Exploring the prognosis of neuroblastoma in adolescents and adults: a case series and literature review
Neoplasma. 2022 Jan 25:210325N399. doi: 10.4149/neo_2021_210325N399. Online ahead of print.ABSTRACTNeuroblastoma (NB) is one of the most common extracranial malignant solid tumors in childhood, and over 90% of NBs are diagnosed in children under the age of 10 years old. For patients between 14 and 18 years old or older than 18 years, due to the rarity of NB, few studies have been performed in this population. Defined "adolescent cases" as individuals in 14-18 years old and "adult cases" as older than 18 years old, we reported five NB cases of adolescents and adults in our hospital. 137 cases presented a...
Source: Neoplasma - January 24, 2022 Category: Cancer & Oncology Authors: Qian-Ya Jin Shi-Bei Du Xiao-Jun Yuan Source Type: research

Role of annexin A family in tumorigenesis and chemoresistance of gastric cancer
Neoplasma. 2022 Jan 25:210629N872. doi: 10.4149/neo_2021_210629N872. Online ahead of print.ABSTRACTGastric cancer (GC) is the sixth most common cancer type and the third leading cause of cancer-related mortality among all malignant tumors worldwide. Due to insidious onset and lack of reliable early diagnostic markers, most GC patients are at an advanced stage at the time of diagnosis. Annexin is an evolutionally-conserved Ca2+-dependent phospholipid-binding protein superfamily, including five members (A, B, C, D, and E). Annexins in the cells of vertebrates comprised the annexin A family, consisting of 12 members in humans...
Source: Neoplasma - January 24, 2022 Category: Cancer & Oncology Authors: Rong-Rong Zhao Xiao-Rong Mao Xiao-Feng Wang Ya Zheng Yu-Ping Wang Yong-Ning Zhou Source Type: research

Prognostic value of circulating tumor cells and its association with the expression of cancer stem cells in nasopharyngeal carcinoma patients
Neoplasma. 2022 Jan 25:210707N906. doi: 10.4149/neo_2021_210707N906. Online ahead of print.ABSTRACTThe release of circulating tumor cells (CTCs) into vasculature is an early event in the metastatic process and the detection of CTCs has been widely used clinically. In addition, cancer stem cells (CSCs) are the source of distant metastasis. However, the relationship between CTCs and CSCs in nasopharyngeal carcinoma (NPC) patients was largely unknown. A total of 93 NPC patients were enrolled in this study. The CTCs in the peripheral blood were detected. The expression of ALDH1A1 in the tumor tissues of the corresponding patie...
Source: Neoplasma - January 24, 2022 Category: Cancer & Oncology Authors: Lin Lu Hao-Wei Huang Huan Du Zhi-Xiang Liu Zhi-Qiang Zha Pei-Pei Wang Yong Wu Xia Liu Cheng-Yin Weng Xi-Sheng Fang Bao-Xiu Li Hai-Bo Mao Li-Na Wang Xiao-Pai Wang Ming-Mei Guan Guo-Long Liu Source Type: research

Genetic contributions of MHC class I antigen processing and presentation pathway to bladder cancer risk and recurrence
The objective of the current study was to examine the association of single nucleotide polymorphisms (SNPs) in the ERAP1, ERAP2, TAP1, TAP2, TAPBP, IFNG genes with the corresponding mRNA expression in bladder cancer (BC) risk and recurrence after transurethral resection of BC. Moreover, we assessed the relationship between HLA class I and VEGF plasma levels and BC recurrence. We analyzed nine SNPs in 124 BC patients using TaqMan genotyping and compared them with the data from 503 healthy individuals from the 1000 Genomes Project. In addition, we quantified the effects of SNPs on the corresponding mRNA expression in tumor a...
Source: Neoplasma - January 24, 2022 Category: Cancer & Oncology Authors: Edyta Wieczorek Zbigniew Jablonowski Monika Lesicka Ewa Jablonska Piotr Kutwin Edyta Reszka Malgorzata Anna Garstka Source Type: research

miRNA-182-5p promotes human bladder cancer proliferation and migration through the FOXF2/SHH axis
Neoplasma. 2022 Jan 25:210903N1266. doi: 10.4149/neo_2021_210903N1266. Online ahead of print.ABSTRACTIncreasing evidence suggests that microRNAs (miRNAs) play critical roles in bladder tumorigenesis and development by combining with the 3' untranslated regions (3'-UTRs) of the corresponding mRNAs to negatively regulate gene expression. The role of miR-182-5p in bladder cancer (BC) remains unclear. Therefore, this study aimed to clarify the functional role of miR-182-5p in BC. We predicted candidate mRNAs for miR-182-5p via three databases (TarBase, ENCORI, and miRDB). Dual-luciferase reporter assays and target prediction c...
Source: Neoplasma - January 24, 2022 Category: Cancer & Oncology Authors: Ze Zhang Chong Wang Tiantian Liu Zhao Tang Rucheng Yan Chen Zhang Chao Cheng Jiawei Wang Hao Wang Houbao Huang Yawei Li Source Type: research

Low-molecular-weight heparin prophylaxis is not associated with decreased incidence of venous thromboembolism in testicular germ cell tumor patients receiving chemotherapy
The objective was to evaluate the effect of low-molecular-weight heparin (LMWH) prophylaxis on the incidence of VTE and outcome in patients with GCT treated with first-line chemotherapy. In this retrospective study, 353 chemotherapy-naive GCT patients were treated with first-line chemotherapy at the National Cancer Institute, Bratislava, Slovakia (2000-2017). Median follow-up was 71 months. VTE was defined as any venous thrombosis or pulmonary embolism, confirmed by imaging, occurring during first-line chemotherapy. Exclusion criteria were LMWH use before starting chemotherapy and VTE on initial staging. We observed 14 (4....
Source: Neoplasma - January 24, 2022 Category: Cancer & Oncology Authors: Nikola Hapakova Michal Chovanec Katarina Rejlekova Katarina Kalavska Jana Obertova Patrik Palacka Valentina De Angelis Zuzana Sycova-Mila Jozef Mardiak Michal Mego Source Type: research

Proteomic analysis of the bone marrow microenvironment in extramedullary multiple myeloma patients
Neoplasma. 2022 Jan 18:210527N715. doi: 10.4149/neo_2021_210527N715. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a heterogeneous hematological malignancy characterized by the uncontrolled clonal proliferation of bone marrow (BM) plasma cells. The poor prognosis of patients is associated with the presence of extramedullary disease (EMD). Previously, different mechanisms involved in the colonization of BM niches by MM cells and their escape during EMD have been described. Thus, we aimed to investigate the expression of selected cytokines in the BM plasma of MM patients as well as EMD patients to reveal novel molec...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jana Gregorova Petra Vychytilova-Faltejskova Tereza Kramarova Zdenka Knechtova Martina Almasi Martin Stork Ludek Pour Jiri Kohoutek Sabina Sevcikova Source Type: research

Prognostic potential of circulating miR-93-5p in patients with colorectal cancer liver metastases
This study aimed to examine the expression pattern of tumoral and circulating miR-93-5p in patients with colorectal cancer (CRC) liver metastasis (CRLM) and to explore its predictive and prognostic potential. CRLM tissue, surrounding non-tumor liver tissue, and serum were obtained from 35 patients with CRLM. The expression pattern of tissue and circulating miR-93-5p in patients with CRLM was determined using quantitative polymerase chain reaction, using miR-16-5p for normalization. Sample-based cut-off values for CRLM and serum miR-93-5p expression were calculated using Receiver Operating Characteristic curve analysis to s...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jovana Despotovi ć Aleksandar Bogdanovi ć Sandra Dragi čević Danijel Galun Zoran Krivokapi ć Aleksandra Nikoli ć Source Type: research

Axillary reverse mapping in breast cancer surgery - functional study
Neoplasma. 2022 Jan 18:210622N830. doi: 10.4149/neo_2021_210622N830. Online ahead of print.ABSTRACTThe aim of the study was to map the lymphatic drainage of the upper extremity that traverses the axilla and elucidate its relationship with the lymphatic drainage of the breast. In 79 breast cancer patients indicated to the axillary lymph node dissection for category cN1, cN2, Technetium-99m (particle size
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: David Pavlista Lukas Dostalek Zuzana Velenska Source Type: research

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma
In this study, we aimed to identify altered circRNA expression profiles in exosomes isolated from plasma of patients with colorectal adenoma using high-throughput sequencing. Exosomes were confirmed by western blotting, transmission electron microscopy, and nanosight assay. The sequencing data indicated that there are 413 differentially expressed circRNAs including 112 upregulated and 301 downregulated circRNAs in colorectal adenoma patients compared with controls. GO analysis and the circRNA-miRNA-mRNA network were performed to predict the potential function of circRNAs, and demonstrate the putative mechanisms in colorect...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Shaobing Cheng Sen Lu Fanlong Liu Source Type: research

Proteomic analysis of the bone marrow microenvironment in extramedullary multiple myeloma patients
Neoplasma. 2022 Jan 18:210527N715. doi: 10.4149/neo_2021_210527N715. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a heterogeneous hematological malignancy characterized by the uncontrolled clonal proliferation of bone marrow (BM) plasma cells. The poor prognosis of patients is associated with the presence of extramedullary disease (EMD). Previously, different mechanisms involved in the colonization of BM niches by MM cells and their escape during EMD have been described. Thus, we aimed to investigate the expression of selected cytokines in the BM plasma of MM patients as well as EMD patients to reveal novel molec...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jana Gregorova Petra Vychytilova-Faltejskova Tereza Kramarova Zdenka Knechtova Martina Almasi Martin Stork Ludek Pour Jiri Kohoutek Sabina Sevcikova Source Type: research

Prognostic potential of circulating miR-93-5p in patients with colorectal cancer liver metastases
This study aimed to examine the expression pattern of tumoral and circulating miR-93-5p in patients with colorectal cancer (CRC) liver metastasis (CRLM) and to explore its predictive and prognostic potential. CRLM tissue, surrounding non-tumor liver tissue, and serum were obtained from 35 patients with CRLM. The expression pattern of tissue and circulating miR-93-5p in patients with CRLM was determined using quantitative polymerase chain reaction, using miR-16-5p for normalization. Sample-based cut-off values for CRLM and serum miR-93-5p expression were calculated using Receiver Operating Characteristic curve analysis to s...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jovana Despotovi ć Aleksandar Bogdanovi ć Sandra Dragi čević Danijel Galun Zoran Krivokapi ć Aleksandra Nikoli ć Source Type: research

Axillary reverse mapping in breast cancer surgery - functional study
Neoplasma. 2022 Jan 18:210622N830. doi: 10.4149/neo_2021_210622N830. Online ahead of print.ABSTRACTThe aim of the study was to map the lymphatic drainage of the upper extremity that traverses the axilla and elucidate its relationship with the lymphatic drainage of the breast. In 79 breast cancer patients indicated to the axillary lymph node dissection for category cN1, cN2, Technetium-99m (particle size
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: David Pavlista Lukas Dostalek Zuzana Velenska Source Type: research

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma
In this study, we aimed to identify altered circRNA expression profiles in exosomes isolated from plasma of patients with colorectal adenoma using high-throughput sequencing. Exosomes were confirmed by western blotting, transmission electron microscopy, and nanosight assay. The sequencing data indicated that there are 413 differentially expressed circRNAs including 112 upregulated and 301 downregulated circRNAs in colorectal adenoma patients compared with controls. GO analysis and the circRNA-miRNA-mRNA network were performed to predict the potential function of circRNAs, and demonstrate the putative mechanisms in colorect...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Shaobing Cheng Sen Lu Fanlong Liu Source Type: research

Proteomic analysis of the bone marrow microenvironment in extramedullary multiple myeloma patients
Neoplasma. 2022 Jan 18:210527N715. doi: 10.4149/neo_2021_210527N715. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a heterogeneous hematological malignancy characterized by the uncontrolled clonal proliferation of bone marrow (BM) plasma cells. The poor prognosis of patients is associated with the presence of extramedullary disease (EMD). Previously, different mechanisms involved in the colonization of BM niches by MM cells and their escape during EMD have been described. Thus, we aimed to investigate the expression of selected cytokines in the BM plasma of MM patients as well as EMD patients to reveal novel molec...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jana Gregorova Petra Vychytilova-Faltejskova Tereza Kramarova Zdenka Knechtova Martina Almasi Martin Stork Ludek Pour Jiri Kohoutek Sabina Sevcikova Source Type: research

Prognostic potential of circulating miR-93-5p in patients with colorectal cancer liver metastases
This study aimed to examine the expression pattern of tumoral and circulating miR-93-5p in patients with colorectal cancer (CRC) liver metastasis (CRLM) and to explore its predictive and prognostic potential. CRLM tissue, surrounding non-tumor liver tissue, and serum were obtained from 35 patients with CRLM. The expression pattern of tissue and circulating miR-93-5p in patients with CRLM was determined using quantitative polymerase chain reaction, using miR-16-5p for normalization. Sample-based cut-off values for CRLM and serum miR-93-5p expression were calculated using Receiver Operating Characteristic curve analysis to s...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jovana Despotovi ć Aleksandar Bogdanovi ć Sandra Dragi čević Danijel Galun Zoran Krivokapi ć Aleksandra Nikoli ć Source Type: research

Axillary reverse mapping in breast cancer surgery - functional study
Neoplasma. 2022 Jan 18:210622N830. doi: 10.4149/neo_2021_210622N830. Online ahead of print.ABSTRACTThe aim of the study was to map the lymphatic drainage of the upper extremity that traverses the axilla and elucidate its relationship with the lymphatic drainage of the breast. In 79 breast cancer patients indicated to the axillary lymph node dissection for category cN1, cN2, Technetium-99m (particle size
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: David Pavlista Lukas Dostalek Zuzana Velenska Source Type: research

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma
In this study, we aimed to identify altered circRNA expression profiles in exosomes isolated from plasma of patients with colorectal adenoma using high-throughput sequencing. Exosomes were confirmed by western blotting, transmission electron microscopy, and nanosight assay. The sequencing data indicated that there are 413 differentially expressed circRNAs including 112 upregulated and 301 downregulated circRNAs in colorectal adenoma patients compared with controls. GO analysis and the circRNA-miRNA-mRNA network were performed to predict the potential function of circRNAs, and demonstrate the putative mechanisms in colorect...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Shaobing Cheng Sen Lu Fanlong Liu Source Type: research

Proteomic analysis of the bone marrow microenvironment in extramedullary multiple myeloma patients
Neoplasma. 2022 Jan 18:210527N715. doi: 10.4149/neo_2021_210527N715. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a heterogeneous hematological malignancy characterized by the uncontrolled clonal proliferation of bone marrow (BM) plasma cells. The poor prognosis of patients is associated with the presence of extramedullary disease (EMD). Previously, different mechanisms involved in the colonization of BM niches by MM cells and their escape during EMD have been described. Thus, we aimed to investigate the expression of selected cytokines in the BM plasma of MM patients as well as EMD patients to reveal novel molec...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jana Gregorova Petra Vychytilova-Faltejskova Tereza Kramarova Zdenka Knechtova Martina Almasi Martin Stork Ludek Pour Jiri Kohoutek Sabina Sevcikova Source Type: research

Prognostic potential of circulating miR-93-5p in patients with colorectal cancer liver metastases
This study aimed to examine the expression pattern of tumoral and circulating miR-93-5p in patients with colorectal cancer (CRC) liver metastasis (CRLM) and to explore its predictive and prognostic potential. CRLM tissue, surrounding non-tumor liver tissue, and serum were obtained from 35 patients with CRLM. The expression pattern of tissue and circulating miR-93-5p in patients with CRLM was determined using quantitative polymerase chain reaction, using miR-16-5p for normalization. Sample-based cut-off values for CRLM and serum miR-93-5p expression were calculated using Receiver Operating Characteristic curve analysis to s...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jovana Despotovi ć Aleksandar Bogdanovi ć Sandra Dragi čević Danijel Galun Zoran Krivokapi ć Aleksandra Nikoli ć Source Type: research

Axillary reverse mapping in breast cancer surgery - functional study
Neoplasma. 2022 Jan 18:210622N830. doi: 10.4149/neo_2021_210622N830. Online ahead of print.ABSTRACTThe aim of the study was to map the lymphatic drainage of the upper extremity that traverses the axilla and elucidate its relationship with the lymphatic drainage of the breast. In 79 breast cancer patients indicated to the axillary lymph node dissection for category cN1, cN2, Technetium-99m (particle size
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: David Pavlista Lukas Dostalek Zuzana Velenska Source Type: research

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma
In this study, we aimed to identify altered circRNA expression profiles in exosomes isolated from plasma of patients with colorectal adenoma using high-throughput sequencing. Exosomes were confirmed by western blotting, transmission electron microscopy, and nanosight assay. The sequencing data indicated that there are 413 differentially expressed circRNAs including 112 upregulated and 301 downregulated circRNAs in colorectal adenoma patients compared with controls. GO analysis and the circRNA-miRNA-mRNA network were performed to predict the potential function of circRNAs, and demonstrate the putative mechanisms in colorect...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Shaobing Cheng Sen Lu Fanlong Liu Source Type: research

Proteomic analysis of the bone marrow microenvironment in extramedullary multiple myeloma patients
Neoplasma. 2022 Jan 18:210527N715. doi: 10.4149/neo_2021_210527N715. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a heterogeneous hematological malignancy characterized by the uncontrolled clonal proliferation of bone marrow (BM) plasma cells. The poor prognosis of patients is associated with the presence of extramedullary disease (EMD). Previously, different mechanisms involved in the colonization of BM niches by MM cells and their escape during EMD have been described. Thus, we aimed to investigate the expression of selected cytokines in the BM plasma of MM patients as well as EMD patients to reveal novel molec...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jana Gregorova Petra Vychytilova-Faltejskova Tereza Kramarova Zdenka Knechtova Martina Almasi Martin Stork Ludek Pour Jiri Kohoutek Sabina Sevcikova Source Type: research

Prognostic potential of circulating miR-93-5p in patients with colorectal cancer liver metastases
This study aimed to examine the expression pattern of tumoral and circulating miR-93-5p in patients with colorectal cancer (CRC) liver metastasis (CRLM) and to explore its predictive and prognostic potential. CRLM tissue, surrounding non-tumor liver tissue, and serum were obtained from 35 patients with CRLM. The expression pattern of tissue and circulating miR-93-5p in patients with CRLM was determined using quantitative polymerase chain reaction, using miR-16-5p for normalization. Sample-based cut-off values for CRLM and serum miR-93-5p expression were calculated using Receiver Operating Characteristic curve analysis to s...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jovana Despotovi ć Aleksandar Bogdanovi ć Sandra Dragi čević Danijel Galun Zoran Krivokapi ć Aleksandra Nikoli ć Source Type: research

Axillary reverse mapping in breast cancer surgery - functional study
Neoplasma. 2022 Jan 18:210622N830. doi: 10.4149/neo_2021_210622N830. Online ahead of print.ABSTRACTThe aim of the study was to map the lymphatic drainage of the upper extremity that traverses the axilla and elucidate its relationship with the lymphatic drainage of the breast. In 79 breast cancer patients indicated to the axillary lymph node dissection for category cN1, cN2, Technetium-99m (particle size
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: David Pavlista Lukas Dostalek Zuzana Velenska Source Type: research

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma
In this study, we aimed to identify altered circRNA expression profiles in exosomes isolated from plasma of patients with colorectal adenoma using high-throughput sequencing. Exosomes were confirmed by western blotting, transmission electron microscopy, and nanosight assay. The sequencing data indicated that there are 413 differentially expressed circRNAs including 112 upregulated and 301 downregulated circRNAs in colorectal adenoma patients compared with controls. GO analysis and the circRNA-miRNA-mRNA network were performed to predict the potential function of circRNAs, and demonstrate the putative mechanisms in colorect...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Shaobing Cheng Sen Lu Fanlong Liu Source Type: research

Proteomic analysis of the bone marrow microenvironment in extramedullary multiple myeloma patients
Neoplasma. 2022 Jan 18:210527N715. doi: 10.4149/neo_2021_210527N715. Online ahead of print.ABSTRACTMultiple myeloma (MM) is a heterogeneous hematological malignancy characterized by the uncontrolled clonal proliferation of bone marrow (BM) plasma cells. The poor prognosis of patients is associated with the presence of extramedullary disease (EMD). Previously, different mechanisms involved in the colonization of BM niches by MM cells and their escape during EMD have been described. Thus, we aimed to investigate the expression of selected cytokines in the BM plasma of MM patients as well as EMD patients to reveal novel molec...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jana Gregorova Petra Vychytilova-Faltejskova Tereza Kramarova Zdenka Knechtova Martina Almasi Martin Stork Ludek Pour Jiri Kohoutek Sabina Sevcikova Source Type: research

Prognostic potential of circulating miR-93-5p in patients with colorectal cancer liver metastases
This study aimed to examine the expression pattern of tumoral and circulating miR-93-5p in patients with colorectal cancer (CRC) liver metastasis (CRLM) and to explore its predictive and prognostic potential. CRLM tissue, surrounding non-tumor liver tissue, and serum were obtained from 35 patients with CRLM. The expression pattern of tissue and circulating miR-93-5p in patients with CRLM was determined using quantitative polymerase chain reaction, using miR-16-5p for normalization. Sample-based cut-off values for CRLM and serum miR-93-5p expression were calculated using Receiver Operating Characteristic curve analysis to s...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Jovana Despotovi ć Aleksandar Bogdanovi ć Sandra Dragi čević Danijel Galun Zoran Krivokapi ć Aleksandra Nikoli ć Source Type: research

Axillary reverse mapping in breast cancer surgery - functional study
Neoplasma. 2022 Jan 18:210622N830. doi: 10.4149/neo_2021_210622N830. Online ahead of print.ABSTRACTThe aim of the study was to map the lymphatic drainage of the upper extremity that traverses the axilla and elucidate its relationship with the lymphatic drainage of the breast. In 79 breast cancer patients indicated to the axillary lymph node dissection for category cN1, cN2, Technetium-99m (particle size
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: David Pavlista Lukas Dostalek Zuzana Velenska Source Type: research

Exosomal circRNAs as novel potential biomarkers for colorectal adenoma
In this study, we aimed to identify altered circRNA expression profiles in exosomes isolated from plasma of patients with colorectal adenoma using high-throughput sequencing. Exosomes were confirmed by western blotting, transmission electron microscopy, and nanosight assay. The sequencing data indicated that there are 413 differentially expressed circRNAs including 112 upregulated and 301 downregulated circRNAs in colorectal adenoma patients compared with controls. GO analysis and the circRNA-miRNA-mRNA network were performed to predict the potential function of circRNAs, and demonstrate the putative mechanisms in colorect...
Source: Neoplasma - January 17, 2022 Category: Cancer & Oncology Authors: Shaobing Cheng Sen Lu Fanlong Liu Source Type: research

Apigenin regulates the migration, invasion, and autophagy of hepatocellular carcinoma cells by downregulating YAP
Neoplasma. 2022 Jan 12:210615N798. doi: 10.4149/neo_2021_210615N798. Online ahead of print.ABSTRACTApigenin is an edible flavonoid with anticancer properties; however, the underlying mechanisms in hepatocellular carcinoma (HCC) remain to be clarified. In the present study, we demonstrated that apigenin decreased the viability of both SMMC-7721 and SK-Hep1 cells in a dose-dependent manner, and inhibited the migration and invasion of HCC cells with different metastatic potential by regulating actin cytoskeletal rearrangements. Moreover, we showed that apigenin decreased the expression of YAP, and subsequently reduced migrati...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Jing Zeng Hua Xie Zhi-Lin Zhang Zi-Xian Li Lin Shi Ke-Yan Wu Yang Zhou Zhen Tian Yu Zhang Wei Zhou Wei-Gan Shen Source Type: research

Increased number and function of endothelial progenitor cells in breast cancer patients and the linear correlation with VEGF level
Neoplasma. 2022 Jan 12:210615N800. doi: 10.4149/neo_2021_210615N800. Online ahead of print.ABSTRACTThe number of circulating endothelial progenitor cells (EPCs) was found to increase in patients with breast cancer, but the alteration in EPC function remains to be elusive. We conducted this study to evaluate the number and function of peripheral EPCs of breast cancer patients and its possible underlying mechanism. Besides, the vascular endothelial growth factor (VEGF), VCAM-1, IL-6, and IL-34 levels were measured in blood samples and also in vitro in a medium of EPCs. We found that the number of circulating EPCs in breast c...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Zhen-Hua Huang Zhao-Xia Tang Rui-Bin Cai Feng Ye Min-Qing Wu Dan Zhang Zhihao Liu Source Type: research

Correlation between radiological and biological features and clinical outcomes in early prostate cancer: an exploratory subgroup analysis
Neoplasma. 2022 Jan 12:210622N828. doi: 10.4149/neo_2021_210622N828. Online ahead of print.ABSTRACTPTEN deletion and Ki-67 expression are two of the most promising biomarkers in prostate cancer (PCa). In the same manner, multiparametric magnetic resonance imaging (mp-MRI) guided core biopsy is a powerful tool for PCa detection and staging. The aim of the study is to assess whether a correlation can be identified between the pathological stage defined by an mp-MRI-guided core-biopsy and Ki-67 expression and PTEN deletion. Such correlation might be useful for staging and treatment personalization in PCa. This investigation w...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Giulia Corrao Giulia Marvaso Mattia Zaffaroni Stefania Volpe Matteo Augugliaro Cristiana Iuliana Fodor Dario Zerini Andrea Vingiani Francesco Alessandro Mistretta Stefano Luzzago Sarah Alessi Paola Pricolo Gennaro Musi Ottavio De Cobelli Giuseppe Renne Ma Source Type: research

Apigenin regulates the migration, invasion, and autophagy of hepatocellular carcinoma cells by downregulating YAP
Neoplasma. 2022 Jan 12:210615N798. doi: 10.4149/neo_2021_210615N798. Online ahead of print.ABSTRACTApigenin is an edible flavonoid with anticancer properties; however, the underlying mechanisms in hepatocellular carcinoma (HCC) remain to be clarified. In the present study, we demonstrated that apigenin decreased the viability of both SMMC-7721 and SK-Hep1 cells in a dose-dependent manner, and inhibited the migration and invasion of HCC cells with different metastatic potential by regulating actin cytoskeletal rearrangements. Moreover, we showed that apigenin decreased the expression of YAP, and subsequently reduced migrati...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Jing Zeng Hua Xie Zhi-Lin Zhang Zi-Xian Li Lin Shi Ke-Yan Wu Yang Zhou Zhen Tian Yu Zhang Wei Zhou Wei-Gan Shen Source Type: research

Increased number and function of endothelial progenitor cells in breast cancer patients and the linear correlation with VEGF level
Neoplasma. 2022 Jan 12:210615N800. doi: 10.4149/neo_2021_210615N800. Online ahead of print.ABSTRACTThe number of circulating endothelial progenitor cells (EPCs) was found to increase in patients with breast cancer, but the alteration in EPC function remains to be elusive. We conducted this study to evaluate the number and function of peripheral EPCs of breast cancer patients and its possible underlying mechanism. Besides, the vascular endothelial growth factor (VEGF), VCAM-1, IL-6, and IL-34 levels were measured in blood samples and also in vitro in a medium of EPCs. We found that the number of circulating EPCs in breast c...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Zhen-Hua Huang Zhao-Xia Tang Rui-Bin Cai Feng Ye Min-Qing Wu Dan Zhang Zhihao Liu Source Type: research

Correlation between radiological and biological features and clinical outcomes in early prostate cancer: an exploratory subgroup analysis
Neoplasma. 2022 Jan 12:210622N828. doi: 10.4149/neo_2021_210622N828. Online ahead of print.ABSTRACTPTEN deletion and Ki-67 expression are two of the most promising biomarkers in prostate cancer (PCa). In the same manner, multiparametric magnetic resonance imaging (mp-MRI) guided core biopsy is a powerful tool for PCa detection and staging. The aim of the study is to assess whether a correlation can be identified between the pathological stage defined by an mp-MRI-guided core-biopsy and Ki-67 expression and PTEN deletion. Such correlation might be useful for staging and treatment personalization in PCa. This investigation w...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Giulia Corrao Giulia Marvaso Mattia Zaffaroni Stefania Volpe Matteo Augugliaro Cristiana Iuliana Fodor Dario Zerini Andrea Vingiani Francesco Alessandro Mistretta Stefano Luzzago Sarah Alessi Paola Pricolo Gennaro Musi Ottavio De Cobelli Giuseppe Renne Ma Source Type: research

Apigenin regulates the migration, invasion, and autophagy of hepatocellular carcinoma cells by downregulating YAP
Neoplasma. 2022 Jan 12:210615N798. doi: 10.4149/neo_2021_210615N798. Online ahead of print.ABSTRACTApigenin is an edible flavonoid with anticancer properties; however, the underlying mechanisms in hepatocellular carcinoma (HCC) remain to be clarified. In the present study, we demonstrated that apigenin decreased the viability of both SMMC-7721 and SK-Hep1 cells in a dose-dependent manner, and inhibited the migration and invasion of HCC cells with different metastatic potential by regulating actin cytoskeletal rearrangements. Moreover, we showed that apigenin decreased the expression of YAP, and subsequently reduced migrati...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Jing Zeng Hua Xie Zhi-Lin Zhang Zi-Xian Li Lin Shi Ke-Yan Wu Yang Zhou Zhen Tian Yu Zhang Wei Zhou Wei-Gan Shen Source Type: research

Increased number and function of endothelial progenitor cells in breast cancer patients and the linear correlation with VEGF level
Neoplasma. 2022 Jan 12:210615N800. doi: 10.4149/neo_2021_210615N800. Online ahead of print.ABSTRACTThe number of circulating endothelial progenitor cells (EPCs) was found to increase in patients with breast cancer, but the alteration in EPC function remains to be elusive. We conducted this study to evaluate the number and function of peripheral EPCs of breast cancer patients and its possible underlying mechanism. Besides, the vascular endothelial growth factor (VEGF), VCAM-1, IL-6, and IL-34 levels were measured in blood samples and also in vitro in a medium of EPCs. We found that the number of circulating EPCs in breast c...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Zhen-Hua Huang Zhao-Xia Tang Rui-Bin Cai Feng Ye Min-Qing Wu Dan Zhang Zhihao Liu Source Type: research

Correlation between radiological and biological features and clinical outcomes in early prostate cancer: an exploratory subgroup analysis
Neoplasma. 2022 Jan 12:210622N828. doi: 10.4149/neo_2021_210622N828. Online ahead of print.ABSTRACTPTEN deletion and Ki-67 expression are two of the most promising biomarkers in prostate cancer (PCa). In the same manner, multiparametric magnetic resonance imaging (mp-MRI) guided core biopsy is a powerful tool for PCa detection and staging. The aim of the study is to assess whether a correlation can be identified between the pathological stage defined by an mp-MRI-guided core-biopsy and Ki-67 expression and PTEN deletion. Such correlation might be useful for staging and treatment personalization in PCa. This investigation w...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Giulia Corrao Giulia Marvaso Mattia Zaffaroni Stefania Volpe Matteo Augugliaro Cristiana Iuliana Fodor Dario Zerini Andrea Vingiani Francesco Alessandro Mistretta Stefano Luzzago Sarah Alessi Paola Pricolo Gennaro Musi Ottavio De Cobelli Giuseppe Renne Ma Source Type: research

Apigenin regulates the migration, invasion, and autophagy of hepatocellular carcinoma cells by downregulating YAP
Neoplasma. 2022 Jan 12:210615N798. doi: 10.4149/neo_2021_210615N798. Online ahead of print.ABSTRACTApigenin is an edible flavonoid with anticancer properties; however, the underlying mechanisms in hepatocellular carcinoma (HCC) remain to be clarified. In the present study, we demonstrated that apigenin decreased the viability of both SMMC-7721 and SK-Hep1 cells in a dose-dependent manner, and inhibited the migration and invasion of HCC cells with different metastatic potential by regulating actin cytoskeletal rearrangements. Moreover, we showed that apigenin decreased the expression of YAP, and subsequently reduced migrati...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Jing Zeng Hua Xie Zhi-Lin Zhang Zi-Xian Li Lin Shi Ke-Yan Wu Yang Zhou Zhen Tian Yu Zhang Wei Zhou Wei-Gan Shen Source Type: research

Increased number and function of endothelial progenitor cells in breast cancer patients and the linear correlation with VEGF level
Neoplasma. 2022 Jan 12:210615N800. doi: 10.4149/neo_2021_210615N800. Online ahead of print.ABSTRACTThe number of circulating endothelial progenitor cells (EPCs) was found to increase in patients with breast cancer, but the alteration in EPC function remains to be elusive. We conducted this study to evaluate the number and function of peripheral EPCs of breast cancer patients and its possible underlying mechanism. Besides, the vascular endothelial growth factor (VEGF), VCAM-1, IL-6, and IL-34 levels were measured in blood samples and also in vitro in a medium of EPCs. We found that the number of circulating EPCs in breast c...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Zhen-Hua Huang Zhao-Xia Tang Rui-Bin Cai Feng Ye Min-Qing Wu Dan Zhang Zhihao Liu Source Type: research

Correlation between radiological and biological features and clinical outcomes in early prostate cancer: an exploratory subgroup analysis
Neoplasma. 2022 Jan 12:210622N828. doi: 10.4149/neo_2021_210622N828. Online ahead of print.ABSTRACTPTEN deletion and Ki-67 expression are two of the most promising biomarkers in prostate cancer (PCa). In the same manner, multiparametric magnetic resonance imaging (mp-MRI) guided core biopsy is a powerful tool for PCa detection and staging. The aim of the study is to assess whether a correlation can be identified between the pathological stage defined by an mp-MRI-guided core-biopsy and Ki-67 expression and PTEN deletion. Such correlation might be useful for staging and treatment personalization in PCa. This investigation w...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Giulia Corrao Giulia Marvaso Mattia Zaffaroni Stefania Volpe Matteo Augugliaro Cristiana Iuliana Fodor Dario Zerini Andrea Vingiani Francesco Alessandro Mistretta Stefano Luzzago Sarah Alessi Paola Pricolo Gennaro Musi Ottavio De Cobelli Giuseppe Renne Ma Source Type: research

Apigenin regulates the migration, invasion, and autophagy of hepatocellular carcinoma cells by downregulating YAP
Neoplasma. 2022 Jan 12:210615N798. doi: 10.4149/neo_2021_210615N798. Online ahead of print.ABSTRACTApigenin is an edible flavonoid with anticancer properties; however, the underlying mechanisms in hepatocellular carcinoma (HCC) remain to be clarified. In the present study, we demonstrated that apigenin decreased the viability of both SMMC-7721 and SK-Hep1 cells in a dose-dependent manner, and inhibited the migration and invasion of HCC cells with different metastatic potential by regulating actin cytoskeletal rearrangements. Moreover, we showed that apigenin decreased the expression of YAP, and subsequently reduced migrati...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Jing Zeng Hua Xie Zhi-Lin Zhang Zi-Xian Li Lin Shi Ke-Yan Wu Yang Zhou Zhen Tian Yu Zhang Wei Zhou Wei-Gan Shen Source Type: research

Increased number and function of endothelial progenitor cells in breast cancer patients and the linear correlation with VEGF level
Neoplasma. 2022 Jan 12:210615N800. doi: 10.4149/neo_2021_210615N800. Online ahead of print.ABSTRACTThe number of circulating endothelial progenitor cells (EPCs) was found to increase in patients with breast cancer, but the alteration in EPC function remains to be elusive. We conducted this study to evaluate the number and function of peripheral EPCs of breast cancer patients and its possible underlying mechanism. Besides, the vascular endothelial growth factor (VEGF), VCAM-1, IL-6, and IL-34 levels were measured in blood samples and also in vitro in a medium of EPCs. We found that the number of circulating EPCs in breast c...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Zhen-Hua Huang Zhao-Xia Tang Rui-Bin Cai Feng Ye Min-Qing Wu Dan Zhang Zhihao Liu Source Type: research

Correlation between radiological and biological features and clinical outcomes in early prostate cancer: an exploratory subgroup analysis
Neoplasma. 2022 Jan 12:210622N828. doi: 10.4149/neo_2021_210622N828. Online ahead of print.ABSTRACTPTEN deletion and Ki-67 expression are two of the most promising biomarkers in prostate cancer (PCa). In the same manner, multiparametric magnetic resonance imaging (mp-MRI) guided core biopsy is a powerful tool for PCa detection and staging. The aim of the study is to assess whether a correlation can be identified between the pathological stage defined by an mp-MRI-guided core-biopsy and Ki-67 expression and PTEN deletion. Such correlation might be useful for staging and treatment personalization in PCa. This investigation w...
Source: Neoplasma - January 11, 2022 Category: Cancer & Oncology Authors: Giulia Corrao Giulia Marvaso Mattia Zaffaroni Stefania Volpe Matteo Augugliaro Cristiana Iuliana Fodor Dario Zerini Andrea Vingiani Francesco Alessandro Mistretta Stefano Luzzago Sarah Alessi Paola Pricolo Gennaro Musi Ottavio De Cobelli Giuseppe Renne Ma Source Type: research

NCAPH regulates gastric cancer progression through DNA damage response
This study aimed to explore the function and potential mechanism of NCAPH in GC. Our study showed that NCAPH expression was significantly upregulated in The Cancer Genome Atlas (TCGA) and Oncomine datasets. Quantitative real-time polymerase chain reaction and western blotting were used to detect NCAPH expression in GC and paracarcinoma tissues. Cell Counting Kit-8 (CCK8) and colony formation assays were used to examine cell proliferation. Cell scratch and Transwell invasion assays were performed to assess cell migration. In addition, western blotting was used to detect the expression of proteins related to cell cycle, DNA ...
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Yan Wang Jun-Qiang Li Zhi-Liang Yang Long Wang Jun-Chang Zhang Yong-Fang Sun Zi-Yue Li Long Qin Source Type: research

Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research

Rhomboid domain containing 1 promotes the growth of non-small cell lung cancer through the activation of EGFR and regulation of the BIK-mediated apoptosis
In conclusion, our research shows that RHBDD1 promotes the progression of NSCLC through enhancement of proliferation and induction of apoptosis by regulating the EGFR/Raf/MEK/ERK signaling pathway and the level of BIK protein level.PMID:34962825 | DOI:10.4149/neo_2021_210804N1107 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Zhe-Yuan Xu Xu Li Rui-Hong Yao Li-Min Yang Hao Peng Wen-Jun Ren Hong Lu Ping Wang Source Type: research

NCAPH regulates gastric cancer progression through DNA damage response
This study aimed to explore the function and potential mechanism of NCAPH in GC. Our study showed that NCAPH expression was significantly upregulated in The Cancer Genome Atlas (TCGA) and Oncomine datasets. Quantitative real-time polymerase chain reaction and western blotting were used to detect NCAPH expression in GC and paracarcinoma tissues. Cell Counting Kit-8 (CCK8) and colony formation assays were used to examine cell proliferation. Cell scratch and Transwell invasion assays were performed to assess cell migration. In addition, western blotting was used to detect the expression of proteins related to cell cycle, DNA ...
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Yan Wang Jun-Qiang Li Zhi-Liang Yang Long Wang Jun-Chang Zhang Yong-Fang Sun Zi-Yue Li Long Qin Source Type: research

Aesculus hippocastanum L. extract differently modulates normal human dermal fibroblasts and cancer-associated fibroblasts from basal/squamous cell carcinoma
In conclusion, we observed specific differences in signaling between HDFs and CAFs that should be considered when developing new therapeutic approaches targeting wound/tumor microenvironments.PMID:34962824 | DOI:10.4149/neo_2021_210622N826 (Source: Neoplasma)
Source: Neoplasma - December 28, 2021 Category: Cancer & Oncology Authors: Nikola Melegov á Mat úš Čoma Luk áš Urban Miriam Ka ňuchová Pavol Szabo Karel Smetana Pavel Mu čaji Peter G ál Source Type: research