FOXO3a-dependent up-regulation of HSP90 alleviates cisplatin-induced apoptosis by activating FUNDC1-mediated mitophagy in hypoxic osteosarcoma cells

In conclusion, our findings suggest that hypoxia alleviates CDDP-induced apoptosis by activating mitophagy through the FOXO3a/HSP90/Ulk1/FUNDC1 signaling pathway in OS cells.PMID:36270475 | DOI:10.1016/j.cellsig.2022.110500

Source: Cellular Signalling - October 21, 2022 Category: Cytology Authors: Dian Lu Rui Liu Yuting Zhou Zhenbo Zhang Xiuqin Jiang Jinjin Xu Airong Su Zhenzhen Hu Source Type: research