Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

Nilotinib, a Discoidin domain receptor 1 (DDR1) inhibitor, induces apoptosis and inhibits migration in breast cancer
This study reports the identification of a potent DDR1 inhibitor, Nilotinib, for the treatment of breast cancer. MTT assay was used to evaluate the inhibitory activity of Nilotinib and meantime we used flow cytometry to evaluate the pro-apoptotic activity of Nilotinib against MCF-7 and MDA-MB-231. Expression of DDR1 was manipulated in MDA-MB-231 and MCF-7 cell lines with low-level DDR1 expression by transfecting with plasmids containing shRNA. The effect of DDR1 or treatment with Nilotinib on cell migration was assayed. The expression of p-DDR1, DDR1, p-ERK1/2, ERK1/2 and E-cadherin, Vimentin, Snail1, and caspase 3 were de...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Shuai Wang Yanping Xie Aina Bao Jing Li Tingting Ye Chu Yang Shufang Yu Source Type: research

The role of the primary cilium in cancer
Neoplasma. 2021 Jul 14:210210N204. doi: 10.4149/neo_2021_210210N204. Online ahead of print.ABSTRACTAs a common lethal disease, cancer is now responsible for the majority of deaths worldwide and has been the single most important barrier to increasing life expectancy in the world. The pathogenesis of cancer has been the key point of cancer therapeutics research. The primary cilium, a solitary microtubule-based organelle, is considered to be an important sensor for receiving mechanical and chemical stimulation from other cells and environments; it plays an important role in a variety of signal transduction and disease proces...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Hong-Tai Cao Miao-Miao Liu Quan-Nian Shao Zuo-Yi Jiao Source Type: research

High-grade serous ovarian carcinoma and detection of inactivated BRCA genes from biopsy material of Slovak patients
Neoplasma. 2021 Jul 14:210226N256. doi: 10.4149/neo_2021_210226N256. Online ahead of print.ABSTRACTOvarian cancer is the leading cause of mortality among all gynecological cancers in developed countries and its most common and most lethal type is the high-grade serous ovarian carcinoma (HGSC). At the molecular level, nearly half of all HGSCs exhibit ineffective homologous DNA recombination and disruption of DNA damage/repair pathway inactivation caused often by BRCA1 and BRCA2 gene mutation. Recently, the detection of BRCA1/2 mutations became important for personalized treatment of HGSC patients with the PARP-inhibitors in...
Source: Neoplasma - July 15, 2021 Category: Cancer & Oncology Authors: Katar ína Janíková Barbora V áňová Mari án Grendár Marek Samec Alenka L íšková Du šan Loderer Ivana Ka šubová Anna Farka šová Karla Scheerova Pavol Sl ávik Zora Lasabov á Zuzana Dankov á Luk áš Plank Source Type: research

An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research

Genetic and phenotypic characteristics of Russian patients with BRAF-mutated colorectal cancer
This article demonstrates the feasibility of analysis of the entire exon 15 of BRAF gene in CRC patients regardless of tumor localization.PMID:34196213 | DOI:10.4149/neo_2021_210204N175 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Anna Loginova Yuri Shelygin Vitaly Shubin Sergey Achkasov Alexey Ponomarenko Dmitry Shakhmatov Sergey Skridlevskiy Yuri Vaganov Vladimir Kashnikov Alexey Tsukanov Source Type: research

Determining the effects of Ephrin Type B Receptor 6 and Type A Receptor 3 on facilitating colorectal epithelial cell malignant transformation
This study represents the first demonstration of EphB6 in enhancing colorectal epithelial cell transformation, suggesting its stipulative role in the early-stage of colorectal tumorigenesis. Our findings primarily uncover novel biomarkers and therapeutic targets of colorectal cancer.PMID:34196214 | DOI:10.4149/neo_2021_210309N304 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Jiaming Wang Yan Zhang Jiaao Ma Cheng Yang Muhong Wang Jiachen Lv Yihui Wang Dazhuang Miao Yan Wang Mingqi Li Cuicui Chai Shixiong Jiang Jinxue Tong Mingzhe Li Zhiwei Yu Source Type: research

Novel long noncoding RNA Linc1749808 promotes hepatocellular carcinoma metastasis by negatively regulating miR-206
In this study, we identified a new lncRNA, Linc1749808 (ID: XR_001749808.1) based on microarray data from HCC tissues. Linc1749808 levels in 72 HCC tissues and paracancerous samples were detected by qRT-PCR. The interaction between Linc1749808 and microRNA-206 (miR-206) was assessed by bioinformatic analysis and luciferase assays. Linc1749808 depletion assays, Transwell assays, and miR-206-inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells. Our results showed that Linc1749808 was highly expressed in both HCC tissues and cell lines. Linc1749808 expression was signifi...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Yi Liu Yuan Gao Si-Yuan Wu Le Ma Chun-Fu Zhu Xu-Dong Zhang Source Type: research

An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research

Genetic and phenotypic characteristics of Russian patients with BRAF-mutated colorectal cancer
This article demonstrates the feasibility of analysis of the entire exon 15 of BRAF gene in CRC patients regardless of tumor localization.PMID:34196213 | DOI:10.4149/neo_2021_210204N175 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Anna Loginova Yuri Shelygin Vitaly Shubin Sergey Achkasov Alexey Ponomarenko Dmitry Shakhmatov Sergey Skridlevskiy Yuri Vaganov Vladimir Kashnikov Alexey Tsukanov Source Type: research

Determining the effects of Ephrin Type B Receptor 6 and Type A Receptor 3 on facilitating colorectal epithelial cell malignant transformation
This study represents the first demonstration of EphB6 in enhancing colorectal epithelial cell transformation, suggesting its stipulative role in the early-stage of colorectal tumorigenesis. Our findings primarily uncover novel biomarkers and therapeutic targets of colorectal cancer.PMID:34196214 | DOI:10.4149/neo_2021_210309N304 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Jiaming Wang Yan Zhang Jiaao Ma Cheng Yang Muhong Wang Jiachen Lv Yihui Wang Dazhuang Miao Yan Wang Mingqi Li Cuicui Chai Shixiong Jiang Jinxue Tong Mingzhe Li Zhiwei Yu Source Type: research

Novel long noncoding RNA Linc1749808 promotes hepatocellular carcinoma metastasis by negatively regulating miR-206
In this study, we identified a new lncRNA, Linc1749808 (ID: XR_001749808.1) based on microarray data from HCC tissues. Linc1749808 levels in 72 HCC tissues and paracancerous samples were detected by qRT-PCR. The interaction between Linc1749808 and microRNA-206 (miR-206) was assessed by bioinformatic analysis and luciferase assays. Linc1749808 depletion assays, Transwell assays, and miR-206-inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells. Our results showed that Linc1749808 was highly expressed in both HCC tissues and cell lines. Linc1749808 expression was signifi...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Yi Liu Yuan Gao Si-Yuan Wu Le Ma Chun-Fu Zhu Xu-Dong Zhang Source Type: research

An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research

Genetic and phenotypic characteristics of Russian patients with BRAF-mutated colorectal cancer
This article demonstrates the feasibility of analysis of the entire exon 15 of BRAF gene in CRC patients regardless of tumor localization.PMID:34196213 | DOI:10.4149/neo_2021_210204N175 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Anna Loginova Yuri Shelygin Vitaly Shubin Sergey Achkasov Alexey Ponomarenko Dmitry Shakhmatov Sergey Skridlevskiy Yuri Vaganov Vladimir Kashnikov Alexey Tsukanov Source Type: research

Determining the effects of Ephrin Type B Receptor 6 and Type A Receptor 3 on facilitating colorectal epithelial cell malignant transformation
This study represents the first demonstration of EphB6 in enhancing colorectal epithelial cell transformation, suggesting its stipulative role in the early-stage of colorectal tumorigenesis. Our findings primarily uncover novel biomarkers and therapeutic targets of colorectal cancer.PMID:34196214 | DOI:10.4149/neo_2021_210309N304 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Jiaming Wang Yan Zhang Jiaao Ma Cheng Yang Muhong Wang Jiachen Lv Yihui Wang Dazhuang Miao Yan Wang Mingqi Li Cuicui Chai Shixiong Jiang Jinxue Tong Mingzhe Li Zhiwei Yu Source Type: research

Novel long noncoding RNA Linc1749808 promotes hepatocellular carcinoma metastasis by negatively regulating miR-206
In this study, we identified a new lncRNA, Linc1749808 (ID: XR_001749808.1) based on microarray data from HCC tissues. Linc1749808 levels in 72 HCC tissues and paracancerous samples were detected by qRT-PCR. The interaction between Linc1749808 and microRNA-206 (miR-206) was assessed by bioinformatic analysis and luciferase assays. Linc1749808 depletion assays, Transwell assays, and miR-206-inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells. Our results showed that Linc1749808 was highly expressed in both HCC tissues and cell lines. Linc1749808 expression was signifi...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Yi Liu Yuan Gao Si-Yuan Wu Le Ma Chun-Fu Zhu Xu-Dong Zhang Source Type: research

An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research

Genetic and phenotypic characteristics of Russian patients with BRAF-mutated colorectal cancer
This article demonstrates the feasibility of analysis of the entire exon 15 of BRAF gene in CRC patients regardless of tumor localization.PMID:34196213 | DOI:10.4149/neo_2021_210204N175 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Anna Loginova Yuri Shelygin Vitaly Shubin Sergey Achkasov Alexey Ponomarenko Dmitry Shakhmatov Sergey Skridlevskiy Yuri Vaganov Vladimir Kashnikov Alexey Tsukanov Source Type: research

Determining the effects of Ephrin Type B Receptor 6 and Type A Receptor 3 on facilitating colorectal epithelial cell malignant transformation
This study represents the first demonstration of EphB6 in enhancing colorectal epithelial cell transformation, suggesting its stipulative role in the early-stage of colorectal tumorigenesis. Our findings primarily uncover novel biomarkers and therapeutic targets of colorectal cancer.PMID:34196214 | DOI:10.4149/neo_2021_210309N304 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Jiaming Wang Yan Zhang Jiaao Ma Cheng Yang Muhong Wang Jiachen Lv Yihui Wang Dazhuang Miao Yan Wang Mingqi Li Cuicui Chai Shixiong Jiang Jinxue Tong Mingzhe Li Zhiwei Yu Source Type: research

Novel long noncoding RNA Linc1749808 promotes hepatocellular carcinoma metastasis by negatively regulating miR-206
In this study, we identified a new lncRNA, Linc1749808 (ID: XR_001749808.1) based on microarray data from HCC tissues. Linc1749808 levels in 72 HCC tissues and paracancerous samples were detected by qRT-PCR. The interaction between Linc1749808 and microRNA-206 (miR-206) was assessed by bioinformatic analysis and luciferase assays. Linc1749808 depletion assays, Transwell assays, and miR-206-inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells. Our results showed that Linc1749808 was highly expressed in both HCC tissues and cell lines. Linc1749808 expression was signifi...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Yi Liu Yuan Gao Si-Yuan Wu Le Ma Chun-Fu Zhu Xu-Dong Zhang Source Type: research

An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research

Genetic and phenotypic characteristics of Russian patients with BRAF-mutated colorectal cancer
This article demonstrates the feasibility of analysis of the entire exon 15 of BRAF gene in CRC patients regardless of tumor localization.PMID:34196213 | DOI:10.4149/neo_2021_210204N175 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Anna Loginova Yuri Shelygin Vitaly Shubin Sergey Achkasov Alexey Ponomarenko Dmitry Shakhmatov Sergey Skridlevskiy Yuri Vaganov Vladimir Kashnikov Alexey Tsukanov Source Type: research

Determining the effects of Ephrin Type B Receptor 6 and Type A Receptor 3 on facilitating colorectal epithelial cell malignant transformation
This study represents the first demonstration of EphB6 in enhancing colorectal epithelial cell transformation, suggesting its stipulative role in the early-stage of colorectal tumorigenesis. Our findings primarily uncover novel biomarkers and therapeutic targets of colorectal cancer.PMID:34196214 | DOI:10.4149/neo_2021_210309N304 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Jiaming Wang Yan Zhang Jiaao Ma Cheng Yang Muhong Wang Jiachen Lv Yihui Wang Dazhuang Miao Yan Wang Mingqi Li Cuicui Chai Shixiong Jiang Jinxue Tong Mingzhe Li Zhiwei Yu Source Type: research

Novel long noncoding RNA Linc1749808 promotes hepatocellular carcinoma metastasis by negatively regulating miR-206
In this study, we identified a new lncRNA, Linc1749808 (ID: XR_001749808.1) based on microarray data from HCC tissues. Linc1749808 levels in 72 HCC tissues and paracancerous samples were detected by qRT-PCR. The interaction between Linc1749808 and microRNA-206 (miR-206) was assessed by bioinformatic analysis and luciferase assays. Linc1749808 depletion assays, Transwell assays, and miR-206-inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells. Our results showed that Linc1749808 was highly expressed in both HCC tissues and cell lines. Linc1749808 expression was signifi...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Yi Liu Yuan Gao Si-Yuan Wu Le Ma Chun-Fu Zhu Xu-Dong Zhang Source Type: research

An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research

Genetic and phenotypic characteristics of Russian patients with BRAF-mutated colorectal cancer
This article demonstrates the feasibility of analysis of the entire exon 15 of BRAF gene in CRC patients regardless of tumor localization.PMID:34196213 | DOI:10.4149/neo_2021_210204N175 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Anna Loginova Yuri Shelygin Vitaly Shubin Sergey Achkasov Alexey Ponomarenko Dmitry Shakhmatov Sergey Skridlevskiy Yuri Vaganov Vladimir Kashnikov Alexey Tsukanov Source Type: research

Determining the effects of Ephrin Type B Receptor 6 and Type A Receptor 3 on facilitating colorectal epithelial cell malignant transformation
This study represents the first demonstration of EphB6 in enhancing colorectal epithelial cell transformation, suggesting its stipulative role in the early-stage of colorectal tumorigenesis. Our findings primarily uncover novel biomarkers and therapeutic targets of colorectal cancer.PMID:34196214 | DOI:10.4149/neo_2021_210309N304 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Jiaming Wang Yan Zhang Jiaao Ma Cheng Yang Muhong Wang Jiachen Lv Yihui Wang Dazhuang Miao Yan Wang Mingqi Li Cuicui Chai Shixiong Jiang Jinxue Tong Mingzhe Li Zhiwei Yu Source Type: research

Novel long noncoding RNA Linc1749808 promotes hepatocellular carcinoma metastasis by negatively regulating miR-206
In this study, we identified a new lncRNA, Linc1749808 (ID: XR_001749808.1) based on microarray data from HCC tissues. Linc1749808 levels in 72 HCC tissues and paracancerous samples were detected by qRT-PCR. The interaction between Linc1749808 and microRNA-206 (miR-206) was assessed by bioinformatic analysis and luciferase assays. Linc1749808 depletion assays, Transwell assays, and miR-206-inhibitor rescue experiments were performed to examine the role of the Linc1749808/miR-206 axis in HCC cells. Our results showed that Linc1749808 was highly expressed in both HCC tissues and cell lines. Linc1749808 expression was signifi...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Yi Liu Yuan Gao Si-Yuan Wu Le Ma Chun-Fu Zhu Xu-Dong Zhang Source Type: research

An oncogenic lncRNA, GLCC1, promotes tumorigenesis in gastric carcinoma by enhancing the c-Myc/IGF2BP1 interaction
Neoplasma. 2021 Jun 29:210121N100. doi: 10.4149/neo_2021_210121N100. Online ahead of print.ABSTRACTAccumulating evidence has shown that long non-coding RNAs (lncRNAs) are vital regulators of the expression of various genes in multiple human diseases. The aim of this study was to investigate the role of glycolysis-associated lncRNA of colorectal cancer (GLCC1) in the progression of gastric carcinoma as well as the underlying mechanism. The expression levels of GLCC1 and c-Myc were determined in 47 pairs of gastric carcinoma tissues and cell lines using qRT-PCR (quantitative real-time polymerase chain reaction). Next, the fu...
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Dong-Liang Yang Lin-Fei Dong Yin-Bing Qiu Gen-Yan Luo Source Type: research

Genetic and phenotypic characteristics of Russian patients with BRAF-mutated colorectal cancer
This article demonstrates the feasibility of analysis of the entire exon 15 of BRAF gene in CRC patients regardless of tumor localization.PMID:34196213 | DOI:10.4149/neo_2021_210204N175 (Source: Neoplasma)
Source: Neoplasma - July 1, 2021 Category: Cancer & Oncology Authors: Anna Loginova Yuri Shelygin Vitaly Shubin Sergey Achkasov Alexey Ponomarenko Dmitry Shakhmatov Sergey Skridlevskiy Yuri Vaganov Vladimir Kashnikov Alexey Tsukanov Source Type: research