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Cancer: Bone Cancers

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Total 366 results found since Jan 2013.

Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells
CONCLUSIONS: Our study found that ADD3 functioned as a tumor suppressor gene during osteosarcoma development. The abnormal upregulation of miR-23b-3p targeted the expression of ADD3 and resulted in accelerated osteosarcoma cell proliferation and migration. Thus, the miR-23b-3p/ADD3 axis contributes to the development of osteosarcoma and ADD3 is a key driver of malignancy.PMID:34632867 | DOI:10.1177/03008916211050687
Source: Tumori - October 11, 2021 Category: Cancer & Oncology Authors: Zhigang Suo Xiucai Ma Yueping Ding Yu Zhou Xiangguo Duan Le Fei Jianmin Song Huiqiang Ding Source Type: research

Knockdown of lncRNA C5orf66-AS1 inhibits osteosarcoma cell proliferation and invasion via miR-149-5p upregulation
Oncol Lett. 2021 Nov;22(5):757. doi: 10.3892/ol.2021.13018. Epub 2021 Sep 2.ABSTRACTOsteosarcoma (OS) is the most common primary malignant bone tumor in the pediatric age group. Despite the various potential treatments for OS, the cure rate of patients with OS remains very low. An increasing number of long non-coding RNAs (lncRNAs) have been identified as key regulators of the progression of malignant human tumors. However, the biological functions of the lncRNA C5orf66-antisense 1 (C5orf66-AS1) in OS are yet to be fully elucidated. The present study aimed to investigate the functions and underlying mechanisms of C5orf66-A...
Source: Oncology Letters - September 20, 2021 Category: Cancer & Oncology Authors: Hui Zhang Jie Song Source Type: research

Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide- α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2021 Sep 8:gmab115. doi: 10.1093/abbs/gmab115. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT), which is a new method for treating tumors, has been used in the treatment of cancer. In-depth research has shown that PDT cannot completely kill tumor cells, indicating that tumor cells are resistant to PDT. Glucose regulatory protein 78 (GRP78), which is a key regulator of endoplasmic reticulum stress, has been confirmed to be related to tumor resistance and recurrence, but there are relatively few studies on the further mechanism of GRP78 in PDT. Our experiment aimed to observe the...
Source: Acta Biochimica et Biophysica Sinica - September 8, 2021 Category: Biochemistry Authors: Qiang Zuo Yunsheng Ou Shenxi Zhong Haoyang Yu Fangbiao Zhan Muzi Zhang Source Type: research

Survey of cancer cell anatomy in non-adhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb-based migration
Mol Biol Cell. 2021 Jul 14:mbcE21040174. doi: 10.1091/mbc.E21-04-0174. Online ahead of print.ABSTRACTCancer cells migrating in confined microenvironments exhibit plasticity of migration modes. Confinement of contractile cells in a non-adhesive environment drives 'leader bleb-based migration' (LBBM), morphologically characterized by a long bleb that points in the direction of movement separated from a cell body by a contractile neck. Although cells undergoing LBBM have been visualized within tumors, the organization of organelles and actin regulatory proteins mediating LBBM is unknown. We analyzed the localization of fluore...
Source: Mol Biol Cell - July 14, 2021 Category: Molecular Biology Authors: Gregory Adams Magdalena Preciado L ópez Alexander X Cartagena-Rivera Clare M Waterman Source Type: research

Spinal Nrf2 translocation may inhibit neuronal NF ‐κB activation and alleviate allodynia in a rat model of bone cancer pain
This study aimed to test the hypothesis that BCP induces the transfer of Nrf2 from the cytoplasm to the nucleus and further promotes nuclear transcription to activate heme oxygenase-1 (HO-1) and inhibit the activation of nuclear factor-kappa B (NF- κB) signalling, ultimately regulating the neuroinflammatory response. Von-Frey was used for behavioural analysis in BCP rats, while western blotting, real-time quantitative PCR (RT-PCR), and enzyme-linked immunosorbent assay (ELISA) were used to detect molecular expression changes, and immunofluore scence was used to detect cellular localization. We demonstrated that BCP induce...
Source: Journal of Neurochemistry - July 14, 2021 Category: Neuroscience Authors: Jie Fu, Chaobo Ni, Hua ‐Dong Ni, Long‐Sheng Xu, Qiu‐Li He, Huan Pan, Dong‐Dong Huang, Yan‐Bao Sun, Ge Luo, Ming‐Juan Liu, Ming Yao Tags: ORIGINAL ARTICLE Source Type: research

GSE169322 Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma
Conclusion: These novel findings demonstrated that STRAP plays a role in tumorigenesis and maintenance of neuroblastoma stemness.
Source: GEO: Gene Expression Omnibus - July 14, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research