Shedding more light on the role of Midkine in Hepatocellular Carcinoma; new perspectives on diagnosis and therapy
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - February 24, 2021 Category: Research Authors: Arezoo Gowhari Shabgah, Fatemeh Ezzatifar, Aravindhan Surendar, Angelina Olegovna Zekiy, Majid Ahmadi, Seyed Mohammad Gheibihayat, Jamshid Gholizadeh Navashenaq Tags: CRITICAL REVIEW Source Type: research

Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38 ‐MAPK/AKT pathway
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - February 24, 2021 Category: Research Authors: Xiaozhan Zhang, Wen Zhang, Fei Chen, Zhaohui Lu Tags: RESEARCH COMMUNICATION Source Type: research

Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - February 24, 2021 Category: Research Authors: Soujanya D. Yelamanchi, Avadhesha Surolia Tags: CRITICAL REVIEW Source Type: research

Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA ‐223/TXNIP/Wnt/β‐catenin pathway
AbstractDysfunction of histone deacetylase 10 (HDAC10) has been suggested in the carcinogenesis of cervical cancer (CC). However, its association with microRNAs (miRNAs) in CC remains exclusive. Hence, this study aims to probe the role of HDAC10 in regulating CC cell proliferation, migration, and invasion and its correlation with the screened ‐out miRNA target. Microarray analysis and RT‐qPCR revealed that HDAC10 expressed poorly in CC cells relative to human immortalized endocervical cells (End1/E6E7). Moreover, HDAC10 downregulation predicted poor survival for patients with CC. Overexpression of HDAC10 reduced CC cel...
Source: IUBMB Life - February 23, 2021 Category: Research Authors: Jinming Zhu, Shichao Han Tags: RESEARCH COMMUNICATION Source Type: research

On the mechanism of sitagliptin inhibition of colorectal cancer cell lines ’ metastatic functionalities
SummaryThe cell membrane glycoprotein CD26 with peptidase activity (DPP4) and/or its soluble CD26/DPP4 counterpart expression and/or activity are altered in several cancers. Its role in metastasis development was recently highlighted by the discovery of CD26+ CSCs subsets and the fact that clinical DPP4 inhibitors showed anti ‐metastatic effects in animal models. Also, diabetic patients treated with the DPP4 inhibitor sitagliptin showed greater overall survival after colorectal or lung cancer surgery than patients under other diabetic therapies.However, the mechanism of action of these inhibitors in this context is uncle...
Source: IUBMB Life - February 22, 2021 Category: Research Authors: Rub én Varela‐Calviño, Marta Rodríguez‐Quiroga, Patrícia Dias Carvalho, Flavia Martins, André Serra‐Roma, Lorena Vázquez‐Iglesias, María Páez Cadena, Sérgia Velho, Oscar J Cordero Tags: RESEARCH COMMUNICATION Source Type: research

SI – CROSSTALK: Mitochondrial‐nuclear p53 trafficking controls neuronal susceptibility in stroke
SUMMARYStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and the impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and a poptosis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which controls protein localization, stability, and pro‐apoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis, through ...
Source: IUBMB Life - February 22, 2021 Category: Research Authors: Angeles Almeida, Irene S ánchez‐Morán, Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research

The LINC01410/miR ‐122‐5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells
ConclusionOur results demonstrated that the LINC01410/miR ‐122‐5p/NDRG3 axis is involved in the progression of OS.This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - February 14, 2021 Category: Research Authors: Weiguo Ma, Xin Zhao, Ning Xue, Yun Gao, Qingxia Xu Tags: RESEARCH COMMUNICATION Source Type: research

Issue Highlights
(Source: IUBMB Life)
Source: IUBMB Life - February 4, 2021 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

Tea bioactive components prevent carcinogenesis via anti ‐pathogen, anti‐inflammation, and cell survival pathways
AbstractCancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improvements in human health. Tea contains many active components, including tea polyphenols, tea polysaccharides,L‐theanine, tea pigments, and caffeine among other common components. Several studies have identified components in tea that can directly or indirectly reduce carcinogenesis with some being used i...
Source: IUBMB Life - February 1, 2021 Category: Research Authors: Xiangqi Fan, Xiangjun Xiao, Xiangbing Mao, Daiwen Chen, Bing Yu, Jianping Wang, Hui Yan Tags: CRITICAL REVIEW Source Type: research

Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - February 1, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research

Issue Highlights
(Source: IUBMB Life)
Source: IUBMB Life - February 1, 2021 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

Issue Information
(Source: IUBMB Life)
Source: IUBMB Life - February 1, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research

Tea bioactive components prevent carcinogenesis via anti ‐pathogen, anti‐inflammation, and cell survival pathways
AbstractCancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improvements in human health. Tea contains many active components, including tea polyphenols, tea polysaccharides,L‐theanine, tea pigments, and caffeine among other common components. Several studies have identified components in tea that can directly or indirectly reduce carcinogenesis with some being used i...
Source: IUBMB Life - January 29, 2021 Category: Research Authors: Xiangqi Fan, Xiangjun Xiao, Xiangbing Mao, Daiwen Chen, Bing Yu, Jianping Wang, Hui Yan Tags: CRITICAL REVIEW Source Type: research

Histone deacetylase 10 exerts anti ‐tumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - January 27, 2021 Category: Research Authors: Jinming Zhu, Shichao Han Tags: RESEARCH COMMUNICATION Source Type: research

Histone deacetylase 10 exerts anti ‐tumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - January 22, 2021 Category: Research Authors: Jinming Zhu, Shichao Han Tags: RESEARCH COMMUNICATION Source Type: research

Diminished substrate ‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats
ConclusionAltered cardiac mitochondrial respiration and autophagy were observed in adult male ODM compared to OCM, while the male and female offspring at weaning stage were less affected. The results of the study show that maternal hyperglycemia affects mitochondrial respiration and autophagy in the ODM heart, which may potentially be responsible for the cardiovascular complications observed in adult life.This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - January 22, 2021 Category: Research Authors: Raji Sasikala Rajendran, Nandini Ravikumar Jayakumari, Ashok Sivasailam, Anand Chellappan Reghuvaran, Vivek Velayudhan Pillai, Jayakumar Karunakaran, Harikrishnan Vijayakumar Sreelatha, Shankarappa Manjunatha, Srinivas Gopala Tags: RESEARCH COMMUNICATION Source Type: research

Diminished substrate ‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats
AbstractObjectiveHeart diseases are common in offspring of gestational diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may be one of the basic reasons behind the abnormal structural and functional behaviour of offspring ’s heart. So the main objective of the present study was to explore the cardiac mitochondrial respiration and autophagy in male and female offspring of diabetic pregnancy at two different developmental stages of life.MethodsHigh ‐resolution respirometry was used to measure substrate‐mediated mitochondrial respiration in isolated mitochondria from ventricular tissues of off...
Source: IUBMB Life - January 22, 2021 Category: Research Authors: Sasikala Rajendran Raji, Ravikumar Jayakumari Nandini, Sivasailam Ashok, Reghuvaran Chellappan Anand, Pillai Velayudhan Vivek, Jayakumar Karunakaran, Harikrishnan Vijayakumar Sreelatha, Shankarappa Manjunatha, Srinivas Gopala Tags: RESEARCH COMMUNICATION Source Type: research

Diminished substrate ‐mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats
ConclusionAltered cardiac mitochondrial respiration and autophagy were observed in adult male ODM compared to OCM, while the male and female offspring at weaning stage were less affected. The results of the study show that maternal hyperglycemia affects mitochondrial respiration and autophagy in the ODM heart, which may potentially be responsible for the cardiovascular complications observed in adult life.This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - January 22, 2021 Category: Research Authors: Raji Sasikala Rajendran, Nandini Ravikumar Jayakumari, Ashok Sivasailam, Anand Chellappan Reghuvaran, Vivek Velayudhan Pillai, Jayakumar Karunakaran, Harikrishnan Vijayakumar Sreelatha, Shankarappa Manjunatha, Srinivas Gopala Tags: RESEARCH COMMUNICATION Source Type: research

Histone deacetylase 10 exerts anti ‐tumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - January 22, 2021 Category: Research Authors: Jinming Zhu, Shichao Han Tags: RESEARCH COMMUNICATION Source Type: research

Histone deacetylase 10 exerts anti ‐tumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway
This article is protected by copyright. All rights reserved. (Source: IUBMB Life)
Source: IUBMB Life - January 22, 2021 Category: Research Authors: Jinming Zhu, Shichao Han Tags: RESEARCH COMMUNICATION Source Type: research

The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: possibilities for therapeutic interventions either as single agents or in combination with conventional therapies
AbstractThe latest advances in the sequencing methods in head and neck squamous cell carcinoma (HNSCC) tissues have revolutionized our understanding of the disease by taking off the veil from the most frequent genetic alterations in the components of the oncogenic pathways. Among all the identified alterations, aberrancies in the genes attributed to the phosphoinositide 3 ‐kinases (PI3K) axis have attracted special attention as they were altered in more than 90% of the tissues isolated from HNSCC patients. In fact, the association between these aberrancies and the increased risk of cancer metastasis suggested this axis a...
Source: IUBMB Life - January 21, 2021 Category: Research Authors: Nader Akbari Dilmaghani, Ava Safaroghli ‐Azar, Atieh Pourbagheri‐Sigaroodi, Davood Bashash Tags: CRITICAL REVIEW Source Type: research

Chitinase 3 ‐like‐1, Tolloid‐like protein 1, and intergenic gene polymorphisms are predictors for hepatocellular carcinoma development after hepatitis C virus eradication by direct‐acting antivirals
This study aimed t o determine the role and combined effect ofCHI3L1 (rs880633),TLL1 (rs1503298), and an intergenic (rs597533) polymorphisms on the risk of developing HCC in Egyptian patients after achieving sustained virological response (SVR) by DAAs. Blood samples were collected from 68 HCC patients, 77 non ‐HCC subjects, and 80 healthy controls. The DNA was extracted and analyzed for rs880633, rs1503298, and rs597533 using Genotyping TaqMan™ assay. The result of the present study showed a significant difference in genotypes and alleles frequencies in both (rs880633) and (rs597533) in HCC group as compared to he...
Source: IUBMB Life - January 14, 2021 Category: Research Authors: Nadia O. M. Mangoud, Sahar A. Ali, Mohamed El Kassas, Sameh H. Soror Tags: RESEARCH COMMUNICATION Source Type: research

Reference intervals for routine biochemical markers and body mass index: A study based on healthcare center database in northeastern Iran
AbstractAge ‐ and sex‐specific reference intervals (RIs) for some biochemical tests may be useful for their interpretation, due to the variations in lifestyle and genetic, or ethnic factors. The aim of this study was to obtain RIs for some routine biochemical markers including a serum lipid profile, fasting blood glucose (FBG), aspartate and alanine aminotransferase (AST and ALT), uric acid, and body mass index (BMI) in subjects who attended primary healthcare centers. The large database of primary healthcare centers uses RIs to report results for children, adolescents, and young and old adults. RIs w ere obtained by u...
Source: IUBMB Life - December 31, 2020 Category: Research Authors: Hamideh Ghazizadeh, Mahdiyeh Yaghooti ‐Khorasani, Atieh Kamel Khodabandeh, Elahe Hasanzadeh, Toktam Sahranavard, Seyed Hamed Banihashem‐Rad, Reza Zare‐Feyzabadi, Mansoureh Sadat Ekhteraee‐Toosi, Ensieh Akbarpour, Ameneh Timar, Maryam Moh Tags: RESEARCH COMMUNICATION Source Type: research

Gallic acid ‐gold nanoparticles enhance radiation‐induced cell death of human glioma U251 cells
AbstractGlioblastoma multiforme (GBM) is among the most common adult brain tumors with invariably fatal character. Following the limited conventional therapies, almost all patients, however, presented with symptoms at the time of recurrence. It is dire to develop novel therapeutic strategies to improve the current treatment of GBM. Gallic acid is a well ‐established antioxidant, presenting a promising new selective anti‐cancer drug, while gold nanoparticles (GNPs) can be developed as versatile nontoxic carriers for anti‐cancer drug delivery. Here, we prepared gallic acid‐GNPs (GA‐GNPs) by loading gallic acid onto...
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Zhou Jing, Minghe Li, Hongyuan Wang, Zhuo Yang, Shaolong Zhou, Jian Ma, Enping Meng, Hengwei Zhang, Wulong Liang, Weihua Hu, Xinjun Wang, Xudong Fu Tags: RESEARCH COMMUNICATION Source Type: research

N6 ‐methyladenosine modification of circular RNA circ‐ARL3 facilitates Hepatitis B virus‐associated hepatocellular carcinoma via sponging miR‐1305
In this study, we performed circRNA microarray profile and found an HBV ‐related circRNA, circ‐ARL3 (hsa_circ_0092493). Stable knockdown of circ‐ARL3 inhibited the proliferation and invasion of HBV+ HCC cells. High circ ‐ARL3 was positively correlated with malignant clinical features and poor prognosis. In terms of mechanism, HBx protein upregulated N6‐methyladenosine (m6A) methyltransferases METTL3 expression, increasing the m6A modification of circ ‐ARL3; then, m6A reader YTHDC1 bound to m6A ‐modified of circ‐ARL3 and favored its reverse splicing and biogenesis. Furthermore, circ‐ARL3 was able to sponge...
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Xi Rao, Lingling Lai, Xiaopeng Li, Liang Wang, Ai Li, Qian Yang Tags: RESEARCH COMMUNICATION Source Type: research

Long noncoding RNA small nucleolar RNA host gene 15 deteriorates liver cancer via microRNA ‐18b‐5p/LIM‐only 4 axis
AbstractExtensive studies have explored the involvements of long noncoding RNAs (lncRNAs) in liver cancer. Limitedly, the concrete function of lncRNA small nucleolar RNA host gene 15 (SNHG15) is still elusive. Therefore, the work was initiated to unearth SNHG15 ‐oriented mechanism in liver cancer. Liver cancer tissues were resected. The connection between SNHG15 expression with prognosis and clinicopathological traits of liver cancer patients was evaluated. Liver cancer cells SMMC‐7721 were transfected with restored microRNA (miR)‐18b‐5p or deplete d SNHG15 to discover their effects on the proliferation, migration,...
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Wei Chen, Li Huang, Junhua Liang, Yingjian Ye, Sihao Yu, Yijing Zhang Tags: RESEARCH COMMUNICATION Source Type: research

Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate ‐dependent autoproteolysis activity
In conclusion, our biophysical study characterizes a novel phosphate ‐dependent breakdown pathway of RbmA, while microbiological data suggest a new, sensory role of this biofilm scaffolding element. (Source: IUBMB Life)
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Manuel Maestre ‐Reyna, Wei‐Cheng Huang, Wen‐Jin Wu, Praveen K. Singh, Raimo Hartmann, Po‐Hsun Wang, Cheng‐Chung Lee, Takaaki Hikima, Masaki Yamamoto, Yoshitaka Bessho, Knut Drescher, Ming‐Daw Tsai, Andrew H.‐J. Wang Tags: RESEARCH COMMUNICATION Source Type: research

Gallic acid ‐gold nanoparticles enhance radiation‐induced cell death of human glioma U251 cells
AbstractGlioblastoma multiforme (GBM) is among the most common adult brain tumors with invariably fatal character. Following the limited conventional therapies, almost all patients, however, presented with symptoms at the time of recurrence. It is dire to develop novel therapeutic strategies to improve the current treatment of GBM. Gallic acid is a well ‐established antioxidant, presenting a promising new selective anti‐cancer drug, while gold nanoparticles (GNPs) can be developed as versatile nontoxic carriers for anti‐cancer drug delivery. Here, we prepared gallic acid‐GNPs (GA‐GNPs) by loading gallic acid onto...
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Zhou Jing, Minghe Li, Hongyuan Wang, Zhuo Yang, Shaolong Zhou, Jian Ma, Enping Meng, Hengwei Zhang, Wulong Liang, Weihua Hu, Xinjun Wang, Xudong Fu Tags: RESEARCH COMMUNICATION Source Type: research

N6 ‐methyladenosine modification of circular RNA circ‐ARL3 facilitates Hepatitis B virus‐associated hepatocellular carcinoma via sponging miR‐1305
In this study, we performed circRNA microarray profile and found an HBV ‐related circRNA, circ‐ARL3 (hsa_circ_0092493). Stable knockdown of circ‐ARL3 inhibited the proliferation and invasion of HBV+ HCC cells. High circ ‐ARL3 was positively correlated with malignant clinical features and poor prognosis. In terms of mechanism, HBx protein upregulated N6‐methyladenosine (m6A) methyltransferases METTL3 expression, increasing the m6A modification of circ ‐ARL3; then, m6A reader YTHDC1 bound to m6A ‐modified of circ‐ARL3 and favored its reverse splicing and biogenesis. Furthermore, circ‐ARL3 was able to sponge...
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Xi Rao, Lingling Lai, Xiaopeng Li, Liang Wang, Ai Li, Qian Yang Tags: RESEARCH COMMUNICATION Source Type: research

Long noncoding RNA small nucleolar RNA host gene 15 deteriorates liver cancer via microRNA ‐18b‐5p/LIM‐only 4 axis
AbstractExtensive studies have explored the involvements of long noncoding RNAs (lncRNAs) in liver cancer. Limitedly, the concrete function of lncRNA small nucleolar RNA host gene 15 (SNHG15) is still elusive. Therefore, the work was initiated to unearth SNHG15 ‐oriented mechanism in liver cancer. Liver cancer tissues were resected. The connection between SNHG15 expression with prognosis and clinicopathological traits of liver cancer patients was evaluated. Liver cancer cells SMMC‐7721 were transfected with restored microRNA (miR)‐18b‐5p or deplete d SNHG15 to discover their effects on the proliferation, migration,...
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Wei Chen, Li Huang, Junhua Liang, Yingjian Ye, Sihao Yu, Yijing Zhang Tags: RESEARCH COMMUNICATION Source Type: research

Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate ‐dependent autoproteolysis activity
In conclusion, our biophysical study characterizes a novel phosphate ‐dependent breakdown pathway of RbmA, while microbiological data suggest a new, sensory role of this biofilm scaffolding element. (Source: IUBMB Life)
Source: IUBMB Life - December 28, 2020 Category: Research Authors: Manuel Maestre ‐Reyna, Wei‐Cheng Huang, Wen‐Jin Wu, Praveen K. Singh, Raimo Hartmann, Po‐Hsun Wang, Cheng‐Chung Lee, Takaaki Hikima, Masaki Yamamoto, Yoshitaka Bessho, Knut Drescher, Ming‐Daw Tsai, Andrew H.‐J. Wang Tags: RESEARCH COMMUNICATION Source Type: research

Tea bioactive components prevent carcinogenesis via anti ‐pathogen, anti‐inflammation and cell survival pathways
AbstractCancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improvements in human health. Tea contains many active components, including tea polyphenols, tea polysaccharides,L‐theanine, tea pigments, and caffeine amongst other common components. Several studies have identified components in tea that can directly or indirectly reduce carcinogenesis with some being used ...
Source: IUBMB Life - December 27, 2020 Category: Research Authors: Xiangqi Fan, Xiangjun Xiao, Xiangbing Mao, Daiwen Chen, Bing Yu, Jianping Wang, Hui Yan Tags: CRITICAL REVIEW Source Type: research

Issue Information
IUBMB Life, Volume 73, Issue 1, Page 1-7, January 2021. (Source: IUBMB Life)
Source: IUBMB Life - December 27, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

Issue Highlights
IUBMB Life, Volume 73, Issue 1, Page 8-8, January 2021. (Source: IUBMB Life)
Source: IUBMB Life - December 27, 2020 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

IUBMB Life enters a new era
IUBMB Life, Volume 73, Issue 1, Page 9-9, January 2021. (Source: IUBMB Life)
Source: IUBMB Life - December 27, 2020 Category: Research Authors: Efstathios S. Gonos, Andrew H. ‐J. Wang Tags: EDITORIAL Source Type: research

Issue Information
IUBMB Life, Volume 73, Issue 1, Page 1-7, January 2021. (Source: IUBMB Life)
Source: IUBMB Life - December 27, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

Issue Highlights
IUBMB Life, Volume 73, Issue 1, Page 8-8, January 2021. (Source: IUBMB Life)
Source: IUBMB Life - December 27, 2020 Category: Research Tags: ISSUE HIGHLIGHTS Source Type: research

IUBMB Life enters a new era
IUBMB Life, Volume 73, Issue 1, Page 9-9, January 2021. (Source: IUBMB Life)
Source: IUBMB Life - December 27, 2020 Category: Research Authors: Efstathios S. Gonos, Andrew H. ‐J. Wang Tags: EDITORIAL Source Type: research

Tea bioactive components prevent carcinogenesis via anti ‐pathogen, anti‐inflammation and cell survival pathways
AbstractCancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improvements in human health. Tea contains many active components, including tea polyphenols, tea polysaccharides,L‐theanine, tea pigments, and caffeine amongst other common components. Several studies have identified components in tea that can directly or indirectly reduce carcinogenesis with some being used ...
Source: IUBMB Life - December 27, 2020 Category: Research Authors: Xiangqi Fan, Xiangjun Xiao, Xiangbing Mao, Daiwen Chen, Bing Yu, Jianping Wang, Hui Yan Tags: CRITICAL REVIEW Source Type: research

Not all mitochondrial DNAs are made equal and the nucleus knows it
AbstractThe oxidative phosphorylation (OXPHOS) system is the only structure in animal cells with components encoded by two genomes, maternally transmitted mitochondrial DNA (mtDNA), and biparentally transmitted nuclear DNA (nDNA). MtDNA ‐encoded genes have to physically assemble with their counterparts encoded in the nucleus to build together the functional respiratory complexes. Therefore, structural and functional matching requirements between the protein subunits of these molecular complexes are rigorous. The crosstalk between nDNA and mtDNA needs to overcome some challenges, as the nuclear‐encoded factors have to b...
Source: IUBMB Life - December 25, 2020 Category: Research Authors: Ana Victoria Lechuga ‐Vieco, Raquel Justo‐Méndez, José Antonio Enríquez Tags: CRITICAL REVIEW Source Type: research

Long non ‐coding RNAs as potential biomarkers in the prognosis and diagnosis of lung cancer: A review and target analysis
In conclusion, LncRNAs could be used as biomarkers in lung cancer due to their roles in control of several signaling pathways related to lung tumors. Also, it seems that lncRNAs, which use epigenetic mechanisms for modulating a large number of pathways, could be considered as important subjects for lung cancer ‐related diagnostic and prognostic biomarkers. (Source: IUBMB Life)
Source: IUBMB Life - December 24, 2020 Category: Research Authors: Younes Aftabi, Khalil Ansarin, Dariush Shanehbandi, Majid Khalili, Ensiyeh Seyedrezazadeh, Leila Rahbarnia, Milad Asadi, Amir Amiri ‐Sadeghan, Venus Zafari, Shirin Eyvazi, Nasim Bakhtiyari, Habib Zarredar Tags: CRITICAL REVIEW Source Type: research

Remimazolan inhibits glioma cell growth and induces apoptosis through down ‐regulation of NF‐κB pathway
AbstractGlioma alone accounts for 30% of various kinds of primary brain tumors and is the highest cause of mortality associated with intracranial malignant cancers. In the present study, Suzuki ‐coupling products of remimazolan were synthesized and investigated for anti‐neoplastic property against glioma cells. RFMSP treatment for 48 hr suppressed viabilities of U‐118MG and U87MG cells in dose dependent manner. Exposure of primary astrocytes to RFMSP at 2–20 μM concentration r ange minimally affected viabilities. RFMSP treatment at 5 μM doses raised apoptotic cell count to 53.8 &plusm...
Source: IUBMB Life - December 24, 2020 Category: Research Authors: Wei Xu, Jiamei Hu, Weiwei Liu, Qiong Zhu, Xuan Gong, Pengpeng Zhu, Xiao Yang, Rui Xia, Rui Xue Tags: RESEARCH COMMUNICATION Source Type: research

Ursolic acid ameliorates hypobaric hypoxia ‐induced skeletal muscle protein loss via upregulating Akt pathway: An experimental study using rat model
AbstractHypobaric hypoxic stress leads to oxidative stress, inflammation, and disturbance in protein turnover rate. Aggregately, this imbalance in redox homeostasis is responsible for skeletal muscle protein loss and a decline in physical performance. Hence, an urgent medical need is required to ameliorate skeletal muscle protein loss. The present study investigated the efficacy of ursolic acid (UA), a pentacyclic triterpene acid to ameliorate hypobaric hypoxia (HH) ‐induced muscle protein loss. UA is a naturally occurring pentacyclic triterpene acid present in several edible herbs and fruits such as apples. It contains ...
Source: IUBMB Life - December 24, 2020 Category: Research Authors: Richa Rathor, Akanksha Agrawal, Ravi Kumar, Geetha Suryakumar, Som Nath Singh Tags: RESEARCH COMMUNICATION Source Type: research

Long non ‐coding RNAs as potential biomarkers in the prognosis and diagnosis of lung cancer: A review and target analysis
In conclusion, LncRNAs could be used as biomarkers in lung cancer due to their roles in control of several signaling pathways related to lung tumors. Also, it seems that lncRNAs, which use epigenetic mechanisms for modulating a large number of pathways, could be considered as important subjects for lung cancer ‐related diagnostic and prognostic biomarkers. (Source: IUBMB Life)
Source: IUBMB Life - December 24, 2020 Category: Research Authors: Younes Aftabi, Khalil Ansarin, Dariush Shanehbandi, Majid Khalili, Ensiyeh Seyedrezazadeh, Leila Rahbarnia, Milad Asadi, Amir Amiri ‐Sadeghan, Venus Zafari, Shirin Eyvazi, Nasim Bakhtiyari, Habib Zarredar Tags: CRITICAL REVIEW Source Type: research

Remimazolan inhibits glioma cell growth and induces apoptosis through down ‐regulation of NF‐κB pathway
AbstractGlioma alone accounts for 30% of various kinds of primary brain tumors and is the highest cause of mortality associated with intracranial malignant cancers. In the present study, Suzuki ‐coupling products of remimazolan were synthesized and investigated for anti‐neoplastic property against glioma cells. RFMSP treatment for 48 hr suppressed viabilities of U‐118MG and U87MG cells in dose dependent manner. Exposure of primary astrocytes to RFMSP at 2–20 μM concentration r ange minimally affected viabilities. RFMSP treatment at 5 μM doses raised apoptotic cell count to 53.8 &plusm...
Source: IUBMB Life - December 24, 2020 Category: Research Authors: Wei Xu, Jiamei Hu, Weiwei Liu, Qiong Zhu, Xuan Gong, Pengpeng Zhu, Xiao Yang, Rui Xia, Rui Xue Tags: RESEARCH COMMUNICATION Source Type: research