Management of ovarian cancer: guidelines of the Italian Medical Oncology Association (AIOM).
CONCLUSION: Women with a clinical suspicion of ovarian cancer should be centralized in referral centers. The BRCA test should be requested for all women with nonmucinous and nonborderline tumors, regardless of age and family history. BRCA testing could be preferentially performed on neoplastic tissue. In the presence of a positive tumor test, a genetic test should always be performed on a blood sample to differentiate between germline mutations, which require counseling and genetic testing of family members, and somatic mutations. PMID: 33106117 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - October 28, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Illusionist techniques as a complement to psychological support for children with cancer.
This study considered the psychological interviews conducted with patients with cancer
Source: Tumori - October 25, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Cancer prevalence by phase of care: an indicator for assessing health service needs.
DISCUSSION: Incidence, survival, and population age structure are the main determinants of prevalence and they can affect differences in all phases of prevalence, as well as in discrete phases. Incidence is the most influential determinant. Ours is the first study that compares prevalence by phase of care between two populations in Italy and the United States. Despite great differences in health care management in the two countries, we found extremely similar distribution of survivors by phase of care for most cancer sites under study. PMID: 33095121 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - October 25, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Prognostic impact of serum procalcitonin in non-small cell lung cancer.
Authors: Kajikawa S, Ohashi W, Kato Y, Fukami M, Yonezawa T, Sato M, Kosaka K, Kato T, Tanaka H, Ito S, Yamaguchi E, Kubo A Abstract INTRODUCTION: Increased serum procalcitonin (PCT), a well-known biomarker for sepsis, has been reported in several cancer types. We aimed to investigate the prognostic impact of PCT in non-small cell lung cancer (NSCLC). METHODS: Medical records of 51 consecutive patients with NSCLC (Aichi Medical University Hospital) admitted between July 2017 and July 2018 were retrospectively reviewed. The patients were divided into PCT-low (PCT
Source: Tumori - October 21, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Frequency and types of EGFR mutations in Moroccan patients with non-small cell lung cancer.
Authors: Lemine Sow M, El Yacoubi H, Moukafih B, Balde S, Akimana G, Najem S, El Khoyaali S, Abahssain H, Chaibi A, Zeb Khan S, Trapani D, Benzekri A, Ghaouti M, Gamra L, Mestari A, Kettani F, Rahali Y, Mrabti H, Elghissassi I, Errihani H Abstract BACKGROUND: Mutations in the epidermal growth factor receptor (EGFR) gene are commonly observed in non-small cell lung cancer (NSCLC), particularly in adenocarcinoma histology. The frequency of EGFR mutations is ethnicity-dependent, with a higher proportion reported in Asian populations than Caucasian populations. There is a lack of data on these mutations in north Africa...
Source: Tumori - October 21, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

LRP8 activates STAT3 to induce PD-L1 expression in osteosarcoma.
CONCLUSIONS: Our results provide evidence for a novel regulation network of LRP8/STAT3/PD-L1 in osteosarcoma and LRP8 may be a potential therapeutic target in osteosarcoma. PMID: 33054597 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - October 20, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

To a new normal in radiation oncology: looking back and planning forward.
Authors: Barcellini A, Filippi AR, Dal Mas F, Cobianchi L, Corvò R, Price P, Orlandi E PMID: 33045932 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - October 15, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Impact of waiting times on tumour growth and pathologic upstaging in patients with non-small cell lung cancer having lung resection.
Authors: Bhat I, Okiror L, Nair A, Bille A Abstract OBJECTIVE: There are limited data on tumour growth or pathologic upstaging in patients with early-stage lung cancer awaiting lung resection. We aimed to evaluate whether waiting times on the current lung cancer treatment pathway were associated with significant tumour growth or pathologic upstaging. METHODS: This is a retrospective observational study of a consecutive series of patients with early-stage, non-small cell lung cancer who underwent resection for lung cancer. The difference between tumour size at diagnostic and preoperative computed tomography (CT)...
Source: Tumori - October 8, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Validation of the Colon Life nomogram in patients with refractory metastatic colorectal cancer enrolled in the RECOURSE trial.
Authors: Pietrantonio F, Fucà G, Manca P, Pagani F, Raimondi A, Prisciandaro M, Randon G, Corti F, de Braud F, Cremolini C, Miceli R Abstract BACKGROUND: The RECOURSE trial (Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies) demonstrated an overall survival (OS) benefit of trifluridine/tipiracil (FTD/TPI) vs placebo in refractory metastatic colorectal cancer (mCRC). Given the limited benefit of later line treatments, we developed the Colon Life nomogram to assess the 12-week death probability in the refractory setting. METHODS: This post hoc analysis of ...
Source: Tumori - October 8, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Development of chimeric antigen receptor-modified T cells for the treatment of esophageal cancer.
CONCLUSIONS: An effective HER2 CAR targeting ESCC was developed successfully. The HER2.CAR-T cell showed promising immunotherapeutic potential for the treatment of HER2-positive esophageal cancer. PMID: 32988314 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - October 1, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Diagnostic role of liquid-based cytology of bronchial lavage fluid in addition to bronchial brushing specimens in lung cancer.
CONCLUSION: The results from our study demonstrated that LBC of brushing samples could be used as an important complement of bronchoscopy and could have the potential to be widely applied. PMID: 32972322 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 26, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Pulmonary and pleural metastasis mimicking COVID-19 infection in stage IV ovarian cancer: a case report.
CONCLUSION: Lung and pleural metastases can mimic SARS-CoV-2 infection. PMID: 32959724 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 24, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Immune-related adverse events associated with immune checkpoint inhibitors in patients with cancer.
CONCLUSION: With the increased use of immunotherapeutic agents, increased awareness and early recognition are required for effective management of irAEs. Our experience as a single institution might be of use for health care providers in oncology. PMID: 32935638 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 18, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Local therapies for liver metastases of rare head and neck cancers: A monoinstitutional case series.
DISCUSSION: This retrospective case series demonstrates that locoregional radiologic approaches for rare HNCs with liver metastases are feasible. These procedures deserve further prospective studies before being considered safe and active in these malignancies where the availability of effective systemic treatments is lacking. PMID: 32924878 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 15, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Long-term palliation of lymph node oligometastatic ovarian carcinoma after repeated stereotactic body radiotherapy: case report.
CONCLUSIONS: SBRT is a promising treatment approach for recurrent oligometastatic EOC with a high control rate and irrelevant iatrogenic toxicity. The possibility to repeat SBRT courses when new oligometastases are encountered in other sites resulted in an adequate long-term palliation approach. PMID: 32912066 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 12, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Differences in PET/CT standardized uptake values involvement and survival compared to histologic subtypes of lung adenocarcinoma.
CONCLUSION: Lung adenocarcinoma consists of a diverse group of diseases. Different SUVmax values are seen in different histologic subtypes of nonmetastatic lung adenocarcinoma. Solid predominant types have high SUVmax values while lepidic predominant types have lower SUVmax values. The solid subtype had a shorter PFS than the other histologic subtypes. PMID: 32878562 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 5, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

PD-1 blockade in deficient mismatch repair mixed adenoneuroendocrine carcinoma of the stomach: new hope for an orphan disease.
CONCLUSIONS: To our knowledge, this is the first report of a heavily pretreated and rapidly progressing deficient MMR gastroesophageal MANEC experiencing a durable benefit from anti-PD1 treatment. PMID: 32878569 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 5, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Emerging functions of PRKDC in the initiation and progression of cancer.
Authors: Yin Y, He Q, Li Y, Long J, Lei X, Li Z, Zhu W Abstract The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is encoded by the protein kinase, DNA-activated, catalytic polypeptide (PRKDC) gene. DNA-PKcs plays a major role in nonhomologous end joining DNA repair, and it has been identified to be an important factor in tumor progression and metastasis. DNA-PKcs may have opposite effects in diseases, depending on the cell and tissue types. In this review, we discuss its role in various tumors. High levels of DNA-PKcs are directly associated with prognosis, neoplasm recurrence rates, and overall surviv...
Source: Tumori - September 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Comment on "Response of a comprehensive cancer center to the COVID-19 pandemic: the experience of the Fondazione IRCCS-Istituto Nazionale dei Tumori di Milano".
Comment on "Response of a comprehensive cancer center to the COVID-19 pandemic: the experience of the Fondazione IRCCS-Istituto Nazionale dei Tumori di Milano". Tumori. 2020 Sep 01;:300891620953471 Authors: Romanzi A, Vannelli A Abstract Although European governments have launched the so-called phase 2 in the coronavirus disease 2019 (COVID-19) pandemic (a transitional phase of beginning to downsize containment measures), intensive care units are not COVID-19-free and this restricts our therapeutic strategies. Moreover, minimally invasive surgery and general anesthesia are under debate as the...
Source: Tumori - September 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

A case of different gene mutations in primary and metastatic lesions after EGFR-TKI treatment of lung cancer.
CONCLUSION: Spatial heterogeneity of the resistance mechanism may explain why patients who continue to receive EGFR-TKIs in combination with local therapies (e.g., radiotherapy) for progressing lesions may benefit even after progression during EGFR-TKI therapy. The loss of the EGFR mutation allele as a putative resistance mechanism requires additional preclinical and clinical confirmation. PMID: 32867626 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - September 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Interstitial pneumonitis in the COVID-19 era: a difficult differential diagnosis in patients with lung cancer.
Authors: Catania C, Stati V, Spitaleri G Abstract In this coronavirus 2019 (COVID-19) era, when pneumonitis occurs in patients with lung cancer receiving immune checkpoint inhibitors (ICIs), a major challenge is to make a rapid and correct differential diagnosis among drug-induced pulmonary toxicity, tumour progression, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced pneumonitis. While waiting for polymerase chain reaction (PCR) testing results, an accurate evaluation of the symptoms and serologic features can help us make a first diagnostic hypothesis and...
Source: Tumori - August 29, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Thoracic paravertebral block and awake surgery: a prospective observational study.
CONCLUSIONS: Quadrantectomy with exclusively regional anaesthesia and thoracic paravertebral block can be performed with the patient awake and collaborating. PMID: 32842912 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 29, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Autoimmune-related encephalitis during treatment with nivolumab for advanced head and neck cancer: a case report and literature review.
CONCLUSIONS: Immunotherapy is a relatively new and promising therapy in the field of oncology. Its mechanism of action, which aims to stimulate the immune system against cancer cells, is not comparable to systemic and cytotoxic chemotherapy, which directly attacks and destroys malignant cells. Despite these differences, immunotherapy is not to be considered free from side effects, sometimes life-threatening. PMID: 32851941 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 29, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Xanthogranulomatous adrenalitis masquerading as a functioning adrenocortical malignancy: a case report.
CONCLUSION: XA can mimic adrenal neoplasms both clinically and radiologically and is associated with staphylococcal infection. It warrants surgical excision and culture-based antibiotics and is mostly diagnosed on postoperative histopathology. PMID: 32830993 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 26, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

A new case of myelodysplastic syndrome associated with t(3;3)(q21;q26) and inv(11)(p15q22).
CONCLUSION: A similar pattern of acquisition was never described before in MDS. The coexistence of two independent, high-risk oncogenic, rare events in the same clone suggests that there may be a functional constraint for synergy between the two events, leading to a proliferative advantage and suggests the utility of extended genotyping in myeloid malignancies. PMID: 32831008 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 26, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Overview on new progress of hereditary diffuse gastric cancer with CDH1 variants.
Authors: Hu MN, Hu SH, Zhang XW, Xiong SM, Deng H Abstract Hereditary diffuse gastric cancer (HDGC), comprising 1%-3% of gastric malignances, has been associated with CDH1 variants. Accumulating evidence has demonstrated more than 100 germline CDH1 variant types. E-cadherin encoded by the CDH1 gene serves as a tumor suppressor protein. CDH1 promoter hypermethylation and other molecular mechanisms resulting in E-cadherin dysfunction are involved in the tumorigenesis of HDGC. Histopathology exhibits characteristic signet ring cells, and immunohistochemical staining may show negativity for E-cadherin and other signali...
Source: Tumori - August 20, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Diagnosis of lung cancer: a necropsy-based study of 128 cases (1997-2016).
CONCLUSIONS: Autopsies confirmed all LC diagnoses received in life, including 46 that would have been considered only possible LC based on clinical workup. The overall survival in this case series was poor. The high prevalence of pleural plaques and asbestosis suggest severity of asbestos exposures. PMID: 32811344 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 20, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

The Severity of Acute Pancreatitis According to Modified Balthazar Classification in Patients With Pancreatic Cancer.
CONCLUSION: AP may be the clinical manifestation of PC or PC may induce AP in various ways. It was shown that the underlying malignancy did not adversely affect the severity and course of AP. PMID: 32811352 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 20, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Advanced pneumonic type of lung adenocarcinoma: survival predictors and treatment efficacy of the tumor.
CONCLUSION: TKI-based therapy could improve the prognosis and OS for advanced P-ADC. This study recommends the analysis of EGFR mutations for all patients with advanced P-ADC. PMID: 32762285 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 13, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Prognostic value of the TGF β1 rs4803455 single nucleotide polymorphism in small cell lung cancer.
Prognostic value of the TGFβ1 rs4803455 single nucleotide polymorphism in small cell lung cancer. Tumori. 2020 Aug 11;:300891620946841 Authors: Ayala de Miguel P, Enguix-Riego MV, Cacicedo J, Delgado BD, Perez M, Praena-Fernández JM, Quintana Cortés L, Borrega García P, Del Campo ER, Lopez Guerra JL Abstract BACKGROUND: Small cell lung cancer (SCLC) is one of the greatest therapeutic challenges of oncology. Potential associations between single nucleotide polymorphisms in heat shock protein β1 (HSPB1) and transforming growth factor β1 (TGFβ1) and survival have b...
Source: Tumori - August 13, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Potential and unsolved problems of anti-PD-1/PD-L1 therapy combined with radiotherapy.
Authors: Cao Y, Li W, Wang Z, Pang H Abstract Tumor immunotherapy has become one of the main treatments for tumors. Inhibition of the pathways involving programmed cell death receptor 1 (PD-1) and its ligand (PD-L1) has gained favor in anticancer therapy, and can effectively prolong the survival of patients with cancer; however, numerous patients have PD-1/PD-L1 inhibitor primary resistance. The efficacy of anti-PD-1/PD-L1 therapy is related to the host tumor microenvironment. Radiation therapy can promote the body's antitumor immunity, change the tumor microenvironment, and synergize with anti-PD-1/PD-L1 treatment...
Source: Tumori - August 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Clinical significance of circPVT1 in patients with non-small cell lung cancer who received cisplatin combined with gemcitabine chemotherapy.
CONCLUSIONS: Our study revealed the clinical significance of circPVT1 in NSCLC after cisplatin combined with gemcitabine chemotherapy. After treatment, circPVT1 expression was decreased and circPVT1 expression in chemotherapy-resistant patients was higher than in chemotherapy-sensitive patients. Decreased circPVT1 expression in chemotherapy-sensitive patients is more notable than in chemotherapy-resistant patients. Therefore, it is possible to determine the effect of therapy after receiving chemotherapy by detecting the expression of circRNA in serum. PMID: 32734834 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Multidisciplinary team approach for Merkel cell carcinoma: the European Institute of Oncology experience with focus on radiotherapy.
CONCLUSIONS: The management of unknown primary and polyomavirus-positive cases, which had a better prognosis in our series, may benefit from a multidisciplinary approach, given the limited data available regarding optimal treatment. PMID: 32734835 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Predictors of ISUP score upgrade in patients with low-risk prostate cancer.
Authors: Haberal HB, Artykov M, Hazir B, Citamak B, Altan M, Yazici S, Akdogan B, Ozen H Abstract INTRODUCTION: The literature contains few studies that focus on the relationship between International Society of Urological Pathology (ISUP) score upgrade and complete blood count (CBC) parameters for patients with low-risk prostate cancer and studies achieved inconclusive results. METHODS: We retrospectively analyzed our institutional database for patients with prostate cancer who underwent radical prostatectomy (RP) between 1994 and 2017. In total, we included 633 patients with low-risk prostate cancer in the st...
Source: Tumori - August 1, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

The use of genomic tests in patients with breast cancer in Lombardy: a successful healthcare model.
CONCLUSION: The introduction of MGAs in the clinical evaluation of patients with luminal eBC with intermediate risk is economically sustainable and contributes towards preserving quality of life of eligible women. PMID: 32729378 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 1, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Is transcatheter arterial chemoembolization plus sorafenib better than chemoembolization plus placebo in the treatment of hepatocellular carcinoma?
CONCLUSIONS: There is no additive benefit of TACE plus sorafenib compared to TACE plus placebo for HCC. PMID: 32729385 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 1, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Management of HER2-positive breast cancer during pregnancy: a case report and literature review.
CONCLUSIONS: When conception occurs inadvertently during assumption of tamoxifen or anti-HER2 agents, their effects on the fetus and on the course of pregnancy are not completely understood. Further studies are needed in this setting, highlighting the importance to share clinical experiences. PMID: 32729389 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 1, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Treating patients with cancer amidst the COVID-19 pandemic: experience of a regional hospital in the Piedmont region in northern Italy.
CONCLUSION: The management of patients with cancer during the pandemic should be carefully balanced and discussed among oncologists and other key professionals involved in the treatment of this vulnerable group of patients, in order to balance the risk of treatment and the risk of infection. PMID: 32703089 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 27, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Do morphologic characteristics play a role in nodal metastatic progression of well-differentiated pancreatic neuroendocrine tumors?
CONCLUSION: The present study revealed that the new findings such as presence of dense stromal hyalinization and absence of remarkable lymphocytic infiltration could be predictive morphologic findings for the development of lymph node metastasis. PMID: 32705937 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 27, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Correlations of UICC tumor stage and tumor regression on T2-weighted MRI sequences during definitive radiotherapy of cervical cancer.
Authors: Arend F, Oechsner M, Weidenbächer CB, Combs SE, Borm KJ, Duma MN Abstract BACKGROUND: The purpose of this study is to detect a correlation between the preradiation tumor staging and the relative volumetric regression of the primary tumor through external beam radiation therapy (EBRT). METHODS: Clinical data of 32 patients with a mean age of 60±12 years treated with primary radiation therapy (RT) of cervical carcinoma were analyzed. Union Internationale Contre le Cancer (UICC) stages were T1 = 4 patients, T2 = 15 patients, T3 = 8 patients, T4 = 5 patients; N1 = 26 patients, N0 = 6 patients; ...
Source: Tumori - July 24, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Ovarian metastasis from malignant pleural mesothelioma.
CONCLUSIONS: This case report highlights the importance of using a complete staging protocol in patients with MPM to improve patient management. A whole-body computed tomography (CT) scan with contrast enhancement and possibly positron emission tomography-CT should be performed to identify any distant metastases before deciding on treatment strategy. PMID: 32684102 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 22, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Impact of sarcopenia on survival of pancreatic cancer patients treated with concurrent chemoradiotherapy.
Authors: Cho WK, Yu JI, Park HC, Lim DH, Kim TH, Chie EK Abstract PURPOSE: To investigate the prognostic impact of sarcopenia on the survival of patients with locally advanced pancreatic cancer (LAPC) treated with concurrent chemoradiotherapy (CCRT). METHODS: We retrospectively reviewed 299 patients diagnosed with LAPC and treated with definitive CCRT from 2000 to 2015. Skeletal muscle index (SMI) was measured using computed tomography scans and sarcopenia was defined as SMI
Source: Tumori - July 12, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Clinical results of active scanning proton therapy for primary liver tumors.
CONCLUSIONS: Our initial results of active scanning PT for primary liver cancer demonstrated the feasibility, safety, and effectiveness of this advanced technique in this setting. The potential of the combination of PT with other locoregional therapies is under evaluation. PMID: 32648818 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 12, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Postoperative risk of pancreatic fistula after distal pancreatectomy with or without spleen preservation.
CONCLUSION: Patients undergoing SPDP developed fewer POPF and were discharged earlier compared to patients undergoing DPS. PMID: 32635820 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 10, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

HPV nonrelated endocervical adenocarcinoma in hereditary cancer syndromes.
CONCLUSIONS: Our study confirms that gynecologic cancers including rare entities such as non-human papillomavirus-related endocervical cancer (NHPVA) are sentinels for inherited cancer syndromes. Endocervical cancer NHPVAs might be considered for cancer genetic counseling in order to improve cancer prevention. For this reason, the role of pathologists is particularly important for the correct identification of the cervical tumor site. PMID: 32635821 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 10, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Breast cancer during pregnancy: matched study of diagnostic approach, tumor characteristics, and prognostic factors.
CONCLUSION: Breast ultrasound shows a high sensitivity to detect breast cancer during pregnancy. BCP is diagnosed at a higher stage than in nonpregnant women. In our series, patients with BCP had poorer outcomes than the not pregnant group. These results were not observed when adjusting for stage. PMID: 32623975 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 7, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Outcome of patients with colorectal cancer undergoing lung metastases resection: a single-institution retrospective analysis.
CONCLUSIONS: This study shows particularly favorable survival outcomes for patients undergoing lung metastasectomy. The validity of some of the main prognostic factors was confirmed and a positive effect of postoperative chemotherapy on relapse-free survival was shown. Contrary to other reports, the presence of KRAS mutations was not associated with significant survival differences. Further studies are needed in order to clarify the interactions between molecular, clinical, and pathologic characteristics and treatment-related factors. PMID: 32597321 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - July 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Ratio of maximum to minimum tumor diameter can predict the pathology type of renal cell carcinoma before surgery.
This study aimed to evaluate the utility of the ratio of maximum to minimum tumor diameter (ROD) in predicting pathologic subtypes of RCC. METHODS: Data from patients with RCC who underwent surgery between January 2015 and December 2019 were reviewed retrospectively. The cutoff value for ROD was calculated using receiver operating characteristic (ROC) curve analysis. RESULTS: In the clear cell RCC (ccRCC) and non-ccRCC groups, the optimal ROD cutoff value to predict ccRCC was determined to be 1.201 (sensitivity, 90.7%; specificity, 76.1%; area under the ROC curve [AUC], 0.827; p
Source: Tumori - July 2, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Corrigendum.
Authors: PMID: 32586213 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - June 27, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Multiple primary malignancies involving lung cancer: a single-center experience.
CONCLUSIONS: Prostate, colorectal, bladder, and larynx were the most frequent anatomical sites of malignancies preceding or following lung cancer. Male sex, squamous cell lung carcinoma, synchronous and LCF MPM might be associated with poorer prognosis. PMID: 32578517 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - June 26, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research