroblastoma stemness.
Source: Cancers - June 26, 2021 Category: Cancer & Oncology Authors: Laura V Bownes Adele P Williams Raoud Marayati Colin H Quinn Sara C Hutchins Jerry E Stewart Trung Vu Juliet L Easlick Elizabeth Mroczek-Musulman David K Crossman Joshua C Anderson Christopher D Willey Pran K Datta Elizabeth A Beierle Tags: Article Source Type: research
Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression
ConclusionOur results suggest that MDR1 is an attractive therapeutic target for chemoresistant OS. Tumor-specific virotherapy is thus a promising strategy for reversing chemoresistance in OS patients via suppression of MDR1 expression.
Source: Cancer Chemotherapy and Pharmacology - June 10, 2021 Category: Cancer & Oncology Source Type: research
GSE173313 Histone H4 lysine 20 mono-methylation directly facilitates chromatin ‘openness’ and promotes transcription of housekeeping genes (ATAC-seq_DRB)
Contributors : Muhammad Shoaib ; Qinming Chen ; Xiangyan Shi ; Nidhi Nair ; Chinmayi Prasanna ; Renliang Yang ; David Walter ; Klaus S Frederiksen ; Einarsson Hjorleifur ; Peter Svenson ; Chuan-Fa Liu ; Karl Ekwall ; Mads Lerdrup ; Lars Nordenski öld ; Claus S SørensenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo study the role of Histone H4 lysine 20 mono- and tri-methylation (H4K20me1, H4K20me3) in relationship to chromatin accessibility and gene expression, we report the application of high-throughput profiling of these marks in synchronized and asynchronous Hu...
Source: GEO: Gene Expression Omnibus - June 4, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE156216 Histone H4 lysine 20 mono-methylation directly facilitates chromatin ‘openness’ and promotes transcription of housekeeping genes (ChIP-seq)
Contributors : Muhammad Shoaib ; Qinming Chen ; Xiangyan Shi ; Nidhi Nair ; Chinmayi Prasanna ; Renliang Yang ; Chuan F Liu ; David Walter ; Klaus S Frederiksen ; Peter Svenson ; Karl Ekwall ; Mads Lerdrup ; Lars Nordenski öld ; Claus S SørensenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusTo study the role of Histone H4 lysine 20 mono- and tri-methylation (H4K20me1, H4K20me3) in relationship to chromatin accessibility and gene expression, we report the application of high-throughput profiling of these marks in Human Osteosarcoma U2OS and Mouse Fibrobl...
Source: GEO: Gene Expression Omnibus - June 4, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE156215 Histone H4 lysine 20 mono-methylation directly facilitates chromatin ‘openness’ and promotes transcription of housekeeping genes (ATAC-seq)
Contributors : Muhammad Shoaib ; Qinming Chen ; Xiangyan Shi ; Nidhi Nair ; Chinmayi Prasanna ; Renliang Yang ; Chuan F Liu ; David Walter ; Klaus S Frederiksen ; Peter Svenson ; Karl Ekwall ; Mads Lerdrup ; Lars Nordenski öld ; Claus S SørensenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusTo study the role of Histone H4 lysine 20 mono- and tri-methylation (H4K20me1, H4K20me3) in relationship to chromatin accessibility and gene expression, we report the application of high-throughput profiling of these marks in synchronized and asynchronous Human Osteo...
Source: GEO: Gene Expression Omnibus - June 4, 2021 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway
In conclusion, our study demonstrated that RUSC1-AS1 promoted osteosarcoma development both in vitro and in vivo through sponging to miR-340-5p and activating the PI3K/AKT signaling pathway. Therefore, RUSC1-AS1 becomes a potential therapeutic target for osteosarcoma.PMID:34048366 | DOI:10.18632/aging.203047
Source: Aging - May 28, 2021 Category: Biomedical Science Authors: Chang-Jun Tong Qing-Chun Deng Di-Jun Ou Xia Long He Liu Kang Huang Source Type: research
Fusion protein EWS-FLI1 is incorporated into a protein granule in cells
We examined EWSR1 and EWS-FLI1 activity in Ewing sarcoma cells by siRNA-mediated knockdown and RNA-seq analysis. More transcripts were affected by the EWSR1 knockdown than expected and these included many EWS-FLI1 regulated genes. We reevaluated physical interactions between EWS-FLI1, EWSR1, and RNA Pol II, and employed a cross-linking based strategy to investigate protein assemblies associated with the proteins. The LC domain of EWS-FLI1 was required for the assemblies observed to form in cells. These results offer new insights into a protein assembly that may enable EWS-FLI1 to bind its wide network of protein partners a...
Source: RNA - May 26, 2021 Category: Genetics & Stem Cells Authors: Nasiha S Ahmed Lucas M Harrell Daniel R Wieland Michelle A Lay Valery F Thompson Jacob C Schwartz Source Type: research
Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF- κB, c-Fos and NFATc1 transcription factors
Exp Ther Med. 2021 May;21(5):412. doi: 10.3892/etm.2021.9856. Epub 2021 Feb 25.ABSTRACTVasodilator-stimulated phosphoprotein (VASP) is essential for osteoclast differentiation, and reduced VASP expression results in depressed osteoclast differentiation. Previously, we demonstrated the importance of VASP and Ras-related C3 botulinum toxin substrate 1 interactions in osteosarcoma cell migration and metastasis using Mg-63 and Saos2 cells. However, the molecular details of the functional role of VASP in cell motility and migration remain to be elucidated. The present study demonstrated that VASP affects the expression of αV-i...
Source: Experimental and Therapeutic Medicine - March 22, 2021 Category: General Medicine Authors: Hao Hu Chao Li Haitao Zhang Gang Wu Yong Huang Source Type: research
LncRNA FOXD2-AS1 knockdown inhibits the resistance of human osteosarcoma cells to cisplatin by inhibiting miR-143 expression.
CONCLUSIONS: LncRNA FOXD2-AS1 knockdown inhibits the resistance of human osteosarcoma cells to cisplatin, promotes their apoptosis and weakens their invasion and migration abilities. The possible underlying mechanism may be related to the inhibition of miR-143 expression by lncRNA FOXD2-AS1 in drug-resistant cell lines.
PMID: 33577022 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - February 14, 2021 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
MicroRNA ‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1.
In conclusion, the present results indicated that miR‑186‑5p could attenuate IL‑1β‑induced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR‑186‑5p may be used as a potential therapeutic target for OA.
PMID: 33537828 [PubMed - in process]
Source: Molecular Medicine - February 6, 2021 Category: Molecular Biology Authors: Li Q, Wu M, Fang G, Li K, Cui W, Li L, Li X, Wang J, Cang Y Tags: Mol Med Rep Source Type: research
MicroRNA ‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1
In conclusion, the present results indicated that miR‑186‑5p could attenuate IL‑1β‑induced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR‑186‑5p may be used as a potential therapeutic target for OA.PMID:33537828 | DOI:10.3892/mmr.2021.11892
Source: Molecular Medicine Reports - February 4, 2021 Category: Molecular Biology Authors: Qing Li Mingjie Wu Guofang Fang Kuangwen Li Wengang Cui Liang Li Xia Li Junsheng Wang Yanhong Cang Source Type: research
