Circular RNA_0000326 accelerates breast cancer development via modulation of the miR-9-3p/YAP1 axis
Neoplasma. 2023 Jun;70(3):430-442. doi: 10.4149/neo_2023_220904N894.ABSTRACTCircular RNA (circ)_0000326 has been reported in bladder cancer and cervical cancer and is concerned to be involved with the development of cancerous cells. Whereas, there have been no reports concentrating on the influences of circ_0000326 in breast cancer (BC). Therefore, the latent modulatory mechanisms of circ_0000326 in BC are researched. circ_0000326 expression in BC tissues and correlative cells was evaluated via RT-qPCR, and the relevance between circ_0000326 expression and overall survival and the clinicopathological feature was also inves...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Xiao-Ling Xue Shuai Zhao Meng-Chang Xu Ying Li Wen-Fei Liu Hong-Zhen Qin Source Type: research

Predictors of outcomes of docetaxel treatment in de novo metastatic hormone-sensitive prostate cancer: A single-center cohort study
We report a cohort of 73 consecutive patients with de novo mHSPC treated with early docetaxel at the Department of Oncology and Radiotherapy, University Hospital of Split, Croatia, from October 2015 until March 2020. The outcomes analyzed were the occurrence of castration-resistant disease (CRPC) and death from any cause (OS). The median follow-up was 54 (50-73) months. Forty-six (63%) patients developed CRPC and 34 (47%) died during the follow-up. The median time to CRPC and median OS were 16.2 and 58.4 months, respectively. The risk of CRPC was higher for patients with high (above median) values of serum alkaline phospha...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Tomislav Omr čen Davor Eterovi ć Tea Jozi ć Eduard Vrdoljak Source Type: research

NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression
In conclusion, this work demonstrated that XPD mRNA stability was elevated by NOP2-mediated m5C methylation modification and then inhibited the malignant progression of HCC, suggesting that XPD may be a potential target for HCC treatment.PMID:37498063 | DOI:10.4149/neo_2023_230110N17 (Source: Neoplasma)
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Guo-Fang Sun Hao Ding Source Type: research

A new pathway for the transformation of AML in MDS: APA mechanism regulated by NUDT21 and RUNX1
Neoplasma. 2023 Jun;70(3):350-360. doi: 10.4149/neo_2023_230115N27.ABSTRACTWe have identified that NUDT21 plays a vital role in MDS transformations, while the transcription factor RUNX1 is essential for normal hematopoiesis, which is a high expression in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), and we aim to explore the linkage between the two genes and new pathways for MDS transformation to AML. Prediction of RUNX1 expression levels and its relationship with NUDT21 in AML and MDS patients was performed using bioinformatics techniques and validated in patients. Using lentiviral packaging technology...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Shuo Li Fanggang Ren Xiao-Li Liu Hong-Yu Zhang Zhi-Fang Xu Daniel Muteb Muyey Zhuanzhen Zheng Yan-Hong Tan Xiu-Hua Chen Hong-Wei Wang Source Type: research

Immunohistochemical p16 expression in the prognosis of patients with sinonasal squamous cell carcinoma
This study aims to examine the immunohistochemical expression of p16 and investigate the possibility of p16 as a prognostic factor for SNSCC. The medical records of 173 individuals with SNSCC between 2010 and 2022 were retrospectively reviewed. The researchers examined patients' demographics, p16 status, staging, tumor histological subtypes, treatment details, recurrence, metastasis, and survival outcomes. p16 was found in 22.0% (38/173) of SNSCC patients, and there was no difference between inverted papilloma-SNSCC (19.6%) and de novo SNSCC (23.0%). p16 status did not correlate with all the cases' age, gender, clinical st...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Li Wang Hua-Tao Quan Jie Wang Tian-Ci Tang Yi Li Xin-Mao Song Source Type: research

Function, drug resistance and prognostic effect of AKR1C2 in human cancer
Neoplasma. 2023 Jun;70(3):319-332. doi: 10.4149/neo_2023_230206N66.ABSTRACTAldo-keto reductases (ARKs), a group of reductases that rely on nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) to catalyze carbonyl, are widely found in various organisms, which play an important role in the physiological and pathological processes of human. Aldo-keto reductase family 1 member C2 (AKR1C2) as a member of the human ARKs family, can regulate steroid hormones and is abnormally expressed in many cancers. According to whether the tumor can be affected by hormones, we divide malignancies in...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Zhao Wang Yue Feng Jiayu Song Di Sun Yun-Yan Zhang Source Type: research

Prognostic implications of the EGFR polymorphism rs763317 and clinical variables among young Chinese lung cancer population
Neoplasma. 2023 Jun;70(3):443-450. doi: 10.4149/neo_2023_230305N115.ABSTRACTThe 5-year survival rate for patients with lung cancer, the world's second most frequent malignant tumor, is less than 20%, and its prognosis cannot be clearly predicted. Our aim was to analyze the epidermal growth factor receptor (EGFR) rs763317 (G>A) single nucleotide polymorphism and its association with prognosis in Chinese Han lung cancer patients. 839 patients with primary lung cancer were recruited, and genomic DNA was extracted and genotyped by SNPscan. Kaplan-Meier technique and multivariate Cox proportional hazards model were used to a...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Zheng-Xing Li Fan Wang Zhen-Yu Sun Chang Xu Zi-Xiu Zou Zong-Xu Zhao Hai-Jian Wang Shi-Cheng Guo Li Jin Qiang Li Jiu-Cun Wang Fan Xia Xiao-Qiang Yue Junjie Wu Source Type: research

TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis
In conclusion, TRIM31 may improve OSCC progression by enhancing AKT phosphorylation and subsequent glycolysis. Hence, TRIM31 has the potential as a treatment target in OSCC.PMID:37498068 | DOI:10.4149/neo_2023_230319N155 (Source: Neoplasma)
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Sheng-Qi Sang Yi-Jie Zhao Meng Wang Xiao-Qi Zhong Zhi-Cheng Yang Meng-Meng Lu Source Type: research

LncRNA SLC7A11-AS1 promotes the progression of hepatocellular carcinoma by mediating KLF9 ubiquitination
Neoplasma. 2023 Jun;70(3):361-374. doi: 10.4149/neo_2023_230323N162.ABSTRACTHepatocellular carcinoma (HCC) is a malignant tumor, which seriously threatens the life of patients. LncRNA SLC7A11-AS1 was reported to be abnormally expressed in HCC. Here, the functions and relative molecular regulatory mechanism of SLC7A11-AS1 in HCC were investigated. Nude mice and HCC cells were used as the experimental subjects. Knockdown or overexpression of exogenous genes was conducted in HCC cells. RT-qPCR, IHC, and western blot were employed to evaluate the abundance of genes and proteins. The malignant behaviors were evaluated using CCK...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Fan-Lin Zeng Jie Lin Xing Xie Yuan-Kang Xie Jian-Hong Zhang Daofeng Xu Xiao He Feng En Liu Bin-Hui Xie Source Type: research

Tumor-targeted suicide gene-directed enzyme prodrug therapy mediated by extracellular vesicles
Neoplasma. 2023 Jun;70(3):333-339. doi: 10.4149/neo_2023_230328N172.ABSTRACTIn this article, we describe the gene-directed enzyme prodrug therapy, also known as the "Trojan Horse" therapy mediated by exosomes - small extracellular vesicles (sEVs) secreted from mesenchymal stem/stromal cells (MSCs) and cancer cells. MSC-EVs possess strong migrating tropism toward tumor sites. EVs derived from tumor cells mimic the parental cells in an invasive metastatic growth trait and the capability to reprogram the recipient cells. The behavior of these EVs when modified with the suicide gene predestinates them to be a drug with guided ...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Jana Jakubechova Ursula Altanerova Cestmir Altaner Source Type: research

What is the best time for postoperative radiation therapy in pN1 prostate cancer?
Neoplasma. 2023 Jun;70(3):458-467. doi: 10.4149/neo_2023_230403N182.ABSTRACTWe retrospectively compared long-term biochemical recurrence rates (BCR) in pN1 PCa patients that underwent adjuvant radiotherapy (aRT) vs. no aRT/early salvage (esRT) after robot-assisted radical prostatectomy and extended pelvic lymphadenectomy. All PCa pN1 M0 patients treated at a single high-volume center between 2010 and 2020 were analyzed. Patients with <10 LNs yield, or >10 positive LNs, or persistently detectable PSA after RARP were excluded. Kaplan-Meier (KM) plots depicted BCR rates. Multivariable Cox regression models (MCRMs) focus...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Francesco Alessandro Mistretta Stefano Luzzago Giulia Marvaso Giulia Corrao Ilaria Sabatini Matteo Fontana Federico Mastroleo Mattia Zaffaroni Maria Giulia Vincini Ettore Di Trapani Gabriele Cozzi Roberto Bianchi Matteo Ferro Ottavio de Cobelli Barbara Al Source Type: research

Chemotherapy versus chemoradiotherapy in borderline resectable and locally advanced pancreatic adenocarcinoma
Neoplasma. 2023 Jun;70(3):468-475. doi: 10.4149/neo_2023_230409N193.ABSTRACTThe role of radiotherapy in borderline resectable (BRPC) and locally advanced pancreatic carcinoma (LAPC) remains controversial. In our study, we retrospectively evaluated 48 patients with BRPC (14; 29.2%) and LAPC (34; 70. 8%) who underwent 6-8 cycles of induction mFOLFIRINOX chemotherapy alone (23; 47.9%) or 4-6 cycles of mFOLFIRINOX followed by hypofractionated radiotherapy (up to the total dose of 39.9 Gy in 15 fractions) (25; 52.1%). Survival parameters were evaluated using the Gehan-Breslow-Wilcoxon Test and compared by using the long-rank te...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: So ňa Argalácsová Michal Vo čka Lubo š Petruželka Miroslav Ryska Pavel Z áruba Zden ěk Krška Vladim ír Frýba Jan Ulrych Vladim ír Černý Tom áš Tůma David Hoskovec Source Type: research

Topical application of local anesthetics to melanoma increases the efficacy of anti-PD-1 therapy
Neoplasma. 2023 Jun;70(3):375-389. doi: 10.4149/neo_2023_230418N216.ABSTRACTExperimental and clinical data have shown that the nervous system can significantly stimulate the initiation and progression of melanoma. In support of this, approaches that reduce the transmission of signals from peripheral nerves to effector tissues reduce the recurrence of melanoma. Therefore, we investigated the effect of topical application of the local anesthetic Pliaglis (7% lidocaine and 7% tetracaine) on the growth of melanoma induced by intradermal application of B16F0 cells in mice without treatment and in mice treated with the anti-PD-1...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Miroslav Tibensky Filip Blasko Peter Vargovic Jana Jakubikova Dana Cholujova Jana Jakubechova Boris Mravec Source Type: research

Functional consequences of altered glycosylation of tumor-associated hypoxia biomarker carbonic anhydrase IX
Neoplasma. 2023 Jun;70(3):416-429. doi: 10.4149/neo_2023_230505N246.ABSTRACTGlycosylation is a posttranslational modification of proteins affecting numerous cellular functions. A growing amount of evidence confirms that aberrant glycosylation is involved in pathophysiological processes, including tumor development and progression. Carbonic anhydrase IX (CAIX) is a transmembrane protein whose expression is strongly induced in hypoxic tumors, which makes it an attractive target for anti-tumor therapy. CAIX facilitates the maintenance of intracellular pH homeostasis through its catalytic activity, which is linked with extrace...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Magdalena Baratova Lucia Skvarkova Maria Bartosova Lenka Jelenska Miriam Zatovicova Barbora Puzderova Ivana Kajanova Lucia Csaderova Silvia Pastorekova Eliska Svastova Source Type: research

Effects of different-sized silver nanoparticles on morphological and functional alterations in lung cancer and non-cancer lung cells
Neoplasma. 2023 Jun;70(3):390-401. doi: 10.4149/neo_2023_230525N283.ABSTRACTSilver nanoparticles (AgNPs) exhibit unique physicochemical properties, making these nanomaterials attractive for various medical applications. Among them, AgNPs have shown great potential in the treatment of cancer by inducing apoptosis in cancer cells, inhibiting tumor growth, and enhancing the efficacy of conventional cancer treatments such as chemotherapy and radiation therapy. Despite the promising therapeutical advantage of AgNPs, there are several challenges that need to be addressed. One of the most important is AgNPs' toxicity, which in ca...
Source: Neoplasma - July 27, 2023 Category: Cancer & Oncology Authors: Kristina Jakic Michal Selc Radka Macova Antonia Kurillova Libor Kvitek Ales Panacek Andrea Babelova Source Type: research