The Efficiency of Verteporfin as a Therapeutic Option in Pre-Clinical Models of Melanoma
In this study we determine if verteporfin has clinical potential by testing this compound on human melanoma cell cultures and in a clinically significant mouse model, BrafCA; Tyr-CreERT2; Ptenf/f, which parallels human melanoma in terms of disease progression, genetics, and histopathology. In culture, Verteporfin treatment induces a rapid drop in YAP and TAZ protein levels and cell numbers. In the transgenic model, utilizing drug levels that correspond to previously determined safe doses in human patients and with a dosing regimen calculated in this study, Verteporfin did not inhibit melanoma initiation or progression in c...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jason W. Lui, Sixia Xiao, Kelsey Ogomori, Jon E. Hammarstedt, Elizabeth C. Little, Deborah Lang Tags: Research Paper Source Type: research

Epithelioid Trophoblastic Tumors: Treatments, Outcomes, and Potential Therapeutic Targets
Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets.Methods: We retrospectively analyzed the clinical features, treatments, survival, and prognostic factors of 21 ETT patients treated at our institution between January 2002 and December 2017. Expression levels of programmed cell death 1 (PD-1), PD-1 ligands (PD-L1and PD-L2), B7 family ligands (B7-H3, B7-H4, V-domain Ig suppressor of T cell activation [VISTA], and B7-...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Junjun Yang, Liju Zong, Jing Wang, Xirun Wan, Fengzhi Feng, Yang Xiang Tags: Research Paper Source Type: research

Pathological and Prognostic Impacts of FGFR2 Overexpression in Gastric Cancer: A Meta-Analysis
Fibroblast growth factor receptor-2 (FGFR2) protein expression by immunohistochemistry has been reported in up to 60% of patients with gastric cancer (GC). However, the clicopathological impacts of high FGFR2 expression have not been consistent among studies. We conducted this meta-analysis to evaluate the pathological and prognostic significance of FGFR2 overexpression in patients with GC. A systematic search of the electronic databases including PubMed, PMC, EMBASE, and Google Scholar was performed. From ten studies, 4,294 patients were included in the pooled analyses of odds ratios (ORs) with 95% confidence intervals (C...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hyeong Su Kim, Jung Han Kim, Hyun Joo Jang, Boram Han, Dae Young Zang Tags: Research Paper Source Type: research

The Risk of Gynecologic and Urinary Tract Cancer with Pelvic Inflammatory Disease: A Population-Based Cohort Study
Conclusion: Our study found that PID was associated with increased risks of gynecologic and urinary tract cancer but not colorectal or breast cancer. The information may lead to a strategy for cancer prevention and a reasonable healthcare usage through understanding PID epidemiology and controlling the inflammatory responses. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hui-Wen Lin, Po-Hui Wang, Chung-Yuan Lee, Jing-Yang Huang, Shun-Fa Yang, Yi-Hsuan Hsiao Tags: Research Paper Source Type: research

Validation of Prognosis Value of Cumulative Prognostic Scores Based on Serum High-Density Lipoprotein Cholesterol and Albumin Levels in Patients with Colorectal Cancer
Aims: Noninvasive tools for the prognosis of colorectal cancer (CRC) are in urgent need. Lipids and proteins have been studied in CRC several years, thus a prognostic indicator based on preoperative serum high-density lipoprotein cholesterol (HDL-C) and serum albumin (ALB) levels (HA score) in CRC patients and to compare the correlation with survival to that of the Glasgow prognostic score.Patient and methods: In the present study, the patient characteristics, clinicopathological factors, and the level of pre-treatment serum markers (HDL-C, ALB, CEA and CA19-9) were analyzed retrospectively in 248 patients with CRC.Results...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Hao Huang, Lin Zhang, Du-bo Chen, Xue-gao Yu, Xiao-hong He, Min Liu, Pei-song Chen Tags: Research Paper Source Type: research

Circulating miR-1290 and miR-320d as Novel Diagnostic Biomarkers of Human Colorectal Cancer
Conclusions: Circulating miR-1290 and miR-320d are novel promising biomarkers for early diagnosis of CRC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiangxiang Liu, Xueni Xu, Bei Pan, Bangshun He, Xiaoxiang Chen, Kaixuan Zeng, Mu Xu, Yuqin Pan, Huiling Sun, Tao Xu, Xiuxiu Hu, Shukui Wang Tags: Research Paper Source Type: research

Identification of Key Genes and Pathways in Female Lung Cancer Patients Who Never Smoked by a Bioinformatics Analysis
In conclusion, our study provides novel insight for a better understanding of the pathogenesis of nonsmoking female lung cancer, and these identified DEGs may serve as biomarkers for diagnostics and treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ke Shi, Na Li, Meilan Yang, Wei Li Tags: Research Paper Source Type: research

Comparison of Clinicopathological Features and Prognosis between ALK Rearrangements and EGFR Mutations in Surgically Resected Early-stage Lung Adenocarcinoma
Conclusion: Clinicopathological features of LAC with ALK rearrangements differ from those of LAC with EGFR mutations. Patients with ALK rearrangements had a significantly worse DFS than those harboring EGFR mutations. Thus, ALK rearrangements are an adverse prognostic factor in surgically-resected LAC patients, while EGFR mutations are associated with a better prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Pupu Li, Qiongqiong Gao, Xiangli Jiang, Zhongli Zhan, Qingna Yan, Zhaona Li, Chun Huang Tags: Research Paper Source Type: research

In-hospital Mortality after Surgical Resection in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus
Conclusion: Total albumin, tumor volume, intraoperative bleeding and frequency of hospitalization were independent predictive factors for in-hospital mortality in HCC patients with PVTT under surgery. Further study is warranted to utilize these factors to lower in-hospital mortality. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiu-Ping Zhang, Yu-Zhen Gao, Zhen-Hua Chen, Kang Wang, Yu-Qiang Cheng, Wei-Xing Guo, Jie Shi, Cheng-Qian Zhong, Fan Zhang, Shu-Qun Cheng Tags: Research Paper Source Type: research

The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score is a Novel Significant Prognostic Factor for Patients with Metastatic Prostate Cancer Undergoing Cytoreductive Radical Prostatectomy
Objective: The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been shown to be an important prognostic marker in some tumor types. The aim of this study was to evaluate the prognostic impact of the preoperative HALP score, with the intent to develop a new prognostic index for patients with metastatic prostate cancer (mPCA) after cytoreductive radical prostatectomy (cRP).Methods: We retrospectively analyzed the data from 82 patients with mPCA after cRP in our institution. Of these patients, 70 patients were diagnosed with oligometastatic prostate cancer (oPCA). The main outcome measure was prostate-specific ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yadong Guo, Donghui Shi, Junfeng Zhang, Shiyu Mao, Longsheng Wang, Wentao Zhang, Ziwei Zhang, Liang Jin, Bin yang, Lin Ye, Xudong Yao Tags: Research Paper Source Type: research

Molecular Mechanism of Anti-Cancer Activity of the Nano-Drug C-PC/CMC-CD59sp NPs in Cervical Cancer
The novel tumor targeted nano-drug C-PC/CMC-CD59sp nanoparticles were constructed with carbocymethyl chitosan (CMC), C-phycocyanin (C-PC) and CD59 specific ligand peptide (CD59sp). The anti-tumor drug mechanism of the C-PC/CMC-CD59sp NPs was further explored in cervical cancer cells (HeLa and SiHa) in vitro and in vivo. We found that the C-PC/CMC-CD59sp NPs could inhibit the proliferation and induce G0/G1 cell cycle arrest in cervical cancer HeLa and SiHa cells, and the cell proliferation was reduced in a dose-dependent manner. We further found that the C-PC/CMC-CD59sp NPs regulated the cell cycle via up-regulating the exp...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Liangqian Jiang, Yujuan Wang, Feng Zhu, Guoxiang Liu, Huihui Liu, Huanhuan Ji, Shuhua Zheng, Bing Li Tags: Research Paper Source Type: research

Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells
Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jinping Liang, Jun Shi, Na Wang, Hui Zhao, Jianmin Sun Tags: Review Source Type: research

Prognostic Value of the Nutritional Risk Screening 2002 Scale in Metastatic Gastric Cancer: A Large-Scale Cohort Study
In this study, 1664 metastatic gastric cancer patients at our institution between 2000 and 2015 were retrospectively analyzed. The characteristics and clinical outcomes of the included patients were analyzed.Results: Receiver operating characteristic (ROC) curves showed that the regrouping NRS 2002 scale (≤ 3 vs.> 3) provided a similar risk stratification predicting 2-year overall survival (OS) (area under the curves [AUCs]: 0.563 vs. 0.564, P> 0.05) but a better stratification predicting the risk of complications of palliative surgery (AUCs: 0.563 vs. 0.522, P = 0.050) than the original NRS 2002 scale ( 3 tended ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yuan-Fang Li, Run-Cong Nie, Ting Wu, Shu-Man Li, Shi Chen, Wei Wang, Xiao-Jiang Chen, Guo-Ming Chen, Ying-Bo Chen, Zhi-Wei Zhou, Shu-Qiang Yuan Tags: Research Paper Source Type: research

Incidence of Ipilimumab-Related Serious Adverse Events in Patients with Advanced Cancer: A Meta-Analysis
Background: Little is known about the incidence of ipilimumab-related serious adverse events (SAEs) across various tumor types, drug doses and treatment regimens.Methods: PubMed database was searched up to November, 2017 to identify prospective clinical trials of ipilimumab therapy for adult patients with cancer. Comparisons of the incidence were based on the χ2 test in univariate analysis and the logistic regression model in multivariate analysis.Results: Twenty-four studies (4549 patients) with 35 independent study cohorts (21 melanoma, 6 prostate cancer, 5 NSCLC, and 3 SCLC cohorts) of ipilimumab were included in th...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chang-Ying Guo, Si-Cong Jiang, Yu-Kang Kuang, Hao Hu Tags: Research Paper Source Type: research

Prognostic Value of PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase (PBK/TOPK) in Patients with Cancer
Conclusions: The findings suggest that PBK/TOPK protein expression might serve as a prognostic tumor marker in cancers. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yi Zhang, Xianjin Yang, Rong Wang, Xu Zhang Tags: Research Paper Source Type: research

Crosstalk between Fisetin-induced Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma
Fisetin (3,3-,4-,7-tetrahydroxyflavone), a naturally occurring flavonoid, has antioxidant, anti-inflammatory, and anticancer effects. Oral squamous cell carcinoma (OSCC) has a 5-year survival rate lower than that of most other carcinomas, and can create functional and aesthetic problems for the patient. New therapies for OSCC are necessary, and treatment using plant-derived natural substances has recently become a trend. It has been suggested that autophagy may play an important role in cancer therapy. Several studies demonstrated that autophagy inhibition enhances apoptotic cell death. Therefore, autophagy inhibition migh...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bong-Soo Park, Nak-Eun Choi, Ji Hye Lee, Hae-Mi Kang, Su-Bin Yu, Hye-Jin Kim, Hyun-Kyung Kang, In-Ryoung Kim Tags: Research Paper Source Type: research

A Functional 5'-UTR Polymorphism of MYC Contributes to Nasopharyngeal Carcinoma Susceptibility and Chemoradiotherapy Induced Toxicities
In this study, we evaluated the association of MYC polymorphisms with nasopharyngeal carcinoma (NPC) risk and chemoradiotherapy induced toxicities among Chinese population. By using bioinformatic tools, five potential functional single nucleotide polymorphisms of MYC were genotyped in a case-control study with 684 NPC patients and 823 healthy controls. We found two SNPs rs4645948 (C>T) and rs2071346 (G>T) were significantly associated with increased risk of developing NPC (TT+CT vs CC, OR=1.557, P=3.34×10-4; TT+GT vs GG, OR=1.361, P=0.007, respectively). In addition, rs4645948 (C>T) was conferred with increa...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhen Guo, Youhong Wang, Yu Zhao, Yi Jin, Liang An, Heng Xu, Zhaoqian Liu, Xiaoping Chen, Honghao Zhou, Hui Wang, Wei Zhang Tags: Research Paper Source Type: research

LXR α Promotes the Differentiation of Human Gastric Cancer Cells through Inactivation of Wnt/ β -catenin Signaling
In this study, the expression of LXRα was significantly lower in poorly differentiated and undifferentiated GC tissues compared with well- and moderately differentiated GC tissues by immunohistochemistry analysis. The activation of LXRα leads to the decreased expression of β-catenin, CD44, and Cyclin D1, whereas the inhibition of LXRα has opposite effect. The same results were obtained in animal experiments. Furthermore, results showed that CD44 and Cyclin D1 expression significantly decreased when Wnt/β-catenin signaling was blocked in LXRα silent GC cells, whereas it was significantly in...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yu Gao, Zihua Chen, Ran Wang, Xiangzhou Tan, Changhao Huang, Guanyang Chen, Zhikang Chen Tags: Research Paper Source Type: research

Modern Radiation Further Improves Survival in Non-Small Cell Lung Cancer: An Analysis of 288,670 Patients
Background: Radiation therapy plays an increasingly important role in the treatment of patients with non-small-cell lung cancer (NSCLC). The purpose of the present study is to assess the survival outcomes of radiotherapy treatment compared to other treatment modalities and to determine the potential role of advanced technologies in radiotherapy on improving survival.Methods: We used cancer incidence and survival data from the Surveillance, Epidemiology, and End Results database linked to U.S. Census data to compare survival outcomes of 288,670 patients with stage I-IV NSCLC treated between 1999 and 2008. The primary endpoi...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Monica Cheng, Shruti Jolly, William O. Quarshie, Nirav Kapadia, Fawn D. Vigneau, Feng-Ming (Spring) Kong Tags: Research Paper Source Type: research

High expression of MiR-98 is a good prognostic factor in acute myeloid leukemia patients treated with chemotherapy alone
It has been demonstrated that microRNA-98 (miR-98) is dysregulated in multiple types of solid tumors, but its expression and impact in acute myeloid leukemia (AML) is unclear. To explore the prognostic role of miR-98 in AML, 164 AML patients with the miR-98 expression data were extracted from The Cancer Genome Atlas (TCGA) database and enrolled in this study. First, patients were divided into chemotherapy-only (chemotherapy) group and allogeneic hematopoietic stem cell transplant (allo-HSCT) group. Each group was then divided in two groups by the median expression level of miR-98. In chemotherapy group, high miR-98 express...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ning Hu, Zhiheng Cheng, Yifan Pang, Hongmian Zhao, Li Chen, Chao Wang, Tong Qin, Qianyu Li, Yu Han, Jinlong Shi, Lin Fu Tags: Research Paper Source Type: research

Additional Chemotherapy with 5-FU plus Leucovorin between Preoperative Chemoradiotherapy and Surgery Improved Treatment Outcomes in Patients with Advanced Rectal Cancer
Purpose: The aim of the preliminary study was to evaluate the efficacy and safety of 4-week chemotherapy with 5-Fluorouracil and leucovorin (LV5FU2) during the resting periods between preoperative CRT and surgery in patients with LARC.Materials and Methods: Standard preoperative CRT was delivered to the entire pelvis at a total dose of 5040 Gy of radiation with concurrent 5-FU or capecitabine for 6 weeks. Twenty-three patients received additional preoperative chemotherapy with two cycles of 5-FU and LV (LV 200 mg/m2 and 5-FU bolus 400 mg/m2 on day 1, and 5-FU infusion 2400 mg/m2 for 46 hrs, every 2 weeks) after preoperativ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Song Ee Park, Jin Hwa Choi, Chang Hwan Choi, Suk Won Park, Beon Gyu Kim, Seong Jae Cha, In Gyu Hwang Tags: Research Paper Source Type: research

Neoadjuvant Chemoradiation Treatment for Resectable Esophago-Gastric Cancer: A Systematic Review and Meta-Analysis
Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas.Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Feasible studies were searched from electronic databases. The outcomes of survival, R0 resection rate and adverse effects were analyzed. The outcomes were measured with relative risk (RR) and odds ratio(OR).Results: Seventeen records including 4095 patients were included. Neoadjuvant CRT improved 1-,2-,3-and 5-yea...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiangyu Meng, Lu Wang, Yan Zhao, Bo Zhu, Ting Sun, Tao Zhang, Xiaohu Gu, Zhichao Zheng Tags: Research Paper Source Type: research

Professional Oral Health Care at General Dental Clinic Reduces Postoperative Complications of Head and Neck Free-Flap Reconstruction Surgery
Conclusion: This study identified history of radiation therapy as a significant risk factor for SSI from univariate and multivariate analysis and revealed that patients receiving preoperative professional oral health care at general dental clinics reduce the risk of SSI. Preoperative professional oral health care in cooperation with general dental clinics has been shown to reduce SSI of head and neck free-flap reconstructive surgery. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Masatoshi Usubuchi, Kazuto Matsuura, Takahiro Goto, Yukinori Asada, Takayuki Imai, Takenori Ogawa, Kengo Kato, Shigeru Saijo Tags: Research Paper Source Type: research

Deciphering Microenvironment of NSCLC based on CD8+ TIL Density and PD-1/PD-L1 Expression
Conclusion: The classification of tumors into four microenvironment subtypes based on PD-1/PD-L1 status and CD8+ TIL is an appropriate approach to stratify patients of different clinical outcome and better guide the practical use of immunotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ziying Lin, Jincui Gu, Xiaoxian Cui, Lixia Huang, ShaoLi Li, Jinlun Feng, Baomo Liu, Yanbin Zhou Tags: Research Paper Source Type: research

An In-Depth Look at Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT): Clinical Implications from Recent Molecular Findings
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a highly aggressive cancer in young women. The histogenesis remains unclear although a potential origin of germ cells has been suggested recently. The high throughput next generation sequencing techniques have facilitated the identification of inactivating SMARCA4 mutations as the driver of SCCOHT. These findings may greatly impact on the prevention, diagnosis, molecular classification and treatment of SCCOHTs. The SMARCA4 mutations, typically associated with dual loss of BRG1 and BRM expression, are highly sensitive and specific for the diagnosis of SCCOHT....
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Bingjian Lu, Haiyan Shi Tags: Review Source Type: research

Association of SMUG1 SNPs in Intron Region and Linkage Disequilibrium with Occurrence of Cervical Carcinoma and HPV Infection in Chinese Population
Conclusions: These findings suggested that there was association between the two genetic polymorphisms of SMUG1 rs3087404(A/G) and rs2029167(A/G) with the susceptibility of CIN III and CSCCs, and there was a linkage disequilibrium between the rs3087404 with the rs2029167 in CIN III and CSCCs. This particular linkage disequilibrium can be used as predictive biomarkers of CIN III and CSCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Feng Ye, Hanzhi Wang, Jia Liu, Qi Cheng, Xiaojing Chen, Huaizeng Chen Tags: Research Paper Source Type: research

Log Odds Could Better Predict Survival in Muscle-Invasive Bladder Cancer Patients Compared with pN and Lymph Node Ratio
Conclusion: LODDS has significant prognostic value for patients with MIBC. Moreover, LODDS is better at predicting prognosis for MIBC patients compared with pN and LNR. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shengming Jin, Beihe Wang, Yiping Zhu, Weixing Dai, Peihang Xu, Chen Yang, Yijun Shen, Dingwei Ye Tags: Research Paper Source Type: research

The Efficacy and Safety of First-line Chemotherapies for Advanced Biliary Tract Cancer: A Network Meta-analysis
Conclusion: Physicians should discuss with the patients the different options outlining potential benefit and toxicity since no clear evidence of an approach of choice can be produced. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wei Zheng, Jie Ying, Yan Zhou, Zhiwen Lu, Ke Min, Weimin Wang, Yun Zhang, Miao Zhang, Jian Yang Tags: Research Paper Source Type: research

High Expression of Indoleamine 2, 3-Dioxygenase in Adenosquamous Lung Carcinoma Correlates with Favorable Patient Outcome
Background: Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in tryptophan (Trp) metabolism, is generally considered to be an immunosuppressive molecule. The prognostic role of IDO expression in tumor has not been well studied in non-small cell lung cancer (NSCLC) and even not been reported in adenosquamous lung carcinoma (AdSqLC). Herein, the aim of this study is to investigate the prognostic significance of IDO expression in patients with AdSqLC.Patients and Methods: We conducted immunohistochemical analyses of IDO expression, as well as CD3 and CD8 expression, in 183 primary tumor tissue samples from patients with ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Wenjuan Ma, Hao Duan, Rongxin Zhang, Xing Wang, Haineng Xu, Qianghua Zhou, Li Zhang Tags: Research Paper Source Type: research

The Significance Role of microRNA-200c as a Prognostic Factor in Various Human Solid Malignant Neoplasms: A Meta-Analysis
Conclusions: Our findings indicated that high miRNA-200c expression was a promising biomarker for patient survival and disease progression in malignant tumors, especially in breast cancer and endometrial cancer. Considering the insufficient evidence, further large-scale researches and clinical studies were needed to verify these results. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Feng Wang, Lei Zhang, Haoxiang Xu, Ran Li, Lingyan Xu, Zhiqiang Qin, Bing Zhong Tags: Research Paper Source Type: research

Amlexanox and UPF1 Modulate Wnt Signaling and Apoptosis in HCT-116 Colorectal Cancer Cells
Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. However, it is unknown how NMD affects Wnt activity in CRC cells that exhibit constitutively activated Wnt signaling. We hypothesize that expression of genes that contain PTCs modulates Wnt signaling and response to butyr...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Michael Bordonaro, Darina Lazarova Tags: Research Paper Source Type: research

Chinese Herbal Medicine Wenxia Changfu Formula Reverses Cell Adhesion-Mediated Drug Resistance via the Integrin β 1-PI3K-AKT Pathway in Lung Cancer
In the treatment of lung cancer, the multidrug resistance to chemotherapeutic drugs is one of the reasons of low rates for cure and treatment failure, the combination of chemotherapeutic drugs and traditional Chinese medicine can increase the sensitivity of chemotherapy and reduce its adverse effects. Our previous study has proved that Chinese herbal medicine (CHM) Wenxia Changfu Formula (WCF for short) effectively enhances chemotherapeutic efficacy in lung cancer treatment and reverses multidrug resistance in lung cancer cells in vitro. The present study aims to investigate the effect and mechanism of WCF in reversing cel...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: YaNan Zhang, ZhiChun Wu, HuaYun Yu, HuaXin Wang, Guowei Liu, ShiJun Wang, XuMing Ji Tags: Research Paper Source Type: research

The Radiosensitization of Sodium Glycididazole on Nasopharyngeal Carcinoma Cells via Enhancing DNA Damage and Promoting Apoptosis
Conclusions: Our results suggested that CMNA enhance the sensitivity of the NPC cells to radiation via enhancing DNA damage and promoting cell apoptosis. It provides clues for further investigation of the molecular mechanism of the radiosensitization of CMNA on NPC cells. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiaoli Min, Fangling Huang, Huichao Huang, Shuang Zhao, Guoqiang Wang, Minze Zhou, Zhuchu Chen, Maoyu Li, Yongheng Chen Tags: Research Paper Source Type: research

Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching
Conclusions: Our propensity matching score study indicated that the smaller tumor size was an independent risk factor for CSS in patients with stage I-III CRC, and for OS and CSS in patients with RCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Xiao Li, Bang An, Jincai Ma, Bo He, Jianni Qi, Wenwen Wang, Chengyong Qin, Qi Zhao Tags: Research Paper Source Type: research

Mutation Profiling of Malignant Lymphoma by Next-Generation Sequencing of Circulating Cell-Free DNA
Conclusion: Our findings demonstrate that NGS-based cfDNA mutation profiling reveals genetic heterogeneity across lymphoma subtypes, with potential implications for the discovery of therapeutic targets, the exploration of genome evolution and the development of risk-adapted treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Peng Sun, Cui Chen, Yi Xia, Yu Wang, Pan-Pan Liu, Xi-Wen Bi, Yang W. Shao, Qiu-Xiang Ou, Xue Wu, Hang Yang, Man Nie, Xue-Wen Zhang, Zhi-Ming Li, Wen-Qi Jiang Tags: Research Paper Source Type: research

Optimal Timing for Postsurgical Adjuvant Therapy in Patients with Gastric Cancer: A Propensity Score Matching Study
Conclusion: We observed that initiation of AT within 8 weeks of curative gastrectomy produces better disease control and may contribute to better overall survival. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shih-Ming Huang, Yen-Chao Chen, Wan-Yu Chen, Lan-Yan Yang, Din-Li Tsan, Ngan-Ming Tsang, Wing-Keen Yap, Chien-Sheng Tsai, Wai-Man Leung, Ji-Hong Hong, Joseph Tung-Chieh Chang, Ta-Sen Yeh, Tsung-Han Wu, Yi-Chan Chen, Yun-Hsuan Lin, Bing-Shen Huang Tags: Research Paper Source Type: research

Short-term Outcomes of Transanal versus Laparoscopic Total Mesorectal Excision: A Systematic Review and Meta-Analysis of Cohort Studies
Conclusion: The present systematic review and meta-analysis suggested some advantages of TaTME, in terms of circumferential resection margin involvement, operative time, blood loss, conversion, hospital stay, overall postoperative complications, and readmission. It appears that the TaTME procedure achieved a better resection quality and smoother recovery in selected patients, without compromising the short-term safety. Nevertheless, it is too early to draw any conclusion, since results of high quality clinical evidence from randomized controlled trials have to be awaited. As it is technically demanding, the procedure needs...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhiyuan Wu, Wenlong Zhou, Fu Chen, Wentao Wang, Yong Feng Tags: Research Paper Source Type: research

Aberrantly DNA Methylated-Differentially Expressed Genes and Pathways in Hepatocellular Carcinoma
Conclusions: In summary, the present study implied possible aberrantly methylated-differentially expressed genes and dysregulated pathways in HCC by bioinformatics analysis and experiments, which could be helpful in understanding the molecular mechanisms underlying the development and progression of HCC. Hub genes including CDC20, AURKB, BIRC5, RRM2, MCM2, PTTG1, CDKN2A, NEK2, CENPF, RACGAP1, GNA14 and especially the new gene CDCA5 may serve as biomarkers for diagnosis, treatment and prognosis of HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Changzhou Cai, Weilin Wang, Zhenhua Tu Tags: Research Paper Source Type: research

Alteration of Adaptive Immunity in a Colorectal Peritoneal Carcinomatosis Model
Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 for intraperitoneal inoculation in the C57BL/6 mice to mimic the development of colorectal PC. We demonstrated that the injected CRC cells preferentially and rapidly migrated and colonized in the visceral fat tissues, but not in other visceral organs. With flow cytometric analysis, we found the proportions of sp...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Rongchen Shi, Wei Xiang, Xia Kang, Lili Zhang, Jinping Wang, Hongming Miao, Fengtian He Tags: Research Paper Source Type: research

The Effect of HER2 Single Nucleotide Polymorphisms on Cervical Cancer Susceptibility and Survival in a Chinese Population
Conclusions: Our results suggested that the combination of HER2 rs1136201and rs1058808 was significantly associated with the susceptibility of CCa. Besides, this combination of polymorphism s also substantially impacted the survival of CCa patients. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Yan Gao, Xiuwu Tang, Jieqin Cao, Rong Rong, Zhengmin Yu, Yang Liu, Yan Lu, Xiaowen Liu, Lei Han, Jiting Liu, Jun Zhang, Ming Xu, Fang Liu Tags: Research Paper Source Type: research

Appraisal of Prognostic Interaction between Sidedness and Mucinous Histology in Colon Cancer: A Population-Based Study Using Inverse Probability Propensity Score Weighting
Introduction: Colon cancer with different sidedness (right vs. left) and histology (mucinous vs. non-mucinous) may represent different disease entities. We investigated whether the prognostic values of sidedness and histology differed according to each other.Materials and Methods: We analyzed 81342 patients with stage II-IV colon cancer from the Surveillance, Epidemiology, and End Results database between 2004 and 2012. Patients were divided into four subgroups on the basis of sidedness and histology: non-mucinous right-sided, non-mucinous left-sided, mucinous right-sided, and mucinous left-sided subgroups. Among each tumo...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zi-Xian Wang, Lu-Ping Yang, Hao-Xiang Wu, Dong-Dong Yang, Pei-Rong Ding, Dan Xie, Gong Chen, Yu-Hong Li, Feng Wang, Rui-Hua Xu Tags: Research Paper Source Type: research

High Expression Levels of AGGF1 and MFAP4 Predict Primary Platinum-Based Chemoresistance and are Associated with Adverse Prognosis in Patients with Serous Ovarian Cancer
Primary platinum-based chemoresistance occurs in approximately one-third of patients with serous ovarian cancer (SOC); however, traditional clinical indicators are poor predictors of chemoresistance. So we aimed to identify novel genes as predictors of primary platinum-based chemoresistance. Gene expression microarray analyses were performed to identify the genes related to primary platinum resistance in SOC on two discovery datasets (GSE51373, GSE63885) and one validation dataset (TCGA). Univariate and multivariate analyses with logistic regression were performed to evaluate the predictive values of the genes for platinum...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Haiyue Zhao, Qian Sun, Lisong Li, Jinhua Zhou, Cong Zhang, Ting Hu, Xuemei Zhou, Long Zhang, Baiyu Wang, Bo Li, Tao Zhu, Hong Li Tags: Research Paper Source Type: research

Elevated Serum S100A9 Indicated Poor Prognosis in Hepatocellular Carcinoma after Curative Resection
We examined the utility of serum S100A9 in predicting prognosis in HCC after curative resection.Methods: We conducted a retrospective study of 379 HCC patients who underwent curative resection. Patients were randomly stratified into two independent groups to evaluate the prognostic value of S100A9. S100A9 was determined by ELISA.Results: Patients with advanced disease showed significantly higher S100A9 levels (all P
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jun Meng, Feng Gu, Hua Fang, Bin Qu Tags: Research Paper Source Type: research

Bevacizumab Added to Neoadjuvant Chemotherapy in HER2-Negative Non-Metastatic Breast Cancer
(Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guoxing Wan, Fengjun Cao, Xuanbin Wang, Xue Sun Tags: Letter To The Editor Source Type: research

Addition of Capecitabine in Breast Cancer First-line Chemotherapy Improves Survival of Breast Cancer Patients
Conclusion: Capecitabine combined with first-line chemotherapy in the treatment of breast cancer is an effective and safe treatment option and is worthy of clinical application to improve survival of breast cancer patients. In the future, we can continue to carry out relevant researches to explore the upmost appropriate dose of capecitabine for breast cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Di Xu, Xiu Chen, Xingjiang Li, Zhixiang Mao, Wenjuan Tang, Wei Zhang, Li Ding, Jinhai Tang Tags: Research Paper Source Type: research

Identification of Putative UL54 (ICP27) Transcription Regulatory Sequences Binding to Oct-1, v-Myb, Pax-6 and Hairy in Herpes Simplex Viruses
An oncolytic herpes simplex virus (oHSV) has proven amenable in oncolytic virotherapy and was approved to treat melanoma. The immediate-early (IE) protein ICP27 encoded by gene UL54 is essential for HSV infection. Post-transcriptional modification of UL54 would increase tumor targeting of oHSVs. However, UL54 gene transcription regulatory sequences and factors were not reported yet. Here we isolated a new strain LXMW of type 1 HSV (HSV-1-LXMW) in China and found it's closely related to HSV-1 strains Patton and H129 in the US by the first and next generation DNA sequencing viral DNA phylogenetic analysis. Using a weight mat...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ying-Ying Wang, Yan-Ning Lyu, Hong-Yi Xin, Jun-Ting Cheng, Xiao-Qin Liu, Xian-Wang Wang, Xiao-Chun Peng, Ying Xiang, Victoria W. Xin, Cheng-Biao Lu, Bo-Xu Ren, Yan-Fang Liang, Jia-Fu Ji, Zhaowu Ma, Shu-Zhong Cui, Hong-Wu Xin Tags: Research Paper Source Type: research

miR-1307-3p Stimulates Breast Cancer Development and Progression by Targeting SMYD4
Recent studies show that dysregulated miRNAs play an important role in breast cancer initiation and progression. Here, we identified upregulated expression of miR-1307-3p in breast cancer tissues and that increased level of miR-1307-3p was closely correlated with lower survival rate in breast cancer patients. Consistent with clinical data, our in vitro data show that expression level of miR-1307-3p was significantly increased in breast cancer cell lines compared to human mammary epithelial cell line MCF10A. Overexpression of miR-1307-3p in MCF10A stimulated cell proliferation and caused their growth in soft agar and tumor ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Sanghak Han, Hua Zou, Jin-Won Lee, Jeonghee Han, Heung Cheol Kim, Jeong Jin Cheol, Lee-Su Kim, Haesung Kim Tags: Research Paper Source Type: research

Elevated Serum Sialic Acid Levels Predict Prostate Cancer As Well As Bone Metastases
Conclusions: Elevated SA level is an independent predictor of prostate cancer as well as its bone metastases. Therefore, SA level may be a promising diagnostic and prognostic biomarker for prostate cancer and bone metastases. (Source: Journal of Cancer)
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Cong Zhang, Lei Yan, Hongkai Song, Zheng Ma, Dongshan Chen, Feilong Yang, Liang Fang, Zeyan Li, Kui Li, Dawei Li, Nengwang Yu, Hainan Liu, Zhonghua Xu Tags: Research Paper Source Type: research

Adjuvant Radiochemotherapy versus Chemotherapy Alone for Gastric Cancer: Implications for Target Definition
The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST trial indicated that the addition of RT to CT did not have a positive impact on disease-free survival (DFS). Nevertheless, in a subgroup of 396 patients with positive pathological lymph nodes, combined treatment with RT was superior to CT alone. A similar randomized Chinese trial confirmed the superiority of ...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jing Xu, Jonathan Zhu, Qichun Wei Tags: Review Source Type: research

TP53 gene rs1042522 allele G decreases neuroblastoma risk: a two-centre case-control study
The TP53 gene plays a crucial role in the prevention of cancer formation, which is closely related to TP53 mutation. TP53 gene polymorphism rs1042522 C>G was largely investigated in various cancers, but its contribution to neuroblastoma is as yet undefined. Here, we evaluated the effect of the TP53 gene rs1042522 C>G polymorphism on the development of neuroblastoma in two different regions, with patients from hospitals in both North and South China. The clinical data involved 374 patients and 812 controls. The resulting odds ratios (ORs) and 95% confidence intervals (CIs) were used with a logistic regression model to...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Jiao Zhang, Yang Yang, Wenya Li, Lizhao Yan, Da Zhang, Jing He, Jiaxiang Wang Tags: Research Paper Source Type: research