Efficacy of second-line treatments for patients with advanced human epidermal growth factor receptor 2 positive breast cancer after trastuzumab-based treatment: a systematic review and bayesian network analysis
Conclusions: Our work comprehensively summarized and analyzed current available RCT-based evidence of the second-line treatments for trastuzumab-treated, HER2-positive, advanced breast cancer. These results provide clinicians and oncologists meaningful references for clinical drug administration and the development of novel effective therapies. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Fei Chen, Naifei Chen, Zheng Lv, Lingyu Li, Jiuwei Cui Tags: Research Paper Source Type: research

Expression of PD1/PDL1 in gastric cancer at different microsatellite status and its correlation with infiltrating immune cells in the tumor microenvironment
Conclusion: The results suggested that PD1/PDL1 expression and immune response varied at different microsatellite statuses in GC. PD1/PDL1 expression was correlated with CD8+ T cell/CD68+ M densities in GC at different microsatellite statuses, especially at the invasion front. The patients exhibiting high PD1/PDL1 expression or high CD8+ T cell/CD68+ M densities MSI GC might be potential beneficiaries of PD1/PDL1 immunotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yan-li Wang, Yuehua Gong, Zhi Lv, Liang Li, Yuan Yuan Tags: Research Paper Source Type: research

Segmentectomy or Wedge Resection in Stage IA Lung Squamous Cell Carcinoma and Adenocarcinoma?
Conclusion: This study suggests that SG can yield superior survival outcome compared with WR in patients with stage IA SQCC. However, the survival outcomes of SG and WR are generally equivalent in patients with stage IA AD. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Guoshu Li, Shuanshuan Xie, Feng Hu, Min Tan, Lihong Fan, Changhui Wang Tags: Research Paper Source Type: research

Clinical significance of site-specific metastases in pancreatic cancer: a study based on both clinical trial and real-world data
Conclusion: MPC patients with isolated lung metastasis had better OS than those with isolated liver or peritoneum metastasis. Moreover, the number of metastatic sites showed prognostic and predictive value in patients with MPC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Lixia Wu, Lina Zhu, Kequn Xu, Siyuan Zhou, Yang Zhou, Tiening Zhang, Junjie Hang, Benny Chung-Ying Zee Tags: Research Paper Source Type: research

HPV58 E7 Protein Expression Profile in Cervical Cancer and CIN with Immunohistochemistry
Conclusions: HPV58 E7 protein is highly expressed in both cervical cancer and CIN tissues. HPV58 E7 IHC could be sensitive and specific for evaluating HPV-driven cervical cancer and pre-cancerous lesions, in combination with p16 and Ki-67 IHC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Qiaoli Zheng, Xianzhen chen, Rui Han, Jiang Zhu, Hui Wang, Lingjing Chen, Yinjing Song, Luxia Chen, Hao Cheng, Na Jin Tags: Research Paper Source Type: research

Preliminary study on SPECT/CT imaging of pancreatic cancer xenografts by targeting integrin α 5 in pancreatic stellate cells
Conclusion: The preliminary study suggests that 125I-AV3 can be used for SPECT/CT imaging of pancreatic cancer via targeting ITGA5 in PSCs, which is independent of the state of cancer cells and may have a special meaning. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Tao Wang, Ye Peng, Rou Li, Xiao Li, Changjing Zuo Tags: Research Paper Source Type: research

Para-aortic lymph node metastasis in lower Thoracic Esophageal Squamous Cell Carcinoma after Radical Esophagectomy: a CT-based atlas and its clinical implications for Adjuvant Radiotherapy
Conclusions: The proposed CTV is the first one to focus on the high-risk area of abdominal failure in LTESCC patients after surgery and can serve as a reference in the adjuvant radiotherapy for LTESCC patients. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Luxi Ye, Lijun Zhou, Shengping Wang, Lining Sun, Jiazhou Wang, Quan Liu, Xi Yang, Li Chu, Xiaofei Zhang, Weigang Hu, Jie Lin, Zhengfei Zhu Tags: Research Paper Source Type: research

AURKA and FAM83A are prognostic biomarkers and correlated with Tumor-infiltrating Lymphocytes in smoking related Lung Adenocarcinoma
Lung adenocarcinoma (LUAD) has become the main histologic type, which account for nearly 40% of lung cancer. The present study aimed to investigate the gene expression signature in smoking related LUAD. A total of 45 smoking related DEGs in LUAD were identified and functional enrichment analysis was also performed. Then Cox's regression model and Kaplan-Meier analysis were used to screen potential prognostic genes. Finally, AURKA and FAM83A were left for further immune-related mechanism exploration. Kaplan-Meier analysis indicated survival rates are related to different immune cell (B cell and Dendritic cell) infiltration ...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Mengyu Zhang, Chen Huo, Yingxiao Jiang, Jianyu Liu, Yican Yang, Yunhong Yin, Yiqing Qu Tags: Research Paper Source Type: research

LINC00665 promotes Ovarian Cancer progression through regulating the miRNA-34a-5p/E2F3 axis
Conclusion: LINC00665/miRNA-34a-5p/E2F3 axis is involved in OC progression, providing novel insights into the clinical treatment of OC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Dan Xu, Qingxia Song, Ying Liu, Wansu Chen, Lijuan LU, Min Xu, Xiaohui Fang, Wenjie Zhao, Huifang Zhou Tags: Research Paper Source Type: research

The clinical value of indocyanine green fluorescence navigation system for laparoscopic partial nephrectomy in the case of complex renal clear cell carcinoma (R.E.N.A.L score ≥ 7)
Conclusion: Without increasing the rate of positive surgical margins, ICG fluorescence navigation system for laparoscopic partial nephrectomy for complex renal clear cell carcinoma could conserve more normal renal tissue. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Rongjiang Wang, Jianer Tang, Yu Chen, Zhihai Fang, Junwen Shen Tags: Research Paper Source Type: research

Preoperative Portal Vein Embolization for Liver Resection: An updated meta-analysis
Conclusions: PVE is a safe and effective procedure with a low occurrence of related complications for inducing sufficient hypertrophy of FLR in liver tumor patients, which could elevate the resection rate of liver tumor patients. Careful patient cohort selection is crucial to avoid overuse of PVE in technically resectable patients. Further multiple central clinical trials are conducive to select optimal patient cohorts and provide a guideline for surgeons. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yu Huang, Wenhao Ge, Yang Kong, Yuan Ding, Bingqiang Gao, Xiaohui Qian, Weilin Wang Tags: Research Paper Source Type: research

Identification of Potential BRAF Inhibitor Joint Therapy Targets in PTC based on WGCAN and DCGA
In this study, we combined transcript data and clinical information from 199 BRAF wild-type (BRAFWT) patients and 283 BRAFV600E mutant patients collected from The Cancer Genome Atlas (TCGA), and screened 455 BRAFV600E- associated genes through differential analysis and weighted gene co-expression network analysis. Based on these BRAFV600E-associated genes, we performed functional enrichment analysis and co-expression differential analysis and constructed a core co-expression network. Next, genes in the differential co-expression network were used to predict drugs for therapy in the crowd extracted expression of differentia...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: YaLi Han, XiaQing Yu, YuZhen Yin, Zhongwei Lv, ChengYou Jia, Yina Liao, Hongyan Sun, Tie Liu, Lele Cong, ZhaoLiang Fei, Da Fu, Xianling Cong, Shen Qu Tags: Research Paper Source Type: research

Transcription factor E2F4 is an indicator of poor prognosis and is related to immune infiltration in hepatocellular carcinoma
Conclusion: E2F4 could serve as a novel biomarker for HCC diagnosis and prognosis prediction. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Qiuxian Zheng, Qiang Fu, Jia Xu, Xinyu Gu, Haibo Zhou, Chen Zhi Tags: Research Paper Source Type: research

CAR-T cells for Colorectal Cancer: Target-selection and strategies for improved activity and safety
Chimeric antigen receptor-T (CAR-T) cell immunotherapy is a novel method that is genetically engineered to recruit T cells against malignant disease. Administration of CAR-T cells has led to progress in hematological malignancies, and it has been proposed for solid tumors like colorectal cancer (CRC) for years. However, this method was not living up to expectations for the intrinsic challenges posed to CAR-T cells by solid tumors, which mainly due to the lacking of tumor-restricted antigens and adverse effects following treatment. New approaches are proposed to overcome the multiple challenges to alleviate the difficult si...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Huali Li, Chao Yang, Huangrong Cheng, Shuoyang Huang, Yongbin Zheng Tags: Review Source Type: research

Androgen Plays a Carcinogenic Role in EOC via the PI3K/AKT Signaling Pathway in an AR-Dependent Manner
Conclusion: We showed that testosterone was able to promote the proliferation of ovarian cancer cells through activating the PI3K/AKT signaling pathway in an AR dependent manner and AR may be a screening indicator for anti-androgen therapy sensitive cases of EOC. (Source: Journal of Cancer)
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yanfang Li, Sha Li, Yizhou Zhang, Shuhong Shi, Shan Qin, Chang Wang, Juan Du, Jingle Ma, Huan Chen, Huixian Cui Tags: Research Paper Source Type: research