Radium-223 for the treatment of bone metastases in castration-resistant prostate cancer: when and why.
Authors: Gallicchio R, Mastrangelo PA, Nardelli A, Mainenti PP, Colasurdo AP, Landriscina M, Guglielmi G, Storto G Abstract Radium-223 dichloride (223Ra) is the first, recently approved, α-particle-emitting radiopharmaceutical for the treatment of patients with bone metastases in castration-resistant prostate cancer (CRPC) and no evidence of visceral metastases. We explored MEDLINE, relevant congresses, and websites for data on 223Ra and prostate cancer therapies, focusing on therapeutic strategies and timing, bone metastases, and diagnostic assessment. 223Ra represents the only bone-targeting agent that has ...
Source: Tumori - May 19, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

The essential role of prevention in reducing the cancer burden in Europe: a commentary from Cancer Prevention Europe.
Authors: Espina C, Bauld L, Bonanni B, Brenner H, Brown K, Dillner J, Kampman E, Nilbert M, Vineis P, Weijenberg MP, Cox A, de Kok TM, Fecht D, Mitrou G, Muller DC, Serrano D, Steindorf K, Storm H, Thorat MA, van Duijnhoven F, Weiderpass E, Schüz J PMID: 31099306 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - May 19, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Female breast cancers (T1-2, N0, M0, HR+, HER2-) with an intermediate genetic-based recurrence risk: a real-world estimate in Italy.
CONCLUSIONS: This article provides reliable estimates on the burden of Italian women with breast cancer who, once tested with multigene testing, could potentially have their treatment changed to hormone therapy only. PMID: 31088341 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - May 16, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Thrombosis of the dorsal vein of the penis as first clinical presentation of pancreatic cancer metastatic to the penis.
CONCLUSIONS: Penile localization is an extremely rare event and a standard of care has not been elaborated. Treatments are palliative and mainly aimed at pain relief and can comprise chemotherapy, radiotherapy, and surgery. Identification of venous thrombosis as an early sign of involvement could potentially offer patients an earlier diagnosis and a better treatment option. PMID: 31072230 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - May 12, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Development, technical validation, and clinical application of a multigene panel for hereditary gastrointestinal cancer and polyposis.
CONCLUSION: Introduction of the CGT-colon-G14 panel into the clinic could provide a higher diagnostic yield than a step-wise approach; however, results may not always be straightforward without the implementation of new genetic counseling models. PMID: 31068090 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - May 11, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Flower cells of tropical descent: a challenging case of adult T-cell leukemia/lymphoma.
CONCLUSIONS: Diagnosis of ATLL outside of endemic areas can be difficult, requiring a high index of clinical suspicion with careful evaluation of the patient's clinical history. Prognosis is affected by disease stage at presentation and degree of immunosuppression. Few effective treatments are available, although new molecular insights have highlighted the role of host immune response and immune checkpoint blockade inhibitors, given the overexpression of PD-L1 on lymphoma cells and on microenvironment cells. PMID: 31041884 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - May 2, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Comparison of ultra-low dose chest CT scanning protocols for the detection of pulmonary nodules: a phantom study.
CONCLUSIONS: ULDCT scanning protocols allowing the detection of PNs can be proposed for the purpose of lung cancer screening. PMID: 31041885 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - May 2, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Complete remission for 4 years with crizotinib in advanced ALK-positive non-small cell lung cancer after thoracostomy for empyema.
CONCLUSION: This case describes a relatively young patient with a poor prognosis but with a remarkable and long-term response to crizotinib monotherapy. PMID: 31023173 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 28, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Diary of a journey to a faraway galaxy.
This article describes a brief account written by a girl treated with chemotherapy and surgery for an ovarian germ cell tumor. The brief novel was conceived in the context of the Youth Project of Milan, dedicated to helping adolescent and young adult cancer patients socialize and express themselves through group activities that focus on art and creativity. It describes the scenery of a new galaxy and is replete with images and metaphors that recall the experience of receiving anticancer treatment, touching on emotional themes including desire, isolation, fear, and hope. PMID: 31023193 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 28, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

The Italian Rare Pancreatic Exocrine Cancer Initiative.
CONCLUSIONS: We expect to gather novel data on rare pancreatic cancer types that will be useful to inform the design of therapeutic choices. PMID: 30967031 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 12, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Anesthetic management of radical nephrectomy in patients with renal cell carcinoma involving renal vein or inferior vena cava.
CONCLUSION:: Anesthetic management and intensive postoperative care play a pivotal role in the success of complete resection of RCC that metastasize into the IVC. PMID: 30940005 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 5, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Clinical characteristics and prognosis associated with multiple primary malignant tumors in non-Hodgkin lymphoma patients.
CONCLUSIONS:: OS time was shorter in patients with NHL who developed a second tumor than in those who were diagnosed with solid cancer synchronously and second neoplasm after previous solid tumors. Long-term follow-up and effective treatment should be provided to these patients. PMID: 30945608 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 5, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Short-course olanzapine to prevent delayed emesis following carboplatin/paclitaxel for gynecologic cancer: a randomised study.
CONCLUSIONS:: In this exploratory study with a small sample size, we did not find any clue about better control of delayed emesis with either olanzapine regimen in gynecologic cancer patients treated with carboplatin/paclitaxel and receiving the same prophylaxis for acute emesis. PMID: 30945623 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 5, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Hepatitis D reactivation in a patient with metastatic renal cell carcinoma receiving sunitinib therapy.
CONCLUSION:: Cancer patients should be screened for viral hepatitis prior to immunosuppressive therapy or chemotherapy. PMID: 30935288 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 4, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Impact of tumor site on the prognosis of small bowel adenocarcinoma.
CONCLUSIONS:: Our results suggest a prognostic role for the primary tumor site. This finding deserves to be further investigated to ensure better classification as well as more effective management strategies for SBA. PMID: 30935289 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 4, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Shoulder girdle impairment in breast cancer survivors: the role of range of motion as predictive factor for dose distribution and clinical outcome.
Authors: Marazzi F, Masiello V, Marchesano D, Boldrini L, Luzi S, Ferrara PE, Amabile E, Piccari D, Landi F, Moschella F, Franceschini G, Masetti R, Mantini G, Valentini V, Smaniotto D Abstract BACKGROUND:: Pain and functional impairment of the ipsilateral shoulder girdle in patients who underwent surgery and radiotherapy for breast cancer (BC) is a late complication reported in the literature. We analyze a correlation with dosimetric parameters and propose an algorithm for sparing strategies. METHODS:: A total of 111 patients treated for BC were included in this observational analysis during follow-up protocol...
Source: Tumori - April 4, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Fulminant blast crisis with de novo 11q23 rearrangement in a Philadelphia-positive CML patient undergoing treatment with dasatinib.
CONCLUSION:: The presence of 11q23 rearrangements in the relapse clone in BC of CML most likely accounts for the adverse clinical outcome. Thus, in the case of rapid and unexpected BC, the presence of 11q rearrangements should be tested together with other additional chromosomal alterations, and immediate addition of chemotherapy to the TKIs should be evaluated. PMID: 30935343 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 4, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Clinical features and treatment of patients with lung adenocarcinoma with bone marrow metastasis.
CONCLUSIONS:: The survival period of patients with lung adenocarcinoma with bone marrow metastasis is short, and targeted drug TKI treatment can prolong the survival time for patients with EGFR mutation-carrying lung adenocarcinoma with bone marrow metastasis. PMID: 30931812 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - April 2, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy.
Authors: Zorzi M, Dal Maso L, Francisci S, Buzzoni C, Rugge M, Guzzinati S, AIRTUM Working Group Abstract OBJECTIVE:: To evaluate the trends of colorectal cancer (CRC) incidence and mortality rates from 2003 to 2014 in Italy by age groups and regions. METHODS:: We used the data of 48 cancer registries from 17 Italian regions to estimate standardized incidence and mortality rates overall and by sex, age groups (
Source: Tumori - March 30, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Treatment of recurrent ovarian cancer with pegylated liposomal doxorubicin: a reappraisal and critical analysis.
Authors: Lorusso D, Sabatucci I, Maltese G, Lepori S, Tripodi E, Bogani G, Raspagliesi F Abstract The vast majority of ovarian cancer relapses on front-line therapy and the optimal treatment of recurrent ovarian cancer remains controversial. This review is based on the relevant published literature indexed in PubMed on pegylated liposomal doxorubicin (PLD), either alone or in combination with other drugs, as one option in relapsed disease. PLD showed an improved pharmacokinetic profile, with a slower plasma clearance and a longer circulation time, compared to other conventional doxorubicin formulations. PLD is cons...
Source: Tumori - March 30, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Thyroid cancer in Friuli Venezia Giulia, northeastern Italy: incidence, overdiagnosis, and impact of type of surgery on survival.
This study aimed to describe TC incidence in the Friuli Venezia Giulia (FVG) region, to estimate the quota of overdiagnosis, and to investigate the impact of surgery on long-term survival after TC diagnosis. METHODS:: TC cases reported to the FVG population-based cancer registry during 2002-2013, aged
Source: Tumori - March 30, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Cancer incidence and mortality trends from 2003 to 2014 in Italy.
CONCLUSIONS:: Incidence among males decreased, supported by trends for prostate, lung, colorectal, and urinary bladder cancers; among females the. The overall cancer incidence trend was stable, or even decreasing, in the northern and central areas and increasing in the southern areas, due to lung, thyroid, and melanoma rising trends. Study results provided information on the outcomes, in terms of cancer incidence and mortality, of primary and secondary prevention measures employed by regional health systems. PMID: 30917768 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - March 30, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Asbestos fiber identification in liver from cholangiocarcinoma patients living in an asbestos polluted area: a preliminary study.
CONCLUSIONS:: This study is the first report about the detection of chrysotile asbestos fibers in the liver of patients with CC. Further studies on larger cohorts are needed to corroborate our preliminary findings. PMID: 30915902 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - March 29, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Interobserver variability (between radiation oncologist and radiation therapist) in tumor bed contouring after breast-conserving surgery.
Authors: La Rocca E, Lici V, Giandini T, Bonfantini F, Frasca S, Dispinzieri M, Gennaro M, Di Cosimo SS, Lozza L, Pignoli E, Valdagni R, De Santis MC Abstract PURPOSE:: To examine interobserver variability between the radiation oncologist (RTO) and the radiation therapist (RTT) in delineating the tumor bed (TB) in early breast cancer (BC). METHODS:: We retrospectively analyzed patients who received a radiotherapy boost to the TB. In a first group, the clinical target volume (CTV) for the boost was the surgical bed, defined by using surgical clips. In a second group, the CTV was defined by identifying a seroma c...
Source: Tumori - March 29, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Maximal cytoreduction is related to improved disease-free survival in low-grade ovarian serous carcinoma.
Authors: Kimyon Comert G, Turkmen O, Mesci CG, Karalok A, Sever O, Sinaci S, Boran N, Basaran D, Turan T Abstract OBJECTIVE:: To evaluate the factors predicting oncologic outcomes in low-grade ovarian serous carcinoma (LGOSC). METHODS:: Seventy patients with LGOSC were included in the study. According to the residual disease present at the end of the initial cytoreductive surgery (CRS), surgical outcomes are defined as follows: maximal CRS for absence of macroscopic residual tumors, optimal CRS for macroscopic residual tumors with diameters ranging from 0.1 to ⩽1 cm diameter, and suboptimal CRS for macroscopi...
Source: Tumori - March 29, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Induction chemoradiation is associated with improved survival in chest wall invasion lung cancer.
Authors: Muñoz-Largacha JA, Rao SR, Brinckerhoff LH, Daly BD, Fernando HC, Litle VR, Suzuki K Abstract OBJECTIVE:: To determine if induction chemotherapy with concurrent high-dose radiation followed by resection is associated with improved survival in patients with nonsuperior sulcus lung cancer with chest wall invasion. METHODS:: We performed a retrospective review of clinical T3 (chest wall invasion) N0/N1 patients with non-small cell lung cancer who underwent surgical resection between January 1, 1992, and January 31, 2017. Exclusion criteria included superior sulcus tumors and resection performed for...
Source: Tumori - March 26, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Excess risk of dying of other causes of cured cancer patients.
CONCLUSION:: Mortality of survivors not directly due to the diagnosed cancer was significantly higher than in the general population. It affected the estimates of cure proportions for all age classes and RS in the elderly. PMID: 30905274 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - March 26, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Survival benefit of first-generation epidermal growth factor receptor-tyrosine kinase inhibitors in female with advanced lung cancer.
This study aimed to estimate therapeutic effects of first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in real-world practice, by analyzing survival outcomes in an unselected, Korean female population with advanced lung cancer based on the National Health Insurance Service database. METHODS:: We identified women with newly diagnosed advanced lung cancer from January 2004 to December 2013. For progression-free survival (PFS) and overall survival (OS) analyses, patients were defined into the following subgroups: group A, treated with first-generation EGFR-TKI ⩾6 months; group B, tr...
Source: Tumori - March 26, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Combining abiraterone and radiotherapy in metastatic castration-resistant prostate cancer: a review of current evidence.
Authors: Livi L, Detti B, Francolini G, Terziani F, Triggiani L, D'Angelillo RM, Ingrosso G Abstract Prostate cancer is the second most frequent cancer worldwide, with a very high rate of progression despite treatment. The most aggressive form of the disease is known as castration-resistant prostate cancer, which carries a poor prognosis. We reviewed available literature regarding the combination of abiraterone acetate antihormonal drug and ablative radiation therapy for the treatment of metastatic castration-resistant prostate cancer. This dual treatment may enhance the effects of second-line hormonal therapy, as ...
Source: Tumori - March 26, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Successful role of adjuvant radiotherapy in a rare case of tracheal inflammatory myofibroblastic tumor: a case report.
CONCLUSIONS:: This report describes an extremely rare case of a tracheal IMT, underlying the key role of radiotherapy as adjuvant treatment able to definitively cure IMT, limiting systemic chemotherapy-related toxicity. PMID: 30900517 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - March 23, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Tubular and mucinous breast cancer: results of a cohort of 917 patients.
CONCLUSION:: This study confirms the need for an axillary exploration for these tumors even for a tumor size
Source: Tumori - March 23, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Updated: 223Ra-chloride therapy in men with hormone-refractory prostate cancer and skeletal metastases: Real-world experience.
Authors: Boni G, Monari F PMID: 30866748 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - March 16, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Discontinuation of first-line bevacizumab in metastatic colorectal cancer: the BEAWARE Italian Observational Study.
Authors: Lonardi S, Nasti G, Fagnani D, Gemma D, Ciuffreda L, Granetto C, Lucchesi S, Ballestrero A, Biglietto M, Proserpio I, Bergamo F, Proietti E, Tonini G Abstract AIMS:: BEAWARE investigated the pattern of first-line bevacizumab early interruption in the Italian real-world setting of metastatic colorectal cancer. METHODS:: A total of 386 patients were followed for 15 months after first-line chemotherapy + bevacizumab start. The rate of bevacizumab interruption for progression or adverse drug reactions (ADRs) constituted the primary endpoint. RESULTS:: A total of 78.2% of patients interrupted bevacizuma...
Source: Tumori - March 13, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Bilateral radiation-induced squamous cell carcinomas of the external auditory canal 30 years after radiotherapy for a pituitary adenoma: a case report.
CONCLUSION:: In young patients with benign tumors, we should always evaluate whether the benefits of radiotherapy outweigh the risks and side effects. After radiotherapy, screening programs should be developed since early detection improves salvage treatment of these secondary and often morbid tumors. PMID: 30808258 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - March 1, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

A rare testicular tumor: primary carcinoid tumor.
CONCLUSION:: Primary neuroendocrine carcinoma of the testis is a very rare malignant tumor. Immunohistochemistry contributes to its diagnosis in relation to other metastatic neuroendocrine carcinomas, carcinoid tumor teratomas, seminoma, and Sertoli cells. PMID: 30799770 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - February 27, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Differential diagnosis between bone relapse of breast cancer and lambda light chain multiple myeloma: role of the clinical biochemist.
CONCLUSION:: In this report, we show how the expertise of the clinical biochemist was instrumental in solving this case. PMID: 30799772 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - February 27, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Histologic transformation to small-cell lung cancer following gefitinib and radiotherapy in a patient with pulmonary adenocarcinoma.
CONCLUSIONS:: To better identify patients who progress after TKIs and radiation therapy, it is important to perform tumor rebiopsy and collect data to study mechanisms of acquired EGFR TKI resistance. PMID: 30799776 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - February 27, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Definitive radiotherapy for recurrent vulvar carcinoma after primary surgery: a two-institutional Italian experience.
CONCLUSIONS:: Primary tumor size, FIGO stage, nodal status, and site of recurrent disease were significant predictors of clinical outcome in patients treated with RT for recurrent squamous cell carcinoma of the vulva. PMID: 30791828 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - February 23, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

The dilemma of metastatic medullary thyroid carcinoma: when to start systemic treatment.
CONCLUSIONS:: Radiologic progression of disease alone seems not to be adequate for MTC patients' selection to be treated. The progression rate, the tumor burden, and the site of disease should also be taken into account for the clinical decision process. PMID: 30782103 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - February 22, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Incidence of rare cancers in the city of S ão Paulo, Brazil.
CONCLUSIONS:: This study presents the burden of rare cancers in Brazil. It is expected to be an incentive for further studies of these entities in order to know the epidemiologic profile of rare tumors in Brazil and to provide a more effective diagnostic and therapeutic approach. PMID: 30700226 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - February 2, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

Semaphorin 4D promotes the proliferation and metastasis of bladder cancer by activating the PI3K/AKT pathway.
Authors: Lu JJ, Su YW, Wang CJ, Li DF, Zhou L Abstract The present study aimed to investigate the role of semaphorin 4D (Sema4D) in bladder cancer cell proliferation and metastasis in vivo and in vitro. Effects of Sema4D modulation on cancer cell viability and clonogenic abilities were assessed by MTT assay and colony formation assay. Cell apoptosis, cell cycle analysis, transwell assays, and wound-healing assays were also assayed. A mouse model of bladder cancer was established to observe the tumorigenesis in vivo. Our data showed that Sema4D was 4-fold upregulated in clinical bladder cancer tissues relative to no...
Source: Tumori - January 26, 2019 Category: Cancer & Oncology Tags: Tumori Source Type: research

On the diagnosis of malignant pleural mesothelioma: a necropsy-based study of 171 cases (1997-2016).
Authors: Barbieri PG PMID: 30592233 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - December 31, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Carfilzomib-induced tumor lysis syndrome in relapsed multiple myeloma: a report of two cases.
CONCLUSION:: Carfilzomib is a next-generation proteasome inhibitor with proven efficacy in relapsed/refractory MM. Recently, increasing frequency of TLS has been reported in MM, especially after treatment with proteasome inhibitors. The potential complications of TLS should be considered especially during the first cycle of carfilzomib treatment. PMID: 30580656 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - December 27, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Role of contrast-enhanced spectral mammography in the post biopsy management of B3 lesions: Preliminary results.
CONCLUSION: In cases of Breast Imaging Reporting and Data System (BI-RADS) 1, BI-RADS 2, or BI-RADS 3 results at CESM, follow-up or VAB rather than surgical biopsy might be performed. PMID: 30558495 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - December 19, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

BAG3 contributes to HGF-mediated cell proliferation, migration, and invasion via the Egr1 pathway in gastric cancer.
CONCLUSION:: This pathway may provide novel therapeutic targets and provide information for further identification of other targets of therapeutic significance in gastric cancer. PMID: 30514177 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - December 7, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Irinotecan toxicity during treatment of metastatic colorectal cancer: focus on pharmacogenomics and personalized medicine.
Authors: Paulík A, Nekvindová J, Filip PS Abstract Colorectal cancer, one of the most frequent types of cancer worldwide, has a high mortality rate. Irinotecan (CPT-11) has been approved for the treatment of advanced or metastatic disease either as a single agent or, more commonly, as part of combined chemotherapeutic regimens. Treatment with irinotecan is often accompanied by severe toxicity (e.g. neutropenia and diarrhea) that can result in treatment interruption or cessation, thus jeopardizing the patient's prognosis and quality of life. Irinotecan is bioactivated into its metabolite SN-38, which i...
Source: Tumori - December 7, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Chemoradiation in female patients with anal cancer: Patient-reported outcome of acute and chronic side effects.
CONCLUSION:: Our results suggest that the use of IMRT decreases acute and chronic adverse effects although reduced QoL also occurred in the IMRT group. These effects are likely to be underreported in retrospective studies using physician-reported outcome measures. PMID: 30484384 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - December 1, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Unexpected postpneumonectomy exertion-induced acute right heart failure.
CONCLUSIONS:: In patients scheduled for major lung resections, preoperative stress echocardiography may give an adjunctive value to cardiopulmonary exercise test, quantifying the exercise-induced reduction in right ventricle ejection fraction and identifying asymptomatic patients at risk for postoperative ARHF. PMID: 30484385 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - December 1, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Patients' understanding of clinical research: An Italian cancer patient survey.
CONCLUSIONS:: Our results show that patients' understanding of clinical research is limited and highlight an interest in learning more. PMID: 30474502 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - November 28, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Time to systemic treatment and prognosis in patients with recurrent and metastatic head and neck squamous cell cancer.
Authors: Siano M, Espeli V, Joerger M Abstract BACKGROUND:: Delay of systemic treatment in recurrent/metastatic head and neck squamous cell cancer (r/mHNSCC) has never been assessed. Whether time span to start systemic treatment affects survival and whether referral to a medical oncologist is important has not been explored. METHODS:: We analyzed our head and neck database to assess the prognostic impact of time between diagnosis of r/mHNSCC and start of systemic treatment (time to treatment [TTT]). Secondarily, we assessed the prognostic impact of time to referral to a medical oncologist (referral time). For t...
Source: Tumori - November 28, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research