Long-Term Survival and Prognostic Factors in Locoregionally Advanced Nasopharyngeal Carcinoma Patients Treated with TPF Induction Chemotherapy followed by Cisplatin-Combined Concurrent Chemoradiotherapy
Conclusion: This study indicated that TPF regimen produced encouraging results in Asian patients with locoregionally advanced nasopharyngeal carcinoma. Toxicity was tolerable and reversible. However, overall treatment time is an important factor that we should take into consideration when make plans of induction chemotherapy related treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Qun Zhang, Yan Wang, Jun-Fang Liao, Yu-Feng Ren, Guo-Ping Shen, Shao-Qing Niu, Wei Luo Tags: Research Paper Source Type: research

circGFRA1 Promotes Ovarian Cancer Progression By Sponging miR-449a
Conclusions: In summary, circGFRA1 regulated GFRA1 expression and ovarian cancer progression by sponging miR-449a. circGFRA1 could be a potential diagnostic biomarker and therapeutic target for ovarian cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jie Liu, Furong Yu, Shufen Wang, Xia Zhao, Feng Jiang, Jing Xie, Min Deng Tags: Research Paper Source Type: research

KPNA3 Confers Sorafenib Resistance to Advanced Hepatocellular Carcinoma via TWIST Regulated Epithelial-Mesenchymal Transition
Sorafenib, a multikinase inhibitor, is a new standard treatment for patients with advanced hepatocellular carcinoma (HCC). However, resistance to this regimen is frequently observed in clinical practice, and the molecular basis of this resistance remains largely unknown. Herein, the antitumor activity of sorafenib was assessed in 16 patient-derived xenograft (PDX) models of HCC. Gene expression analysis was conducted to identify factors that promote sorafenib resistance. Quantitative RT-PCR and immunoblotting were used to determine gene expression and activation of signaling pathways. Cell proliferation, clone formation, a...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Bo Hu, Jian-Wen Cheng, Jin-Wu Hu, Hong Li, Xiao-Lu Ma, Wei-Guo Tang, Yun-Fan Sun, Wei Guo, Ao Huang, Kai-Qian Zhou, Ping-Ting Gao, Ya Cao, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Xin-Rong Yang Tags: Research Paper Source Type: research

GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a highly metastatic tumor that occurs frequently in Southeast Asia, particularly including southern China. Epstein-Barr virus infection is well established as a primary cause of NPC; nevertheless, the mechanisms underlying NPC pathogenesis remain largely unknown. In our previous study, we conducted whole-genome sequencing to screen for genomic variations that were associated with NPC. Of the resultantly identified variations, glypican-6 (GPC6), was shown, for the first time, to be frequently mutated in NPC. In the present study, we verified this finding and conducted a series of functional...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chunmei Fan, Chaofeng Tu, Peng Qi, Can Guo, Bo Xiang, Ming Zhou, Xiayu Li, Xu Wu, Xiaoling Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng Tags: Research Paper Source Type: research

Surgical Resection plus Radiofrequency Ablation versus Radical Surgery for Hepatocellular Carcinoma: A Propensity Score Matching Analysis
Conclusion: SR-RFA provides a similar long-term survival to that on SR in HCC patients with 2 or 3 nodules, and its application should be carefully considered. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Cheng Zhou, Xiangyu Zhang, Yuanfei Peng, Kaiqian Zhou, Jie Hu, Lei Yu, Feiyu Chen, Shuangjian Qiu, Jian Zhou, Jia Fan, Lan Zhang, Zheng Wang Tags: Research Paper Source Type: research

The role of postoperative radiotherapy for completely resected pIIIA-N2 non-small cell lung cancer patients with different clinicopathological features: a systemic review and meta-analysis
Conclusions: The findings of this meta-analysis supported a role for PORT in patients with completely resected pIIIA-N2 NSCLC having multiple N2 metastases and favored withholding PORT to patients with single N2 station involvement. Further prospective randomized controlled trials are needed to confirm the findings. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Tingting Liu, Yanshu Mu, Jun Dang, Guang Li Tags: Research Paper Source Type: research

Anatomical versus Non-anatomical Resection for Hepatocellular Carcinoma with Microscope Vascular Invasion: A Propensity Score Matching Analysis
Conclusions: Anatomical resection was superior to non-anatomical resection for improving DFS in hepatocellular carcinoma patients with microscope vascular invasion. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiao-Ping Zhong, Yong-Fa Zhang, Jie Mei, Shao-Hua Li, Anna Kan, Liang-He Lu, Min-Shan Chen, Wei Wei, Rong-Ping Guo Tags: Research Paper Source Type: research

Risk Prediction for Early Mortality in Patients with Newly Diagnosed Primary CNS Lymphoma
Conclusion: Early mortality is not uncommon in patients with PCNSL. Identification of patients with higher risk may help clinicians with initiating appropriate surveillance and management. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chia-Hsin Lin, Ching-Fen Yang, Huai-Che Yang, Li-Yu Fay, Chiu-Mei Yeh, Ai-Seon Kuan, Hao-Yuan Wang, Jyh-Pyng Gau, Liang-Tsai Hsiao, Tzeon-Jye Chiou, Po-Min Chen, Yao-Chung Liu, Po-Shen Ko, Jin-Hwang Liu, Chia-Jen Liu Tags: Research Paper Source Type: research

Predictors of Distant Metastasis in Patients with Cervical Cancer Treated with Definitive Radiotherapy
Objective: To identify the predictors of distant metastasis in patients with cervical cancer treated with definitive radiotherapy and develop a model for predicting distant metastasis.Methods: We reviewed the clinical records of patients with cervical cancer treated with definitive radiotherapy (IMRT) at Peking Union Medical College Hospital between January 2011 and December 2015. Eligible patients were randomly assigned into model development cohort and validation cohort in a 2:1 ratio. Distant metastasis rate (DMR) was calculated with Kaplan-Meier method. Univariate and multivariate analyses using cox proportional hazard...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiaoliang Liu, Qingyu Meng, Weiping Wang, Ziqi Zhou, Fuquan Zhang, Ke Hu Tags: Research Paper Source Type: research

ENKUR acts as a tumor suppressor in lung adenocarcinoma cells through PI3K/Akt and MAPK/ERK signaling pathways
In this study we analyzed the expression profile of ENKUR mRNA in clinical LAD samples and examined ENKUR mRNA expression and ENKUR protein level in LAD cells. Significant down-regulated ENKUR expression was observed in clinical tumor tissues of LAD as well as in human LAD cells. To evaluate the effects of aberrant ENKUR expression on cellular biology of LAD cells in vitro and tumor growth in vivo, ENKUR-overexpressed and -silenced LAD cell lines were constructed using lentiviral vectors. Our results showed that overexpression of ENKUR in LAD cells inhibited cell proliferation, migration and invasion, while silencing of EN...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Qing Ma, Yin Lu, Jie Lin, Ye Gu Tags: Research Paper Source Type: research

Quantitative Proteomic Analysis and Evaluation of the Potential Prognostic Biomarkers in Cholangiocarcinoma
Conclusions: The results suggested that the expression of PPP3CA in CCA patients is a new independent factor for poor prognosis and a useful prognostic predictor for patients with CCA. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zengwei Tang, Yuan Yang, Jinduo Zhang, Wenkang Fu, Yanyan Lin, Gang Su, Yan Li, Wenbo Meng, Xun Li, Xiaodong Xie Tags: Research Paper Source Type: research

Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma
In this study, by analyzing online RNA-Seq data, we found that RHPN1-AS1 was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade. High expression of RHPN1-AS1 was also confirmed in HNSCC tissues. Knockdown of RHPN1-AS1 inhibited tumor cell migration, invasion and proliferation in HNSCC. Furthermore, inhibition of RHPN1-AS1 suppressed the expression of epithelial-mesenchymal transition (EMT)-related genes (β-Catenin, Claudin-1 and Vimentin) in HNSCC cells. Collectively, our results suggest that RHPN1-AS1, acting as an oncogene, may be a potential diagnostic and thera...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiaowen Qiu, Zhuo Lei, Zeyou Wang, Yuming Xu, Chang Liu, Panchun Li, Hanjiang Wu, Zhaojian Gong Tags: Research Paper Source Type: research

The Prognostic Value of the MiR-200 Family in Colorectal Cancer: A Meta-analysis with 1882 Patients
Conclusions: High expression levels of miR-200 microRNAs were associated with poor clinical outcomes in colorectal cancer patients. The miR-200 family can therefore potentially serve as a prognostic biomarker. Further studies should be performed to verify the clinical utility of the miR-200 family in colorectal cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chengpeng Yu, Haiting Wan, Renfeng Shan, Wu Wen, Jianfeng Li, Daya Luo, Renhua Wan Tags: Research Paper Source Type: research

The Role of the Tumor Microenvironment in Neuropilin 1-Induced Radiation Resistance in Lung Cancer Cells
Conclusion: Our results verified that NRP1, inflammatory factors, chemokines and related signaling pathways, which affect the transformation of related cell components and thus lung cancer cell immune tolerance and migratory ability, all play an important role in radiation resistance. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Zhuo Dong, Haiyang Zhang, Xinkou Gong, Wei Wei, Yahui Lv, Zhiyuan Chen, Rui Wang, Junxuan Yi, Yannan Shen, Shunzi Jin Tags: Research Paper Source Type: research

A randomized trial of conventional fraction versus hypofraction radiotherapy for bone metastases from hepatocellular carcinoma
This study aimed to compare toxicity and efficacy for conventional fraction versus hypofraction schedules. From January 2009 through December 2014, 183 patients with HCC bone metastases were randomly assigned to conventional fraction EBRT (Group A) or hypofraction radiotherapy (Group B). Study outcomes were pain relief, response rate and duration, overall survival, and toxicity incidence. Median follow-up time was 9.3 months. Response times were 6.7 ± 3.3 fractions in Group A and 4.1 ± 1.2 fractions in Group B (p
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jian He, Shiming Shi, Luxi Ye, Guifen Ma, Xiangou Pan, Yan Huang, Zhaochong Zeng Tags: Research Paper Source Type: research

A review on the accuracy of bladder cancer detection methods
Conclusion: The results of this review can positively help to identify accurate methods for detecting bladder cancer and highlight areas to be further improved for future research work. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chao-Zhe Zhu, Hua-Nong Ting, Kwan-Hoong Ng, Teng-Aik Ong Tags: Review Source Type: research

Effects of Dynamin-related Protein 1 Regulated Mitochondrial Dynamic Changes on Invasion and Metastasis of Lung Cancer Cells
This study investigated the effects of mitochondrial dynamics regulated by dynamin-related protein 1 (Drp1) on the invasion and metastasis of lung cancer cells at the cellular level.Methods: Lentivirus-mediated RNAi and gene overexpression vectors containing shDrp1 and Lv-Drp1 were transfected into lung adenocarcinoma cell lines 95D and A549, respectively. An MTT assay was used to assess cell viability and a cell clone assay was used to evaluate the tumorigenic ability of lentivirus-infected cells. Cell invasion and wound healing assays were used to assess cell invasiveness and the migration rate after lentivirus infection...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jie-Tao Ma, Xiang-Yan Zhang, Rui Cao, Li Sun, Wei Jing, Jian-Zhu Zhao, Shu-Ling Zhang, Le-Tian Huang, Cheng-Bo Han Tags: Research Paper Source Type: research

Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation
Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell invasion. Recently, through chronic exposure model, more extensive pathological effects due to areca nut have been found. These include the induction of autophagy, promotion of epithelial- mesenchymal transition, and facilitation of cancer stemness conversion. Clinical findings support these adverse effects. Oral...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yi-Chen Li, Ann-Joy Cheng, Li-Yu Lee, Yu-Chen Huang, Joseph Tung-Chieh Chang Tags: Review Source Type: research

Comparison of macrovascular invasion-free survival in early-intermediate hepatocellular carcinoma after different interventions: A propensity score-based analysis
Objectives: The purpose of this study was to compare macrovascular invasion (MVI)-free survival (MFS) at the three-year follow-up in patients with hepatocellular carcinoma (HCC) who underwent hepatic resection (HR), transcatheter arterial chemoembolization (TACE), or TACE combined with radiofrequency ablation (TACE-RFA).Materials and Methods: We retrospectively analyzed the medical records of 828 patients who were diagnosed with Barcelona Clinic Liver Cancer (BCLC) stage A or stage B HCC. Of these patients, 116 underwent HR, 395 underwent TACE-RFA, 239 underwent TACE, and 78 patients received conservative treatment (contro...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yao Liu, Dongying Xue, Shanzhong Tan, Qun Zhang, Xue Yang, Yuxin Li, Bingbing Zhu, Shuaishuai Niu, Li Jiang, Xianbo Wang Tags: Research Paper Source Type: research

Overexpression of SMYD3 in Ovarian Cancer is Associated with Ovarian Cancer Proliferation and Apoptosis via Methylating H3K4 and H4K20
Conclusion: Our results demonstrated that SMYD3 was overexpressed in ovarian cancer and contributes to the regulation of tumor proliferation and apoptosis via SMYD3-H4K20me3-CDKN2A pathway and SMYD3-H3K4me3-BIRC3 pathway. Thus, SMYD3 is a promising epigenetic therapeutic target for ovarian cancer. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yahui Jiang, Tianjiao Lyu, Xiaoxia Che, Nan Jia, Qin Li, Weiwei Feng Tags: Research Paper Source Type: research

Regulation of response to radiotherapy by β -arrestin1 in Non-small cell lung cancer
β-arrestin1 serves as scaffold proteins participating in multiple signaling pathways. However, there were few researches focusing on the impact of β-arrestin1 on DNA damage response (DDR). Non-small cell lung cancer cell (NSCLC) lines were transfected with β-arrestin1 plasmids or siRNA and received radiation treatment. MTT and colony formation assay were performed to assess the proliferation and viability of tumor cells. Flow cytometry was used to evaluate the impact of β-arrestin1 on radiation-induced apoptosis. Western blotting was applied to detect protein expression in apoptosis, DDR, ERK and NF-kB ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Liguang Wang, Kai Wang, Wei Dong, Hongchang Shen, Jiajun Du Tags: Research Paper Source Type: research

Association of Preoperative Plasma D-dimmer and Fibrinogen and Renal Cell Carcinoma Outcome
Background: the plasma D-dimer and fibrinogen which are indicators of coagulation-fibrinolysis system has been reported to be associated with survival in several types of cancers, including RCC. The aim of our study was to assess the prognostic significance of preoperative plasma D-dimer and fibrinogen levels in RCC patients.Methods: Data from 449 patients with RCC were assessed retrospectively. Cutoff value for plasma D-dimer and fibrinogen were tested by the standardized cutoff-finder algorithm. Overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method. Univariate and Multivariate...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiaobo He, Tao Huang, Yunfei Xue, Meng Zhang, Qiaodan Liu, Yongqiang Wang, Kai Yao, Shengjie Guo Tags: Research Paper Source Type: research

Difference in the short-term outcomes of laparoscopic gastrectomy for gastric carcinoma between the east and west: a retrospective study from the IMIGASTRIC trial
Conclusions: The selections and short-term surgical outcomes of LG for GC were widely different between East and West. To obtain more objective and accurate results, these differences should be considered in future international prospective studies. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jian-Xian Lin, Jun-Peng Lin, Jacopo Desiderio, Jian-Wei Xie, Alessandro Gemini, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Mi Lin, Ruhong Tu, Chao-Hui Zheng, Ping Li, Amilcare Parisi, Chang-Ming Huang Tags: Research Paper Source Type: research

Effects of Notch Signaling Pathway in Cervical Cancer by Curcumin Mediated Photodynamic Therapy and Its Possible Mechanisms in Vitro and in Vivo
Curcumin, as a high effect and low toxicity anti-cancer drug and photosensitiser, has synergistic and complementary effects with photodynamic therapy (PDT). However, due to its unclear mechanism, PDT's application and efficacy were limited. Notch signaling pathway, which is highly correlates with carcinogenesis and development of cervical cancer, could be a potential therapeutic targets to improve the effectiveness of PDT. Therefore, in this study, we explored the effects of Notch signaling pathway in cervical cancer by curcumin mediated PDT with/without Notch receptor blocker (DAPT), and hope to elucidate its mechanism.Fi...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Guifang He, Tianlong Mu, Yali Yuan, Wenyan Yang, Yuan Zhang, Qingyun Chen, Meilu Bian, Yanshu Pan, Qing Xiang, Zhihua Chen, Aiping Sun Tags: Research Paper Source Type: research

The Loss of SMAD4/DPC4 Expression Associated with a Strongly Activated Hedgehog Signaling Pathway Predicts Poor Prognosis in Resected Pancreatic Cancer
Background: Pancreatic ductal adenocarcinoma (PDAC) progression is mediated by mutations in driver genes and a complex stroma that is mainly dependent on the Sonic hedgehog (Shh) signaling pathway. However, the association between driver genes and Shh-pathway proteins and their potential prognostic significance remain unclear.Methods: We analyzed protein expressions of the KRAS, TP53, SMAD4, and CDKN2A/P16 driver genes and the Shh-pathway molecules, including Shh, glioma-associated oncogene (Gli) 1, Gli2, and smoothened (SMO) by immunohistochemistry using tissue microarrays in 237 patients with resectable PDAC and statisti...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jin-Zhi Xu, Wen-Quan Wang, Wu-Hu Zhang, Hua-Xiang Xu, He-Li Gao, Shi-Rong Zhang, Chun-Tao Wu, Shuo Li, Hao Li, Jin Xu, Xian-Jun Yu, Liang Liu Tags: Research Paper Source Type: research

Comparison of Safety and Outcomes between Endoscopic and Surgical Resections of Small ( ≤ 5 cm) Primary Gastric Gastrointestinal Stromal Tumors
Background and aims: Endoscopic resection is increasingly performed for gastric gastrointestinal stromal tumors (GIST). However, the safety and outcomes remain elusive. We aimed in this retrospective study to compare operative complications and prognosis between endoscopically and surgically resected small (≤ 5 cm) GIST tumor groups.Methods: In this single-center retrospective study, we compared demographics, clinical outcomes, and the R0 resection rate between the endoscopy (n =268) and surgery (n =141) groups. Only GIST tumors in size of ≤ 5.0 cm were recruited for this comparison study.Results: Overall, the mean a...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Taohong Pang, Yan Zhao, Ting Fan, Qingqing Hu, Dekusaah Raymond, Shouli Cao, Weijie Zhang, Yi Wang, Bin Zhang, Ying Lv, Xiaoqi Zhang, Tingsheng Ling, Yuzheng Zhuge, Lei Wang, Xiaoping Zou, Qin Huang, Guifang Xu Tags: Research Paper Source Type: research

HBV Integration-mediated Cell Apoptosis in HepG2.2.15
In this study, HepG2.2.15 cells showed decreased proliferation, G1 cell cycle arrest and increased apoptosis, when compared to HepG2 cells. HBV capture sequencing was conducted in both genome and transcriptome level, followed by RNA expression sequencing in HepG2.2.15. Here, CAMSAP2/CCDC12/DPP7/OR4F3 were found to be targets for HBV integration in both genome and transcriptome level, accompanied by alteration in their expression when compared to HepG2. Among these genes, DPP7 was the only one gene with HBV integration into its exon, meanwhile DPP7 expression level was also downregulated in HepG2.2.15 as compared to HepG2. ...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xiaoge Hu, Jiahong Jiang, Chao Ni, Qiuran Xu, Song Ye, Junjie Wu, Feimin Ge, Yong Han, Yinyuan Mo, Dongsheng Huang, Liu Yang Tags: Research Paper Source Type: research

Factors associated with improvement in symptoms and quality of life for first-line EGFR-tyrosine kinase inhibitor treatment in patients with EGFR-mutated non-small-cell lung cancer - A multicenter prospective SMILE study
Introduction: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a standard first-line treatment for advanced EGFR-mutated NSCLC patients. Factors associated with symptoms and quality of life (QOL) improvements have not been investigated.Methods: We conducted a multicenter, prospective study to evaluate improvements in QOL and symptoms in NSCLC patients treated with first-line EGFR-TKIs. QOL was assessed using the instrument of Functional Assessment of Cancer Therapy-Lung questionnaire (FACT-L) and Treatment Outcome Index (TOI). Assessment of symptoms was evaluated using the Lung cancer subscale (L...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yu-Feng Wei, Wen-Tsung Huang, Tu-Chen Liu, Jiunn-Min Shieh, Chih-Feng Chian, Ming-Fang Wu, Chih-Cheng Chang, Ching-Hsiung Lin, Jen-Chung Ko, Chia-Mo Lin, Te-Chun Hsia Tags: Research Paper Source Type: research

PARP1 gene polymorphisms and neuroblastoma susceptibility in Chinese children
Neuroblastoma is a heterogeneous cancer frequently occurring in childhood. Germline mutations of PARP1 oncogene are implicated in several types of cancer. However, whether common single nucleotide polymorphisms (SNPs) in PARP1 gene are associated with neuroblastoma risk has received relatively few attentions. In this multi-center study, we aimed to elucidate the contributing role of PARP1 SNPs in neuroblastoma risk. We successfully genotyped three potentially functional PARP1 SNPs (rs1136410 A>G, rs2666428 T>C, rs8679 A>G) in 469 neuroblastoma cases and 998 controls. We did not detect any significant association b...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jiwen Cheng, Zhenjian Zhuo, Pu Zhao, Jinhong Zhu, Yijuan Xin, Jiao Zhang, Peng Li, Ya Gao, Jing He, Baijun Zheng Tags: Research Paper Source Type: research

iTRAQ-based Comparative Serum Proteomic Analysis of Prostate Cancer Patients with or without Bone Metastasis
Conclusion: Mass spectrometry analysis showed that there were more differentially expressed proteins in the serum of patients with bone metastasis than those without metastasis. It has been verified that CD59, haptoglobin and tetranectin are prostate cancer bone metastasis related proteins. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Bo Yan, Binshen Chen, Shaoju Min, Yubo Gao, Yiming Zhang, Peng Xu, Chaoming Li, Jiasheng Chen, Guangheng Luo, Chunxiao Liu Tags: Research Paper Source Type: research

Androgen Receptor Promotes Gastric Carcinogenesis via Upregulating Cell Cycle-Related Kinase Expression
In conclusion, our study demonstrated that AR and CCRK acted as oncogenes in GC progression. However, their clinical roles require further exploration. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ren Wang, Xiao-yi Xu, Hong Zhu, Xiong Liang, Xue Li, Ming-xu Jia, Qing-hua Wang, Hui-yun Wang, Xiao-xing Li, Gui-jun Zhao Tags: Research Paper Source Type: research

Prediction of 10-year Overall Survival in Patients with Operable Cervical Cancer using a Probabilistic Neural Network
Conclusion: The PNN model effectively and reliably predicted 10-year overall survival in women with operable cervical cancer, and may therefore serve as a tool for decision-making process in cancer treatment. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Bogdan Obrzut, Maciej Kusy, Andrzej Semczuk, Marzanna Obrzut, Jacek Kluska Tags: Research Paper Source Type: research

Verteporfin suppresses the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1
Conclusions: Our results indicate that YAP1 overexpression is involved in HNSCC tumorigenesis and verteporfin is a potential therapeutic drug for HNSCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Kui Liu, Shanmei Du, Peng Gao, Jie Zheng Tags: Research Paper Source Type: research

The Role of Upregulated DDX11 as A Potential Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma
Conclusion: DDX11 was significantly upregulated and predicted poor prognosis in ADC. This gene might serve as a potential novel prognostic and diagnostic biomarker for ADC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jianhao Li, Liwen Liu, Xin Liu, Penglin Xu, Qiuyue Hu, Yan Yu Tags: Research Paper Source Type: research

Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging
Background: To develop and validate a radiomic nomogram incorporating radiomic features with clinical variables for individual local recurrence risk assessment in nasopharyngeal carcinoma (NPC) patients before initial treatment.Methods: One hundred and forty patients were randomly divided into a training cohort (n = 80) and a validation cohort (n = 60). A total of 970 radiomic features were extracted from pretreatment magnetic resonance (MR) images of NPC patients from May 2007 to December 2013. Univariate and multivariate analyses were used for selecting radiomic features associated with local recurrence, and multivariate...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Lu Zhang, Hongyu Zhou, Dongsheng Gu, Jie Tian, Bin Zhang, Di Dong, Xiaokai Mo, Jing Liu, Xiaoning Luo, Shufang Pei, Yuhao Dong, Wenhui Huang, Qiuyin Chen, Changhong Liang, Zhouyang Lian, Shuixing Zhang Tags: Research Paper Source Type: research

Comparative study of large cell neuroendocrine carcinoma and small cell lung carcinoma in high-grade neuroendocrine tumors of the lung: a large population-based study
Conclusion: These results suggested that high-grade LCNEC and high-grade SCLC were different histological types, and that a detailed classification for high-grade NETs of the lung was needed. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jian Wang, Ling Ye, Hui Cai, Meiling Jin Tags: Research Paper Source Type: research

Impact of gender as a prognostic factor in HBV-related Hepatocellular Carcinoma: the survival strength of female patients in BCLC stage 0-B
Conclusions: Different outcomes in OS or PFS with respect to gender only exist in BCLC stage 0-B HBV-related HCC patients. Female patients have a better outcome than male patients in BCLC stage 0-B. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Lihua Yu, Xiaoli Liu, Xinhui Wang, Zhibo Dang, Yuyong Jiang, Xianbo Wang, Zhiyun Yang Tags: Research Paper Source Type: research

Dihydromyricetin induced lncRNA MALAT1-TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Dihydromyricetin (DHM), a Rattan tea extract, has been shown to have antitumor activity with no obvious toxicity to normal cells in vitro and in vivo. However, its efficacy in the treatment of CSCC and the underlying antitumor mechanism has not been fully elucidated yet. In our study, DHM increased autophagic flux in the A431 cells, as evidenced by the upregulation of LC3-II and downregulation of P62/SQSTM1. Moreover, the pharmacological or genetic blocking autophagy decreased DHM-induced cell death, indicating DHM triggered autophagic cell dea...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Miduo Tan, Bin Jiang, Haihua Wang, Wei Ouyang, Xiang Chen, Taoli Wang, Dan Dong, Shun Yi, Jiansheng Yi, Yan Huang, Manling Tang, Yan Xiao, Zuiming Jiang, Wei Zhou Tags: Research Paper Source Type: research

Treatment of cancer cells with chemotherapeutic drugs results in profound changes in expression of genes encoding aldehyde-metabolizing enzymes
Using RNA-seq, RT-qPCR, and bioinformatics we have studied the influence of a wide spectrum of chemotherapeutic drugs on transcription of AKR1B10, AKR1C1, ALDH1A1, and ALDH1A3 genes, which encode the major aldehyde-metabolizing enzymes. The strongest alterations were detected in case of AKR1B10 mRNA that was significantly upregulated in wild type p53 cancer cells, but downregulated in mutant p53 cancer cells. Subsequent experiments demonstrated the significant and consistent decrease in the AKR1B10 mRNA content in sera of colon cancer patients, as compared to sera of healthy donors (p
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Olga L. Zinovieva, Evgeniya N. Grineva, George S. Krasnov, Dmitry S. Karpov, Andrei O. Zheltukhin, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Tamara D. Mashkova, Nikolai A. Lisitsyn Tags: Research Paper Source Type: research

SphK1 functions downstream of IGF-1 to modulate IGF-1-induced EMT, migration and paclitaxel resistance of A549 cells: A preliminary in vitro study
Insulin-like growth factor-1 (IGF-1) -induced epithelial-mesenchymal transition (EMT) plays a key role in the metastasis and drug resistance of non-small cell lung cancer (NSCLC). Sphingosine kinase-1 (SphK1) is also involved in EMT of NSCLC. However, the interaction between SphK1 and IGF-1 in the EMT of NSCLC is largely unknown. To clarify this issue, we examined the involvement of SphK1 in IGF-1-induced EMT using human lung cancer cell line A549, and its paclitaxel-resistant subline. Cell viability was evaluated by cell counting kit-8 assay; Migratory ability was examined using scratch wound healing test; Protein express...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xingping Wu, Qibiao Wu, Xiqiao Zhou, Jianan Huang Tags: Research Paper Source Type: research

High NRBP1 expression promotes proliferation and correlates with poor prognosis in bladder cancer
Nuclear receptor binding protein 1 (NRBP1) is an evolutionarily highly conserved adaptor protein with multiple domains. Recently, its role in cancers has received increasing attention. To investigate whether NRBP1 is involved in the development of bladder cancer, we used tissue microarray and analyzed the association between the expression levels of NRBP1 and clinico-pathological features of 56 patients diagnosed with bladder cancer. Subsequently, NRBP1 was silenced using siRNA in bladder cancer cell lines T24 and 5637, and cell phenotype such as proliferation and apoptosis were observed. Further, in vivo tumor formation a...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Qi Wu, Xiaoqing Zhou, Peng Li, Wei Wang, Jun Wang, Mingyue Tan, Le Tao, Jianxin Qiu Tags: Research Paper Source Type: research

GnRHa for Ovarian Protection and the Association between AMH and Ovarian Function during Adjuvant Chemotherapy for Breast Cancer
Conclusion: Data showed that GnRHa may have a protective effect on young breast cancer patients regardless of HR during chemotherapy. AMH could reflect changes of OVF during chemotherapy and predict OVF after chemotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Ying Zhong, Yan Lin, Xinqi Cheng, Xin Huang, Yidong Zhou, Feng Mao, Yajing Wang, Jinghong Guan, Songjie Shen, Yali Xu, Li Peng, Yan li, Xi Cao, Qiang Sun Tags: Research Paper Source Type: research

High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia
Background: Actinins are major cytoskeletal proteins that mediate sarcomere function, and they also have important non-muscle functions such as regulating cytokinesis, cell adhesion and migration. There are four isoforms of actinins in mammals (ACTN1-4). Recently, the relationship between actinins and cancer has been discovered in many types of malignancy, yet their prognostic significance in acute myeloid leukemia (AML) remains unclear.Methods: We collected data of 155 de novo AML patients from The Cancer Genome Atlas (TCGA) database; 85 patients received chemotherapy only and 70 patients underwent allogeneic hematopoieti...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Xinrui Yang, Yifan Pang, Jilei Zhang, Jinlong Shi, Xinpei Zhang, Gaoqi Zhang, Siyuan Yang, Jing Wang, Kai Hu, Jijun Wang, Hongmei Jing, Xiaoyan Ke, Lin Fu Tags: Research Paper Source Type: research

BolA family member 2 enhances cell proliferation and predicts a poor prognosis in hepatocellular carcinoma with tumor hemorrhage
Conclusions: Our results suggest that BOLA2 plays an important role in cancer biology and is an independent predictor of prognosis in HCC. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jia Luo, Dong Wang, Sai Zhang, Kuan Hu, Haijun Wu, Juanni Li, Zhiming Wang, Yiming Tao Tags: Research Paper Source Type: research

Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies
In conclusion, our results suggested that elevated pretreatment RDW level could be a negative predictor for cancer prognosis. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Peng-Fei Wang, Si-Ying Song, Hang Guo, Ting-Jian Wang, Ning Liu, Chang-Xiang Yan Tags: Review Source Type: research

Nutritional Therapy in Cancer Patients Receiving Chemoradiotherapy: Should We Need Stronger Recommendations to Act for Improving Outcomes?
One of the challenges during chemotherapy and radiotherapy is to complete the planned cycles and doses without dose-limiting toxicity. Growing evidence clearly demonstrates the relationship between dose-limiting toxicity and low muscle mass. Moreover, malnutrition leads to low performance status, impaired quality of life, unplanned hospital admissions, and reduced survival.In the past, the lack of clear and authoritative recommendations and guidelines has meant that oncologists have not always fully appreciated the importance of nutritional therapy in patients receiving anticancer treatments. Therefore, collaboration betwe...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Paolo Cotogni, Paolo Pedrazzoli, Elisabeth De Waele, Giuseppe Aprile, Gabriella Farina, Silvia Stragliotto, Francesco De Lorenzo, Riccardo Caccialanza Tags: Review Source Type: research

Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas
Conclusion: Our findings highlight the highly expression of SR-B1 in liposarcomas. SR-B1 may be a potential biomarker for the diagnosis of liposarcoma and may indicate the degree of differentiation of liposarcomas. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Qianqian Liu, Zhenzhen Li, Hao Shang, Qiaochu Zhang, Xiaomeng Wang, Yangyang Zhang, Yang Wang, Qianru Li, Chunsen Li, Chunxia Liu, Feng Li Tags: Research Paper Source Type: research

Elevated MRE11 expression associated with progression and poor outcome in prostate cancer
Conclusion: In conclusion, our study reveals that elevated MRE11 expression is significantly correlated with cancer progression and poor survival in PCa patients. These data suggest that MRE11 may act as an oncoprotein and a promising prognostic marker for PCa patients. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Jun Wang, Wen-Hao Xu, Yu Wei, Yao Zhu, Xiao-Jian Qin, Hai-Liang Zhang, Ding-Wei Ye Tags: Research Paper Source Type: research

Detection of Plasma EGFR Mutations in NSCLC Patients with a Validated ddPCR Lung cfDNA Assay
Conclusions: We validated in this study that the ddPCR Lung cfDNA Assay is reliable for detection of EGFR mutations in lung cancers, in terms of analytical performance, clinical validity and utility. (Source: Journal of Cancer)
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Qiao-mei Guo, Lin Wang, Wen-jun Yu, Li-hua Qiao, Ming-na Zhao, Xiao-meng Hu, Ya-meng Sun, Sheng Ni, Yun-hua Xu, Jia-tao Lou Tags: Research Paper Source Type: research

MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment
Myeloid-derived suppressor cells (MDSCs), one heterogeneous population of immature myeloid cells, have suppressive function on immune response during tumor, inflammation, infection and autoimmune diseases. The molecular mechanism underlying expansion and function of MDSCs is becoming appreciated to manipulate immune response in the diseases. MicroRNA (miRNAs) as one short noncoding RNAs, are involved in regulating cell proliferation, differentiation and maturation. However, it needs to be further studied how miRNAs mediate the development and function of MDSC in association with cancer and other diseases. In the review, we...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yanping Su, Ye Qiu, Zhidong Qiu, Peng Qu Tags: Review Source Type: research