Prognostic Values of TIGAR Expression and 18F-FDG PET/CT in Clear Cell Renal Cell Carcinoma
Conclusion: The expression of TIGAR is significantly correlated with SUVmax in clear cell RCC. The combined use of TIGAR expression and 18F-FDG PET/CT can provide additional information for tumor glucose metabolic status and disease prognosis in patients with clear cell RCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaoyan Wang, Rui Li, Ruohua Chen, Gang Huang, Xiang Zhou, Jianjun Liu Tags: Research Paper Source Type: research

Effect of Perioperative CEA and CA24-2 on Prognosis of Early Resectable Pancreatic Ductal Adenocarcinoma
In this study, 103 patients diagnosed with PDAC who underwent radical resection were recruited. The predictive value of preoperative carcinoembryonic antigen (CEA), postoperative CA24-2 and the combination of two for overall survival (OS) were evaluated. Both pre-CEA and post-CA24-2 were found to be independent prognostic factors for OS according to multivariate analyses. Kaplan-Meier analysis revealed that CEA and CA24-2 as well as the combination of two were correlated with poor OS. In addition, patients with both markers elevated have worse prognosis than patients with either pre-CEA or post-CA24-2 elevated. Thus, we co...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaojie Li, Shengnan Li, Lili Liu, Jiahui Hong, Tiansuo Zhao, Chuntao Gao Tags: Research Paper Source Type: research

The study on copy number alteration of clear cell renal cancer in Chinese population
Conclusions: In this study, the whole-genome ccRCC CNA landscape in Chinese population was acquired, a few functional genes and fusion genes were found out. However, a larger scale of samples is still needed to validate our results. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ning Zhang, Siteng Chen, Guangliang Jiang, Yishuo Wu, Jialiang Shao, Wennuan Liu, Xiang Wang, Rong Na, Jianfeng Xu Tags: Research Paper Source Type: research

Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells
Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2 (MDM2) and murine double minute X (MDMX) inhibitor in reversing the DOX resistance of BC. Both DOX-resistant human breast carcinoma cell lines exhibited a multidrug resistance (MDR) phenotype. The ability of the dual-target MDM2/MDMX inhibitor in reversing doxorubicin resistance was subsequently verified, (9....
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yangwei Fan, Ke Ma, Jiayu Jing, Chuying Wang, Yuan Hu, Yu Shi, Enxiao Li, Qianqian Geng Tags: Research Paper Source Type: research

Risk of immune-related diarrhea with PD-1/PD-L1 inhibitors in different cancer types and treatment regimens
Conclusions: PD-1/PD-L1 inhibitors have a lower risk of developing diarrhea than chemotherapy and CTLA-4 inhibitor. There is no direct relationship between the dose of PD-1/PD-L1 inhibitors and the risk of developing diarrhea. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lei Zhao, Jing Yu, Jing Wang, Huihui Li, Juanjuan Che, Bangwei Cao Tags: Research Paper Source Type: research

CEA as a risk factor in predicting ocular metastasis from colorectal cancer
In this study, we detected some recognized tumor biomarkers and tried to differentiate the discrepancy between CRC patients with and without OM in order to clarify the risk factor for OM in patients with colorectal cancer. Methods: 1735 patients with colorectal cancer in total from August 2005 to August 2017 were involved in this study. Nonparametric rank sum test and Chi-square test were applied to prescribe whether there were significant differences between OM group and non-ocular metastasis (NOM) group. And binary logistic regression analysis was used to determine the risk factor. Then, we used receiver operating curve ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: You-Lan Min, Ying-Xin Gong, Pei-Wen Zhu, Qi Lin, Biao Li, Wen-Qing Shi, Qing Yuan, Yi Shao Tags: Research Paper Source Type: research

High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center
Conclusion: TLR9 and PD-L1 expression may be a novel predictor of prognosis for patients with AITL and may serve as potential therapeutic strategy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jingrong Qian, Hongxue Meng, Bowen Lv, Jie Wang, Yingying Lu, Liju Su, Shu Zhao, Wenhui Li Tags: Research Paper Source Type: research

Recent advances of drug delivery nanocarriers in osteosarcoma treatment
Osteosarcoma is the most common primary malignant bone tumor mainly occurred in children and adolescence, and chemotherapy is limited for the side effects and development of drug resistance. Advances in nanotechnology and knowledge of cancer biology have led to significant improvements in developing tumor-targeted drug delivery nanocarriers, and some have even entered clinically application. Delivery of chemotherapeutic agents by functionalized smart nanocarriers could protect the drugs from rapid clearance, prolong the circulating time, and increase the drug concentration at tumor sites, thus enhancing the therapeutic eff...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Shang-Yu Wang, Hong-Zhi Hu, Xiang-Cheng Qing, Zhi-Cai Zhang, Zeng-Wu Shao Tags: Review Source Type: research

Glutathione S-transferase A1 suppresses tumor progression and indicates better prognosis of human primary hepatocellular carcinoma
Glutathione S-transferase (GST) family members play an important role in detoxification, metabolism and carcinogenesis. The aim of this study is to investigate the effect of Glutathione S-transferase A1 (GSTA1) on the prognosis of HCC and to understand its role in tumor progression and the possible mechanism. GSTA1 in HCC was assessed using immunohistochemical staining, and it was found that HCC patients with better pathological differentiation had higher GSTA1 abundance. Further, high GSTA1 expression was correlated with low AFP, absent PVTT, and early stage TNM for HCC patients. Higher GSTA1 indicated longer overall surv...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaojia Liu, Xianxian Sui, Canjing Zhang, Kelu Wei, Yun Bao, Ji Xiong, Zhongwen Zhou, Zhongqing Chen, Chaoqun Wang, Hongguang Zhu, Feng Tang Tags: Research Paper Source Type: research

Novel Oral Anticoagulant versus Warfarin in Cancer Patients with Atrial Fibrillation: An 8-Year Population-Based Cohort Study
Conclusion: In cancer patients with AF, NOAC were associated with significant reduced IS/SE, major bleeding, and ICH compared to warfarin. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Victor Chien-Chia Wu, Chun-Li Wang, Yu-Tung Huang, Wen-Ching Lan, Michael Wu, Chang-Fu Kuo, Shao-Wei Chen, Pao-Hsien Chu, Ming-Shien Wen, Chi-Ching Kuo, Shang-Hung Chang Tags: Research Paper Source Type: research

Liposarcoma: Advances in Cellular and Molecular Genetics Alterations and Corresponding Clinical Treatment
This study reviews the present research status and progress of cellular and molecular alterations of liposarcoma and corresponding clinical treatment progress. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lingge Yang, Shiqi Chen, Peng Luo, Wangjun Yan, Chunmeng Wang Tags: Review Source Type: research

Identification of a six-lncRNA signature based on a competing endogenous RNA network for predicting the risk of tumour recurrence in bladder cancer patients
Bladder cancer (BC) is the most common malignancy involving the urinary system, and is characterized by a high recurrence rate. It is important to identify potential lncRNA signatures capable of predicting tumour recurrence risk and assessing recurrence prognosis in BC patients. We extracted data from The Cancer Genome Atlas and identified 381 differentially expressed lncRNAs, 855 mRNAs and 70 miRNAs between non-recurrent and recurrent BC tissues. Subsequently, a competing endogenous RNA (ceRNA) network composed of 29 lncRNAs, 13 miRNAs and 4 mRNAs was established. We used univariate and multivariate Cox regression to anal...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Danfeng Zhao, Qiang Peng, Lu Wang, Cong Li, Yulin Lv, Yong Liu, Zhichao Wang, Ruizhe Fang, Jiaqi Wang, Zhongqing Liu, Wanhai Xu Tags: Research Paper Source Type: research

Overexpressing PLOD family genes predict poor prognosis in gastric cancer
In this study, we mined the expression and survival data in GC patients through ONCOMINE, UALCAN and Kaplan-Meier Plotter database. STRING portal couple with DAVID was used to establish a functional protein interaction network of PLOD family genes and analyze the GO and KEGG enriched pathways. Differential gene expression correlated with PLOD family genes was identified with LinkedOmics. We found that PLOD1, 2 and 3 were up-regulated in GC patients compared with normal tissues. High expression levels of PLOD1 and PLOD3 were associated with shorter overall survival (OS), first progression (FP) and post progression survival ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Shan-Shan Li, Yi-Fan Lian, Yan-Lin Huang, Yue-Hua Huang, Jian Xiao Tags: Research Paper Source Type: research

Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067
Conclusion: We demonstrate that CDK9 expression in chordoma correlates with patient outcome, and, when inhibited, chordoma cell growth and proliferation significantly decreases. Taken together, these results support CDK9 as an emerging potential target in chordoma therapy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Shen Shen, Dylan C. Dean, Zujiang Yu, Francis Hornicek, Quancheng Kan, Zhenfeng Duan Tags: Research Paper Source Type: research

Cancer Stem Cells of Diffuse Large B Cell Lymphoma Are Not Enriched in the CD45+CD19- cells but in the ALDHhigh Cells
Although the existence of cancer stem cells (CSCs) has been suggested in diffuse large B cell lymphoma (DLBCL), there is still no definitive marker. CD45+CD19- has been regarded as a potential marker of CSCs in mantle cell lymphoma (MCL). So, we explored the role of CD45+CD19- in DLBCL. However, both CD45+CD19- cells and CD45+CD19+ cells did not generate tumors until more than 100,000 cells were inoculated in NOD/SCID mice, even CD45+CD19+ cells generated more and larger tumors, as well as the soft agar colony formation in vitro; The aldehyde dehydrogenase (ALDH) activity was also identified in this study. Only 1,500 ALDHh...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Shupeng Song, Yongguo Li, Kaili Zhang, Xi Zhang, Yanxin Huang, Mingyan Xu, Shuangxing Li, Xue Guan, Tao Yang, Zhiyu Liu, Jie Jiang, Yunping Luo, Yinghua Lan Tags: Research Paper Source Type: research

Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma
Conclusion: Our results showed hypoxia upregulated the protein levels of VEGFA and ANGPT2 in lung cancer cell lines, and the roles of VEGFA and ANGPT2 were distinct in ADC and SQC. Combined detections of VEGFA and ANGPT2 may be valuable prognostic biomarkers for ADC and double block of VEGFA and ANGPT2 may improve therapeutic outcome. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Shuang Qin, Ming Yi, Dechao Jiao, Anping Li, Kongming Wu Tags: Research Paper Source Type: research

Value of intra-tumor heterogeneity evaluated by diffusion-weighted MRI for predicting pathological stages and therapeutic responses to chemoradiotherapy in lower rectal cancer
Conclusion: Intra-tumor heterogeneity on DWI corresponded with stromal pathological heterogeneity. It is useful for predicting T3 or deeper tumor invasion, pathological N(+), and the therapeutic effects of pCRT. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Michihiro Kudou, Masayoshi Nakanishi, Yoshiaki Kuriu, Yasutoshi Murayama, Tomohiro Arita, Mitsuo Kishimoto, Eiichi Konishi, Mariko Goto, Kei Yamada, Eigo Otsuji Tags: Research Paper Source Type: research

Correlation between Prostatitis, Benign Prostatic Hyperplasia and Prostate Cancer: A systematic review and Meta-analysis
Background: No consensus has been reached on the definite associations among prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Hence, this meta-analysis was conducted to explore their triadic relation by summarizing epidemiological evidence.Methods: Systematical and comprehensive retrieval of online databases PubMed, PMC, EMBASE and Web of Science was performed to acquire eligible studies, up to April 1st, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to clarify their correlations.Results: A total of 42 studies were enrolled in the quality assessment and 35 were...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lei Zhang, Yi Wang, Zhiqiang Qin, Xian Gao, Qianwei Xing, Ran Li, Wei Wang, Ninghong Song, Wei Zhang Tags: Research Paper Source Type: research

C-MYC, BCL2 and BCL6 Translocation in B-cell Non-Hodgkin Lymphoma Cases
This study aims to elucidate the patterns of BCL6, BCL2 and C-MYC gene aberrations among Malaysian B-cell Non-Hodgkin Lymphoma (NHL) using fluorescence in situ hybridization (FISH). Eighty-one B-cell NHL tissue blocks were retrieved between the year 2011 to 2015 and investigated using immunohistochemistry and interphase FISH dual colour break-apart probes of BCL2, BCL6, C-MYC and IgH. A significant difference was detected between the nodal and extranodal sites in all the BCL2 (p=0.01), C-MYC (p=0.03) and IgH (p=0.006) cases except for BCL6 (p=0.2). Our study showed that BCL6 had the highest gene translocation while BCL2/BC...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Dayang Sharyati Datu Abdul Salam, Ei Ei Thit, Siew Hoon Teoh, Soo Yong Tan, Suat Cheng Peh, Shiau-Chuen Cheah Tags: Research Paper Source Type: research

Prognostic and clinicopathological significance of Hapto and Gremlin1 expression in extrahepatic cholangiocarcinoma
We examined Hapto and Gremlin1 expression in 100 ECC, 30 peritumoral tissues, 10 adenoma and 15 normal biliary tract tissues using EnVision immunohistochemistry. The relationship between Hapto and Gremlin 1 expression and clinicopathological parameters was evaluated using the χ2 test or Fisher's exact test. The overall survival of patients was analyzed using Kaplan-Meier univariate survival analysis and log-rank tests.Results: Hapto and Gremlin1 proteins were overexpressed in ECC compared to peritumoral tissues, adenoma, and normal biliary tract (P
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhengchun Wu, Rushi Liu, Xiongying Miao, Daiqiang Li, Qiong Zou, Yuan Yuan, Zhulin Yang Tags: Research Paper Source Type: research

Frequency and Clinical Characteristics of Unselected Korean Gastric Cancer Patients with a Germline CDH1 V832M Mutation
Conclusion: This study demonstrates that the germline CDH1 V832M mutation is common in sporadic, late onset, and intestinal type gastric cancer as well as familial, early onset, and diffuse type gastric cancer. Our finding suggests that guidelines for managing CDH1 mutation carriers should be refined through additional data on penetration according to CDH1 mutation type in sporadic cases. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Saeam Shin, Yoonjung Kim, Jin Kyung Lee, Kyung-A Lee Tags: Research Paper Source Type: research

Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model
A higher incidence of gastric cancer has been found in East Asia compared to the incidence in other regions. Gastric cancer patients have a poor prognosis due to distant metastasis and advanced cancer stages. Tumor escape pathways include the expansion of the immunosuppressive myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment. We have successfully established an orthotopic immunocompetent gastric cancer model in C57BL/6 mice. The cell line is named M12 and was deposited at the Bioresource Collection and Research Center of Taiwan on Sep. 13, 2016 (Patent No. I604054). The orthotopic animal model of gast...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Hui-Ping Hsu, Chih-Yang Wang, Pei-Yin Hsieh, Jung-Hua Fang, Yi-Ling Chen Tags: Research Paper Source Type: research

HIF-1 α Promotes the Metastasis of Esophageal Squamous Cell Carcinoma by Targeting SP1
Conclusion: The results of our study indicate that HIF-1α promotes metastasis of ESCC by targeting SP1 in a hypoxic microenvironment. Further study on this mechanism may elucidate the possibility of HIF-1α and SP1 as new targets for the treatment of ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xueting Hu, Jiatong Lin, Ming Jiang, Xiaotian He, Kefeng Wang, Wenjian Wang, Chuwen Hu, Zhiwen Shen, Zhanghai He, Huayue Lin, Duoguang Wu, Minghui Wang Tags: Research Paper Source Type: research

Inhibition of Tumor Lymphangiogenesis is an Important Part that EGFR-TKIs Play in the Treatment of NSCLC
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms contribute to the anti-tumour effects of EGFR-TKIs. Three different EGFR-TKIs (Gefitinib, Afatinib, and AZD9291) were used to determine the possible biological effects of EGFR-TKIs on lymphangiogenesis in vitro and in vivo. EGFR-TKIs inhibited human lymphatic endothelial cells (HLEC) proliferation, migration and t...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yan Zhang, Xinying Yang, Hongchun Liu, Minghui Cai, Yang Shentu Tags: Research Paper Source Type: research

A 6-Membrane Protein Gene score for prognostic prediction of cytogenetically normal acute myeloid leukemia in multiple cohorts
Conclusions: We identified the MPG6 score as a stable indicator with great potential for clinical application in risk stratification and outcome prediction in CN-AML. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Sheng-Yan Lin, Ya-Ru Miao, Fei-Fei Hu, Hui Hu, Qiong Zhang, Qiubai Li, Zhichao Chen, An-Yuan Guo Tags: Research Paper Source Type: research

CD44v6 Targeted by miR-193b-5p in the Coding Region Modulates the Migration and Invasion of Breast Cancer Cells
Previous studies have shown that CD44 containing variant exon v6 (CD44v6) is highly expressed in many cancers and is related to tumor metastasis. However, the detailed mechanism of the regulatory pattern of CD44v6 in breast cancer remains unclear. Here, we found that CD44v6 was significantly upregulated in invasive breast cancer cell lines compared with low-invasive breast cancer cell lines. Cell migration and invasion could be suppressed by CD44v6 downregulation. MiRWalk and RNAhybrid software revealed miR-193b-5p as a miRNA targeting CD44v6 by binding to the exon v6 region. We found that the overexpression of miR-193b-5p...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Song Hu, Manlin Cao, Yiqing He, Guoliang Zhang, Yiwen Liu, Yan Du, Cuixia Yang, Feng Gao Tags: Research Paper Source Type: research

CD105 overexpression mediates drug-resistance in choriocarcinoma cells through BMP9/Smad pathway
Conclusions: This study provides evidence suggesting that CD105 is critical for the development of drug-resistance in choriocarcinoma and might serve as a therapeutic target for reversing chemoresistance in choriocarcinoma patients. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xiaoyu Wang, Liju Zong, Wenze Wang, Junjun Yang, Yang Xiang Tags: Research Paper Source Type: research

Association between Vaginal Micro-environment Disorder and Cervical Intraepithelial Neoplasia in a Community Based Population in China
This study aimed to investigate the association between vaginal micro-environment factors, including H2O2, vaginal PH value, vagina cleanness, β-glucuronidase, coagulase, neuraminidase and leukocyte esterase and cervical intraeipithelial neoplasia (CIN). In total 1019 participants, including 623 normal cervical (NC) women, 303 patients with low-grade cervical intraepithelial neoplasia (CIN1) and 93 patients with high-grade cervical intraepithelial neoplasia (CIN2/3), were enrolled into the study. HPV genotyping was detected by flow-through hybridization and gene chip. Vaginal H2O2, β-glucuronidase, coagulase, neu...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Li Li, Ling Ding, Tao Gao, Yuanjing Lyu, Ming Wang, Li Song, Xiaoxue Li, Wen Gao, Yang Han, Haixia Jia, Jintao Wang Tags: Research Paper Source Type: research

Pattern of distant metastases in inflammatory breast cancer - A large-cohort retrospective study
In conclusion, our results would provide more information for clinical decision and future studies. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zheng Wang, Mo Chen, Junjie Pan, Xuan Wang, Xiao-Song Chen, Kun-Wei Shen Tags: Research Paper Source Type: research

E2F1 promotes cancer cell sensitivity to cisplatin by regulating the cellular DNA damage response through miR-26b in esophageal squamous cell carcinoma
In conclusion, our results indicate that E2F1 promotes the chemosensitization to cisplatin in ESCC. The effect may be due to the upregulation of miR-26b because cisplatin-induced cycle arrest depends on miR-26b, which may also disturb the DNA damage response by reducing the expression of ATM and Rb. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Kun Zhang, Bo Zhang, Yun Bai, Limeng Dai Tags: Research Paper Source Type: research

Long Noncoding RNA DCST1-AS1 Promotes Cell Proliferation and Metastasis in Triple-negative Breast Cancer by Forming a Positive Regulatory Loop with miR-873-5p and MYC
Conclusions: DCST1-AS1 is activated by MYC and is degraded by binding to miR-873-5p, thereby upregulating the expression of miR-873-5p downstream proteins IGF2BP1, MYC, LEF1 and CD44. MYC, DCST1-AS1 and miR-873-5p form a positive regulatory loop to promote TNBC cell proliferation and metastasis. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Li Tang, Yuli Chen, Xun Tang, Da Wei, Xinyu Xu, Feng Yan Tags: Research Paper Source Type: research

Integrin-Linked Kinase Is Involved In the Proliferation and Invasion of Esophageal Squamous Cell Carcinoma
In conclusion, our results indicated that ILK may play a crucial role in ESCC invasion and metastasis and may serve as a prognostic biomarker and therapeutic target for ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhonghua Ning, Xiaozhong Zhu, Youqin Jiang, Aidi Gao, Shitao Zou, Chao Gu, Chao He, Yihong Chen, Wei-Qun Ding, Jundong Zhou Tags: Research Paper Source Type: research

SFI Enhances Therapeutic Efficiency of Gefitinib: An Insight into Reversal of Resistance to Targeted Therapy in Non-small Cell Lung Cancer Cells
Conclusions: Taken together, MAPK/SREBP1 pathway could be regarded as the potential treatment target for overcoming resistance to EGFR-TKIs in NSCLC and adjuvant therapy of SFI could be a potential therapeutic strategy for gefitinib resistant treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Zhenzhen Pan, Kai Wang, Qiufang Chen, Xiulan Zheng, Zhengyu Song, Xuansheng Ding Tags: Research Paper Source Type: research

Integrin-mediated Signaling via Paxillin-GIT1-PIX Promotes Localized Rac Activation at the Leading Edge and Cell Migration
Rac activation is precisely regulated temporally and spatially by intracellular signaling pathways in migrating cells to guarantee the formation of specific cell protrusions-lamellipodia at the leading edge. Integrins-mediated adhesions also control the signaling pathway for localized Rac activation in the cells, but very few studies have been addressed in this field. In the study, we aim to focus on how integrin-mediated signaling affects localized Rac activation by reducing the paxillin expression with shRNA targeting paxillin. The results revealed that reduction of the paxillin expression in the cells inhibited the form...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Youjun Li, Xinzhou Wu, Zhiqiang Liu, Kanghui Lu, Rushi Liu, Xiangrong Guo Tags: Research Paper Source Type: research

Depletion of CDC5L inhibits bladder cancer tumorigenesis
Cell division cycle 5-like (CDC5L) protein is a cell cycle regulator of the G2/M transition and has been reported to participate in the catalytic step of pre-messenger RNA (mRNA) splicing and DNA damage repair. Recently, CDC5L was also found to act as a candidate oncogene in osteosarcoma and cervical tumours. However, the role of CDC5L expression in bladder cancer remains unclear. Here, we analysed the expression and clinical significance of CDC5L in bladder cancer tissues. The expression of CDC5L in fresh bladder cancer tissues and paraffin-embedded slices was evaluated by western blot and immunohistochemistry, respective...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ziwei Zhang, Weipu Mao, Longsheng Wang, Mengnan Liu, Wentao Zhang, Yuan Wu, Junfeng Zhang, Shiyu Mao, Jiang Geng, Xudong Yao Tags: Research Paper Source Type: research

Anti-oral Squamous Cell Carcinoma Effects of a Potent TAZ Inhibitor AR-42
In this study, we constructed a stable transfected cell line HEK293-TAZ to screen TAZ inhibitor using dual-luciferase reporter assay, and found a potential TAZ inhibitor AR-42. The results showed that AR-42 effectively suppressed the viability and proliferation of OSCC cells, and induced cellular apoptosis and cell cycle arrest in G2/M phase. Moreover, AR-42 potently inhibited cell invasion and the capacity of sphere-forming, as well as the expression of EMT and cancer stem cell related proteins in OSCC cells, exhibiting potential efficacy against OSCC metastasis and self-renewal of oral cancer stem cell. Further mechanism...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lingyu Su, Si Wang, Ting Yuan, Xudong Xie, Xiaoming Fu, Ping Ji, Lei Zhong, Wenzhao Liu Tags: Research Paper Source Type: research

TRPV6 as A Target for Cancer Therapy
Two decades ago a class of ion channels, hitherto unsuspected, was discovered. In mammals these Transient Receptor Potential channels (TRPs) have not only expanded in number (to 26 functional channels) but also expanded the view of our interface with the physical and chemical environment. Some are heat and cold sensors while others monitor endogenous and/or exogenous chemical signals. Some TRP channels monitor osmotic potential, and others measure cell movement, stretching, and fluid flow. Many TRP channels are major players in nociception and integration of pain signals. One member of the vanilloid sub-family of channels ...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: John M. Stewart Tags: Review Source Type: research

TBX2 Identified as a Potential Predictor of Bone Metastasis in Lung Adenocarcinoma via Integrated Bioinformatics Analyses and Verification of Functional Assay
Objective: Bone metastasis from patients with advanced lung adenocarcinoma (LAC) is a very serious complication. To better understand the molecular mechanism, our current study sheds light on identification of hub genes mediating bone metastatic spread by combining bioinformatic analysis with functional verification.Methods: First, we downloaded a lung adenocarcinoma dataset (GSE76194) from Gene Expression Omnibus, analyzed differentially expressed genes (DEGs) through Limma package in R software and constructed a protein-protein interaction network. Based on that preliminary data, we further performed modular and topologi...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Huajian Yu, Fangyu Zhao, Jing Li, Kechao Zhu, Hechun Lin, Zhen Pan, Miaoxin Zhu, Ming Yao, Mingxia Yan Tags: Research Paper Source Type: research

Aberrant AFP expression characterizes a subset of hepatocellular carcinoma with distinct gene expression patterns and inferior prognosis
Conclusion High expression of AFP defined a subtype of liver cancer with distinct gene expression profiles and clinical features. De-methylation of cytosine from CpG di-nucleotides in AFP promoter may be the cause of AFP re-expression in adult human liver cancer tissue. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wei Chen, Jianjun Peng, Jinning Ye, Weigang Dai, Guanghua Li, Yulong He Tags: Research Paper Source Type: research

Downregulation of SPARC Expression Decreases Cell Migration and Invasion Involving Epithelial-Mesenchymal Transition through the p-FAK/p-ERK Pathway in Esophageal Squamous Cell Carcinoma
Conclusions: These results demonstrated that downregulation of SPARC could decrease cell migration and invasion involving EMT via the p-FAK/p-ERK pathway that might serve as a novel therapeutic target against ESCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fei Zhang, Yiyin Zhang, Jie Da, Zhenya Jia, Hongyang Wu, Kangsheng Gu Tags: Research Paper Source Type: research

Blockade of Adenosine A2b Receptor Reduces Tumor Growth and Migration in Renal Cell Carcinoma
Conclusion: Our findings suggest the A2bR potentially plays an important role in RCC progression and A2bR blockade may be a promising candidate for therapeutic intervention for renal cell carcinoma. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ye Yi, Yihong Zhou, Xi Chu, Xiaoping Zheng, Deng Fei, Jun Lei, Huiyue Qi, Yingbo Dai Tags: Research Paper Source Type: research

Tankyrases/ β -catenin Signaling Pathway as an Anti-proliferation and Anti-metastatic Target in Hepatocarcinoma Cell Lines
Conclusion: The TNKS/β-catenin signaling pathway is a potential anti-proliferation and anti-metastatic target in HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jianghai Huang, Qiang Qu, Yong Guo, Yuqi Xiang, Deyun Feng Tags: Research Paper Source Type: research

Twenty Metabolic Genes Based Signature Predicts Survival of Glioma Patients
Conclusions: In summary, our risk score model is predictive for 967 glioma patients' survival from four independent datasets, and the risk score is a meaningful and independent parameter of the clinicopathological information. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Wenfang Xu, Zhenhao Liu, He Ren, Xueqing Peng, Aoshen Wu, Duan Ma, Gang Liu, Lei Liu Tags: Research Paper Source Type: research

LINC00511 influences cellular proliferation through cyclin-dependent kinases in papillary thyroid carcinoma
Conclusions: Our results certified the role and function of LINC00511 in PTC, and it could become a novel tumor therapeutic target. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jingjing Xiang, Yaoyao Guan, Adheesh Bhandari, Erjie Xia, Jialiang Wen, Ouchen Wang Tags: Research Paper Source Type: research

Genipin increases oxaliplatin-induced cell death through autophagy in gastric cancer
In this study, we found that genipin sensitizes oxaliplatin-induced apoptosis for the first time using colony forming assay, FACS analysis, and western blotting in gastric cancer. Additionally, genipin induced p53 expression in AGS, MKN45, and MKN28 cells. Also, genipin induced autophagy and LC3 expression. Knockdown of LC3 decreased cell death enhanced by the combination of oxaliplatin and genipin. In summary, we showed that genipin increases the oxaliplatin-induced cell death via p53-DRAM autophagy. Based on this, we suggest that genipin is a sensitizer of oxaliplatin. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Bo Ram Kim, Yoon A Jeong, Dae Young Kim, Jung Lim Kim, Soyeon Jeong, Yoo Jin Na, Hye Kyeong Yun, Seong Hye Park, Min Jee Jo, Hassan Ashktorab, Duane T Smoot, Dae-Hee Lee, Sang Cheul Oh Tags: Research Paper Source Type: research

Polymorphisms in the PVT1 Gene and Susceptibility to the Lung Cancer in a Chinese Northeast Population: a Case-control Study
Conclusion: The polymorphism rs13254990 in PVT1 gene is associated with the risk of lung adenocarcinoma in a Chinese northeast population. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Ziwei Zhang, Hang Li, Juan Li, Xiaoting Lv, Zitai Yang, Min Gao, Yanhong Bi, Shengli Wang, Zhigang Cui, Baosen Zhou, Zhihua Yin Tags: Research Paper Source Type: research

Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1
In this study, we evaluated the efficacy of metformin, an inhibitor of oxidative phosphorylation, in combination with LW6, which impairs malate dehydrogenase 2 activities, in treating pancreatic cancer cells. We observed that this combinational therapy significantly reduced cell proliferation, migration, and significantly induced cell death when compared to cells treated by each monotherapy or Sham. In addition, we found that the combination of metformin and LW6 increased the phosphorylation of yes-associated protein 1 at serine 127 and attenuated the nuclear localization of this transcription factor. This combinatorial tr...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xianbin Zhang, Peng Liu, Yuru Shang, Hagen Kerndl, Simone Kumstel, Peng Gong, Brigitte Vollmar, Dietmar Zechner Tags: Research Paper Source Type: research

Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway
In this study, we found that CTT inhibited bladder cancer cell proliferation, migration, and invasion and promoted apoptosis. In addition, CTT modulated the expression of proteins via the PI3K/AKT pathway, and the inhibition of PI3K/AKT signalling was due to induction of PTEN expression. Taken together, the results of the present study demonstrated the anticancer effect of CTT on bladder cancer cells, which might be associated with the downregulation of PI3K/AKT/mTOR and NF-κB signalling pathway proteins, and this inhibition was mediated by the induction of PTEN. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yadong Liu, Fanlu Lin, Yaodong Chen, Rui Wang, Jiannan Liu, Yinshan Jin, Ruihua An Tags: Research Paper Source Type: research

Rhein induces liver cancer cells apoptosis via activating ROS-dependent JNK/Jun/caspase-3 signaling pathway
Conclusions: The present study showed that Rhein promotes apoptosis via regulating ROS/JNK/Jun/caspase-3 signaling pathway both in HepG2 and Huh7 cells. Rhein may be a promising therapeutic candidate for the treatment of liver cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Aili Wang, Huihong Jiang, Yuanyuan Liu, Jing Chen, Xue Zhou, Chenxi Zhao, Xia Chen, Mobin Lin Tags: Research Paper Source Type: research

Evaluation of different scoring systems and gene mutations for the prognosis of myelodysplastic syndrome (MDS) in Chinese population
MDS is a heterogeneous disease with diverse clinical manifestations, and an effective prognostic evaluation tool for MDS patients is needed. To achieve more accurate prognosis assessment for Chinese MDS patients, here we examined several scoring systems and explored the implications of gene mutations. The prognostic conditions were stratified against three different score systems (International Prognostic Scoring System (IPSS), WHO Prognostic Scoring System (WPSS), and Revised International Prognostic Scoring System (IPSS-R)) were retrospectively applied to 110 de novo MDS patients in study cohort in our hospital and the p...
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Meng-yi Du, Min Xu, Jun Deng, Lin Liu, Tao Guo, Ling-hui Xia, Yu Hu, Heng Mei Tags: Research Paper Source Type: research