Issue Information
IUBMB Life, Volume 72, Issue 11, Page 2233-2239, November 2020. (Source: IUBMB Life)
Source: IUBMB Life - October 28, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

Issue Highlights
IUBMB Life, Volume 72, Issue 11, Page 2240-2240, November 2020. (Source: IUBMB Life)
Source: IUBMB Life - October 28, 2020 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine
AbstractPregnancy complications including preeclampsia, preterm birth, intrauterine growth restriction, and gestational diabetes are the main adverse reproductive outcomes. Excessive inflammation and oxidative stress play crucial roles in the pathogenesis of pregnancy disorders. Curcumin, the main polyphenolic compound derived fromCurcuma longa, is mainly known by its anti ‐inflammatory and antioxidant properties. There are in vitro and in vivo reports revealing the preventive and ameliorating effects of curcumin against pregnancy complications. Here, we aimed to seek mechanisms underlying the modulatory effects of curcu...
Source: IUBMB Life - October 27, 2020 Category: Research Authors: Zahra Ghaneifar, Zahra Yousefi, Fatemeh Tajik, Banafsheh Nikfar, Fatemeh Ghalibafan, Elham Abdollahi, Amir Abbas Momtazi ‐Borojeni Tags: CRITICAL REVIEW Source Type: research

Effects of the MTOR and AKT1 genes polymorphisms on papillary thyroid cancer development
In conclusion, our results suggest the MTOR rs2295080 and AkT1 rs1130233 as the protective and risk factors for PTC development, respectively. (Source: IUBMB Life)
Source: IUBMB Life - October 26, 2020 Category: Research Authors: Rostam Maruei ‐Milan, Mohsen Saravani, Zahra Heidari, Mina Asadi‐Tarani, Saeedeh Salimi Tags: RESEARCH COMMUNICATION Source Type: research

M2 macrophage ‐derived exosomal miR‐25‐3p improves high glucose‐induced podocytes injury through activation autophagy via inhibiting DUSP1 expression
AbstractDiabetic nephropathy (DN) is the primary reason of chronic kidney disease. The aim of our study is to explore the role and action mechanism of M2 macrophage ‐derived exosomes in high glucose (HG)‐induced podocytes injury. Here, 30 mmol/L of HG was used to induce podocytes injury. Annexin V‐FITC/PI double staining was performed to measure podocytes apoptosis, and western blot was carried out to ensure proteins expression. The shape of exosomes wa s identified using TEM. Besides, the expression of miR‐25‐3p was determined by qRT‐PCR, FAM‐labeled miR‐25‐5p combined with DiI‐labeled exosomes ...
Source: IUBMB Life - October 26, 2020 Category: Research Authors: Haihua Huang, Huiyun Liu, Jiazhen Tang, Wenqiong Xu, Huaxia Gan, Qiwei Fan, Wei Zhang Tags: RESEARCH COMMUNICATION Source Type: research

Exosomes derived from T regulatory cells relieve inflammatory bowel disease by transferring miR ‐195a‐3p
In conclusion, Treg‐Exo alleviated the DSS‐induced IBD through transferring miR‐195a‐3p. (Source: IUBMB Life)
Source: IUBMB Life - October 26, 2020 Category: Research Authors: Fei Liao, Xiaohong Lu, Weiguo Dong Tags: RESEARCH COMMUNICATION Source Type: research

Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta ‐analysis
In this study, we performed a systematic evaluation and meta ‐analysis to elucidate the overall relationship between neopterin concentration and RA disease activity. Following the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines, a systematic review was conducted using PubMed, Google Scholar, Web of Science, and Scopus from 20 00 to August 2020. The Newcastle–Ottawa scale was used to assess the quality of eligible studies. The effect size (ES) and corresponding 95% confidence intervals (CIs) were calculated to evaluate this association. A total of 15 studies out of 98 met our inclusio...
Source: IUBMB Life - October 22, 2020 Category: Research Authors: Alireza Hejrati, Mahdi Taghadosi, Reza Alizadeh ‐Navaei, Shahnaz Hosseinzadeh, Davood Bashash, Mozhgan Esmaili, Parisa Zafari Tags: CRITICAL REVIEW Source Type: research

Circulating exosomal microRNAs as emerging non ‐invasive clinical biomarkers in heart failure: Mega bio‐roles of a nano bio‐particle
In conclusion, circulating Exo‐miRs represent emerging diagnostic (Exo‐miR‐92b‐5p, Exo‐miR‐146a, Exo‐miR‐181c, and Exo‐miR‐495) and prognostic (Exo‐miR‐192, Exo‐miR‐194, Exo‐miR‐34a, Exo‐miR‐425, Exo‐miR‐744) biomarkers for HF. (Source: IUBMB Life)
Source: IUBMB Life - October 14, 2020 Category: Research Authors: Runfa Zhou, Leiyan Wang, Gang Zhao, Dan Chen, Xiaoning Song, Amir A. Momtazi ‐Borojeni, Haitao Yuan Tags: CRITICAL REVIEW Source Type: research

The apoptosis ‐inducing factor family: Moonlighting proteins in the crosstalk between mitochondria and nuclei
AbstractInHomo sapiens, the apoptosis ‐inducing factor (AIF) family is represented by three different proteins, known as AIF, AMID and AIFL, that have in common the mitochondrial localisation in healthy cells, the presence of FAD‐ and NADH‐dependent domains involved in an ‐albeit yet not well understood‐ oxidoreductase functio n and their capability to induce programmed cell death. AIF is the best characterised family member, while the information about AMID and AIFL is much scarcer. Nonetheless, available data support different roles as well as mechanisms of action of their particular apoptogenic and redox domai...
Source: IUBMB Life - October 9, 2020 Category: Research Authors: Nerea Novo, Patricia Ferreira, Milagros Medina Tags: SPECIAL ISSUE Source Type: research

Nanotized curcumin ‐benzothiophene conjugate: A potential combination for treatment of cerebral malaria
AbstractThe declining effectiveness of the available antimalarial drugs due to drug resistance requires a continued effort to develop new therapeutic approaches. In this context, combination therapies hold a great promise for developing effective first ‐line antimalarial treatments for reducing malaria mortality. The present study explores the antimalarial efficacy of nanotized formulation of curcumin in combination with benzothiophene compound 6 (3‐bromo‐N‐(4‐fluorobenzyl)‐benzo[b]thiophene‐2‐carboxamide) with a view to achieve better efficacy at a very low dose in comparison to that accomplished with mono...
Source: IUBMB Life - October 9, 2020 Category: Research Authors: Aparajita Ghosh, Tanushree Banerjee Tags: RESEARCH COMMUNICATION Source Type: research

The apoptosis ‐inducing factor family: Moonlighting proteins in the crosstalk between mitochondria and nuclei
AbstractInHomo sapiens, the apoptosis ‐inducing factor (AIF) family is represented by three different proteins, known as AIF, AMID and AIFL, that have in common the mitochondrial localisation in healthy cells, the presence of FAD‐ and NADH‐dependent domains involved in an ‐albeit yet not well understood‐ oxidoreductase functio n and their capability to induce programmed cell death. AIF is the best characterised family member, while the information about AMID and AIFL is much scarcer. Nonetheless, available data support different roles as well as mechanisms of action of their particular apoptogenic and redox domai...
Source: IUBMB Life - October 9, 2020 Category: Research Authors: Nerea Novo, Patricia Ferreira, Milagros Medina Tags: SPECIAL ISSUE Source Type: research

Nanotized curcumin ‐benzothiophene conjugate: A potential combination for treatment of cerebral malaria
AbstractThe declining effectiveness of the available antimalarial drugs due to drug resistance requires a continued effort to develop new therapeutic approaches. In this context, combination therapies hold a great promise for developing effective first ‐line antimalarial treatments for reducing malaria mortality. The present study explores the antimalarial efficacy of nanotized formulation of curcumin in combination with benzothiophene compound 6 (3‐bromo‐N‐(4‐fluorobenzyl)‐benzo[b]thiophene‐2‐carboxamide) with a view to achieve better efficacy at a very low dose in comparison to that accomplished with mono...
Source: IUBMB Life - October 9, 2020 Category: Research Authors: Aparajita Ghosh, Tanushree Banerjee Tags: RESEARCH COMMUNICATION Source Type: research

Angiotensin ‐converting enzyme 2: A protective factor in regulating disease virulence of SARS‐COV‐2
AbstractNovel SARS ‐CoV‐2 named due to its close homology with severe acute respiratory syndrome coronavirus (SARS‐CoV) is the etiologic agent for the ongoing pandemic outbreak causing loss of life and severe economic burden globally. The virus is believed to be evolved in a recombined form of bat and animal cor onavirus with the capacity to infect human host using the ACE2 receptors as an entry point. Though the disease pathogenesis is not elucidated completely, the virus‐mediated host response retains a similar pattern to that of previous SARS‐CoV. Based on the available trend it is assumed that pedia tric grou...
Source: IUBMB Life - October 8, 2020 Category: Research Authors: Vignesh Mariappan, Rao S. R., Agieshkumar Balakrishna Pillai Tags: CRITICAL REVIEW Source Type: research

Silencing of long non ‐coding RNA DLX6‐AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis
AbstractEmerging evidence has demonstrated the crucial roles of long noncoding RNAs in human cancers, including neuroblastoma (NB). DLX6 antisense RNA 1 (DLX6 ‐AS1) has been identified as an oncogenic driver in NB. However, the mechanisms of DLX6‐AS1 in NB progression are not fully understood. Our data showed that DLX6‐AS1 was significantly overexpressed in NB tissues and cells. Moreover, DLX6‐AS1 silencing repressed NB cell viability, colony form ation, migration, and invasion, and promoted cell cycle arrest and apoptosis in vitro, as well as decreased tumor growth in vivo. Mechanistically, DLX6‐AS1 operated as ...
Source: IUBMB Life - October 8, 2020 Category: Research Authors: Peisheng Jia, Erhu Wei, Huiqiong Liu, Tingting Wu, Huaili Wang Tags: RESEARCH COMMUNICATION Source Type: research

Angiotensin ‐converting enzyme 2: A protective factor in regulating disease virulence of SARS‐COV‐2
AbstractNovel SARS ‐CoV‐2 named due to its close homology with severe acute respiratory syndrome coronavirus (SARS‐CoV) is the etiologic agent for the ongoing pandemic outbreak causing loss of life and severe economic burden globally. The virus is believed to be evolved in a recombined form of bat and animal cor onavirus with the capacity to infect human host using the ACE2 receptors as an entry point. Though the disease pathogenesis is not elucidated completely, the virus‐mediated host response retains a similar pattern to that of previous SARS‐CoV. Based on the available trend it is assumed that pedia tric grou...
Source: IUBMB Life - October 8, 2020 Category: Research Authors: Vignesh Mariappan, Rao S. R., Agieshkumar Balakrishna Pillai Tags: CRITICAL REVIEW Source Type: research

Silencing of long non ‐coding RNA DLX6‐AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis
AbstractEmerging evidence has demonstrated the crucial roles of long noncoding RNAs in human cancers, including neuroblastoma (NB). DLX6 antisense RNA 1 (DLX6 ‐AS1) has been identified as an oncogenic driver in NB. However, the mechanisms of DLX6‐AS1 in NB progression are not fully understood. Our data showed that DLX6‐AS1 was significantly overexpressed in NB tissues and cells. Moreover, DLX6‐AS1 silencing repressed NB cell viability, colony form ation, migration, and invasion, and promoted cell cycle arrest and apoptosis in vitro, as well as decreased tumor growth in vivo. Mechanistically, DLX6‐AS1 operated as ...
Source: IUBMB Life - October 8, 2020 Category: Research Authors: Peisheng Jia, Erhu Wei, Huiqiong Liu, Tingting Wu, Huaili Wang Tags: RESEARCH COMMUNICATION Source Type: research

The immunomodulatory effects of mesenchymal stromal cell ‐based therapy in human and animal models of systemic lupus erythematosus
This report aims to review the beneficial and therapeutic properties of MSCs; it also focuses on the results of animal model studies, preclinical studie s, and clinical trials of MSC therapy in SLE from the immunoregulatory aspect. (Source: IUBMB Life)
Source: IUBMB Life - October 2, 2020 Category: Research Authors: Fereshteh Radmanesh, Mahmoud Mahmoudi, Esmaeil Yazdanpanah, Vahideh Keyvani, Nadia Kia, Amin Reza Nikpoor, Parisa Zafari, Seyed ‐Alireza Esmaeili Tags: CRITICAL REVIEW Source Type: research

Issue Information
IUBMB Life, Volume 72, Issue 10, Page 2057-2063, October 2020. (Source: IUBMB Life)
Source: IUBMB Life - September 20, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

Issue Highlights
IUBMB Life, Volume 72, Issue 10, Page 2064-2064, October 2020. (Source: IUBMB Life)
Source: IUBMB Life - September 20, 2020 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

LncRNA SOX2OT/Smad3 feedback loop promotes myocardial fibrosis in heart failure
In conclusion, our work verifies that SOX2OT/Smad3 feedback loop promotes MF in HF. Thus, SOX2OT is potentially a novel therapeutic target for MF in HF. (Source: IUBMB Life)
Source: IUBMB Life - September 20, 2020 Category: Research Authors: Yali Ou, Chunfeng Liao, He Li, Guolong Yu Tags: RESEARCH COMMUNICATION Source Type: research

Issue Information
IUBMB Life, Volume 72, Issue 10, Page 2057-2063, October 2020. (Source: IUBMB Life)
Source: IUBMB Life - September 20, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

Issue Highlights
IUBMB Life, Volume 72, Issue 10, Page 2064-2064, October 2020. (Source: IUBMB Life)
Source: IUBMB Life - September 20, 2020 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

LncRNA SOX2OT/Smad3 feedback loop promotes myocardial fibrosis in heart failure
In conclusion, our work verifies that SOX2OT/Smad3 feedback loop promotes MF in HF. Thus, SOX2OT is potentially a novel therapeutic target for MF in HF. (Source: IUBMB Life)
Source: IUBMB Life - September 20, 2020 Category: Research Authors: Yali Ou, Chunfeng Liao, He Li, Guolong Yu Tags: RESEARCH COMMUNICATION Source Type: research

Glycolytic and immunological alterations in human U937 monocytes in response to H1N1 infection
In conclusion, H1N1 infection triggers transcriptional and translational changes in immortalized human monocytes, which might serve as markers for infection subject for further validation for their specificities. (Source: IUBMB Life)
Source: IUBMB Life - September 16, 2020 Category: Research Authors: Tarek Kamal Motawi, Nancy Nabil Shahin, Kareem Awad, Amany Sayed Maghraby, Dina Nadeem Abd ‐Elshafy, Mahmoud Mohamed Bahgat Tags: RESEARCH COMMUNICATION Source Type: research

SARS ‐CoV‐2 multifaceted interaction with the human host. Part II: Innate immunity response, immunopathology, and epigenetics
AbstractThe SARS ‐CoV‐2 makes its way into the cell via the ACE2 receptor and the proteolytic action of TMPRSS2. In response to the SARS‐CoV‐2 infection, the innate immune response is the first line of defense, triggering multiple signaling pathways to produce interferons, pro‐inflammatory cytokines and ch emokines, and initiating the adaptive immune response against the virus. Unsurprisingly, the virus has developed strategies to evade detection, which can result in delayed, excessive activation of the innate immune system. The response elicited by the host depends on multiple factors, including heal th status, ...
Source: IUBMB Life - September 15, 2020 Category: Research Authors: Tasnim H. Beacon, Ruey ‐Chyi Su, Ted M. Lakowski, Geneviève P. Delcuve, James R. Davie Tags: CRITICAL REVIEW Source Type: research

Nuclear ‐mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog‐1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer
AbstractLiver receptor homolog ‐1 (LRH‐1, NR5A2) is an orphan nuclear receptor with widespread activities in the regulation of development, stemness, metabolism, steroidogenesis, and proliferation. Many of the LRH‐1‐regulated processes target the mitochondria and associated activities. While under physiological conditions , a balanced LRH‐1 expression and regulation contribute to the maintenance of a physiological equilibrium, deregulation of LRH‐1 has been associated with inflammation and cancer. In this review, we discuss the role and mechanism(s) of how LRH‐1 regulates metabolic processes, cell survival, a...
Source: IUBMB Life - September 14, 2020 Category: Research Authors: Svenja Michalek, Thomas Brunner Tags: CRITICAL REVIEW Source Type: research

CircMMP1 promotes the progression of glioma through miR ‐433/HMGB3 axis in vitro and in vivo
AbstractCircular RNAs (circRNAs) are non ‐coding RNAs that have shown to regulate the progression of human diseases, including a variety of cancers. We aimed to investigate the function and the underlying working mechanism of circRNA matrix metallopeptidase 1 (circMMP1; hsa_circ_0024108) in glioma progression. Quantitative real‐time po lymerase chain reaction (qRT‐PCR) was performed to examine the expression of circMMP1, microRNA‐433‐3p (written as “miR‐433”) and high mobility group box 3 (HMGB3). Nanoparticle tracking analysis (NTA) was used to analyze the relative concentration and size distributi...
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Kai Yin, Xianzhi Liu Tags: RESEARCH COMMUNICATION Source Type: research

Melatonin as a potential inhibitor of kidney cancer: A survey of the molecular processes
AbstractStudies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re ‐evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which is the main treatment of this disease, may lead to higher morbidity rates. Consequently, new safer approaches must be examined and considered. Major advancements have been made in the field of targeted agents as well as treatments based on immunotherapy since renal cell carcinoma (RCC) does not resp...
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Parisa Maleki Dana, Russel J. Reiter, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi Tags: CRITICAL REVIEW Source Type: research

SARS ‐CoV‐2 multifaceted interaction with human host. Part I: What we have learnt and done so far, and the still unknown realities
AbstractSARS ‐CoV‐2, the causing agent of the ongoing COVID‐19 pandemic, is a beta‐coronavirus which has 80% genetic homology with SARS‐CoV, but displays increased virulence and transmissibility. Initially, SARS‐CoV‐2 was considered a respiratory virus generally causing a mild disease, only severe and fatal in the elderly and individuals with underlying conditions. Severe illnesses and fatalities were attributed to a cytokine storm, an excessive response from the host immune system. However, with the number of infections over 10 millions and still soaring, the insidious and stealthy nature of the virus has em...
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Genevi ève P. Delcuve, Ted M. Lakowski, Ruey‐Chyi Su, Tasnim H. Beacon, James R. Davie Tags: CRITICAL REVIEW Source Type: research

DNMT1 maintains the methylation of miR ‐152‐3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells
ConclusionThe study highlights that silenced DNMT1 results in non ‐methylated miR‐152‐3p to depress TMSB10 expression, thereby inhibiting CRC development, which provides a new approach for CRC therapy. (Source: IUBMB Life)
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Chenchen Wang, Xiaoji Ma, Jieyun Zhang, Xiaobin Jia, Mingzhu Huang Tags: RESEARCH COMMUNICATION Source Type: research

CircMMP1 promotes the progression of glioma through miR ‐433/HMGB3 axis in vitro and in vivo
AbstractCircular RNAs (circRNAs) are non ‐coding RNAs that have shown to regulate the progression of human diseases, including a variety of cancers. We aimed to investigate the function and the underlying working mechanism of circRNA matrix metallopeptidase 1 (circMMP1; hsa_circ_0024108) in glioma progression. Quantitative real‐time po lymerase chain reaction (qRT‐PCR) was performed to examine the expression of circMMP1, microRNA‐433‐3p (written as “miR‐433”) and high mobility group box 3 (HMGB3). Nanoparticle tracking analysis (NTA) was used to analyze the relative concentration and size distributi...
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Kai Yin, Xianzhi Liu Tags: RESEARCH COMMUNICATION Source Type: research

Melatonin as a potential inhibitor of kidney cancer: A survey of the molecular processes
AbstractStudies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re ‐evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which is the main treatment of this disease, may lead to higher morbidity rates. Consequently, new safer approaches must be examined and considered. Major advancements have been made in the field of targeted agents as well as treatments based on immunotherapy since renal cell carcinoma (RCC) does not resp...
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Parisa Maleki Dana, Russel J. Reiter, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi Tags: CRITICAL REVIEW Source Type: research

SARS ‐CoV‐2 multifaceted interaction with human host. Part I: What we have learnt and done so far, and the still unknown realities
AbstractSARS ‐CoV‐2, the causing agent of the ongoing COVID‐19 pandemic, is a beta‐coronavirus which has 80% genetic homology with SARS‐CoV, but displays increased virulence and transmissibility. Initially, SARS‐CoV‐2 was considered a respiratory virus generally causing a mild disease, only severe and fatal in the elderly and individuals with underlying conditions. Severe illnesses and fatalities were attributed to a cytokine storm, an excessive response from the host immune system. However, with the number of infections over 10 millions and still soaring, the insidious and stealthy nature of the virus has em...
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Genevi ève P. Delcuve, Ted M. Lakowski, Ruey‐Chyi Su, Tasnim H. Beacon, James R. Davie Tags: CRITICAL REVIEW Source Type: research

DNMT1 maintains the methylation of miR ‐152‐3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells
ConclusionThe study highlights that silenced DNMT1 results in non ‐methylated miR‐152‐3p to depress TMSB10 expression, thereby inhibiting CRC development, which provides a new approach for CRC therapy. (Source: IUBMB Life)
Source: IUBMB Life - September 11, 2020 Category: Research Authors: Chenchen Wang, Xiaoji Ma, Jieyun Zhang, Xiaobin Jia, Mingzhu Huang Tags: RESEARCH COMMUNICATION Source Type: research

Expression level and diagnostic value of exosomal NEAT1/miR ‐204/MMP‐9 in acute ST‐segment elevation myocardial infarction
AbstractAcute myocardium infarction (AMI) is one of the main causes of cardiovascular death, and timely intervention and diagnosis are essential. Owing to the irreversible apoptosis and death of myocardial cells, which ultimately causes heart failure, the problem of myocardial repair after myocardial infarction needs to be urgently addressed. Exosomes can act as messengers between cells, delivering large amounts of proteins, RNA, and lipids to receptor cells, and regulating target cell functions. Studies have shown that exosomes can repair infarcted myocardium. We aimed to investigate the relationship between long non ‐c...
Source: IUBMB Life - September 10, 2020 Category: Research Authors: Zhenzhen Chen, Youyou Yan, Junduo Wu, Chao Qi, Jia Liu, Junnan Wang Tags: RESEARCH COMMUNICATION Source Type: research

The malate –aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway
This article presents a personal and critical review of the history of the malate –aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the oxidation of cytosolic NADH by the mitochondria in Ehrlich ascites cell tumor lacking other routes, and to explain the need for a mitochondrial aspartate aminotransferase (glutamate oxa loacetate transaminase 2 [GOT2]). The MAS was soon adopted in the field as a major pathway for NADH oxidation in mammalian tissues, such as liver and heart, even though the energetics of the MAS remained a mystery. Only in the 1970s, LaNoue an...
Source: IUBMB Life - September 10, 2020 Category: Research Authors: Piet Borst Tags: SPECIAL ISSUE Source Type: research

Expression level and diagnostic value of exosomal NEAT1/miR ‐204/MMP‐9 in acute ST‐segment elevation myocardial infarction
AbstractAcute myocardium infarction (AMI) is one of the main causes of cardiovascular death, and timely intervention and diagnosis are essential. Owing to the irreversible apoptosis and death of myocardial cells, which ultimately causes heart failure, the problem of myocardial repair after myocardial infarction needs to be urgently addressed. Exosomes can act as messengers between cells, delivering large amounts of proteins, RNA, and lipids to receptor cells, and regulating target cell functions. Studies have shown that exosomes can repair infarcted myocardium. We aimed to investigate the relationship between long non ‐c...
Source: IUBMB Life - September 10, 2020 Category: Research Authors: Zhenzhen Chen, Youyou Yan, Junduo Wu, Chao Qi, Jia Liu, Junnan Wang Tags: RESEARCH COMMUNICATION Source Type: research

The malate –aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway
This article presents a personal and critical review of the history of the malate –aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the oxidation of cytosolic NADH by the mitochondria in Ehrlich ascites cell tumor lacking other routes, and to explain the need for a mitochondrial aspartate aminotransferase (glutamate oxa loacetate transaminase 2 [GOT2]). The MAS was soon adopted in the field as a major pathway for NADH oxidation in mammalian tissues, such as liver and heart, even though the energetics of the MAS remained a mystery. Only in the 1970s, LaNoue an...
Source: IUBMB Life - September 10, 2020 Category: Research Authors: Piet Borst Tags: SPECIAL ISSUE Source Type: research

Targeting SARS CoV2 (Indian isolate) genome with miRNA: An in silico study
AbstractThe newly identified SARS CoV2 has become a global pandemic since December 2019. Various researchers are trying to design a vaccine candidate against the virus. On the other hand, another group is focussing on repurposing approved or clinically tested drugs for treatment. However, there is always a search for alternative therapies. Thus, we propose an alternative approach apart from chemotherapy that is the usage of miRNA as novel antisense therapy to cure SARS CoV2 infected patients. To address the objective, miRNAs have been designed by targeting the genome of SARS CoV2 (Indian isolate). First, the open reading f...
Source: IUBMB Life - September 9, 2020 Category: Research Authors: Arpita Devi, Nyshadham S. N. Chaitanya Tags: RESEARCH COMMUNICATION Source Type: research

Regulation of ferroptosis by ncRNA: A new direction
AbstractFerroptosis is a metabolic disorder of lipid oxides in cells, which leads to abnormal metabolism under the catalysis of iron, which produces an expansive number of lipids, wrecks the redox in cells, attacks biological macromolecules and triggers cell death. This death process was marked by the increase of cytoplasmic and lipid reactive oxygen species, the decrease of mitochondria and the higher density of mitochondrial membrane. Non ‐coding RNA (ncRNA) is a kind of small RNA molecules found in recent years, which can transcribe but do not encode proteins and have specific functions. These ncRNAs play a key role i...
Source: IUBMB Life - September 9, 2020 Category: Research Authors: Yujia Li, Min Shen, Chun Jin, Liyuan Gao, Baoyu Liang, Zhenyi Wang, Shanzhong Tan, Anping Chen, Feng Zhang, Zili Zhang, Shizhong Zheng Tags: CRITICAL REVIEW Source Type: research

Targeting SARS CoV2 (Indian isolate) genome with miRNA: An in silico study
AbstractThe newly identified SARS CoV2 has become a global pandemic since December 2019. Various researchers are trying to design a vaccine candidate against the virus. On the other hand, another group is focussing on repurposing approved or clinically tested drugs for treatment. However, there is always a search for alternative therapies. Thus, we propose an alternative approach apart from chemotherapy that is the usage of miRNA as novel antisense therapy to cure SARS CoV2 infected patients. To address the objective, miRNAs have been designed by targeting the genome of SARS CoV2 (Indian isolate). First, the open reading f...
Source: IUBMB Life - September 9, 2020 Category: Research Authors: Arpita Devi, Nyshadham S. N. Chaitanya Tags: RESEARCH COMMUNICATION Source Type: research

Regulation of ferroptosis by ncRNA: A new direction
AbstractFerroptosis is a metabolic disorder of lipid oxides in cells, which leads to abnormal metabolism under the catalysis of iron, which produces an expansive number of lipids, wrecks the redox in cells, attacks biological macromolecules and triggers cell death. This death process was marked by the increase of cytoplasmic and lipid reactive oxygen species, the decrease of mitochondria and the higher density of mitochondrial membrane. Non ‐coding RNA (ncRNA) is a kind of small RNA molecules found in recent years, which can transcribe but do not encode proteins and have specific functions. These ncRNAs play a key role i...
Source: IUBMB Life - September 9, 2020 Category: Research Authors: Yujia Li, Min Shen, Chun Jin, Liyuan Gao, Baoyu Liang, Zhenyi Wang, Shanzhong Tan, Anping Chen, Feng Zhang, Zili Zhang, Shizhong Zheng Tags: CRITICAL REVIEW Source Type: research

Diverse species in the genus Cryptococcus: Pathogens and their non ‐pathogenic ancestors
AbstractThe genusCryptococcus comprises of more than 30 species. It consists of clinically significant pathogenicCryptococcus neoformans/Cryptococcus gattii species complex comprising of a minimum of seven species. These pathogens cost more than 200,000 lives annually by causing cryptococcal meningoencephalitis. The evolution of the pathogenic species from closely related non ‐pathogenic species of theCryptococcus amylolentus complex is of particular importance and several advances have been made to understand their phylogenetic and genomic relationships. The current review briefly describes the sexual reproduction proce...
Source: IUBMB Life - September 7, 2020 Category: Research Authors: Shelly Gupta, Karan Paul, Sukhmanjot Kaur Tags: CRITICAL REVIEW Source Type: research

miR ‐141‐3p inhibits vascular smooth muscle cell proliferation and migration via regulating Keap1/Nrf2/HO‐1 pathway
AbstractmiR ‐141‐3p is proven to play a prominent role in various inflammation‐related diseases. Nonetheless, little is known concerning the function of miR‐141‐3p in vascular smooth muscle cells (VSMCs) dysfunction and the underlying mechanism. ApoE knockdown (ApoE−/−) C57BL/6 mice and human VSMCs were employed to establish atherosclerosis (AS) animal model and cell model, respectively. The expressions of miR ‐141‐3p and Keap1 mRNA were detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). Enzyme‐linked immunosorbent assay (ELISA) was conducted to determine inflammatory cy...
Source: IUBMB Life - September 7, 2020 Category: Research Authors: Cuicui Zhang, Xianghui Kong, Deliang Ma Tags: RESEARCH COMMUNICATION Source Type: research

Diverse species in the genus Cryptococcus: Pathogens and their non ‐pathogenic ancestors
AbstractThe genusCryptococcus comprises of more than 30 species. It consists of clinically significant pathogenicCryptococcus neoformans/Cryptococcus gattii species complex comprising of a minimum of seven species. These pathogens cost more than 200,000 lives annually by causing cryptococcal meningoencephalitis. The evolution of the pathogenic species from closely related non ‐pathogenic species of theCryptococcus amylolentus complex is of particular importance and several advances have been made to understand their phylogenetic and genomic relationships. The current review briefly describes the sexual reproduction proce...
Source: IUBMB Life - September 7, 2020 Category: Research Authors: Shelly Gupta, Karan Paul, Sukhmanjot Kaur Tags: CRITICAL REVIEW Source Type: research

miR ‐141‐3p inhibits vascular smooth muscle cell proliferation and migration via regulating Keap1/Nrf2/HO‐1 pathway
AbstractmiR ‐141‐3p is proven to play a prominent role in various inflammation‐related diseases. Nonetheless, little is known concerning the function of miR‐141‐3p in vascular smooth muscle cells (VSMCs) dysfunction and the underlying mechanism. ApoE knockdown (ApoE−/−) C57BL/6 mice and human VSMCs were employed to establish atherosclerosis (AS) animal model and cell model, respectively. The expressions of miR ‐141‐3p and Keap1 mRNA were detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). Enzyme‐linked immunosorbent assay (ELISA) was conducted to determine inflammatory cy...
Source: IUBMB Life - September 7, 2020 Category: Research Authors: Cuicui Zhang, Xianghui Kong, Deliang Ma Tags: RESEARCH COMMUNICATION Source Type: research