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Cancer: Bone Cancers

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Total 366 results found since Jan 2013.

siRNA targeting TCTP suppresses osteosarcoma cell growth and induces apoptosis in vitro and in vivo
Abstract Osteosarcoma (OS) remains the most frequent primary malignant bone tumor in adolescents. However, the molecular cause of the disease is poorly elucidated. In the present study, we primarily found that translationally controlled tumor protein (TCTP) was overexpressed in human OS tissues and cell lines. To investigate the function of TCTP in OS cell growth, an RNA interference lentivirus system was employed to deplete TCTP expression in Saos‐2 and U2OS cell lines. Specific knockdown of TCTP significantly impaired cell proliferation and colony‐formation capacity in both OS cell lines. Moreover, depletion of TCTP ...
Source: Biotechnology and Applied Biochemistry - December 22, 2015 Category: Biochemistry Authors: Jian‐Hui Shen, Cheng‐Bo Qu, Hai‐Kun Chu, Ming‐Yu Cui, Yu‐Lan Wang, Yuan‐Xin Sun, Yin‐Dong Song, Gang Li, Feng‐Jun Shi Tags: Original Article Source Type: research

Clinical and biological significance of PIM1 kinase in osteosarcoma
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - December 19, 2015 Category: Orthopaedics Authors: Yunfei Liao, Yong Feng, Jacson Shen, Yan Gao, Gregory Cote, Edwin Choy, David Harmon, Henry Mankin, Francis Hornicek, Zhenfeng Duan Tags: Research Article Source Type: research

Effect and mechanism analysis of siRNA in inhibiting VEGF and its anti-angiogenesis effects in human osteosarcoma bearing rats.
CONCLUSIONS: The growth of tumor tissue in osteosarcoma bearing rats is inhibited in Ad-VEGF-siRNA group, Ad-VEGF-siRNA + neoadjuvant chemotherapy group and Ad-VEGF-siRNA + anti-angiogenesis chemotherapy group. The effect in Ad-VEGF-siRNA + neoadjuvant chemotherapy is more significant than simple biological therapy or Ad-VEGF-siRNA + anti-angiogenesis chemotherapy. PMID: 26636524 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 6, 2015 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MicroRNA-145 Suppresses Osteosarcoma Metastasis via Targeting MMP16
Background: Metastasis is a leading cause of mortality for osteosarcoma (OS) patients, and its molecular pathological mechanisms remain to be elucidated. Previous studies have suggested a significant role of microRNAs (miRNAs) in the control of cancel cell migration and invasion. Methods: Real-time PCR was used to screen the differentially expressed miRNAs between OS with or without metastasis, and miR-145 underexpression was observed in metastatic OS. Luciferase assay was performed to validate the target gene. Results: Further, we identified three genes, MMP16, ADAM17 and metadherin, as possible targets of miR-145. We ide...
Source: Cellular Physiology and Biochemistry - November 25, 2015 Category: Cytology Source Type: research

RLN2 regulates in vitro invasion and viability of osteosarcoma MG-63 cells via S100A4/MMP-9 signal.
CONCLUSIONS: Our results indicate that RLN2 regulats cell migration, invasiveness and proliferation of osteosarcoma cells in vitro, which may be mediated through S100A4/MMP-9 signaling. PMID: 25855929 [PubMed - indexed for MEDLINE]
Source: Pharmacological Reviews - November 20, 2015 Category: Drugs & Pharmacology Authors: Ren XF, Zhao H, Gong XC, Wang LN, Ma JF Tags: Eur Rev Med Pharmacol Sci Source Type: research

Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma
This article is protected by copyright. All rights reserved
Source: Journal of Orthopaedic Research - November 17, 2015 Category: Orthopaedics Authors: Xianyi Cai, Yunlu Liu, Wen Yang, Yun Xia, Cao Yang, Shuhua Yang, Xianzhe Liu Tags: Research Article Source Type: research

GSE73422 Expression data from human osteosarcoma cells treated with CDK11 siRNA
Contributors : Yong Feng ; Zhenfeng DuanSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe U-2OS and KHOS osteosarcoma cell lines where seeded onto the 100mm cell culture plate, then treated with CDK11 siRNA (40nM) or nonspecificsiRNA (40nM). Change with regular medium 24 hour later. Total RNA was collected from these cells using TRIzol® Reagent (GIBCO Grand Island, NY) according to the manufacturer’s instructions. To account for and eliminate biologic noise, RNA was isolated from three distinct flasks of each cell line and pooled together. RNA quality was determined via ethidium bromide staining foll...
Source: GEO: Gene Expression Omnibus - October 7, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Focal adhesion kinase overexpression and its impact on human osteosarcoma.
Authors: Ren K, Lu X, Yao N, Chen Y, Yang A, Chen H, Zhang J, Wu S, Shi X, Wang C, Sun X Abstract Focal adhesion kinase (FAK) has been implicated in tumorigenesis in various malignancies. We sought to examine the expression patterns of FAK and the activated form, phosphorylated FAK (pFAK), in human osteosarcoma and to investigate the correlation of FAK expression with clinicopathologic parameters and prognosis. In addition, the functional consequence of manipulating the FAK protein level was investigated in human osteosarcoma cell lines. Immunohistochemical staining was used to detect FAK and pFAK in pathologic arc...
Source: Oncotarget - September 26, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor β‐dependent manner in human osteosarcoma
Angiogenesis plays an important role in tumor growth and metastasis and has been reported to be inversely correlated with overall survival of osteosarcoma patients. It has been shown that apurinic/apyrimidinic endonuclease 1 (APE1), a dually functional protein possessing both base excision repair and redox activities, is involved in tumor angiogenesis, although these mechanisms are not fully understood. Our previous study showed that the expression of transforming growth factor β (TGFβ) was significantly reduced in APE1‐deficient osteosarcoma cells. Transforming growth factor β promotes cancer metastasis through vario...
Source: Cancer Science - September 25, 2015 Category: Cancer & Oncology Authors: Xuan Jiang, Jinlu Shan, Nan Dai, Zhaoyang Zhong, Yi Qing, Yuxing Yang, Shiheng Zhang, Chongyi Li, Jiangdong Sui, Tao Ren, Mengxia Li, Dong Wang Tags: Original Article Source Type: research

Doxorubicin Inhibits Proliferation of Osteosarcoma Cells Through Upregulation of the Notch Signaling Pathway.
Authors: Ji P, Yu L, Guo WC, Mei HJ, Wang XJ, Chen H, Fang S, Yang J Abstract Doxorubicin plays a major role in the treatment of osteosarcoma disorders. The Notch signaling pathway exerts various biological functions, including cell proliferation, differentiation, and apoptosis. In the present study, we investigated the effects of different doses of doxorubicin on proliferation and apoptosis of osteosarcoma cells with or without Notch signaling. Results found that cellular viability was downregulated while caspase 3 activity and expression were promoted in osteosarcoma cells following treatment with various doses o...
Source: Oncology Research - September 11, 2015 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Mitogen-activated protein kinase 7 promotes cell proliferation, migration and invasion in SOSP-M human osteosarcoma cell line.
CONCLUSIONS: Our results indicate that overexpression of MAPK7 in human OS cells could promote cell proliferation, migration and invasion, whereas knockdown of MAPK7 expression had the opposite effect. All the results suggest that MAPK7 may serve as a potent target for drug development. PMID: 26350187 [PubMed - as supplied by publisher]
Source: Tumori - September 11, 2015 Category: Cancer & Oncology Tags: Tumori Source Type: research

Inhibition of hypoxia-inducible factor-1 alpha radiosensitized MG-63 human osteosarcoma cells in vitro.
CONCLUSIONS: Our results indicate that inhibition of HIF-1α effectively decreases hypoxia-induced transcription and radiosensitizes hypoxic MG-63 human osteosarcoma cells in vitro. PMID: 26350185 [PubMed - as supplied by publisher]
Source: Tumori - September 11, 2015 Category: Cancer & Oncology Tags: Tumori Source Type: research

Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells
We reported that aspidin PB induced cell cycle arrest and apoptosis through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells. Aspidin PB inhibited the proliferation of Saos-2, U2OS, and HOS cells in a dose-dependent and time-dependent manner. Aspidin PB induced changes in the cell cycle regulators (cyclin A, pRb, CDK2, p53, and p21), which caused cell cycle arrest in the S phase. We also explored the role of siRNA targeted to p53; it led to a dose-dependent attenuation of aspidin PB-induced apoptosis signaling. Moreover, after treatment with aspidin PB, the p21-silenced cells decreased significan...
Source: Anti-Cancer Drugs - September 3, 2015 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

TGF-β1-induced miR-202 mediates drug resistance by inhibiting apoptosis in human osteosarcoma
Conclusions This study provides new insights into miRNA-202 in osteosarcoma as a potential molecular target for chemotherapy.
Source: Journal of Cancer Research and Clinical Oncology - August 15, 2015 Category: Cancer & Oncology Source Type: research

Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis via a transforming growth factor β‐dependent manner in human osteosarcoma
This article is protected by copyright. All rights reserved.
Source: Cancer Science - August 6, 2015 Category: Cancer & Oncology Authors: Xuan Jiang, Jinglu Shan, Nan Dai, Zhaoyang Zhong, Yi Qing, Yuxing Yang, Shiheng Zhang, Chongyi Li, Jiangdong Sui, Tao Ren, Mengxia Li, Dong Wang Tags: Original Article Source Type: research