How many Italian cancer patients are eligible for, and may respond to, Italian Medicines Agency-approved checkpoint immune inhibitors?
CONCLUSIONS: In conclusion, although the number of ICI-eligible patients is a relatively small proportion of the yearly burden of cancers, about half of them may respond to ICI-treatment.PMID:38372036 | DOI:10.1177/03008916241229649 (Source: Tumori)
Source: Tumori - February 19, 2024 Category: Cancer & Oncology Authors: Emanuele Crocetti Alessandra Ravaioli Fabio Falcini Rosa Vattiato Silvia Mancini Flavia Baldacchini Federica Zamagni Benedetta Vitali Chiara Balducci Lauro Bucchi Orietta Giuliani Source Type: research
Melanoma and sex hormones: Pathogenesis, progressive disease and response to treatments
Tumori. 2024 Feb 19:3008916241231687. doi: 10.1177/03008916241231687. Online ahead of print.ABSTRACTCutaneous melanoma represents the fifth tumor in terms of incidence in young adults, with a major involvement of males than females. Despite the significant changes in available effective treatments for cutaneous melanoma, there is still a proportion of patients that do not benefit long-term disease control with immune checkpoint inhibitors and/or BRAF/MEK inhibitors, and eventually develop progressive disease. In addition to the emerging biomarkers under investigation to understand resistance to treatments, recent studies r...
Source: Tumori - February 19, 2024 Category: Cancer & Oncology Authors: Ida Taglialatela Alice Indini Giulia Santanelli Giorgia Di Liberti Lorenza Di Guardo Filippo De Braud Michele Del Vecchio Source Type: research
Nivolumab in pretreated pleural mesothelioma: Results from an observational real-world study of patients treated within the AIFA 5% Fund
CONCLUSION: Nivolumab as a single agent is fairly active in a cohort of unselected pretreated pleural mesothelioma patients. Further investigations on clinical and translational factors are needed to define which patient might benefit most from nivolumab treatment in pleural mesothelioma.PMID:38372045 | DOI:10.1177/03008916241229287 (Source: Tumori)
Source: Tumori - February 19, 2024 Category: Cancer & Oncology Authors: Luigi Cerbone Sara Delfanti Stefania Crivellari Antonina Maria De Angelis Laura Mazzeo Claudia Proto Mario Occhipinti Giuseppe Lo Russo Chiara Dellepiane Federica Biello Irene Alabiso Francesco Verderame Roberta Gauna Irene De Simone Federica Cuppone Sand Source Type: research
The Italian Rare Biliary tract Cancer initiative (IRaBiCa): A multicentric observational study of Gruppo Oncologico dell'Italia Meridionale (GOIM) in collaboration with Gruppo Italiano Colangiocarcinoma (GICO)
CONCLUSIONS: We expect to gather novel data on rare histotypes of biliary tract cancer that will be useful to support their molecular and immunological characterization.PMID:38326240 | DOI:10.1177/03008916231222761 (Source: Tumori)
Source: Tumori - February 7, 2024 Category: Cancer & Oncology Authors: Desir èe Speranza Elena Sapuppo Giuseppe Aprile Alessandra Auriemma Francesca Bergamo Roberto Bianco Roberto Bordonaro Giovanni Brandi Oronzo Brunetti Carlo Carnaghi Domenico Ciliberto Saverio Cinieri Salvatore Corallo Ferdinando De Vita Samantha Di Dona Source Type: research
Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance
Tumori. 2024 Feb 5:3008916231225576. doi: 10.1177/03008916231225576. Online ahead of print.ABSTRACTProstate cancer is the second most common malignancy among men in the world, posing a serious threat to men's health and lives. RB1 is the first human tumor suppressor gene to be described, and it is closely associated with the development, progression, and suppression of a variety of tumors. It was found that the loss of RB1 is an early event in prostate cancer development and is closely related to prostate cancer development, progression and treatment resistance. This paper reviews the current status of research on the rela...
Source: Tumori - February 5, 2024 Category: Cancer & Oncology Authors: Min Ma Yazhi Zhu Changkai Xiao Ruidong Li Xingyu Cao Ran Kang Xiaolan Wang Ermao Li Source Type: research
Is motherhood still possible after pelvic carbon ion radiotherapy? A promising combined fertility-preservation approach
CONCLUSION: The patient achieved optimal oncological response and delivered a healthy infant following the completion of cancer treatment.PMID:38183176 | DOI:10.1177/03008916231218794 (Source: Tumori)
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Amelia Barcellini Chiara Cassani Ester Orlandi Rossella E Nappi Federica Broglia Maria Paola Delmonte Silvia Molinelli Alessandro Vai Viviana Vitolo Alessandro Gronchi Gioacchino D'Ambrosio Lorenzo Cobianchi Maria Rosaria Fiore Source Type: research
Non-neoplastic cells as prognostic biomarkers in diffuse large B-cell lymphoma: A system review and meta-analysis
Tumori. 2024 Jan 5:3008916231221636. doi: 10.1177/03008916231221636. Online ahead of print.ABSTRACTThe microenvironment of diffuse large B-cell lymphoma (DLBCL) is composed of various components, including immune cells and immune checkpoints, some of which have been correlated with the prognosis of DLBCL, but their results remain controversial. Therefore, we conducted a systematic review and meta-analysis to investigate the association between the microenvironment and prognosis in DLBCL. We searched PubMed, Web of Science, and EMBASE for relevant articles between 2001 and 2022. Twenty-five studies involving 4495 patients w...
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Min Zhao Lixing Wang Xingyu Wang Juan He Kuai Yu Dan Li Source Type: research
Is motherhood still possible after pelvic carbon ion radiotherapy? A promising combined fertility-preservation approach
CONCLUSION: The patient achieved optimal oncological response and delivered a healthy infant following the completion of cancer treatment.PMID:38183176 | DOI:10.1177/03008916231218794 (Source: Tumori)
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Amelia Barcellini Chiara Cassani Ester Orlandi Rossella E Nappi Federica Broglia Maria Paola Delmonte Silvia Molinelli Alessandro Vai Viviana Vitolo Alessandro Gronchi Gioacchino D'Ambrosio Lorenzo Cobianchi Maria Rosaria Fiore Source Type: research
Non-neoplastic cells as prognostic biomarkers in diffuse large B-cell lymphoma: A system review and meta-analysis
Tumori. 2024 Jan 5:3008916231221636. doi: 10.1177/03008916231221636. Online ahead of print.ABSTRACTThe microenvironment of diffuse large B-cell lymphoma (DLBCL) is composed of various components, including immune cells and immune checkpoints, some of which have been correlated with the prognosis of DLBCL, but their results remain controversial. Therefore, we conducted a systematic review and meta-analysis to investigate the association between the microenvironment and prognosis in DLBCL. We searched PubMed, Web of Science, and EMBASE for relevant articles between 2001 and 2022. Twenty-five studies involving 4495 patients w...
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Min Zhao Lixing Wang Xingyu Wang Juan He Kuai Yu Dan Li Source Type: research
Is motherhood still possible after pelvic carbon ion radiotherapy? A promising combined fertility-preservation approach
CONCLUSION: The patient achieved optimal oncological response and delivered a healthy infant following the completion of cancer treatment.PMID:38183176 | DOI:10.1177/03008916231218794 (Source: Tumori)
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Amelia Barcellini Chiara Cassani Ester Orlandi Rossella E Nappi Federica Broglia Maria Paola Delmonte Silvia Molinelli Alessandro Vai Viviana Vitolo Alessandro Gronchi Gioacchino D'Ambrosio Lorenzo Cobianchi Maria Rosaria Fiore Source Type: research
Non-neoplastic cells as prognostic biomarkers in diffuse large B-cell lymphoma: A system review and meta-analysis
Tumori. 2024 Jan 5:3008916231221636. doi: 10.1177/03008916231221636. Online ahead of print.ABSTRACTThe microenvironment of diffuse large B-cell lymphoma (DLBCL) is composed of various components, including immune cells and immune checkpoints, some of which have been correlated with the prognosis of DLBCL, but their results remain controversial. Therefore, we conducted a systematic review and meta-analysis to investigate the association between the microenvironment and prognosis in DLBCL. We searched PubMed, Web of Science, and EMBASE for relevant articles between 2001 and 2022. Twenty-five studies involving 4495 patients w...
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Min Zhao Lixing Wang Xingyu Wang Juan He Kuai Yu Dan Li Source Type: research
Is motherhood still possible after pelvic carbon ion radiotherapy? A promising combined fertility-preservation approach
CONCLUSION: The patient achieved optimal oncological response and delivered a healthy infant following the completion of cancer treatment.PMID:38183176 | DOI:10.1177/03008916231218794 (Source: Tumori)
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Amelia Barcellini Chiara Cassani Ester Orlandi Rossella E Nappi Federica Broglia Maria Paola Delmonte Silvia Molinelli Alessandro Vai Viviana Vitolo Alessandro Gronchi Gioacchino D'Ambrosio Lorenzo Cobianchi Maria Rosaria Fiore Source Type: research
Non-neoplastic cells as prognostic biomarkers in diffuse large B-cell lymphoma: A system review and meta-analysis
Tumori. 2024 Jan 5:3008916231221636. doi: 10.1177/03008916231221636. Online ahead of print.ABSTRACTThe microenvironment of diffuse large B-cell lymphoma (DLBCL) is composed of various components, including immune cells and immune checkpoints, some of which have been correlated with the prognosis of DLBCL, but their results remain controversial. Therefore, we conducted a systematic review and meta-analysis to investigate the association between the microenvironment and prognosis in DLBCL. We searched PubMed, Web of Science, and EMBASE for relevant articles between 2001 and 2022. Twenty-five studies involving 4495 patients w...
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Min Zhao Lixing Wang Xingyu Wang Juan He Kuai Yu Dan Li Source Type: research
